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Prospective evaluation of health status, quality of life and clinical outcomes following implantable defibrillator generator exchange

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journal of Geriatric Cardiology 2021年第9期18卷 720-727页

作者： Faisal M Merchant john Larson Leon Darghosian Paige Smith Soroosh Kiani Stacy Westerman Anand D.Shah David S.Hirsh Michael S.Lloyd angel R.Leon Mikhael F.El-Chami Section of Cardiac Electrophysiology Emory University School of MedicineAtlantaGAUSA Department of Medicine University of Michigan School of MedicineAnn ArborMIUSA Grady Health System AtlantaGAUSA

BACKGROUND Little is known about health status and quality of life(QoL)after implantable cardioverter-defibrillator(ICD)generator exchange(GE).METHODS We prospectively followed patients undergoing first-time ICD *** assessments of health status were performed by administering the 36-Item Short Form Survey(SF-36).RESULTS Mean age was 67.5±14.3 years,left ventricle ejection fraction(LVEF)was 36.5%±15.0%and over 40%of the cohort had improved LVEF to>35%at the time of ***-36 scores were significantly worse in physical/general health domains compared to domains of emotional/social well-being(Pjudicated as non-arrhythmic in *** patients experienced appropriate ICD shocks after GE,three of whom had LVEF which remains impaired LVEF(i.e.,<35%)at the time of *** Patients undergoing ICD GE have significantly worse physical health compared to emotional/social well-being,which is associated with the presence of medical *** terms of clinical outcomes,the incidence of appropriate shocks after GE among those with improvement in LVEF is very low,and most deaths post-procedure appear to be non-arrhythmic in *** data represent an attempt to more fully characterize the spectrum of QoL and clinical outcomes after GE.

关键词： ICD quality of life and clinical outcomes following implantable defibrillator generator exchange Prospective evaluation of health status

An alternative,zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants

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Molecular Plant 2022年第1期15卷 151-166页

作者： Kun-Peng jia jianing Mi Shawkat Ali Hajime Ohyanagi juan C.Moreno Abdugaffor Ablazov Aparna Balakrishna Lamis Berqdar Alessia Fiore Gianfranco Diretto Claudio Martínez angel R.de Lera Takashi Gojobori Salim Al-Babili Biological and Environmental Sciences and Engineering Division Center for Desert AgricultureThe BioActives LabKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia State Key Laboratory of Cotton Biology Henan Joint International Laboratory for Crop Multi-Omics ResearchSchool of Life SciencesHenan UniversityJinming RoadKaifeng 475004China Biological and Environmental Sciences and Engineering Division Computational Bioscience Research CenterKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia Italian National Agency for New Technologies Energy and Sustainable Economic Development00123 RomeItaly Universidade de Vigo Facultade de Química and CINBIO36310 VigoSpain Agriculture and Agri-Food Canada Kentville Research and Development Center32 Main StreetKentvilleNS B4N1J5Canada

Abscisic acid(ABA)is an important carotenoid-derived phytohormone that plays essential roles in plant response to biotic and abiotic stresses as well as in various physiological and developmental *** Arabidopsis,ABA biosynthesis starts with the epoxidation of zeaxanthin by the ABA DEFICIENT 1(ABA1)enzyme,leading to epoxycarotenoids;e.g.,*** oxidative cleavage of 9-cis-epoxycaro-tenoids,a key regulatory step catalyzed by 9-C/S-EPOXYCAROTENOID DIOXYGENASE,forms xanthoxin,which is converted in further *** mediated by ABA DEFICIENT 2(ABA2),ABA DEFICIENT 3(ABA3),and ABSCISIC ALDEHYDE OXIDASE 3(AAO3)into *** combining genetic and biochemical approaches,we unravel here an ABA1-independent ABA biosynthetic pathway starting upstream of *** iden-tified the carotenoid cleavage products(i.e.,apocarotenoids,β-apo-11-carotenal,9-cis-β-apo-11-carotenal,3-OH-β-apo-11-carotenal,and 9-cis-3-OH-β-apo-11-carotenal)as intermediates of this ABA1-independent ABA biosynthetic *** labeled compounds,we showed thatβ-apo-11-carotenal,9-cis-β-apo-11-carotenal,and 3-OH-β-apo-11-carotenal are successively converted into 9-cis-3-OH-β-apo-11-carotenal,xanthoxin,and finally into ABA in both Arabidopsis and *** applied to Arabidopsis,theseβ-apo-11-carotenoids exert ABA biological functions,such as maintaining seed dormancy and inducing the expression of ABA-responsive ***,the transcdptomic analysis revealed a high overlap of differentially expressed genes regulated byβ-apo-11-carotenoids and ABA,suggesting thatβ-apo-11-carot-enoids exert ABA-independent regulatory *** together,our study identifies a biological function for the common plant metabolites,β-apo-11-carotenoids,extends our knowledge about ABA biosynthesis,and provides new insights into plant apocarotenoid metabolic networks.

