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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 23-24页

作者： ang g.c. Werth V.P. 王琼 Dr.Department of Dermatology 2 Rhoads Pavilion 36th and Spruce Philadelphia PA 19104 United States

Objective: To observe whether the use of antimalarials in combination resulted in significant improvement in the cutaneous signs and symptoms of patients with dermatomyositis who did not otherwise respond to the use of single-agent antimalarial therapy. Design: Retrospective case series of 17 patients treated between January 1, 1991, and December 31, 2002. Setting: An ambulatory medical dermatology clinic in an academic center. Patients: Patients had adult-onset dermatomyositis with predominantly cutaneous symptoms and a follow-up period at our clinic of at least 6 months. cases in which it was not possible to assess the effect of treatment on cutaneous symptoms were not included. Intervention: Treatment regimens varied and included the use of antimalarials, prednisone, methotrexate, and other medications. Main Outcome Measures: Physician-observed and patient-reported improvement based on erythema, pruritus, and extent of affected skin. Results: Seven of 17 patients experienced at least near clearance in cutaneous symptoms with the use of antimalarial therapy alone: 4 of these patients required combination therapy (hydroxychloroquine sulfate-quinacrine hydrochloride or chloroquine phosphate-quinacrine),while 3 of them responded well to antimalarial monotherapy. The median time required to reach the response milestones on the final working therapeutic regimen was 3 months (mean, 4.8 months; range, 2-14 months). Six patients did not respond significantly to any type of therapy, including nonantimalarials. conclusion: Our experience suggests that a significant subgroup of patients whose skin lesions have been unresponsive to a single antimalarial benefit from combination therapy with hydroxychloroquine and quinacrine or chloroquine and quinacrine, but controlled clinical trials are warranted to assess the extent of benefit.

关键词：皮肌炎抗疟药物皮肤型硫酸羟氯喹皮肤症状甲氨蝶呤病型临床对照试验磷酸氯喹亚群

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Interface catalytic reduction of alumina by nickle for the aluminum nanowire growth: Dynamics observed by in situ TEM

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Nano Research 2024年第3期17卷 1225-1231页

作者： Zichun Wang Dan Wang ang Li Lizhuo Wang Xiaodong Han Yijiao Jiang Jianfeng.c.en Jun Huang Beijing Advanced Innovation center for Soft Matter Science and Engineering State Key Laboratory of Organic–Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029China Laboratory for catalysis Engineering School of Chemical and Biomolecular EngineeringThe University of SydneyNew South Wales 2006Australia Beijing Key Laboratory of Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100024China Department of Engineering Macquarie UniversitySydneyNew South Wales 2109Australia

Metal nanowires show promise in a broad range of applications and can be fabricated via a number of methods,such as vapor–liquid–solid process and template-based ***,the synthesis of Al nanowires(NWs)is still challenging from the stable alumina *** this work,the Ni-catalyzed fabrication of Al NWs has been realized using various Al_(2)O_(3) *** growth dynamics of Al NWs on Ni/Al_(2)O_(3) was studied using in situ transmission electron microscopy(TEM).The effect of alumina structures,compositions,and growth temperature were *** growth of Al NWs correlates with the Na addition to the alumina *** no eutectic mixture of nickel aluminide was formed,a mechanism of Ni-catalyzed reduction of Al_(2)O_(3) for Al NWs growth has been proposed instead of the vapor–liquid–solid *** key insights reported here are not restricted to Ni-catalyzed Al NWs growth but can be extended to understanding the dynamic change and catalytic performance of Ni/Al_(2)O_(3) under working.c.nditions.

关键词： in situ transmission electron microscopy(TEM) Al nanowires alumina reduction nanowire growth

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D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

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Food Science and Human Wellness 2024年第1期13卷 173-182页

作者： Xuejiao Zhang ang Li Yuanyifei Wang Jin Wang Bowei Zhang Yan Zhang Jingmin Liu Shuo Wang Tianjin Key Laboratory of Food Science and Health School of MedicineNankai UniversityTianjin 300072China college of Food Science and Technology Hebei Agricultural UniversityBaoding 071001China

