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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael j.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando j.Espadas-Alvarez Manuel A.Fernandez-Parrilla juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Interleukin-1:an important target for perinatal neuroprotection?

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中国神经再生研究：英文版 2023年第1期18卷 47-50页

作者： Sharmony B.Kelly Elys green Rod W.Hunt Claudia A.Nold-Petry Alistair j.Gunn Marcel F.Nold Robert Galinsky The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVictoriaAustralia Department of Obstetrics and Gynaecology Monash UniversityVictoriaAustralia Department of Pediatrics Monash UniversityVictoriaAustralia Monash Newborn Monash Children’s HospitalMelbourneAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Perinatal inflammation is a significant risk factor for lifelong neurodevelopmental impairments such as cerebral *** clinical and preclinical evidence links the severity and pattern of perinatal inflammation to impaired maturation of white and grey matters and reduced brain *** pathways are involved in the pathogenesis of perinatal ***,studies of human and experimental perinatal encephalopathy have demonstrated a strong causative link between perinatal encephalopathy and excessive production of the pro-inflammatory effector cytokine *** this review,we summarize clinical and preclinical evidence that underpins interleukin-1 as a critical factor in initiating and perpatuating systemic and central nervous system inflammation and subsequent perinatal brain *** also highlight the important role of endogenous interleukin-1 receptor antagonist in mitigating interleukin-1-driven neuroinflammation and tissue damage,and summarize outcomes from clinical and mechanistic animal studies that establish the commercially available interleukin-1 receptor antagonist,anakinra,as a safe and effective therapeutic *** reflect on the evidence supporting clinical translation of interleukin-1 receptor antagonist for infants at the greatest risk of perinatal inflammation and impaired neurodevelopment,and suggest a path to advance interleukin-1 receptor antagonist along the translational path for perinatal neuroprotection.

关键词： brain inflammation interleukin-1 receptor antagonist interleukin-1 interleukin-1β neonatal encephalopathy neuroprotection preterm brain injury

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Extracting structural motifs from pair distribution function data of nanostructures using explainable machine learning

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npj Computational Materials 2022年第1期8卷 2053-2063页

作者： andy S.Anker Emil T.S.Kjær Mikkel juelsholt Troels Lindahl Christiansen Susanne Linn Skjærvø Mads Ry Vogel jørgensen Innokenty Kantor Daniel Risskov Sørensen Simon j.L.Billinge Raghavendra Selvan Kirsten M.Ø.jensen Department of Chemistry and Nano-Science Center University of Copenhagen2100CopenhagenDenmark Department of Materials University of OxfordParks RoadOxfordUK Department of Chemistry&iNANO Aarhus University8000AarhusDenmark MAX IV Laboratory Lund University22484LundSweden Department of Physics Technical University of Denmark2880LyngbyDenmark Department of Applied Physics and Applied Mathematics Columbia UniversityNew YorkNY10027USA Condensed Matter Physics and Materials Science Department Brookhaven National LaboratoryUptonNY11973USA Department of Computer Science University of Copenhagen2100CopenhagenDenmark Department of Neuroscience University of Copenhagen2200CopenhagenDenmark

Characterization of material structure with X-ray or neutron scattering using *** Distribution Function(PDF)analysis most often rely on refining a structure model against an experimental ***,identifying a suitable model is often a ***,automated approaches have made it possible to test thousands of models for each dataset,but these methods are computationally expensive and analysing the output,*** structural information from the resulting fits in a meaningful way,is *** Machine Learning based Motif Extractor(ML-MotEx)trains an ML algorithm on thousands of fits,and uses SHAP(SHapley Additive exPlanation)values to identify which model features are important for the fit *** use the method for 4 different chemical systems,including disordered nanomaterials and ***-MotEx opens for a type of modelling where each feature in a model is assigned an importance value for the fit quality based on explainable ML.

关键词： explain structural meaningful

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Chemotherapy for gynaecological malignancies and fertility preservation

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World journal of Obstetrics and Gynecology 2014年第2期3卷 54-60页

作者： joseph j Sacco joanne Cliff john A green Department of Medical Oncology Clatterbridge Cancer Centre Bebington Wirral CH63 4JY United Kingdom

Infertility is an increasingly important issue for patients surviving cancer. Significant improvements in cancer management have led to greater numbers of patients living healthy and fulfilling lives for many years after a diagnosis of cancer, and the ability to bear children is a major component of well-being. Infertility is particularly challenging in gynaecological cancer, where multiple treatment modalities are often employed. Surgery may involve the removal of reproductive organs and subsequent chemotherapy may also lead to infertility. Mitigation of this through the use of cryopreservation of embryos, oocytes or ovarian tissue before chemotherapy may enable subsequent pregnancy in the patient or a surrogate mother. Suppression of ovarian function during chemotherapy is less well established, but promises a reduction in infertility without the risks associated with surgery. Similarly, evolving chemotherapy regimens with replacement of alkylating agents will reduce the incidence of infertility. With a combination of these techniques, an increasing proportion of patients may be able to conceive after completion of treatment, and there is no evidence of an increase in congenital abnormalities. This review discusses chemotherapy-inducedinfertility, interventions and success rates, and demonstrates that individualisation of management is required for optimum outcome.

