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microstructural development and mechanical properties of drop tube atomized Al-2.85 wt%Fe

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Journal of materials Science & Technology 2022年第9期104卷 41-51页

作者： mehmet R.Abul Robert F.Cochrane andrew m.mullis School of Chemical&Process Engineering University of LeedsLeeds LS29JTUK

Al-2.85 wt%Fe alloy has been subjected to non-equilibrium container-less solidification using a 6.5 m drop *** samples were collected and sieved into 7 sizes fractions ranging from 850μm to 53μm,with the estimated cooling rates being 150 to 11000 K s^(-1)*** analysis was employed on all droplet size fractions for identification and evolution of the phases,showing that Al,Al_(6)Fe and Al_(13)Fe_(4)were formed for all sizes while Al_(5)Fe_(2)was observed only in droplets≤150μm in *** evaluation was conducted by using SEm and optical microscopy,showing that droplet larger than 300μm in diameter exhibited distinct morphologies;microcellular,dendriticα-Al with inter-dendritic Al_(13)Fe_(4)eutectic and an AI-Al_(6)Fe eutectic *** increasing cooling rate,the Al-Al_(6)Fe region *** analysis reveals that increasing the cooling rate increased the dissolved Fe content inα-Al from 0.37 wt%Fe to 1.105 wt%Fe,and correspondingly the eutectic fraction decreased from 49.7 vol.%to 26.7 vol.%.measurement of the lamellar spacing allowed the eutectic growth velocity and interfacial undercooling to be calculated,wherein the Al-rich boundary of the eutectic coupled zone could be *** shows a coupled zone skewed significantly towards the intermetallic side of the *** order to understand the effect of non-equilibrium the solidification on the mechanical properties micro hardness of the droplets was *** micro-hardness has risen from 55.3 HV_(0.01)to 66.5 HV_(0.01)for≥850μm and≤75μm droplets,respectively.

关键词： Al-Fe alloys Container-less solidification microstructure TEm micro-hardness

Cardiovascular care for older adults： hypertension and stroke in the older adult

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Journal of Geriatric Cardiology 2016年第5期13卷 373-379页

作者： andrew P miller Ann m Navar Gary S Roubin Suzanne Oparil CardioVascular Associates Birmingham Alabama USA Duke Clinical Research Institute Durham North Carolina USA Vascular Biology & Hypertension Program Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham Alabama USA

Hypertension and cerebrovascular disease incidence and prevalence rise dramatically with age, owing to longer exposure time to age-associated alterations in vascular function and structure and cardiovascular risk factors. This chapter is aimed at connecting age-related alterations in vascular function and structure to the resultant target organ damage, and to raise awareness of unique presentations and treatment strategies for hypertension and stroke in older adults.

关键词：高血压老年人心血管中风护理年龄相关血管功能脑血管疾病

Th17 cells and their associated cytokines in liver diseases

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Cellular & molecular Immunology 2010年第4期7卷 250-254页

作者： Fouad Lafdil andrew m.miller Sung Hwan Ki Bin Gao Section on Liver Biology Laboratory of Physiologic StudiesNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMDUSA INSERm U955Cre´teilFrance Faculte´de me´decine Universite´Paris 12Cre´teilFrance

T helper 17(Th17)cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune *** functions of Th17 cells are mediated via the production of several cytokines including interleukin(IL)-17 and *** studies show that the frequency of IL-171 cells is significantly elevated in a variety of chronic liver diseases including alcoholic liver disease,viral hepatitis and hepatocellular ***-17 receptor is expressed virtually on all types of liver cells,while IL-22 receptor expression is restricted to epithelial cells including hepatocytes in the ***-17 seems to play an important role in inducing liver inflammation via stimulating multiple types of liver nonparenchymal cells to produce proinflammatory cytokines and chemokines,while IL-22 appears to be an important factor in promoting hepatocyte survival and proliferation.

