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Monoclonal antibodies and aptamers:The future therapeutics for Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2795-2814页

作者： Alvaro barrera-Ocampo Facultad de Ingenierıa Diseno y Ciencias AplicadasDepartamento de Ciencias Farmaceuticas y QuimicasGrupo NaturaUniversidad IcesiCali 760031Colombia

Alzheimer’s disease(AD)is considered the most common and prevalent form of dementia of adult-onset with characteristic progressive impairment in cognition and *** cure for AD has not been found yet and the treatments available until recently were only *** of multidisciplinary approaches and efforts made by pharmaceutical companies,it was only in the past two years that new drugs were approved for the treatment of the *** beta(Aβ)immunotherapy is at the core of this therapy,which is one of the most innovative approaches looking to change the course of *** technology is based on synthetic peptides or monoclonal antibodies(mAb)to reduce Ab levels in the brain and slow down the advance of ***,this article reviews the state of the art about AD neuropathogenesis,the traditional pharmacologic treatment,as well as the modern active and passive immunization describing approved drugs,and drug prototypes currently under investigation in different clinical *** addition,future perspectives on immunotherapeutic strategies for AD and the rise of the aptamer technology as a non-immunogenic alternative to curb the disease progression are discussed.

关键词： Aβ Monoclonal antibody DNA aptamers Cognitive impairment Alzheimer’s disease Clinical trials Immunotherapy Machine learning

Do new neurons contribute to functional reorganization after brain damage?

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Neural Regeneration Research 2018年第12期13卷 2083-2084页

作者： Clorinda Arias angelica Zepeda Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México

The finding that adult neurogenesis occurs constitutively in the brain was a breakthrough in neuroscience and soon gained attention as a possible mechanism for neurorepair after brain damage. In a recent study we show that the dentate gyrus （DG） reorganizes anatomically over neurons undergo maturation time after damage, while new and activate in response to a contextual fear memory recall （Aguilar-Arredondo and Zepeda, 2018）. These findings provide new evidence on the possible role of neurogenesis in cognitive recovery after brain injury.

关键词： Do new neurons contribute to functional reorganization after brain damage

Activated Natural Killer Cells Hit Neurogenesis in the Aging Brain

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Neuroscience Bulletin 2021年第7期37卷 1072-1074页

作者： angelica Cuapio Hans-Gustaf Ljunggren Center of Infectious Medicine Department of Medicine HuddingeKarolinska Institutet14152 StockholmSweden

Why neurogenesis is attenuated in elderly individuals is an intriguing question that has raised renewed *** associated with declined neurogenesis in the aged brain have been attributed to inflammatory cytokines[1].More recently,a specific role for interferon-y(IFN-y)produced by CD8-expressing cytotoxic T cells has been implicated[2].These observations suggest a scenario in which neurogenesis,at least in part,is regulated by immune cells within the aging *** raises several interesting questions with regards to the characteristics of specific immune cells within the brain,the signals for their expansion and maintenance,and their role in affecting neurogenesis and cognition during normal brain aging.

关键词： interferon Killer attributed

Parabolic Trough Collector and Central Receiver Coupled with Fresnel Lens:Experimental Tests

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International Journal of Automation and computing 2020年第4期17卷 572-587页

作者： angelica Palacios Dario Amaya Olga Ramos Universidad Militar Nueva Granada Bogota 110121Colombia

Renewable energies have a high impact on power energy production and reduction of environmental pollution worldwide,so high efforts have been made to improve renewable technologies and research about *** paper presents the thermal performance results obtained by simulation and experimental tests of a parabolic trough collector with central receiver coupled to Fresnel lens,under different configurations on the *** simulation method was computational fluid dynamics(CFD)analysis in SolidWorks(R)soft-ware tool,which works with Naiver-Stokes equations to converge on a *** tests were formed with all configurations proposed and three observations for each one,a total of 12 observations were performed in all *** a result,the best thermal performance in simulation was achieved with the Fresnel lens and black pipe collector,with a maximum temperature of 116℃under 1000 W/m^2 radiation,the same system achieved in experimental tests a maximum temperature of 96℃with a radiation of 983 W/m^2.