关键词： Infertility Chemotherapy Gynaecological malignancies Ovarian Cryopreservation

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Rapid, cost-effective DNA quantification via a visuallydetectable aggregation of superparamagnetic silicamagnetite nanoparticles

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Nano Research 2014年第5期7卷 755-764页

作者： Qian Liu jingyi Li Hongxue Liu Ibrahim Tora Matthew S. Ide jiwei Lu Robert j. Davis David L. green james P. Landers Department of Chemistry University of Virginia McCormick Road P. O. Box 400319 Charlottesville 22904 Virginia USA Department of Pathology University of Virginia Health Science Center Charlottesville 22908 Virginia USA Department of Mechanical Engineering University of Virginia Charlottesville 22904 Virginia USA Center for Microsystems forthe Life Sciences University of Virginia Charlottesville 22904 Virginia USA Department of Materials Science & Engineering University of Virginia P. O. Box 400745 395 McCormick Road Charlottesville 22904-4745 Virginia USA Department of Chemical Engineering University of Virginia. 123 Engineers Way Charlottesville 22904 Virginia USA

DNA and silica-coated magnetic particles entangle and form visible aggregates under chaotropic conditions with a rotating magnetic field, in a manner that enables quantification of DNA by image analysis. As a means of exploring the mechanism of this DNA quantitation assay, nanoscale SiO2-coated Fe304 （Fe3O4@SiO2） particles are synthesized via a solvothermal method. Characterization of the particles defines them to be -200 nm in diameter with a large surface area （141.89 m2/g）, possessing superparamagnetic properties and exhibiting high saturation magnetization （38 emu/g）. The synthesized Fe3O4@SiO2 nanoparticles are exploited in the DNA quantification assay and, as predicted, the nanoparticles provide better sensitivity than commercial microscale Dynabeads for quantifying DNA, with a detection limit of 4 kilobase-pair fragments of human DNA. Their utility is proven using nanoparticle DNA quantification to guide efficient polymerase chain reaction （PCR） amplification of short tandem repeat loci for human identification.

关键词： silica/magnetite core-shell superparamagnetic DNA quantification polymerase chain reaction(PCR)

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Timing of Hepatitis C Virus Treatment in Liver Transplant Candidates in the Era of Direct-acting Antiviral Agents

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journal of Clinical and Translational Hepatology 2017年第4期5卷 363-367页

作者： George Cholankeril Mairin joseph-Talreja Brandon j.Perumpail andy Liu Eric R.Yoo Aijaz Ahmed Aparna Goel Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA Department of Medicine Drexel University College of MedicinePhiladelphiaPAUSA Department of Medicine California Pacific Medical CenterSan FranciscoCAUSA Department of Medicine Santa Clara Valley Medical CenterSan JoseCAUSA

Chronic hepatitis C virus(HCV)infection remains the leading indication for liver transplantation(LT)in the United *** most patients with chronic HCV infection remain asymptomatic,up to one-third develop progressive liver disease resulting in *** is often the only curative treatment once significant hepatic decompensation ***,antiviral therapy for HCV infection has advanced markedly in the past 5 years with the discovery and approval of direct-acting antiviral *** new regimens are well tolerated,of short duration and highly effective,unlike the traditional treatment with pegylated-interferon and *** achieving sustained virological response becomes increasingly attainable for a majority of HCV-infected patients,concerns have been raised regarding the optimal timing of treatment for HCV infection in the setting of end-stage liver disease and during the peri-transplant *** one hand,HCV treatment may improve hepatic function and negate the need for LT in some,which is crucial given the scarcity of donor organs and mortality on the waiting list in certain *** the other hand,HCV treatment may result in lowering the priority for LT without improving quality of life,thereby delaying potentially curative LT *** review evaluates the evidence supporting the use of direct-acting antiviral agents in the period before and following LT.

