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昌九高铁扬子洲赣江公铁大桥西支主桥桥塔设计

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世界桥梁 2024年第2期52卷 14-20页

作者：郭安娜严爱国王新国崔苗苗周刚中铁第四勘察设计院集团有限公司湖北武汉430063

昌九高铁扬子洲赣江公铁大桥西支主桥采用竖琴形索面箱桁组合梁斜拉桥,跨径布置为(48+144+320+144+48)m。根据桥梁结构特点,针对花瓶形、H形和钻石形桥塔方案,从结构受力、景观效果、施工难度、经济性等方面进行比选,最终采用适应宽主... 详细信息

昌九高铁扬子洲赣江公铁大桥西支主桥采用竖琴形索面箱桁组合梁斜拉桥,跨径布置为(48+144+320+144+48)m。根据桥梁结构特点,针对花瓶形、H形和钻石形桥塔方案,从结构受力、景观效果、施工难度、经济性等方面进行比选,最终采用适应宽主梁、竖琴形索面的花瓶形桥塔。2座桥塔高度分别为143.5 m和147.1 m,采用C50钢筋混凝土结构,由上、中、下塔柱组成,塔柱圆弧过渡,设上、下2道横梁,下横梁采用预应力混凝土结构,上横梁由2道反向圆弧的预应力混凝土小横梁和中间的装饰性钢结构共同组成“昌”字造型。索塔锚固区采用钢锚箱锚固体系与预应力锚固体系相结合的方式。桥塔下塔柱采用翻模法施工,中、上塔柱外部采用爬模法施工、内部采用翻模法施工。对桥塔进行整体静力、局部应力、稳定性及抗震分析,结果表明桥塔强度、刚度、稳定性及抗震性能均满足规范要求。

关键词：斜拉桥公路铁路两用桥花瓶形桥塔文字装饰横梁索塔锚固受力分析桥梁设计

Heterogeneous catalysts with programmable topologies generated by reticulation of organocatalysts into metal-organic frameworks:The case of squaramide

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nano Research 2021年第2期14卷 458-465页

作者： anna Broto-Ribas Claudia Vignatti Alicia Jimenez-Almarza Javier Luis-Barrera Zahra Dolatkhah Felipe Gandara Inhar Imaz Ruben Mas-Balleste Jose Aleman Daniel Maspoch Catalan Institute of nanoscience and nanotechnology(ICn2) CSIC and The Barcelona Institute of Science and Technology08193 BarcelonaSpain Inorganic Chemistry Department Modulo 7Universidad Autonoma de Madrid28049 MadridSpain Organic Chemistry Department Modulo 1Universidad Autonoma de Madrid28049 MadridSpain Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM)Consejo Superior de Investigaciones Cientificas(CSIC)Calle Sor Juana Ines de la Cruz328049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Campus Universidad Autonoma de Madrid28049 MadridSpain Institucio Catalana de Recerca i Estudis Avangats(ICREA) 08100 BarcelonaSpain

A well-established strategy to synthesize heterogeneous,metal-organic framework(MOF)catalysts that exhibit nanoconfinement effects,and specific pores with highly-localized catalytic sites,is to use organic linkers containing organocatalytic ***,we report that by combining this linker approach with reticular chemistry,and exploiting three-dimensioanl(3D)MOF-structural data from the Cambridge Structural Database,we have designed four heterogeneous MOF-based catalysts for standard organic *** programmable MOFs are isoreticular versions of pcu IRMOF-16,feu UiO-68 and pillared-pcu SnU-8X,the three most common topologies of MOFs built from the organic linker p.p'-terphenyldicarboxylic acid(tpdc).To synthesize the four squaramide-based MOFs,we designed and synthesized a linker,4,4’-((3,4-dioxocyclobut-1-ene-1,2-diyl)bis(azanedyil))dibenzoic acid(Sq_tpdc),which is identical in directionality and length to tpdc but which contains organocatalytic squaramide *** were chosen because their immobilization into a framework enhances its reactivity and stability while avoiding any self-quenching ***,the four MOFs share the same organocatalytic squaramide moiety,but confine it within distinct pore *** then evaluated these MOFs as heterogeneous H-bonding catalysts in organic transformations:a Friedel-Crafts alkylation and an epoxide *** of them exhibited good performance in both reactions but all showed distinct catalytic profiles that reflect their structural differences.