关键词： IL-17 IL-22 hepatitis alcoholic liver disease liver cancer

Ca2+ signaling during vertebrate somitogenesis

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Acta Pharmacologica Sinica 2006年第7期27卷 781-790页

作者： Sarah E WEBB andrew L miller Department of Biology the Hong Kong University of Science and TechnologyClear Water BayHong Kong SARChina

A variety of Ca2+signals,in the form of intercellular pulses and waves,have beenreported to be associated with the various sequential stages of somitogenesis:from convergent extension and the formation of the paraxial mesoderm;during thepatterning of the paraxial mesoderm to establish segmental units;throughout theformation of the morphological boundaries that delineate the segmental units,andfinally from within the maturing somites as they undergo subsequent develop-ment and *** to both the technical challenges presented in imag-ing intact,developing embryos,and the subtle nature of the Ca2+transientsgenerated,they have proved to be difficult to ***,a combinationof cultured cell preparations and improvements in explant and whole embryo im-aging techniques has begun to reveal a new and exciting class of developmentalCa2+*** this chapter,we review the small,but expanding,number ofreports in the literature and attempt to identify common characteristics of thesomitogenic Ca2+transients,such as their mode of generation,as well as theirspatial and temporal *** may help to elucidate the significance andfunction of these intriguing Ca2+transients and thus integrate them into the com-plex signaling networks that orchestrate early developmental events.

关键词： Ca2+ signaling somitogenesis zebrafish Xenopus mouse chick

A Scalable Testing Framework for Location-Based Services

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Journal of Computer Science & Technology 2009年第2期24卷 386-404页

作者： Jiang Yu andrew Tappenden James miller michael Smith University of Alberta Edmonton T6G 2E1 Canada University of Calgary Calgary T2N 1N4 Canada

A novel testing framework for location based services is introduced. In particular, the paper showcases a novel architecture for such a framework. The implementation of the framework illustrates both the functionality and the feasibility of the framework proposed and the utility of the architecture. The new framework is evaluated through comparison to several other methodologies currently available for the testing of location-based applications. A case study is presented in which the testing framework was applied to a typical mobile service tracking system. It is concluded that the proposed testing framework achieves the best coverage of the entire location based service testing problem of the currently available methodologies; being equipped to test the widest array of application attributes and allowing for the automation of testing activities.

关键词： location based applications location-based services m-commerce software testing

Coprophilous contributions to the phylogeny of Lasiosphaeriaceae and allied taxa within Sordariales(Ascomycota,Fungi)

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Fungal Diversity 2015年第1期70卷 101-113页

作者： Åsa Kruys Sabine m.Huhndorf andrew N.miller Systematic Biology Department of Organismal BiologyEvolutionary Biology CentreUppsala UniversityNorbyvägen 18DSE-75236 UppsalaSweden Botany Department Field MuseumChicagoIL 60605USA Illinois Natural History Survey University of IllinoisChampaignIL 61820US

The phylogenetic relationships of Lasiosphaeriaceae are complicated in that the family is paraphyletic and includes Sordariaceae and Chaetomiaceae,as well as several polyphyletic *** study focuses on the phylogenetic relationships of the coprophilous genera,Anopodium,Apodospora,Arnium,Fimetariella and *** are traditionally circumscribed based on ascospore characters,which have proven homoplasious in other genera within the *** results based on LSU nrDNA andß–tubulin sequences distinguish four lineages of Lasiosphaeriaceae *** joins the clade of mor-phologically similar,yellow-pigmented species of Cercophora and *** is monophyletic and joins a larger group of taxa with unclear affinities to each other,while Arnium is polyphyletic being scattered throughout three of the four major clades of *** is represented by a single collection and joins the clade containing Cercophora scortea and Podospora *** shows affinities to the Lasiosphaeris *** on a combination of morphological and molecular data,Echria *** recognized at the genus level for the former Arnium section and two new combinations are proposed:*** and ***.

