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Cerebral venous sinus thrombosis:changing trends in the incidence,age and gender(findings from the CMC Vellore CVt registry)

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Stroke & Vascular Neurology 2024年第3期9卷 252-257页

作者： angel miraclin t.john davis prasad George Abraham Ninan Mahasampath Gowri Deepti Bal Atif Iqbal Ahmed Shaikh Rohit N Benjamin Appaswamy thirumal Prabhakar Ajith Sivadasan Vivek Mathew Sanjith Aaron Department of Neurological Sciences Christian Medical CollegeVelloreTamil NaduIndia Department of Biostatistics Christian Medical CollegeVelloreTamil NaduIndia

Background Multiple cerebral venous sinus thrombosis(CVt)registries from various geographical regions indicate that female gender,the use of contraceptive pills,pregnancy and puerperium are important risk *** this study,we report the changes in the epidemiology of patients with CVt managed over the past 26 *** the CMC Vellore CVt registry is a prospectively maintained database at the Christian Medical College,Vellore since January *** software was used to analyse the data and assess the changes in the incidence,age and gender distribution over the previous 26 *** Among 1701 patients treated during the study period,908(53%)were women and 793(47%)were *** mean incidence of CVt was 49 per 100000 admissions before 2010,which increased to 96 per 100000 after *** gender had a higher odds of developing CVt OR–2.07(CI 1.68 to 2.55,pthis could be attributed to the declining incidence of postpartum CVt after 2010 compared with the decade before 2010(50%vs 20%).the mean age at presentation had increased from 24.5 to 33.2 years in the last *** there was a clear change in the gender pattern from being a condition with female preponderance,to one where equal or more men are being *** incidence of postpartum CVt cases could be the driving *** increase in the overall incidence of CVt cases was noted,probably due to a higher index of clinical suspicion and better diagnostic imaging modalities.

关键词： CVt driving maintained

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Remodeling of the plasma for sperm-egg recognition： proteins membrane in preparation roles of acrosomal

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Asian Journal of Andrology 2015年第4期17卷 574-582页

作者： Nongnuj tanphaichitr Kessiri Kongmanas Hathairat Kruevaisayawan Arpornrad Saewu Clarissa Sugeng Jason Fernandes Puneet Souda Jonathan B angel Kym F Faull R john Aitken Julian Whitelegge Daniel Hardy trish Berger Mark Baker Chronic Disease Program Ottawa Hospital ResearchInstitute Ottawa Ontario Canada Department ofObstetrics and Gynaecology University of OttawaOntario Canada Department of Biochemistry Microbiology and Immunology University of OttawaOntario Canada Department of Anatomy Faculty ofMedical Sciences Naresuan University PhitsanulokThailand Division of Infectious Diseases OttawaHospital - General Campus Ottawa Ontario Canada Pasarow Mass Spectrometry Laboratory Universityof California Los Angeles California USA theARC Centre of Excellence in Biotechnology andDevelopment School of Environmental and LifeSciences University of Newcastle Callaghan NewSouth Wales Australia Department of Cell Biologyand Biochemistry Health Sciences Center Texas TechUniversity Texas USA Department of Animal ScienceUniversity of California Davis California USA

the interaction of sperm with the egg＇s extracellular matrix, the zona pellucida （ZP） is the first step of the union between male and female gametes. the molecular mechanisms of this process have been studied for the past six decades with the results obtained being both interesting and confusing. In this article, we describe our recent work, which attempts to address two lines of questions from previous studies. First, because there are numerous ZP binding proteins reported byvarious researchers, how do these proteins act together in sperm-ZP interaction？ Second, why do a number of acrosomal proteins have ZP affinity？ Are they involved mainly in the initial sperm-ZP binding or rather in anchoring acrosome reacting/reacted spermatozoa to the ZP？ Our studies reveal that a number of ZP binding proteins and chaperones, extracted from the anterior sperm head plasma membrane, coexist as high molecular weight （HMW） complexes, and that these complexes in capacitated spermatozoa have preferential ability to bind to the ZP. Zonadhesin （ZAN）, known as an acrosomal protein with ZP affinity, is one of these proteins in the HMW complexes. Immunoprecipitation indicates that ZAN interacts with other acrosomal proteins, proacrosin/acrosin and sp32 （ACRBP）, also present in the HMW complexes. Immunodetection of ZAN and proacrosin/acrosin on spermatozoa further indicates that both proteins traffic to the sperm head surface during capacitation where the sperm acrosomal matrix is still intact, and therefore they are likely involved in the initial sperm-ZP binding step.

关键词： SPERM CAPACItAtION ANDSPERM-ZONA PELLUCIDAINtERACtION- BACKGROUND ANDCONFUSION IN tHE FIELDS

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