关键词： reticular chemistry metal-organic frameworks H-bond catalysis squaramide Friedel-Cratts epoxide ring-opening

Causal analysis of competing atomistic mechanisms in ferroelectric materials from high-resolution scanning transmission electron microscopy data

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npj Computational Materials 2020年第1期6卷 570-578页

作者： Maxim Ziatdinov Christopher T.nelson Xiaohang Zhang Rama K.Vasudevan Eugene Eliseev anna n.Morozovska Ichiro Takeuchi Sergei V.Kalinin The Center for nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Computational Sciences and Engineering Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Institute for Problems of Materials Science National Academy of Sciences of UkraineKrjijanovskogo 3Kyiv 03142Ukraine Institute of Physics National Academy of Sciences of Ukraine46pr.NaukyKyiv 03028Ukraine

Machine learning has emerged as a powerful tool for the analysis of mesoscopic and atomically resolved images and spectroscopy in electron and scanning probe microscopy,with the applications ranging from feature extraction to information compression and elucidation of relevant order parameters to inversion of imaging data to reconstruct structural ***,the fundamental limitation of machine learning methods is their correlative nature,leading to extreme susceptibility to confounding ***,we implement the workflow for causal analysis of structural scanning transmission electron microscopy(STEM)data and explore the interplay between physical and chemical effects in a ferroelectric perovskite across the ferroelectric–antiferroelectric phase transitions.

关键词： ferroelectric analysis founding

Median arcuate ligament syndrome often poses a diagnostic challenge: A literature review with a scope of our own experience

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1048-1055页

作者： Alexandros Giakoustidis Stavros Moschonas Gregory Christodoulidis Danae Chourmouzi anna Diamantidou Sophia Masoura Eleni Louri Vasileios n Papadopoulos Dimitrios Giakoustidis Department of Surgery General Hospital PapageorgiouAristotle University of ThessalonikiThessaloniki 56429Greece Fifth Department of Surgery Interbalkan European Medical CentreThessaloniki 55535Greece Department of General Surgery University Hospital of LarissaLarissa 41110Greece

The median arcuate ligament syndrome(MALS)is recognized as a rare clinical entity,characterized by chronic post-prandial abdominal pain,nausea,vomiting,and unintentional weight *** to its vague symptomatology,it is mainly regarded as a diagnosis of *** can often be misdiagnosed for several years before a correct diagnosis is established,also due to a medical team’s clinical *** present a case series of two patients who suffered from MALS and were treated *** first patient is a 32-year-old woman,presenting with post-prandial abdominal pain and weight loss that have lasted for the past ten *** second patient,a 50-year-old woman,presented with similar symptomatology,with the symptoms lasting for the last five *** cases were treated by laparoscopic division of the median arcuate ligament fibers,which alleviated extrinsic pressure from the celiac *** cases of MALS were retrieved from PubMed,to assemble a better diagnostic algorithm and propose a treatment method of *** literature review suggests an angiography with a respiratory variation protocol as the diagnostic modality of choice,along with the laparoscopic division of the median arcuate ligament fibers as the proposed treatment of choice.

关键词： Median arcuate ligament syndrome Dunbar syndrome Celiac trunk compression syndrome Celiac artery compression syndrome Case series Review

Effects of chronic and subtoxic chlorobenzenes on adrenocorticotrophic hormone release

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Journal of Environmental Sciences 2015年第8期27卷 165-170页

作者： Zsolt Molnár Regina Pálf?ldi anna László Marianna Radács Krisztián Sepp Péter Hausinger László Tiszlavicz Zsuzsanna Valkusz Márta Gálfi Institute of Applied Science Department of Environmental Biology and Education Gyula Juhász Faculty of Education University of Szeged Department of Pulmonology Faculty of Medicine University of Szeged Department of Medical Physics and Informatics Faculty of Medicine University of Szeged Endocrine Unit of First Department of Internal Medicine Faculty of Medicine University of Szeged Invasive Cardiology Department Second Department of Internal Medicine and Cardiology Faculty of Medicine University of Szeged Department of Pathology Faculty of Medicine University of Szeged