关键词： Solar collector parabolic trough collector Fresnel lens thermal conductivity solar power

New determinants of prognosis in bacterial infections in cirrhosis

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World Journal of Gastroenterology 2014年第23期20卷 7252-7259页

作者： Juan acevedo Javier Fernández Department of Gastroenterology and Hepatology Hospital of Calella08370 BarcelonaCatalunyaSpain Liver Unit Hospital ClínicUniversity of Barcelona08150 BarcelonaCatalunyaSpain Institut d’Investigacions Biomèdiques August-Pi-Sunyer (IDIBAPS) 08036 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHED) 08150 BarcelonaSpain

Despite major advances in the knowledge and management of liver diseases achieved in recent decades,decompensation of cirrhosis still carries a high burden of morbidity and *** infections are one of the main causes of *** is very important for clinical management to be aware of the population with the highest risk of poor *** review deals with the new determinants of prognosis in patients with cirrhosis and bacterial infections reported *** of multiresistant bacteria has led to an increasing failure rate of the standard empirical antibiotic therapy recommended by international ***,it has been recently reported that endothelial dysfunction is associated with the degree of liver dysfunction and,in infected patients,with the degree of *** has also been reported that relative adrenal insufficiency is frequent in the non-critically ill cirrhotic population and it is associated with a higher risk of developing infection,severe sepsis,hepatorenal syndrome and *** advise a change in the standard empirical antibiotic therapy in patients with high risk for multiresistant infections and also to take into account endothelial and adrenal dysfunction in prognostic models in hospitalized patients with decompensated cirrhosis.

关键词： Bacterial infections Liver cirrhosis Drug resistance Bacterial Endothelial dysfunction Relative adrenal insufficiency

Multiresistant bacterial infections in liver cirrhosis: Clinical impact and new empirical antibiotic treatment policies

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World Journal of Hepatology 2015年第7期7卷 916-921页

作者： Juan acevedo Department of Gastroenterology and Hepatology Queen Alexandra Hospital

Recently, important changes have been reported regarding the epidemiology of bacterial infections in liver cirrhosis. There is an emergence of multiresistant bacteria in many European countries and also worldwide, including the United States and South Korea. The classic empirical antibiotic treatment(third-generation cephalosporins, e.g., ceftriaxone, cefotaxime or amoxicillin-clavulanic acid) is still effective in infections acquired in the community, but its failure rate in hospital acquired infections and in some health-care associated infections is high enough to ban its use in these settings. The current editorial focuses on the different epidemiology of bacterial infections in cirrhosis across countries and on its therapeutic implications.

关键词： Bacterial infections Multiresistant bacteria Antibiotic Liver cirrhosis

Representation of an Electrical Engineering Curriculum Using an Ontology of Controlled Quality

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Journal of Mechanics Engineering and Automation 2014年第2期4卷 130-141页

作者： Carolina Sarmiento Oscar Duarte angelica Ghisays Maria barrera Rene Soto Department of Systems and Industrial Engineering Faculty of Engineering Universidad Nacional de Colombia Bogota 111321Colombia Department of Electrical and Electronic Engineering Faculty of Engineering Universidad Nacional de Colombia Bogota 111321Colombia

A curriculum is a complex system that includes a set of core competencies, objectives, contents, methodological and evaluation criteria, regulation among other things. In order to represent a curriculum as a piece of software the common tools used are databases, trees and lists of courses. However, none of these tools can capture the deep and complex relationships among the elements of a curriculum. To avoid this problem, a more complete representation of an engineering curriculum using ontologies has been developed. This paper presents the construction of an ontology for undergraduate electrical engineering curriculum domain at Universidad Nacional de Colombia, which aims to represent, organize, formalize and standardize the knowledge of this domain, so that it can be shared and reused by different groups of people in the field of education and engineering. The ontology includes four curriculum aspects： knowledge in electrical engineering, skills in engineering, electrical engineering curriculum and regulation. For the ontology development, Methontology was selected as methodology and Protege as implementation tool. In addition, there is a proposal of documentation for this methodology, based on principles of quality management systems. This ontology is designed in order to be used in any field of engineering.

关键词： Curriculum Methontology ontological engineering Protege quality management systems.