关键词： seed germination apocarotenoids ABA ABA biosynthesis ABA1 carotenoids ultra-high-performance liquid chromatography-mass spectrometry Arabidopsis thaliana

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运动表现分析的发展及展望

体育学刊 2016年第2期23卷 112-117页

作者：刘鸿优崔一雄张绍良 Miguel-angel GOMEZ 华南师范大学体育科学学院广东广州510006 马德里理工大学身体锻炼与体育科学学院西班牙马德里28040

采用文献计量学的方法,对运动表现分析的历史、主要教材和主要期刊论文刊载情况进行简要的概述。结果显示运动表现分析于20世纪70—80年代开始在运动科学领域站稳脚跟,90年代后期至今则进入了高速平稳发展期。作为一个学科门类,运动表... 详细信息

采用文献计量学的方法,对运动表现分析的历史、主要教材和主要期刊论文刊载情况进行简要的概述。结果显示运动表现分析于20世纪70—80年代开始在运动科学领域站稳脚跟,90年代后期至今则进入了高速平稳发展期。作为一个学科门类,运动表现分析拥有较为完善的学科体系和人才培养机制,同时拥有权威的教材和广泛的教师与学生群体基础。作为一个科研领域,运动表现分析拥有庞大的、逐步增长的论文、研究者数量和被引用次数,但该领域内活跃的作者、期刊、研究机构、国家(或地区)绝大多数都集中于欧美和大洋洲等经济发达地区。同时运动表现分析领域的研究范围覆盖了绝大多数奥运会比赛项目。

关键词：竞赛与训练运动表现分析综述

局部晚期乳腺癌患者双时相18F-FDGPET/CT显像的纹理特征及基于标准摄取值的相关参数

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中华核医学与分子影像杂志 2018年第6期38卷 454-455页

作者：唐军 Ana María garcia-Vicente David Molina julián Pérez-Beteta Mariano AmoSalas Alicia Martínez-González Gloria Bueno María jesús Tello-Galán angel Soriano-Castrejón 上海交通大学医学院附属苏州九龙医院核医学科 Nuclear Medicine Department University General Hospital Ciudad RealSpain

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显... 详细信息

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显像(注药后3 h显像,PET-2)。图像经软件分割后计算得到基于SUV的相关参数[最大SUV(SUVmax)、平均SUV(SUVmean)和SUV峰值(SUVpeak)]、代谢肿瘤体积(MTV)和病灶糖酵解总量(TLG)。同时计算18项三维纹理特征分析参数,其中包括行程长度矩阵(RLM)特征、共生矩阵(CM)特征和能量特征(空间能量和总能量)。研究PET-1和PET-2上述参数的差别。结果 PET-1、PET-2间基于SUV的相关参数和MTV的差异有统计学意义,与PET-1相比,PET-2的SUV相关参数更高,但MTV更低。PET-1、PET-2间有明显差异的纹理特征分析参数为短行程增强(RSE)、低灰度行程增强(LGLRE)、短行程高灰度增强(SRHGLE)、行程百分比(RP)、长行程增强(LRE)、灰度非均匀性(GLNU)、同质性(HOM)和差异性(DIS)。纹理特征分析参数与MTV和TLG相关。结论双时相18F-FDG PET/CT显像图像的纹理特征分析参数间有明显差异。因此,18F-FDG PET/CT显像时应考虑到代谢特征的动态变化,即延迟显像时肿瘤组织表现出的异质性更强,且瘤体越大异质性越强。

