Prospective evaluation of health status, quality of life and clinical outcomes following implantable defibrillator generator exchange

作     者：Faisal M Merchant John Larson Leon Darghosian Paige Smith Soroosh Kiani Stacy Westerman Anand D.Shah David S.Hirsh Michael S.Lloyd Angel R.Leon Mikhael F.El-Chami Faisal M Merchant;John Larson;Leon Darghosian;Paige Smith;Soroosh Kiani;Stacy Westerman;Anand D.Shah;David S.Hirsh;Michael S.Lloyd;Angel R.Leon;Mikhael F.El-Chami

作者机构：Section of Cardiac ElectrophysiologyEmory University School of MedicineAtlantaGAUSA Department of MedicineUniversity of Michigan School of MedicineAnn ArborMIUSA Grady Health SystemAtlantaGAUSA 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2021年第18卷第9期

页      面：720-727页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by a Pilot Translational&Clinical Studies Program grant from the National Center for Advancing Translational Studies of the National Institutes of Health(UL1TR002378) a FAME grant from the Emory University Department of Medicine 

主　　题：ICD quality of life and clinical outcomes following implantable defibrillator generator exchange Prospective evaluation of health status 

摘      要：BACKGROUND Little is known about health status and quality of life(QoL)after implantable cardioverter-defibrillator(ICD)generator exchange(GE).METHODS We prospectively followed patients undergoing first-time ICD *** assessments of health status were performed by administering the 36-Item Short Form Survey(SF-36).RESULTS Mean age was 67.5±14.3 years,left ventricle ejection fraction(LVEF)was 36.5%±15.0%and over 40%of the cohort had improved LVEF to35%at the time of ***-36 scores were significantly worse in physical/general health domains compared to domains of emotional/social well-being(P0.001 for each comparison).Physical health scores were significantly worse among those with medical comorbidities including diabetes,chronic obstructive pulmonary disease and atrial *** follow-up was 1.6±0.5 years after *** SF-36 scores remained stable across all domains during *** at 3 years post-GE was estimated at 80%.Five patients died during follow-up and most deaths were adjudicated as non-arrhythmic in *** patients experienced appropriate ICD shocks after GE,three of whom had LVEF which remains impaired LVEF(i.e.,35%)at the time of *** Patients undergoing ICD GE have significantly worse physical health compared to emotional/social well-being,which is associated with the presence of medical *** terms of clinical outcomes,the incidence of appropriate shocks after GE among those with improvement in LVEF is very low,and most deaths post-procedure appear to be non-arrhythmic in *** data represent an attempt to more fully characterize the spectrum of QoL and clinical outcomes after GE.