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Mortality Trends for Neglected Tropical Diseases in the State of Sergipe,Brazil,1980-2013

Infectious Diseases of Poverty 2017年第1期6卷 173-180页

作者： Marcos Antonio Costa de Albuquerque danielle Menezes Dias Lucas Teixeira Vieira Carlos Anselmo Lima angela maria da silva University Hospital Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil Post-doc Medicine Unit Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil

Background:Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status,particularly 1.4 billion people who are living below the poverty *** study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe,Northeast Region of ***:We conducted an ecological study of time series,based on secondary data derived from the Mortality Information System of the Ministry of *** mortality rates(crude,age-standardized rates and proportional ratio)were calculated from the deaths due to Neglected Tropical Diseases in the state of Sergipe,from 1980 to *** time trends were obtained using the Joinpoint regression ***:Three hundred six thousand and eight hundred seventy-two deaths were certified in the state and Neglected Tropical Diseases were mentioned as the underlying cause in 1,203 certificates(0.39%).Mean number of deaths was 35.38 per year,and crude and age-standardized mortality rates were,respectively:2.16 per 100000 inhabitants(95%CI:1.45-2.87)and 2.87 per 100000 inhabitants(95%CI:1.93-3.82);the proportional mortality ratio was 0.41%(95%CI:0.27-0.54).In that period,Schistosomiasis caused 654 deaths(54.36%),followed by Chagas disease,with 211(17.54%),and by Leishmaniases,with 142(11.80%)*** other diseases totalized 196 deaths(16.30%).There were increasing mortality trends for Neglected Tropical Diseases,Schistosomiasis and Chagas disease in the last 15 years,according to the age-standardized rates,and stability of the mortality trends for ***:The Neglected Tropical Diseases show increasing trends and are a real public health problem in the state of Sergipe,since they are responsible for significant mortality *** following diseases call attention for showing greater number of deaths in the period of study:Schistosomiasis,Chagas disease and *** finally suggest that public managers take appropri

关键词： Mortality Neglected tropical diseases Trends Joinpoint

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Correlation of Disgust and Contempt Expressions with Conjugal Dissatisfaction

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Journal of Behavioral and Brain Science 2018年第10期8卷 562-573页

作者： Rui Mateus Joaquim Tariane Franciele Bastos Pereira Laiza de Oliveira Vilela Tayná Maiara Pilla Rodrigues angela maria da silva Muniz Brandino Sandro Caramaschi Faculty of Human Sciences Federal University of Grande Dourados-UFGD Dourados Mato Grosso do Sul Brazil Postgraduate Program in Developmental and Learning Psychology S&#227 o Paulo State University-UNESP/Bauru S&#227 o Paulo Brazil Faculdade Anhanguera Educacional de Bauru Bauru S&#227 o Paulo Brazil

Research has shown that dissatisfied couples in the relationship commonly exhibit facial expressions of contempt in interactions. At this point, based on the study of cognition and physiology, researchers were able to predict by longitudinal studies the probability of divorce in a marriage, with accuracy of up to 94%. Our objective was to investigate whether the occurrence of facial expressions of disgust and contempt in married women is associated with marital dissatisfaction. This is an experimental study that correlated, through filmed interviews, the frequency of facial expressions of disgust and disgust (Facial Action Coding System) to the Marital State’s Golombok Rust Inventory, in a sample composed of 20 women. data analysis based on the Spearman Correlation Test showed a positive correlation between facial expressions of disgust and disdain and conjugal dissatisfaction (rs = 0.2198, p = 0.0280), corroborating the data in the literature.

关键词： Facial Expressions Disgust Contempt Nonverbal Communication Marital Dissatisfaction

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Siderophore-Producing Rhizobacteria as a Promising Tool for Empowering Plants to Cope with Iron Limitation in Saline Soils:A Review

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Pedosphere 2019年第4期29卷 409-420页

作者： maria J.FERREIRA Helena silva angela CUNHA Biology Department and Centre for Environmental and Marine Studies(CESAM) University of Aveiro Campus de Santigo

Iron(Fe) bioavailability to plants is reduced in saline soils;however, the exact mechanisms underlying this effect are not yet completely understood. Siderophore-expressing rhizobacteria may represent a promising alternative to chemical fertilizers by simultaneously tackling salt-stress effects and Fe limitation in saline soils. In addition to draught, plants growing in arid soils face two other major challenges: high salinity and Fe deficiency. Salinity attenuates growth, affects plant physiology, and causes nutrient imbalance,which is, in fact, one of the major consequences of saline stress. Iron is a micronutrient essential for plant development, and it is required by several metalloenzymes involved in photosynthesis and respiration. Iron deficiency is associated with chlorosis and low crop productivity. The role of microbial siderophores in Fe supply to plants and the effect of plant growth-promoting rhizobacteria(PGPR) on the mitigation of saline stress in crop culture are well documented. However, the dual effect of siderophore-producing PGPR, both on salt stress and Fe limitation, is still poorly explored. This review provides a critical overview of the combined effects of Fe limitation and soil salinization as challenges to modern agriculture and intends to summarize some indirect evidence that argues in favour of siderophore-producing PGPR as biofertilization agents in salinized soils. Recent developments and future perspectives on the use of PGPR are discussed as clues to sustainable agricultural practices in the context of present and future climate change scenarios.

