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World Journal of Gastroenterology 2008年第5期14卷 713-719页

作者： Pierre Nahon angela sutton Pierre Rufat Chantal Simon Jean-Claude Trinchet Liliane Gattegno Michel Beaugrand Nathalie Charnaux Department of Hepatology Jean Verdier Hospital (AP-HP) Bondy 93140 France Department of Biochemistry Jean Verdier Hospital (AP-HP) Bondy 93140 France Department of Public Health Pitié-Salpetrière Hospital (AP-HP) Paris 75013 France

AIM： To explore the influence of polymorphisms in genes encoding for the chemokines Stromal cell-Derived Factor-1 （SDF-1）/CXCL12 and Monocyte Chemotactic Protein-1 （MCP-1）/CCL2, or for the chemokine receptor CCR5 on the risks of liver-related death and hepatocellular carcinoma （HCC） occurrence in hepatitis C virus （HCV）-infected patients. METHODS： SDF-1 3＇A, MCP-1 （-2518） and CCRS-△32 polymorphisms, SDF-1α, Regulated upon Activation Normal T cells Expressed and Secreted （RANTES）/CCL5 and MCP-1 serum levels were determined in 120 HCV- infected patients, included at time of cirrhosis diagnosis and prospectively followed-up. RESULTS： During follow-up, 23/120 （19.1%） patients died and 47/120 （39.1%） developed HCC. Carriers and noncarriers of each genetic marker had similar baseline characteristics estimating the severity of liver disease. The occurrence of death or HCC during follow-up was similar among carriers and noncarriers of each polymorphism. There was no association between the carriage of mutated alleles and chemokine serum levels and the latter were not associated with the risks of death or HCC. CONCLUSION： This study suggests the lack of association of SDF-1 3＇A, MCP-1 （-2518）, CCRS-△32 polymorphisms with death and HCC occurrence in cirrhotic HCV-infected patients.

关键词： Chemokine Polymorphism Cirrhosis Hepatocarcinoma Hepatitis C virus

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FPGA设计视时序为一切

中国电子商情(基础电子) 2014年第12期 43-46页

作者： angela sutton Paul Owens Synopsys公司FPGA产品部 Synopsys公司

当FPGA设计无法满足时序性能目标时,其原因可能并不明显。解决方案不仅取决于FPGA实现工具为满足时序要求而优化设计的能力,还取决于设计人员指定前方目标,诊断并隔离下游时序问题的能力。目前,设计人员掌握了一些使用技巧,可以帮助您... 详细信息

当FPGA设计无法满足时序性能目标时,其原因可能并不明显。解决方案不仅取决于FPGA实现工具为满足时序要求而优化设计的能力,还取决于设计人员指定前方目标,诊断并隔离下游时序问题的能力。目前,设计人员掌握了一些使用技巧,可以帮助您设置时钟。通过Synopsys Synplify Premier等工具正确设置时序约束,然后调整参数,以满足赛灵思FPGA设计的性能目标。

关键词：时序性能目标 RTL FPGA 综合工具时钟树移位寄存器

Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

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World Journal of Gastroenterology 2012年第22期18卷 2805-2812页

作者： Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux angela sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow INSERM U577(National Institute of Health and Medical Research) Inra Cnam University of Paris 13 (UREN) SMBH 74 rue Marcel Cachin F-93017 Bobigny France Department of Biochemistry Jean Verdier Hospital F-93140 Bondy France INSERM U698 University of Paris 13 F-93017 Bobigny France Department of Public Health Avicenne Hospital (AP-HP) University of Paris 13 F-93017 Bobigny France Department of Nutrition Ambroise Paré Hospital (AP-HP) University of Versailles Saint Quentin F-92100 Boulogne-Billancourt France

AIM： To examine the relationships between pre-diag- nostic biomarkers and colorectal cancer risk and assess their relevance in predictive ***： A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplemen- tation en VItamines et Min^raux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases （n = 50） were matched with two randomly selected con- trols （n = 100）. Conditional logistic regression models were used to investigate the associations between pre- diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 （sVCAM-1）, soluble intercellular adhesion molecule-I, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves （AUC） and relative integrated discrimination improvement （RIDI） statistics were used to assess the discriminatory poten- tial of the models. RESULTS： Plasma adiponectin level was associated with decreased colorectal cancer risk （P for linear trend -- 0.03）. Quartiles of sVCAM-1 were associated with increased colorectal cancer risk （P for linear trend = 0.02）. No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction （P for AUC improve- ment = 0.01, RIDI = 26.5%）. CONCLUSION： These results suggest that pre-diag- nostic plasma adiponectin and sVCAM-1 levels are as- sociated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies.