关键词：双时相18F-FDG PET/CT 乳腺肿瘤肿瘤异质性纹理特征

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葡聚糖和腐植酸:对免疫系统的协同作用

腐植酸 2015年第6期 34-40页

作者： Vaclav Vetvicka Roberto Baigorri angel M.Zamarre?o jose M.garcia-Mina jean-Claude Yvin 周霞萍樊兴明美国路易斯维尔大学病理学系肯塔基州40292 钛美农业国际鲁利耶集团研发部奥尔科延999019 西班牙纳瓦拉大学化学和土壤化学系潘普洛纳999023 法国钛美农业国际研发部迪纳尔999019 华东理工大学科学技术发展研究院上海200237

腐植酸是由有机物质分解产生的混合物。尽管它们普遍存在,但对它们的生物学效应了解有限,且目前的研究结果存在争议。因此对来源不同且具有不同的生化特性的两种类型的腐植酸的免疫效果进行评估。单独使用这两种腐植酸或与已知发酵衍生... 详细信息

腐植酸是由有机物质分解产生的混合物。尽管它们普遍存在,但对它们的生物学效应了解有限,且目前的研究结果存在争议。因此对来源不同且具有不同的生化特性的两种类型的腐植酸的免疫效果进行评估。单独使用这两种腐植酸或与已知发酵衍生的免疫调节剂葡聚糖结合使用,并测其在细胞(吞噬作用和肿瘤抑制)和体液(抗体的产生和细胞因子的分泌)的免疫反应。研究结果表明,腐植酸是具有生物活性的免疫调节剂,影响体液免疫和细胞免疫反应。此外,本文研究的两种腐植酸在免疫反应的刺激下具有协同效应,为这些天然免疫调节剂的进一步研究提供了支持。

关键词：葡聚糖腐植酸免疫力吞噬作用

Plant cell wall-mediated disease resistance:Current understanding and future perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa jorda Miguel angel Torres Marina Martın-Dacal Diego jose Berlanga Patricia Fernandez-Calvo Elena Gomez-Rubio Sonsoles Martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific ECD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,Nod/MYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their ECDs(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KINASE 1-LIKE group(CrRLK1L)with Malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

里德尔剪切的组合型式与走滑盆地组合型式的相似性

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地质论评 2017年第2期63卷 287-301页

作者：许顺山彭华 angel F.NIETO-SAMANIEGO 陈书平吴习东墨西哥国立自治大学地球科学中心墨西哥76001 中国地质科学院地质力学研究所北京100037 中国石油大学(北京)地球科学学院北京102249

走滑断裂体系中经常发育里德尔剪切的断裂组合,世界上不同构造背景下与走滑断裂相关的盆地(走滑盆地)也很多见。因此里德尔剪切是地质构造研究中的重要方面。我们从三个方面对里德尔剪切的节理构造组合及盆地组合进行了对比:(1)里德尔... 详细信息

走滑断裂体系中经常发育里德尔剪切的断裂组合,世界上不同构造背景下与走滑断裂相关的盆地(走滑盆地)也很多见。因此里德尔剪切是地质构造研究中的重要方面。我们从三个方面对里德尔剪切的节理构造组合及盆地组合进行了对比:(1)里德尔剪切构造组合与比例尺无关。里德尔剪切带的(转换)拉张区与沉积盆地的分布区是相似的;(2)断裂的最大位移区与断陷盆地的沉积中心是一致的,断陷盆地长轴平行于断裂走向;(3)物理模拟试验及数学模拟试验都证实了走滑盆地的演化。基于上述认识,我们通过厘米级岩芯标本的观察,结合已发表的盆地资料,提出了6类与里德尔剪切有关的构造组合及断陷盆地组合。(1)雁列状构造及盆地组合:许多盆地发育雁列状构造。同时,与里德尔剪切相关的雁列状盆地的宽度与主剪切断裂的剪切位移呈正相关。(2)帚状或马尾状构造及盆地组合:二者在形态上相似,所以归为一类。成因上,马尾状构造及盆地主要发育在走滑断裂的拉张端部,而帚状构造或盆地反映走滑断裂的旋扭作用,可以在走滑断裂影响区域的任何部位。(3)串珠状构造及盆地组合:该类型的盆地主要是指释压盆地的组合,拉分盆地也可以形成串珠状盆地。(4)S状或Z状构造或盆地组合:左行走滑形成Z状构造或盆地,而右行走划形成S状构造或盆地。(5)多字型构造及盆地组合:是拉分盆地的典型组合,可以过渡到串珠状盆地。(6)复杂的网状构造及盆地组合:通常是由于分布型简单剪切的作用结果。以上盆地组合类型包括大型盆地内次级单元(次级盆地或更次级盆地)的组合,但不包括多成因、多期活动的构造及盆地。

