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Review of the SiC LDMOS power device

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Journal of Semiconductors 2024年第8期45卷 4-17页

作者： Ziwei Hu Jiafei Yao ang Li Qi Sun Man Li Kemeng Yang Jun Zhang Jing chen Maolin Zhang Yufeng Guo College of Integrated Circuit Science and Engineering(Industry-Education Integration School) Nanjing University of Posts andT elecommunicationsNanjing 210023China National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology Nanjing 210023China Nantong Institute of Nanjing University of Posts and Telecommunications Nantong 226000China

Silicon carbide(SiC),as a third-generation semiconductor material,possesses exceptional material properties that significantly enhance the performance of power *** SiC lateral double-diffused metal–oxide–semiconductor(LDMOS)power devices have undergone continuous optimization,resulting in an increase in breakdown voltage(BV)and ultra-low specific on-resistance(Ron,sp).This paper has summarized the structural optimizations and experimental progress of SiC LDMOS power devices,including the trench-gate technology,reduced surface field(RESURF)technology,doping technology,junction termination techniques and so *** paper is aimed at enhancing the understanding of the operational mechanisms and providing guidelines for the further development of SiC LDMOS power devices.

关键词： SiC LDMOS specific on-resistance breakdown voltage

Segregation of Mg-6Gd alloy under natural convection:From macro solute distribution to micro dendrite growth

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China Foundry 2024年第5期21卷 613-624页

作者： Hong-xu chen ang Zhang Hao Li Yu Gao Yu-hong Cui Guang-sheng Huang Bin Jiang Fu-sheng Pan National Engineering Research Center for Magnesium Alloys National Key Laboratory of Advanced Casting TechnologiesCollege of Materials Science and EngineeringChongqing UniversityChongqing 400044China

Segregation is a serious defect in alloy ingots which severely deteriorates materials *** segregation defect in Mg-6Gd alloy is studied by coupling macro thermal-solutal-convection transport and micro dendrite *** macroscopic fluid dynamics and mass transfer equations are resolved to forecast the segregation behavior under conditions of continuous temperature variation during the solidification *** numerical model is validated by testing double-diffusive natural convection in a closed square cavity.A phase field model is then applied to simulate the micro dendrite growth,using macro undercooling and liquid flow velocity as boundary *** show that the multiscale segregation behavior,including macro solute distribution and micro dendritic morphology,is strongly dependent on the temperature condition and the liquid convection,which provides guidance for reducing and eliminating the segregation defect.

关键词： magnesium alloy segregation numerical simulation phase-field simulation multiscale

Kinetic Studies on Axial Coordination Reaction of Tetraphenylporphinatocobalt（Ⅱ） Chloride

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Chemical Research in Chinese Universities 1994年第3期10卷 211-219页

作者： XIA Xin(Dept. of Chem., Beijuig Sci & Tech,Univ. , Beijing, 100083 )ZHU Zhi-ang and chen Yun-ti(Dept.of Chem., Nanlai University , Tianjin, 30007 1 )

he axial coordination reactions of tetraphenylporphinatocobalt (Ⅲ) chloride(Co TPPC1) with various imidazoles RIm ( HIm . imidazole; Melm , 2-methylimida-zole) were investigated in acetone and dichloromethand solvents at different temper-atures. The reaction mechanisms were proposed and the differences between experi-mental results in the two solvents h ave been interpreted using the proposed mecha-nisms and rate equations for the first time , and the reaction scheme for the axial re-action of the metalloporphyrin has been developed. Hydrogen bonding plays an im-portant role in the reactions. The effects of various imidazoles for these reactionsand the solvents are reported. The comparison between iron and cobalt porphyrinsin the kinetics are discussed.