关键词： Hepatitis C virus Direct-acting antiviral therapy Liver transplantation

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还原性的类立方烷型金属有机原子簇[M_4(μ~3-Se)_4(η-C_5H_4R)_4](M=Mo,R=Pr^i;M=Cr,R=Me)的合成、晶体结构和电子性质

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有机化学 1989年第5期9卷 422-425页

作者：秦金贵 M.L.H.green j.C.green j.A.Bandy 武汉大学化学系 Inorganic. Chemistry. Laboratory. Oxford University OX1 3QR UK Chemical. Crysttallography. Laboratory. Oxford University OX1 3PD UK

类立方烷型金属原子簇化合物M_4E_4(M为过渡金属,E为硫属元素)的研究长期以来受到重视,其主要原因有二:(1)一些类立方烷型金属原子簇(如Fe_4S_4及Fe-Mo-S原子簇)在生物体系(如固氮酶、铁氧还蛋白)中有重要意义;(2)由于可以方便地对M或E... 详细信息

类立方烷型金属原子簇化合物M_4E_4(M为过渡金属,E为硫属元素)的研究长期以来受到重视,其主要原因有二:(1)一些类立方烷型金属原子簇(如Fe_4S_4及Fe-Mo-S原子簇)在生物体系(如固氮酶、铁氧还蛋白)中有重要意义;(2)由于可以方便地对M或E作系列性的改变,因而M_4E_4成为研究原子簇化合物的电子结构及检测各种有关的理论假设的重要模型化合物。

关键词：族合物金属有机化物硒化合物

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Accent on Australia 1st ed.

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丛书名： Materials for language practice

1985年

作者： green j

来源：畅想之星图书光盘版（南... 评论

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Chemically robust superhydrophobic surfaces with a self‐replenishing nanoscale liquid coating

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Droplet 2024年第1期3卷 136-148页

作者： Xiaoteng Zhou Pranav Sudersan Diego Diaz Benjamin Leibauer Chirag Hinduja Fahimeh Darvish Pravash Bista Lukas Hauer Manfred Wagner Werner Steffen jie Liu Michael Kappl Hans‐jürgen Butt Max Planck Institute for Polymer Research MainzGermany Key Laboratory of green Printing Institute of ChemistryChinese Academy of SciencesBeijingChina School of Chemical Sciences University of Chinese Academy of SciencesBeijingChina

Due to poor chemical robustness,superhydrophobic surfaces become susceptible to failure,especially in a highly oxidative *** ensure the longterm efficacy of these surfaces,a more stable and environmentally friendly coating is required to replace the conventional salinization ***,soottemplated surfaces with re‐entrant nanostructures are precoated with polydimethylsiloxane(PDMS)*** additional nanometer‐thick lubricant layer of PDMS was then applied to increase chemical *** surface is superhydrophobic with a nanoscale liquid *** the lubricant layer is thin,ridge formation is suppressed,which leads to low drop sliding friction and fast drop *** introducing a bottom“reservoir”of a free lubricant as an oil source for self‐replenishing to the upper layer,the superhydrophobic surface becomes more stable and heals spontaneously in response to alkali erosion and O2 plasma *** design also leads to a higher icing delay time and faster removal of impacting cooled water drops than for uncoated surfaces,preventing icing at low temperatures.

关键词： coating friction liquid

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Microglia as hackers of the matrix:sculpting synapses and the extracellular space

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Cellular & Molecular Immunology 2021年第11期18卷 2472-2488页

作者： joshua D.Crapser Miguel A.Arreola Kate I.Tsourmas Kim N.green Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA

Microglia shape the synaptic environment in health and disease,but synapses do not exist in a ***,pre-and postsynaptic terminals are surrounded by extracellular matrix(ECM),which together with glia comprise the four elements of the contemporary tetrapartite synapse *** research in this area is still just beginning,accumulating evidence points toward a novel role for microglia in regulating the ECM during normal brain homeostasis,and such processes may,in turn,become dysfunctional in *** it relates to synapses,microglia are reported to modify the perisynaptic matrix,which is the diffuse matrix that surrounds dendritic and axonal terminals,as well as perineuronal nets(PNNs),specialized reticular formations of compact ECM that enwrap neuronal subsets and stabilize proximal *** interconnected relationship between synapses and the ECM in which they are embedded suggests that alterations in one structure necessarily affect the dynamics of the other,and microglia may need to sculpt the matrix to modify the synapses ***,we provide an overview of the microglial regulation of synapses,perisynaptic matrix,and PNNs,propose candidate mechanisms by which these structures may be modified,and present the implications of such modifications in normal brain homeostasis and in disease.

关键词： Neuroscience Perineuronal nets Microglia Extracellular matrix Neuroinflammation

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