D-Psicose,as a low-calorie rare sugar,has attracted a lot of attention in recent years for alternating to *** anti-obesity effect of D-psicose has been extensively confirmed in previous studies,however,the impact of D-psicose on colitis remains ***,we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in c57BL/6 *** patholog.c.l symptoms,inflammatory cytokines levels,gut microbiota composition,short chain fatty acids(ScFAs)production and colonic barrier integrity were comprehensively *** results confirmed that D-psicose intervention aggravated colitis,characterized by the exacerbation of colon shortening,increase of colonic inflammatory infiltration,and marked exaltation of disease activity indices and IL-6,IL-1βand TNF-α***,the dysfunction of gut microbiota was identified in the psicose *** abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the psicose group compared to the model ***,the production of ScFAs was suppressed in the psicose group,accompanied by a decrease in the level of mucin 2(Muc-2).collectively,the underlying mechanism of the exacerbation of colitis by D-psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of ScFAs,which leads to the damage of the mucosal barrier and the intensifi cation of inflammatory invasion.

关键词： D-Psicose colitis gut microbiota Short chain fatty acids Mucin 2

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Design and fabrication of self-suspending aluminum-plastic/semiconductor photocatalyst devices for solar energy conversion

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Journal of Environmental Sciences 2024年第2期136卷 615-625页

作者： Zhi-ang Zhao Jingyun Mao chengjing Lu Shuangqiao Yang Qingrong Qian Qinghua chen Hun Xue Xiaoli Sun Min-Quan Yang college of Environmental and Resource Sciences College of Carbon Neutral Modern IndustryFujian Key Laboratory of Pollution Control and Resource ReuseFujian Normal UniversityFuzhou 350007China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

The design and synthesis of self-suspending photocatalyst device with easy recyclability is important for practical ***,this work utilizes aluminum-plastic package waste as raw material to prepare an aluminum-plastic supported TiO_(2)(AP-TiO_(2))photocatalyst device through 3D printing design and surface deposition method.A series of characterizations were carried out to explore the structure,morphology and performance of the AP-TiO_(2)*** UV light illumination,the AP-TiO_(2)-50 efficiently degrade 93.6%tetracycline hydrochloride(THc)after 4 hr,which increases by 8.3%compared with that of TiO_(2)powder suspension system with the same catalyst *** on it,AP-ZnO,AP-cdS,AP-g.c.3N_4and AP-Pt-TiO_(2)are also fabricated,and applied in photocatalytic degradation and hydrogen evolution,which all exhibit higher photoactivities than powder suspension *** work provides a new avenue for the fabrication of advanced recyclable photocatalyst ***,the work offers a novel sight for the high-value utilization of aluminum-plastic package waste,which has positive implications for environmental protection.

关键词： TiO_(2) Self-suspending Photocatalyst device Aluminum plastic

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Multifunctional properties of a polar spin chain compound[N(c_(3)H_(7))_(4)][cu(c_(8)H_(4)NO_(4))]·H_(2)O exhibiting both one-dimensional magnetism and nonlinear optical activity

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chinese chemical Letters 2024年第2期35卷 622-625页

作者： ang Li Yanhong Wang Haotian Tian Alimujiang Yalikun Yves Journaux Min Luo Hongcheng Lu Key Laboratory of Material chemistry for Energy conversion and Storage School of Chemistry and Chemical EngineeringHubei Key Laboratory of Bioinorganic Chemistry & Materia MedicaHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of optoelectronic Materials chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 35002China Institut Parisien de chimie Moléculaire IPCMSorbonne UniversitéCNRSParis F-75252France

Functional materials with multiple properties are urgent to be explored to reach high requirements for applications *** this work,a new multifunctional one-dimensional(1D)chain compound[N(c_(3)H_(7))_(4)][cu(ohpma)]·H_(2)O 1(ohpma=deprotonated N-(2-hydoxyphenyl)oxamic acid)exhibiting both 1D antiferromagnetic and nonlinear optical properties,which are both originated from the same polar[cu(c_(8)H_(4)NO_(4))]magnetic units,has been successfully synthesized by evaporation at room ***-polydentate nature of the(ohpma)3−ligand with constrained tridentate and bidentate coordination sites conducts cu^(2+)ions coordinating in different geometries and forms 1D chains along the c axis,which are further separated by the[N(c_(3)H_(7))_(4)]+*** the 1D magnetic chains further exhibit noncentrosymmetric polar *** optical study shows polar compound 1 exhibits a discernible second-harmonic generation(SHg)efficiency and the calculation of the partial density of states indicates that the SHg efficiency of 1 is mainly originated from the polar[cu(c_(8)H_(4)NO_(4))]magnetic ***,magnetic susceptibility shows a broad maximum around 70 K with strong intrachain interaction of J/k B=−113.0 K but no long-range order is observed down to 2 K,suggesting that 1 shows a good 1D *** good 1D magnetism and SHg activity suggest that 1 could be as a potential multifunctional material,particularly.