关键词：里德尔剪切走滑盆地拉分盆地构造组合盆地组合类型

Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications

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Molecular Plant 2020年第11期13卷 1654-1661页

作者： jian You Wang Muhammad jamil Pei-Yu Lin Tsuyoshi Ota Valentina Fiorilli Mara Novero Randa A.Zarban Boubacar AKountche Ikuo Takahashi Claudio Martinez Luisa Lanfranco Paola Bonfante angel R.de Lera Tadao Asami Salim Al-Babili King Abdullah University of Science and Technology Division of Biological and Environmental Science and Engineeringthe BioActives LabThuwal 23955-6900Saudi Arabia Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan Department of Life Sciences and Systems Biology University of TorinoTorinoItaly Universidade de Vigo Facultade de Quimica and CINBIOVigoSpain

Zaxinone is an apocarotenoid regulatory metabolite required for normal rice growth and *** addition,zaxinone has a large application potential in agriculture,due to its growth-promoting activity and capability to alleviate infestation by the root parasitic plant Striga through decreasing strigolactone(SL)***,zaxinone is poorly accessible to the scientific community because of its laborious organic synthesis that impedes its further investigation and *** this study,we developed easy-to-synthesize and highly efficient mimics of zaxinone(MiZax).We performed a structure-activity relationship study using a series of apocarotenoids distinguished from zaxinone by different structural *** the obtained results,we designed several phenyl-based compounds synthesized with a high-yield through a simple *** tests showed that MiZax3 and MiZax5 exert zaxinone activity in rescuing root growth of a zaxinone-deficient rice mutant,promoting growth,and reducing SL content in roots and root exudates of wild-type ***,these compounds were at least as efficient as zaxinone in suppressing transcript level of SL biosynthesis genes and in alleviating Striga infestation under greenhouse conditions,and did not negatively impact *** together,MiZax are a promising tool for elucidating zaxinone biology and investigating rice development,and suitable candidates for combating Striga and increasing crop growth.

关键词： apocarotenoids zaxinone zaxinone mimics strigolactone Striga root parasitic plants

Point Charge between Two Grounded and Conducting Planes Forming a 60°Angle and for Yukawa’s Potential and Coulomb’s Potential

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journal of Electromagnetic Analysis and Applications 2021年第4期13卷 57-66页

作者： Miguel angel López-Mariño Omar Olmos López josé Manuel Pardo Regueiro Tecnologico de Monterrey Escuela de Ingeniería y Ciencias Chihuahua México Tecnologico de Monterrey Escuela de Ingeniería y Ciencias Monterrey México Tecnologico de Monterrey Escuela de Ingeniería y Ciencias Torreón México

For a point charge between two grounded conductor planes forming a 60° angle, the potential and electric field generated by point charge for Yukawa’s potential (e-μr/r) and Coulomb’s potential (1/r) are modeled and simulated. The expression for the potential that generalizes the cases discussed in López-Mariño, M. and Trujillo Caballero, j. (2017) Point Charges and Conducting Planes for Yukawa’s Potential and Coulomb’s Potential. journal of Electromagnetic Analysis and Applications, 9, 135-146. jemaa.2017.910012" target="_blank">https://***/10.4236/jemaa.2017.910012 is presented. Graphs for the potential and electric field for both cases are showed using Maple, that of Coulomb and that of Yukawa for different values of μ . The purpose of this work is to offer students a practical guide for problem analysis of electrostatics using Maple’s capabilities as a computational tool.

关键词： Yukawa’s Potential Coulomb’s Potential Method of Images