Many environmental chemicals and pesticides have been found to alter neuroendocrine communication in exposed biological objects. The environmental loads have primary and secondary effects that can alter the homeostatic regulation potential. Since it is difficult to avoid human exposition, a potentially important area of research to develop in vivo and in vitro experimental models. In this context, the primary aim of this study was to demonstrate the effects of chlorobenzenes on adrenocorticotrophic hormone（ACTH） release. In our experimental study, male Wistar rats were exposed to 0.1, 1.0 and 10 μg/b.w.（body weight） kg of 1,2,4-trichlorobenzene and hexachlorobenzene（Cl B） mix via gastric tube for 30, 60 or 90 days. At the endpoints of the experiment blood samples were taken and animals were decapitated. Primary,monolayer adenohypophysis cell cultures were prepared by enzymatic and mechanical digestion. The ACTH hormone content in serum and supernatant media was measured by immuno-chemiluminescence assay. The Mg2＋-dependent ATPase activity was determined by modified method of Martin and Dotty. Significant differences were detected in the hormone release between the control and treated groups. The hormone release was enhanced characteristically in exposed groups depending upon the dose and duration of exposure. The Mg2＋-ATPase activity enhanced after chronic and subtoxic Cl B exposition. Light microscopy revealed that the adenohypophysis seemed to be more abundant. Results indicate that Wistar rats exposed to subtoxic Cl B have direct and indirect effects on hypothalamus–hypophysis–adrenal axis.

关键词： Chlorobenzenes Subtoxic Adrenocorticotrophic hormone release Mg2+ -dependent ATPase

Low-Cost Tiled Display System Architecture with Dynamic Web-Based Management

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China Communications 2022年第10期19卷 143-168页

作者： Daniel Marfil Fernando Boronat F.Javier Pastor anna Vidal Communications Department Gandia CampusUniversitat Politecnica de ValenciaCalle Paraninfo146730Grao de GandiaValencia(Spain) Drawing Department Gandia CampusUniversitat Politecnica de ValenciaCalle Paraninfo146730Grao de GandiaValencia(Spain) Applied Mathematics Department Gandia CampusUniversitat Politecnica de ValenciaCalle Paraninfo146730Grao de GandiaValencia(Spain)

In this paper, a scalable hardware and software architecture for tiled display systems (a.k.a. videowalls), which can be implemented by using low-cost devices, together with a dynamic web-based management and configuration service are proposed. It has been designed to support both stored and live broadcast/broadband content, in mosaic or warp distributions. The displays and devices can be dynamically configured via web in different ways: the displays can create a single display of a larger size;or they can be configured in a customized way in order to playout different media contents in different display combinations. As display renderers, low-cost devices are proposed as the main hardware element to obtain affordable videowall systems. As a proof of concept, two prototypes have been implemented, including an accurate synchronization mechanism based on a Master/Slave control scheme and aggressive and smooth playout adjustment techniques. To evidence the good performance of the prototypes and configuration service, both objective and subjective evaluations have been conducted regarding synchronization accuracy and usability. On the one hand, the mean values of the asynchronies between the video playout processes in each display are kept below 25ms (i.e., frame accuracy). On the other hand, the obtained usability score in the System Usability Scale (SUS) test has been 88.65, which is considered as excellent.

关键词： AMP media synchronization multi-screen playout adjustment tiled displays videowall

富含半胱氨酸和甘氨酸蛋白2在神经母细胞瘤恶性进展中的功能和机制

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北京大学学报（医学版） 2024年第3期56卷 495-504页

作者：张瑶郭金鑫战世佳洪恩宇杨慧贾安娜常艳郭永丽张璇国家儿童医学中心首都医科大学附属北京儿童医院儿科重大疾病研究教育部重点实验室北京市儿科研究所儿童耳鼻咽喉头颈外科疾病北京市重点实验室北京100045

目的:探究富含半胱氨酸和甘氨酸蛋白2(cysteine and glycine-rich protein 2,CSRP2)在神经母细胞瘤(neuroblastoma,nB)恶性进展中的功能和作用机制。方法:利用R2数据库分析nB临床样本中CSRP2基因的mRnA水平与nB患儿临床预后的相关性;在n... 详细信息