关键词： aridity bioavailability biofertilizer Fe deficiency high salinity plant growth-promoting rhizobacteria(PGPR) saline stress soil salinization

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Therapeutic and biological activities of Calotropis procera(Ait.) ***.

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 332-336页

作者： Marcia Calheiros Chaves silva Antonio Batista da silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira angela Nadyla Martins Holonda silvania maria Mendes de Vasconcelos Enfermeira Mestre em Farmacologia/Universidade Federal do Ceara/UFC Farmaceutico Mestre em Patologia Tropical/Universidade Federal do Amazonas/UFAM Biologo Mestre em Bioquimica/Universidade Federal do Ceara/UFC Farmaceutico Mestre em Ciencias Farmaceutica/Universidade Federal do Ceara/UFC Biologa Mestre em Producao Animal/Universidade Estadual do Ceara/UECE Biologo Mestre em Fisiologia da Universidade Estadual do Ceara/UECE Enfermeiro Mestrando em Farmacologia da Universidade Federal do Ceara/UFC Aluna de Farmacia da Universidade Federal do Ceara/UFC Enfermeira Professora Adjunto do Depto.de Fisiologia e Farmacologia da Universidade Federal do Ceara/UFC

Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being *** Calotropis procera(***) is a plant original from Africa,commonly found in northeastern *** is well known for their pharmacological properties,since it produces large amounts of *** important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera.

关键词： Calotropis procera Pharmacological activity Medicinal plants

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Validation of a HPLC Method for Quantification of Thiamine and Its Phosphate Esters in Rat Brain Tissue

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Journal of Behavioral and Brain Science 2017年第2期7卷 79-93页

作者： Polliana Toledo Nunes Patrí cia da silva Oliveira Vany Ferraz angela maria Ribeiro Programa de Pó s-graduaç ã o em Neurociê ncias Laborat&oacute rio de Neurociê ncias Comportamental e Molecular LaNeC Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Quí mica Universidade Federal de Minas Gerais Belo Horizonte Brazil

The present data show a fast and efficient biological sample processing method for the extraction of thiamine (vitamin B1) and its mono-(TMP) and di-(TDP) phosphate esters from hippocampus, thalamus and prefrontal cortex (PFC) and blood sample of the rodents. In addition, using the hippocampus and standards of these three compounds we validated an isocratic fluorescence HPLC procedure for a simultaneous detection of them in a single chromatogram within a total run time of about 12 min. Reproducibility for TDP, TMP and B1 was 2.66%, 4.50% and 7.43% (intraday) and 37.54%, 25.39% and 25.87% (interday), respectively. Recovery assays were between 96.0% and 101.7%. The calibration curves were linear and the concentrations of the three compounds, all in nanomolar range, were determined in the brain areas and in the blood samples. When compared to the current methods in the literature, this new method provides information on essential variables, such as linearity range and limit of detection, reproducibility and stability of thiamine, TMP and TDP in rat brain samples. The present data on sample processing and B1 and its phosphate ester level determinations are the first to be validated using hippocampus samples of rats.

关键词： Thiamine HPLC Rat Brain Samples Validation Method

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Patients’ perceptions, health and psychological changes with obesity treatment: Success and failure in a triangulation study

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Health 2013年第11期5卷 1750-1759页

作者： Susana Sofia Pereira da silva angela da Costa Maia School of Management and Industrial Studies Institute Polytechnic of PortoPortoPortugal Center for Research in Psychology School of PsychologyUniversity of MinhoBragaPortugal

The present study aims to understand changes in health problems, health complaints and coping strategies, during the obesity treatment process with qualitative and quantitative data. Thirty bariatric patients were interviewed before bariatric surgery and at a 12-month follow-up, and fulfilled self-report measures about health problems, health complaints and coping strategies before surgery, at 6-and 12-month follow-ups. Before surgery, failure cases differ from success on the conceptualization of obesity, However, there are no other differences between groups. At 6-and 12-month follow-ups, failure cases had the highest BMI, health problems and complaints and less % EWL than success cases. One year after the surgery, one in each three persons did not lose the expected weight, i.e., are failure cases. Before surgery, there are no differences between success and failure cases in the report of health problems, health complaints and coping strategies, but they have different conceptualizations of their obesity and treatment. One year after the surgery, success cases understood bariatric surgery as an important moment in their lives related to their expected results, whereas failures valued unexpected dimensions and still waiting for a miracle surgery without their personal commitment. Accordingly, it is necessary to consider lifestyle changes in the obesity treatment process.