关键词： Porphyrin Axial coordination reaction . Kinetics . Mechanism

Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice

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Neural Regeneration Research 2024年第1期19卷 220-225页

作者： Yin Yang Zhaoxi Yang Maoxia Lv ang Jia Junjun Li Baitao Liao Jing’an chen Zhengzheng Wu Yi Shi Yang Xia Dezhong Yao Ke chen Department of Ophthalmology Sichuan Provincial People’s HospitalMedical SchoolUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina The Clinical Hospital of chengdu Brain Science Institute MOE Key Lab for NeuroInformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit of NeuroInformation Chinese Academy of Medical SciencesChengduSichuan ProvinceChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Health Management Center Sichuan Provincial Key Laboratory for Human Disease Gene StudySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan ProvinceChina School of Electrical Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the ***,it is not yet clear how the primary visual cortex(V1)is altered in *** study used DBA/2J mice as a model for spontaneous secondary *** aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J *** conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band *** morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue ***-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were *** with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial *** r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J *** findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual *** findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse *** study might offer some innovative perspectives regarding the treatment of glaucoma.

关键词： DBA/2J degeneration gamma band oscillations glaucoma primary visual cortex(V1) retina single-unit recording tuning curve

A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts

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Science China(Life Sciences) 2024年第6期67卷 1242-1254页

作者： Xianliang Huang Qing Li Yanan Xu ang Li Shanzheng Wang Yusheng chen Chunrui Zhang Xia Zhang Hailin Wang Cong Lv Baofa Sun Shaoqin Li Le Kang Bing chen School of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230601China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain ***,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta *** results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or *** individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary ***,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of *** summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria

中山市流动儿童注意缺陷多动障碍发生情况家长知晓情况及影响因素分析

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中国妇幼保健 2024年第6期39卷 971-977页

作者：何淑华高建慧孔笛陈雯陈昂谢斌华张艳红曾小菊张文蔚梁志聪谢永娥中山市博爱医院广东中山528403 中山大学公共卫生学院医学统计学系中山大学流动人口卫生政策研究中心

目的了解中山市流动儿童注意缺陷多动障碍(ADHD)发生情况,分析家长对ADHD相关知识的知晓情况及其影响因素。方法 2021年4—12月采用便利抽样法在中山市抽取540名流动儿童及其家长为研究对象。采用网络问卷调查的形式对儿童ADHD进行筛查... 详细信息

目的了解中山市流动儿童注意缺陷多动障碍(ADHD)发生情况,分析家长对ADHD相关知识的知晓情况及其影响因素。方法 2021年4—12月采用便利抽样法在中山市抽取540名流动儿童及其家长为研究对象。采用网络问卷调查的形式对儿童ADHD进行筛查,并调查家长的社会人口学信息、对ADHD的认知情况和亲子关系。分析ADHD的影响因素。结果共筛查出ADHD儿童92例,ADHD阳性率为17.0%。男生、学习成绩差、出生时抢救史、父母关系差的儿童阳性率更高(均P<0.05)。中山市流动儿童家长ADHD相关知识知晓率为37.2%。ADHD阳性儿童家长对ADHD知识的知晓率(48.9%)显著高于阴性儿童家长(34.8%),差异有统计学意义(χ^(2)=6.486,P<0.05)。多因素分析结果显示:家长高学历、日常亲子交流多、经常进行亲子交流、儿童为女生、儿童ADHD阳性是家长ADHD知晓率的影响因素(均P<0.05)。结论流动儿童ADHD阳性率高,但家长对相关知识的知晓情况普遍较差,需引起重点关注。

关键词：注意缺陷多动障碍流动人口儿童知晓率影响因素

Cucurbitacin E inhibits the metabolism pathway of CYPderived arachidonic acid in the breast cancer

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Cucurbitacin E inhibits the metabolism pathway of CYPderived...

Effect of oxygen on regulation of properties of moderately boron-doped diamond films

第十二届全国化疗药理学术研讨会

作者： Xin Wang Jian Lu ang chen Xuan Qin Mingyao Liu Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal University