关键词： Ascomal wall Ascomycete β-tubulin LSU nrDNA Systematics,Taxonom

The development of a high-performance Ni-superalloy additively manufactured heat pipe

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Advances in manufacturing 2022年第4期10卷 610-624页

作者： Sheng Li Khamis Essa James Carr States Chiwanga andrew Norton moataz m.Attallah School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Engineering University of BirminghamEdgbastonBirmingham B152TTUK Henry moseley X-ray Imaging Facility Henry Royce Institute for Advanced MaterialsDepartment of MaterialsUniversity of ManchesterManchester M139PLUK European Thermodynamics Ltd 8 Priory Business ParkWistow RoadKibworthLeicestershire LE80RXUK Rolls-Royce plc P.O.Box 31Derby DE248BJUK School of metallurgy and materials University of BirminghamEdgbastonBirmingham B152TTUK

Additively manufacturing(Am)has been used to manufacture fine structures with structured/engineered porosity in heat management *** this study,laser powder bed fusion(LPBF)was used to manufacture a high-performance Ni-superalloy heat pipe,through tailoring LPBF process parameters to fabricate thin wall and *** using novel laser scanning strategies,wick structure heat pipes with maximised surface-area-to-volume ratio,fine features size around 100µm,and controlled porosity were successfully *** and X-ray microtomography(micro-CT)were used to investigate the 3D structure of the void space within the *** test results showed that most of the heat pipes made by LPBF had better performance than the conventionally manufactured *** study also investigated the influences of the process parameters on the porosity volume fraction and the feature *** results showed that LPBF process could fabricate thin structure due to the change of melt pool contact *** relationship between process parameters and bead size reported in this study could help design and manufacture heat pipe with complex fine structure.

关键词： Laser powder bed fusion(LPBF) Heat pipe melt pool microtomography(micro-CT)

Calcium signaling during the early meroblastic cleavages of zebrafish and medaka embryos

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Frontiers in Biology 2010年第4期5卷 283-285页

作者： andrew L.miller Section of Biochemistry and Cell Biology and State Key Laboratory for Molecular NeuroscienceDivision of Life ScienceHong Kong University of Science and TechnologyHong KongChina

The regulation of cytokinesis in“giant”embryonic cells(i.e.,>500μm in diameter)presents exacting challenges that include long-range signaling with respect to time and space;the transport and assembly,followed by disassembly,of an extensive contractile apparatus;and the remodeling and addition of new surface membrane to the resulting daughter cells.

关键词： fish daughter apparatus

microbiome and colorectal carcinogenesis:Linked mechanisms and racial differences

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 375-395页

作者： Sofia C Tortora Vimal m Bodiwala andrew Quinn Laura A martello Shivakumar Vignesh Department of medicine and Division of Gastroenterology&Hepatology SUNY Downstate Health Sciences UniversityBrooklynNY 11203United States

Various studies have shown the interplay between the intestinal microbiome,environmental factors,and genetic changes in colorectal cancer(CRC)*** this review,we highlight the various gut and oral microbiota associated with CRC and colorectal adenomas,and their proposed molecular mechanisms in relation to the processes of“the hallmarks of cancer”,and differences in microbial diversity and abundance between race/*** with CRC showed increased levels of Bacteroides,Prevotella,Escherichia coli,enterotoxigenic Bacteroides fragilis,Streptococcus gallolyticus,Enterococcus faecalis,Fusobacterium nucleatum(***)and Clostridium *** levels of Bacteroides have been found in African American(AA)compared to Caucasian American(CA)***-inflammatory bacteria such as *** and Enterobacter species were significantly higher in ***,AA patients have been shown to have decreased microbial diversity compared to CA *** studies have shown that using microbiome profiles in conjunction with certain risk factors such as age,race and body mass index may help predict healthy colon vs one with adenomas or *** is one of the most common bacterial infections in humans and is more prevalent in Non-Hispanic-Blacks as compared to Non-Hispanic *** condition causes increased systemic inflammation,immune dysregulation,gut microbiota dysbiosis and thereby possibly influencing colorectal ***-associated bacteria such as Fusobacterium,Prevotella,Bacteroides and Porphyromonas have been found in CRC tissues and in feces of CRC ***,a deeper understanding of the association between oral and gastrointestinal bacterial profile,in addition to identifying prevalent bacteria in patients with CRC and the differences observed in ethnicity/race,may play a pivotal role in predicting incidence,prognosis,and lead to the development of new treatments.

关键词： Colorectal cancer Oral microbiome Gut microbiome Hallmarks of cancer Racial/ethnic microbial diversity