关键词： Multifunctional properties Magnetic property Nonlinear optical property Evaporation One-dimensional chain

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microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

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JOURNAL OF gENETIcS AND gENOMIcS 2024年第9期51卷 911-921页

作者： chen, Xinghan Shen, Yueru Song, Zheng Wang, Xinliang Yao, Huaitong.c.i, Yuan Zhao, Zi-ang Hu, Bing Univ Sci & Technol china Hefei Natl Res Ctr Phys Sci Microscale Hefei 230026 Anhui Peoples R China Univ Sci & Technol china Ctr Adv Interdisciplinary Sci & Biomed IHM Div Life Sci & Med Hefei 230026 Anhui Peoples R China Univ Sci & Technol china Affiliated Hosp USTC 1 Div Life Sci & Med Hefei 230026 Anhui Peoples R China

MicroRNAs (miRNAs) play a significant role in axon regeneration following spinal cord injury. However, the functions of numerous miRNAs in axon regeneration within the central nervous system (cNS) remain largely unexplored. Here, we elucidate the positive role of microRNA-2184 (miR-2184) in axon regeneration within zebrafish Mauthner cells (M-cells). The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration, while the specific sponge-induced silencing of miR-2184 leads to impeded regeneration. We show that syt3, , a downstream target of miR-2184, negatively regulates axon regeneration, and the regeneration suppression modulated by syt3 depends on its binding to ca2 & thorn;. 2 & thorn; . Furthermore, pharmacolog.c.l stimulation of the cAMP/PKA pathway suggests that changes in the readily releasable pool may affect axon regeneration. Our data indicate that miR-2184 promotes axon regeneration of M-cells within the cNS by modulating the downstream target syt3, , providing valuable insights into potential therapeutic strategies. copyright (c) 2024, Institute of genetics and Developmental Biology, chinese Academy of Sciences, and genetics Society of china. Published by Elsevier Limited and Science Press. All rights reserved.

关键词： Axon regeneration Axon ablation miR-2184 syt3 Readily releasable pool READILY RELEASABLE POOL cA2+ SENSORS SMALL RNAS PHOSPHORYLATION SYNAPSES SPONgES FORM SIZE

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Diabetes and high-glucose could upregulate the expression of receptor for activated c kinase 1 in retina

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World Journal of Diabetes 2024年第3期15卷 519-529页

作者： Jian Tan ang Xiao Lin Yang Yu-Lin Tao Yi Shao Qiong Zhou Department of Ophthalmology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BAcKgROUND Diabetic retinopathy(DR)is a major ocular complication of diabetes mellitus,leading to visual *** pigment epithelium(RPE)injury is a key component of the outer blood retinal barrier,and its damage is an important indicator of *** for activated c kinase 1(RAcK1)activates protein kinase c-ε(PKc-ε)to promote the generation of reactive oxygen species(ROS)in RPE cells,leading to ***,we hypothesize that the activation of RAcK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKc-ε/ROS,thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of *** To investigate the role and associated underlying mechanisms of RAcK1 in the development of early *** In this study,Sprague-Dawley rats and adult RPE cell line-19(ARPE-19)cells were used as in vivo and in vitro models,respectively,to explore the role of RAcK1 in mediating PKc-εin early ***,the impact of RAcK1 on apoptosis and barrier function of RPE cells was also investigated in the former *** Streptozotocin-induced diabetic rats showed increased apoptosis and upregulated expression of RAcK1 and PKc-εproteins in RPE cells following a prolonged ***,ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RAcK1 and PKc-ε,accompanied by an increases in ROS production,apoptosis rate,and monolayer ***,silencing RAcK1 significantly downregulated the expression of PKc-εand ROS,reduced cell apoptosis and permeability,and protected barrier *** RAcK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.