Arachidonic acid（AA）can significantly increase the incidence of breast *** and leukotrienes,as the best known AA metabolites,are generated by two pathways controlled by the enzyme systems cyclooxygenase and lipoxygenase,***,AA is also substrate for a third enzymatic pathway,the cytochrome P450（CYP）*** third eicosanoid pathway consists of two main branches:ω-hydroxylases convert arachidonic acid to hydroxyeicosatetraenoic acids（HETEs）and epoxygenases convert it to epoxyeicosatrienoic acids（EETs）.These lipid autacoids may be involved in cancer in a few different ways:either in cell-autonomous tumor survival and growth or in modulating stromal processes,such as angiogenesis and inflammation that can support tumor *** EETs and HETEs pathways should be evaluated as potential targets in cancer therapy,directed both against tumor cells and their surrounding *** E（CuE）has significant anti-tumor activity,and is a potential candidate as new anti-tumor herbal *** studies found CuE inhibits tumor angiogenesis through VEGFR2 mediated Jak2/STAT3 signaling pathway and inhibits breast tumor metastasis by suppressing cell migration and *** studies in this research investigate the effects of CuE on the pathway of CYP-derived AA in the breast cancerand the CYP isoforms ***,the present study also reveals the relationship of AA,CYP,HETEs and EETs in breast cancer,and provides novel mechanisms for the pathogenesis of breast cancer and evidence for development new strategy for breast cancer ***,CYP-associated CuE metabolic studies not only are one of the major attritions in drug development,but also are considered cost-effective for predicting the potential drug-drug interaction in the clinic.

关键词：

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Chinese Physics B 2022年第12期31卷 591-597页

作者： Dong-Yang Liu Li-Cai Hao Wei-Kang Zhao Zi-ang chen Kun Tang Shun-Ming Zhu Jian-Dong Ye Rong Zhang You-Dou Zheng Shu-Lin Gu School of Electronic Science and Engineering Nanjing UniversityNanjing 210093China The Shanghai Huahong Grace Semiconductor Manufacturing Corporation Shanghai 201203China Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics Nanjing UniversityNanjing 210093China

Regulation of oxygen on properties of moderately boron-doped diamond films is fully *** show that,with adding a small amount of oxygen(oxygen-to-carbon ratio<5.0%),the crystal quality of diamond is improved,and a supp... 详细信息

Regulation of oxygen on properties of moderately boron-doped diamond films is fully *** show that,with adding a small amount of oxygen(oxygen-to-carbon ratioange of hole concentration is also ***,the results of Hall effect measurement with temperatures from 300 K to 825 K show that,with adding a small amount of oxygen,boron and oxygen complex structures(especially B_(3)O and B_(4)O)are formed and exhibit as shallow donor in diamond,which results in increase of donor *** further increase of ratio of O/C,the inhibitory behaviors of oxygen on boron leads to decrease of acceptor concentration(the optical emission spectroscopy has shown that it is decreased with ratio of O/C more than 10.0%).This work demonstrates that oxygen-doping induced increasement of the crystalline and surface quality could be restored by the co-doping with *** technique could achieve boron-doped diamond films with both high quality and acceptable hole concentration,which is applicable to electronic level of usage.

关键词： moderately boron doped diamond crystal quality suppression effect boron and oxygen complex structures

氢溴酸加兰他敏在小鼠血浆、脑组织中的药物动力学研究

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中国医药工业杂志 2006年第5期37卷 332-334页

作者：陈昂贺芬上海医药工业研究院上海200437

建立了HPLC-荧光法测定小鼠血浆和脑组织中氢溴酸加兰他敏的浓度。采用IntersilC18柱,流动相为甲醇-水(40∶60,含0.2%三乙胺,磷酸调至pH6.4),激发波长和发射波长分别为290和320nm。小鼠单剂量口服氢溴酸加兰他敏4mg/kg后血浆和脑组织中... 详细信息

建立了HPLC-荧光法测定小鼠血浆和脑组织中氢溴酸加兰他敏的浓度。采用IntersilC18柱,流动相为甲醇-水(40∶60,含0.2%三乙胺,磷酸调至pH6.4),激发波长和发射波长分别为290和320nm。小鼠单剂量口服氢溴酸加兰他敏4mg/kg后血浆和脑组织中的药物动力学参数tmax均为0.5h,Cmax分别为(691±80.34)和(1402±230.46)μg/L,AUC0→12h分别为(1138.2±160.5)和(2787.7±212.4)μg·h·L-1,AUC0→∞分别为(1147.01±198.94)和(2829.06±171.99)μg·h·L-1,t1/2分别为(4.6±1.4)和(5.0±0.2)h。

关键词：加兰他敏药物动力学高效液相色谱