Influence of microbial priming and seeding depth on germination and growth of native wildflowers

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Ecological Processes 2021年第1期10卷 266-273页

作者： Daniela barrera Juan Luera Kaitlynn Lavallee Pushpa Soti Mathematics and Science Academy University of Texas-Rio Grande ValleyEdinburg 78539USA Sharyland Pioneer High School MissionTX 78573USA. Department of Biology University of Texas-Rio Grande ValleyEdinburgTX 78539USA. School of Earth Environmentand Marine SciencesUniversity of Texas-Rio Grande ValleyEdinburgTX 78539USA.

Background:Using native wildflowers for restoring marginal lands has gained considerable *** of wildflowers can be challenging due to several environmental *** the microbial community in degraded habitats can potentially result in the native plant performance and habitat *** study was conducted to investigate the impact of native soil microbes and seeding depth on germination of south Texas native *** wildflower species,Ratibida columnifera(Nutt.)(Mexican Hat)and Verbesina encelioides(Cav.)(cowpen daisy),were treated with microbial wash extracted from native soils,and germination rate was recorded for 14-day *** further analyzed the growth,biomass allocation,and root colonization by mycorrhizal fungi in these two plants growing them in a plant growth chamber for 6 *** determine the impact of seeding depth,we planted the seeds of the two plant species at 2-cm,6-cm,and 12-cm depth and monitored germination and plant ***:The two species responded differently to the seeding depth and microbial wash *** wash treatment resulted in higher germination rate in *** compared to control,while it did not have any impact on *** seed *** microbial treatment did not influence the total biomass,it had a significant impact on the biomass allocation in both the plant *** seeds germinated at both 2-cm and 6-cm depth and did not germinate at 12 cm,while the *** seeds germinated only at 2 cm and did not germinate at 6-cm or 12-cm seeding ***:While our results are species specific,our results indicate that native soil microbes can potentially improve the seed germination and growth of *** results also indicate the importance of specific seeding depth when sowing wildflower seeds for habitat restoration.

关键词： Habitat restoration Soil microbes Seeding depth Wildflowers Root endophytes

Estrogen rapid effects:a window of opportunity for the aging brain?

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Neural Regeneration Research 2022年第8期17卷 1629-1632页

作者： Ivanny Marchant Jana Stojanova Lilian acevedo Pablo Olivero Laboratorio de Modelamiento en Medicina Escuela de MedicinaUniversidad de ValparaísoViña del MarChile Interdisciplinary Centre for Health Studies(CIESAL) Universidad de ValparaísoViña del MarChile Servicio de Neurología Hospital Carlos van Buren ValparaísoChile Laboratorio de Estructura y Función Celular Escuela de MedicinaFacultad de MedicinaUniversidad de ValparaísoValparaísoChile Centro Interoperativo en Ciencias Odontológicas y Médicas Universidad de ValparaísoValparaísoChile

Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective *** therapy has been widely used to treat menopausal estrogen deficiency for more than 80 *** high initial expectations of cardioprotective effects,there has been substantial distrust following important randomized clinical trials,such as the Women’s Health ***,the timing of treatment in relation to the onset of menopause came under consideration and led to the proposal of the timing hypothesis,that early initial treatment is important,and benefits are lost as the timing since menopause becomes *** analyses of the Women’s Health Initiative data,together with more recent data from randomized and observational trials,consistently show reductions in coronary heart disease and mortality in younger menopausal *** cognitive function,the timing hypothesis is consistent with observations from basic and animal *** is some clinical evidence to support the benefits of hormonal therapy in this context,though skepticism remains due to the paucity of clinical trials of substantial length in younger menopausal *** is likely that the effects of estrogens on cognitive performance are due to rapid mechanisms,including mechanisms that influence Ca2+homeostasis dynamics,provide protection in a hostile environment and reduce inflammatory signals from neural *** the future,inflammatory profiles accounting for early signs of pathological inflammation might help identify the‘window of opportunity’to use estrogen therapy for successful cognitive protection.

关键词： aging cardiovascular prevention cognitive function estrogen hormone treatment inflammaging rapid effects timing hypothesis TRPV1 window of opportunity