关键词： Diabetic retinopathy Receptor for activated c kinase 1 Protein kinase c-ε Adult retinal pigment epithelium cell line-19

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Molecular properties of dissolved organic matter across Earth systems: A meta-analysis

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Journal of Earth Science 2024年

作者： Lei Han ang Hu Hellen Lucas Mzuka Xingting.c.en Ji Shen Jianjun Wang Key Laboratory of Lake and Watershed Science for Water Security， Nanjing Institute of geography and Limnology， chinese Academy of Sciences School of geography and Ocean Science， Nanjing University

Dissolved organic matter （DOM） represents the largest pool of reactive carbon on the Earth and plays a crucial role in various biogeochemical processes and ecosystem functions. However， it is understudied for a global understanding of DOM molecular properties such as molecular weight， stoichiometry， and oxidation state， and the linkages among them across Earth systems. Here， a meta-analysis of 2，707 sites in 204 literatures was conducted by synthesizing four representative molecular properties of DOM， i.e.， mass， double bond equivalent （DBE）， modified aromaticity index (AImod)， and nominal oxidation state of carbon （NOSc）. By exploring H/c and O/c ratios， we examined the relationships among these DOM properties across waters and land systems， and their geographical patterns and environmental drivers. We found that， compared to land system， the mass， DBE， and AImodwere all significantly higher in water systems， with river sediments exhibiting the highest values. DOM oxidation state indicated by NOSc was greater on average in wastewater （NOSc = 0.226 ± 0.06） and marine water （NOSc = 0.133 ± 0.06） than in other habitats. compared to waters， the mass in land system showed more strongly positive correlations with oxidation states such as NOSc and O/c， and the NOSc showed stronger relations to bioavailability properties such as DBE， AImod， and H/c. Among all the properties， H/c and AImodcontributed to the most variations in global DOM properties. In waters， NOSc monotonically increased towards high latitudes， while DBE and AImodshowed significant hump-shaped patterns indicating peaked unsaturation and aromaticity at mid-latitudes of approximately absolute 30°-50°. The variations in DOM properties were significantly correlated with environmental factors such as annual mean temperature and pH. collectively， we revealed the spatial distribution and environmental drivers of DOM molecular properties across Earth ecosystems， which could shed light on our comprehensive understan

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Morpholog.c.l disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice

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Neural Regeneration Research 2024年第1期19卷 220-225页

作者： Yin Yang Zhaoxi Yang Maoxia Lv ang Jia Junjun Li Baitao Liao Jing’an chen Zhengzheng Wu Yi Shi Yang Xia Dezhong Yao Ke chen Department of Ophthalmology Sichuan Provincial People’s HospitalMedical SchoolUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina The clinical Hospital of chengdu Brain Science Institute MOE Key Lab for NeuroInformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit of NeuroInformation Chinese Academy of Medical SciencesChengduSichuan ProvinceChina Institute of Basic Medical Sciences chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Health Management center Sichuan Provincial Key Laboratory for Human Disease Gene StudySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit for Blindness Prevention of chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan ProvinceChina School of Electrical Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

glaucoma is a leading.c.use of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the ***,it is not yet clear how the primary visual cortex(V1)is altered in *** study used DBA/2J mice as a model for spontaneous secondary *** aim of the study was to compare the electrophysiolog.c.l and histomorpholog.c.l chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched c57BL/6J *** conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band *** morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue ***-seven neurons from eight DBA/2J mice and eighty-one neurons from eight c57BL/6J mice were *** with the c57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial *** r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with c57BL/6J *** findings suggest that DBA/2J mice have fewer neurons in the VI compared with c57BL/6J mice,and that these neurons have impaired visual *** findings provide a better understanding of the patholog.c.l changes that occur in V1 neuron function and morphology in the DBA/2J mouse *** study might offer some innovative perspectives regarding the treatment of glaucoma.

关键词： DBA/2J degeneration gamma band oscillations glaucoma primary visual cortex(V1) retina single-unit recording tuning.c.rve

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A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts

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Science china(Life Sciences) 2024年第6期67卷 1242-1254页

作者： Xianliang Huang Qing Li Yanan Xu ang Li Shanzheng Wang Yusheng.c.en chunrui Zhang Xia Zhang Hailin Wang.c.ng Lv Baofa Sun Shaoqin Li Le Kang Bing.c.en School of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China college of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230601China Beijing Institute of genomics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Environmental chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain ***,we conducted a comprehensive molecular and physiolog.c.l characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta *** results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or *** individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary ***,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of *** summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria

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