关键词： Bariatric Surgery Success Longitudinal Study

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Impact of hormonal modulation at proestrus on ovarian responses and uterine gene expression of suckled anestrous beef cows

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Journal of Animal Science and Biotechnology 2018年第1期9卷 77-90页

作者： Manoel Francisco de Sá Filho angela maria Gonella-Diaza mariana Sponchiado Marcio Ferreira Mendanha Guilherme Pugliesi Roney dos Santos Ramos Sónia Cristina da silva Andrade Gustavo Gasparin Luiz Lehmann Coutinho Marcelo Demarchi Goissis Fernando Silveira Mesquita Pietro Sampaio Baruselli Mario Binelli Departamento de Reproducao Animal FMVZ USP Sao Paulo SP Brazil Departamento de Genetica e Biologia Evolutiva IB-USP- Sao Paulo SP Brazil Laboratorio de Biotecnologia Animal ESALQ USP Av Padua Dias Piracicaba SP 11 Brazil Universidade Federal do Pampa Uruguaiana RS Brazil Universidade de Sao Paulo Faculdade de Medicina Veterinriae Zootecnia Departamento de Reprodcao Animal Avenida Duque de Caxias Norte 225 Pirassununga SP Zip Code 13635900 Brazil

Background： This study evaluated the impact of hormonal modulation at the onset of proestrus on ovarian response and uterine gene expression of beef ***： A total of 172 anestrous beef cows were assigned to one of four groups according to the treatment with estradiol cypionate（ECP） and/or equine chorionic gonadotropin（eCG） [CON（n = 43）, ECP（n = 43）, eCG（n = 44）and ECP ＋ eCG（n = 42）].Results： ECP-treated cows（ECP and ECP ＋ eCG groups） presented greater occurrence of estrus（44.6% vs. 65.4%; P = 0.01） and pregnancy per AI [47.1% vs. 33.3%; P = 0.07], but similar progesterone（P4） concentration at subsequent diestrus than cows not treated with ECP（CON and eCG groups）. Nonetheless, eCG-treated cows（eCG and ECP ＋ eCG groups） presented larger follicle at timed AI（12.6 ± 0.3 vs. 13.5 ± 0.3 mm; P = 0.03）, greater ovulation rate（96.5%vs. 82.6%; P = 0.008） and greater P4 concentration at d 6（3.9 ± 0.2 vs. 4.8 ± 0.2 ng/mL; P = 0.001） than cows not treated with eCG（CON and ECP groups）. Next, cows with a new corpus luteum 6 d after TAI were submitted to uterine biopsy procedure. Uterine fragments [CON（n = 6）, ECP（n = 6）] were analyzed by RNA-Seq and a total of 135 transcripts were differentially expressed between groups（73 genes up-regulated by ECP treatment）. Subsequently,uterine samples were analyzed by q PCR（genes associated with cell proliferation）. ECP treatment induced greater abundance of PTCH2（P = 0.07） and COL4 A1（P = 0.02）, whereas suppressed EGFR（P = 0.09） expression. Conversely, eCG treatment increased abundance of HB-EGF（P = 0.06）, ESR2（P = 0.09）, and ITGB3（P = 0.05）, whereas it reduced transcription of ESR1（P = 0.05）. Collectively, supplementation with ECP or eCG at the onset of proestrous of anestrous beef cows influenced ovarian responses, global and specific endometrial gene ***： Proestrus estradiol regulate the endometrial transcriptome, particularly stimulating proliferative activity in the endometrium.

关键词： Cattle eCG Endometrium Estradiol Transcriptome

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Intrauterine Exposure to Chronic 22 kHz Sound Affects Inhibitory Avoidance and Serotonergic Parameters in Forebrain Areas of dams and Rat Offspring

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Journal of Behavioral and Brain Science 2015年第2期5卷 25-39页

作者： Patrícia da silva Oliveira Ariomester Nascimento daniel Polliana Toledo Nunes Karina Abdo Costa Hani Camille Yehia angela maria Ribeiro Programa de Pós-Graduaç ã o em Neurociências Laboratório de Neurociências Comportamental e Molecular LaNeC Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Engenharia Eletrô nica Escola de Engenharia Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Bioquímica e Imunologia ICB and Departamento de Psicologia FaFiCH Laboratório de Neurociências Comportamental e Molecular LaNeC Universidade Federal de Minas Gerais Belo Horizonte Brazil