目的:探究富含半胱氨酸和甘氨酸蛋白2(cysteine and glycine-rich protein 2,CSRP2)在神经母细胞瘤(neuroblastoma,nB)恶性进展中的功能和作用机制。方法:利用R2数据库分析nB临床样本中CSRP2基因的mRnA水平与nB患儿临床预后的相关性;在nB细胞系SK-n-BE(2)和SH-SY5Y中利用靶向小干扰RnA(small interfering RnA,siRnA)干扰CSRP2的表达或利用质粒转染过表达CSRP2;通过结晶紫染色和实时无标记动态细胞分析技术观察nB细胞的增殖情况;采用克隆形成方法观察nB细胞长时间的克隆形成能力;利用免疫荧光实验检测细胞增殖标记物Ki-67的水平;利用碘化丙啶(propidium iodide,PI)染色流式细胞术分析细胞周期比例,Annexin V/7AAD染色分析细胞凋亡比例;采用划痕实验观察细胞的迁移能力;利用Western blot或实时荧光定量PCR(quantitative real-time PCR,RT-qPCR)检测nB原发肿瘤组织和细胞系中蛋白和基因的表达水平。结果:nB临床数据库中,国际神经母细胞瘤分期(international neuroblastoma staging system,InSS)为高危险度3/4期的nB组织中CSRP2的mRnA水平显著高于低危险度的1/2期,且高表达水平组nB患儿的生存期显著低于低表达组;Western blot结果显示,CSRP2在3/4期nB组织中的蛋白水平显著高于1/2期。nB细胞中敲低CSRP2,细胞的活力减弱、增殖能力降低;nB细胞中过表达CSRP2促进细胞增殖;敲低CSRP2后,sub-G1、G0/G1和S期细胞的比例增加,Annexin V阳性细胞的比例增多;敲低CSRP2的nB细胞的划痕愈合率显著小于对照组。机制研究发现,敲低CSRP2后细胞增殖标记分子Ki-67和细胞外信号调节激酶1/2(extracellular signal-regulated kinases 1/2,ERK1/2)磷酸化水平显著低于对照组。结论:CSRP2在高危险度3/4期nB组织中高表达,表达水平与nB患儿生存期呈负相关;CSRP2通过促进ERK1/2活化,促进nB细胞的增殖和迁移,抑制细胞凋亡,表明CSRP2通过激活ERK1/2促进nB进展,为高危nB的靶向治疗提供了潜在的靶点。

关键词：富含半胱氨酸和甘氨酸蛋白2 神经母细胞瘤细胞增殖细胞迁移细胞外信号调节激酶1/2

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Inter-sexual multimodal communication during mating in wild geladas:the leading role of females

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Current Zoology 2022年第5期68卷 570-580页

作者： anna Zanoli Marco Gamba Alban Lemasson Ivan norscia Elisabetta Palagi 无 Department of Life Sciences and Systems Biology University of TurinVia Accademia Albertina 13Torino 10123Italy University of Rennes University of NormandieCNRSEthoS(Éthologie Animale et Humaine)263 Av.Général LeclercRennes 35700France Institut Universitaire de France 1 Rue DescartesParis 75005France natural History Museum University of PisaVia Roma 79Calci(Pisa)56011Italy Department of Biology Unit of EthologyUniversity of Pisa Via Alessandro Volta 6Pisa 50126Italy

Female primates can emit vocalizations associated with mating that can function as honest signals of ***,we investigated the role of mating calls and visual signals in female geladas(Theropithecus gelada).Because females have a central role in the gelada society and seem to solicit sexual interactions,we answered whether they emit vocalizations in conjunction with gazing to increase mating success *** and during copulations,females can emit pre-copulation calls and copulation *** the first time,we identified a new female vocalization emitted at the final stage of copulations(end-copulation call),possibly marking the occurrence of *** found that longer pre-copulation call sequences were followed by both prolonged copulations and the presence of end-copulation calls,thus suggesting that females use pre-copulation calls to ensure successful copula ***,we found that different combinations of female vocal types and gazing had different effects on male vocal behavior and motivation to complete the *** analysis of the vocal and visual signals revealed a complex inter-sexual multimodal chattering with the leading role of females in the signal *** chattering,led by females,modulates male sexual arousal,thus increasing the probability of the copula success.

关键词： copulation calls female end-copulation call inter-sexual coordination mating success multimodal communication Theropithecus gelada

Determination of drug,excipients and coating distribution in pharmaceutical tablets using nIR-CI

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Journal of Pharmaceutical Analysis 2012年第2期2卷 90-97页

作者： anna Palou Jordi Cruz Marcelo Blanco Jaume Tomàs Joaquín de los Ríos Manel Alcalà Unitat de Química Analítica Departament de QuímicaFacultat de CiènciesUniversitat Autònoma de Barcelona08193 BellaterraBarcelonaSpain Escola Universitària Salessiana de Sarrià Passeig Sant Joan Bosco7408017 BarcelonaSpain Esteve Farma c/Sant Martí s/n08197 MartorellesBarcelonaSpain

The growing interest of the pharmaceutical industry in near Infrared-Chemical Imaging (nIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been *** addition,the same nIR-CI allowed the coating thickness and its surface distribution to be *** were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS) *** concentrations of Active Pharmaceutical Ingredient (API) and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical *** the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased.

关键词： near infrared Chemical Imaging (nIR-CI) Hyperspectral imaging Component distribution Tablet coating distribution Partial Least Squares (PLS) regression