关键词： Colorectal cancer Adiponectin Soluble vascu-lar cell adhesion molecule-l Nested case-control study Prospective study

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty angela S.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

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Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

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Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： Elena Ambrosini angela Lanciotti Maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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Role of lipid rafts in liver health and disease

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World Journal of Gastroenterology 2011年第20期17卷 2520-2535页

作者： angela Dolganiuc Department of Medicine University of Massachusetts Medical School

Liver diseases are an increasingly common cause of morbidity and mortality; new approaches for investigation of mechanisms of liver diseases and identification of therapeutic targets are emergent. Lipid rafts (LRs) are specialized domains of cellular membranes that are enriched in saturated lipids; they are small, mobile, and are key components of cellular architecture, protein partition to cellular membranes, and signaling events. LRs have been identified in the membranes of all liver cells, parenchymal and non-parenchymal; more importantly, LRs are active participants in multiple physiological and pathological conditions in individual types of liver cells. This article aims to review experimental-based evidence with regard to LRs in the liver, from the perspective of the liver as a whole organ composed of a multitude of cell types. We have gathered up-to-date information related to the role of LRs in individual types of liver cells, in liver health and diseases, and identified the possibilities of LR-dependent therapeutic targets in liver diseases.

关键词： Hepatocytes Stellate cells Kupffer cells Endothelial cells Signaling Therapeutic Viral HepatitisC virus Metabolism

A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base

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National Science Review 2019年第1期6卷 3-4页

作者： Jianbin Wang angela Wu School of Life Sciences Tsinghua University Division of Life Science Hong Kong University of Science and Technology Department of Chemical and Biological Engineering Hong Kong University of Science and Technology

Today, many next-generation sequencing (NGS) methods, technologies and platforms have been developed that allow users to produce Tera base pairs of data in less than one day or ultralong reads covering multiple genes. By far the most popular NGS approach to date is cyclic sequencing-by-synthesis (SBS),whereby each DNA template’s complementary strand is synthesized by DNA polymerase and, as the new strand grows base by base, the identity of each

关键词： A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base

Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

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Signal Transduction and Targeted Therapy 2020年第1期5卷 299-300页

作者： angela M.Otto Munich Institute of BioEngineering Technical University of Munich85748 GarchingGermany

Even though the mTOR complex has been known for decades as a nutrient sensor,being thus in focus for drug targeting in metabolic disease and cancer metabolism,it has remained puzzling how it is able to get a sense of glucose availability in ***,a small metabolite of the glycolytic pathway,dihydroxyacetone phosphate,has been identified by Sabatini and his coworkers,who show how mTORC1-activity is regulated in glucose-starved and replenished cancer cells.

关键词： metabolism cancer mTORC1

How Africa Is Promoting Agricultural Innovations and Technologies amidst the COVID-19 Pandemic

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Molecular Plant 2020年第10期13卷 1345-1346页

作者： angela Joseph Fernando Consultant-The Alliance of Bioversity International and CIAT Km 17 Recta Cali-PalmiraApartado Aéreo 6713763537 CaliColombia

The COVID-19 pandemic has left an indelible mark on Africa's Agribusiness *** of households whose livelihoods depend on farming are facing a huge food *** mitigate these effects,the African Agricultural Technology Foundation(AATF)gathered a panel of renowned agricultural experts through an interactive webinar themed"Promotion of Agricultural Technologies and Innovations for Agri-Business Resilience in Africa in the Wake of COVID-19",the first in a series of several interactive seminars to be held virtually until the end of December *** seminars will focus on several topics specific to agricultural transformation,which revolve around smallholder farmers in Sub-Saharan Africa(SSA)and aim to help them come out of the cataclysmic effect of COVID-19 and recover their business and livelihoods.

关键词： Agricultural Africa interactive