In the present study we evaluated the effects of chronic exposure to sounds at 22 kHz during pregnancy on the central serotonergic and behavioral parameters in Wistar rat dams after the suckling period and on their male rat offspring. In addition, we also assessed the effects of an acute 22 kHz sound, associated with the chronic intrauterine exposure, on the emotional responses of adult offspring. The primary hypothesis was that experiencing 22 kHz stimuli during an early stage of development would interfere with brain serotonergic parameters and, later, with the adult rat’s defensive responses. The corollary question was whether a 22 kHz sound exposure would differentially affect inhibitory avoidance and escape responses and central serotonergic parameters. Female rats were divided into four groups: non-pregnant control;non-pregnant chronic exposure;pregnant control;and pregnant chronic exposure. Male offspring were divided into four groups: chronic intrauterine sound exposure;acute sound exposure in adulthood;chronic intrauterine exposure with acute exposure in adulthood;and no exposure. Chronic sound exposure affected inhibitory avoidance and serotonergic parameters in female rats. For offspring, there was an interaction between chronic and acute sound exposure effects on inhibitory avoidance response but not on escape response. There were significant effects of chronic intrauterine exposure on serotonin turnover in the hippocampus and PFC of females. For offspring, the turnover was increased by chronic exposure only in PFC, and in amygdala it was increased by acute exposure. These results illuminate the potential of an early acoustic sound exposure for causing central serotonergic and emotional behavioral changes that can persist into later periods of life.

关键词： Intrauterine 22 kHz Sound Exposure Defensive Responses Serotonergic Parameters Adult Offspring

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Mandibular cementoblastoma:Case report

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Open Journal of Stomatology 2012年第1期2卷 50-53页

作者： Cintia Mussi Milani César Augusto Thomé Rosangela Sayuri Saga Kamikawa mariana daniel da silva maria angela Naval Machado Universidade Tuiuti do Paraná CuritibaBrazil Center for Health and Biological Sciences Pontifícia Universidade Católica do ParanáCuritibaBrazil Associacao Brasileira de Odontologia-Secao Paraná CuritibaBrazil Private Practice CuritibaBrazil Universidade Federal do Paraná CuritibaBrazil

Cementoblastoma is a rare benign lesion that represents less than 1% of all odontogenic tumours. It’s characterized by proliferation of cementum-like tissue and in almost all cases tends to be associated with an erupted permanent tooth, most often the first mo- lar. We present an unusual case of a large cemento-blastoma that affected the right mandibular body, extending from the first premolar to the second molar, of a 19-years-old male. In this case an initial surgery was attempted under local anaesthesia, resulting in incomplete tumor removal. A second surgical procedure was performed under general anaesthesia, ensuring the complete excision of the lesion. The patient was monitored for 1 year after surgery and did not show any signs of recurrence.

关键词： Odontogenic Tumor Cementoblasts Oral Surgery

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Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor

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Neural Regeneration Research 2017年第9期12卷 1381-1389页

作者： Carolina Castillo Hernández Carlos Felipe Burgos angela Hidalgo Gajardo Tiare silva-Grecchi Javiera Gavilan Jorge Roberto Toledo Jorge Fuentealba Laboratory of Screening of Neuroactive Compounds Department of Physiology School of Biological Sciences University of Concepción Laboratory of Biotechnology and Biopharmaceutical Department of Pathophysiology School of Biological Sciences University of Concepción

Erythropoietin （Epo） is a fundamental hormone in the regulation of hematopoiesis, and other secondary roles mediated by the binding of the hormone to its specific receptor （EpoR）, which leads to an activation of key signaling pathways that induce an increase in cell differentiation, apoptosis control and neuroprotection. It has been suggested that their ftmction depends on final conformation of glycosylations, related with affinity to the receptor and its half-life. The presence of EpoR has been reported in different tissues including central nervous system, where it has been demonstrated to exert a neuroprotective function against oxidative stress conditions, such as ischemic injury and neurodegenerative diseases. There is also evidence of an increase in EpoR expression in brain cell lysates of Alzheimer＇s patients with respect to healthy patients. These results are related with extensive in vitro experimental data of neuroprotection obtained from cell lines, primary cell cultures and hippocampal slices. Additionally, this data is correlated with in vivo experiments （water maze test） in mouse models of Alzheimer＇s disease where Epo treatment improved cognitive function. These stud- ies support the idea that receptor activation induces a neuroprotective effect in neurodegenerative disorders including dementias, and especially Alzheimer＇s disease. Taken together, available evidence suggests that Epo appears to be a central element for EpoR activation and neuroprotective properties in the central nervous system. In this review, we will describe the mechanisms associated with neuroprotection and its relation with the activation of EpoR in order with identify new targets to develop pharmacological strategies.

关键词： erythropoietin erythropoietin receptor neuroprotection anti-apoptosis Alzheimer's disease

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