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Chip-integrated van der Waals PN heterojunction photodetector with low dark current and high responsivity

Light(Science & Applications) 2022年第5期11卷 901-910页

作者： Ruijuan Tian Xuetao Gan Chen Li Xiaoqing Chen Siqi Hu Linpeng Gu Dries Van Thourhout andres Castellanos-Gomez Zhipei Sun Jianlin Zhao Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical University710129 Xi’anChina Photonics Research Group and Center for Nano and Biophotonics Ghent UniversityB-9000 GentBelgium Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)E-28049 MadridSpain Department of Electronics and Nanoengineering and QTF Centre of Excellence Aalto UniversityFI-02150 EspooFinland

Two-dimensional materials are attractive for constructing high-performance photonic chip-integrated photodetectors because of their remarkable electronic and optical properties and dangling-bond-free ***,the reported chip-integrated two-dimensional material photodetectors were mainly implemented with the configuration of metalsemiconductor-metal,suffering from high dark currents and low responsivities at high operation ***,we report a van der Waals PN heterojunction photodetector,composed of p-type black phosphorous and n-type molybdenum telluride,integrated on a silicon nitride *** built-in electric field of the PN heterojunction significantly suppresses the dark current and improves the *** a bias of 1 V pointing from n-type molybdenum telluride to p-type black phosphorous,the dark current is lower than 7 nA,which is more than two orders of magnitude lower than those reported in other waveguide-integrated black phosphorus *** intrinsic responsivity up to 577 mA W^(−1) is ***,the van der Waals PN heterojunction is tunable by the electrostatic doping to further engineer its rectification and improve the photodetection,enabling an increased responsivity of 709 mA W^(−1).Besides,the heterojunction photodetector exhibits a response bandwidth of~1.0 GHz and a uniform photodetection over a wide spectral range,as experimentally measured from 1500 to 1630 *** demonstrated chip-integrated van der Waals PN heterojunction photodetector with low dark current,high responsivity and fast response has great potentials to develop high-performance on-chip photodetectors for various photonic integrated circuits based on silicon,lithium niobate,polymer,etc.

关键词： heterojunction responsivity waveguide

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Distal nucleotides affect the rate of stop codon read-through

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Quantitative Biology 2023年第1期11卷 44-58页

作者： Luciana I.Escobar andres M.Alonso Jorge R.Ronderos Luis Diambra CREG Universidad Nacional de La Plata-CONICETLa Plata CP 1900Argentina INTechUniversidad Nacional de San MartinChascomus CP 7130Argentina FCNyMUniversidad Nacional de La PlataLa Plata CP 1900Argentina

Background:A key step in gene expression is the recognition of the stop codon to terminate translation at the correct ***,it has been observed that ribosomes can misinterpret the stop codon and continue the translation in the 3′UTR *** phenomenon is called stop codon read-through(SCR).It has been suggested that these events would occur on a programmed basis,but the underlying mechanisms are still not well ***:Here,we present a strategy for the comprehensive identification of SCR events in the Drosophila melanogaster transcriptome by evaluating the ribosomal density *** associated ribosomal leak rate was estimated for every event identified.A statistical characterization of the frequency of nucleotide use in the proximal region to the stop codon in the sequences associated to SCR events was ***:The results show that the nucleotide usage pattern in transcripts with the UGA codon is different from the pattern for those transcripts ending in the UAA codon,suggesting the existence of at least two mechanisms that could alter the translational termination ***,a linear regression models for each of the three stop codons was developed,and we show that the models using the nucleotides at informative positions outperforms those models that consider the entire sequence context to the stop ***:We report that distal nucleotides can affect the SCR rate in a stop-codon dependent manner.

关键词： translational readthrough stop codons translational termination ribosomal density profiles nucleotide usage frequency

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Role of platelet-rich plasma in the treatment of rotator cuff tendinopathy

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World Journal of Orthopedics 2023年第7期14卷 505-515页

作者： Ausberto Velasquez Garcia Liborio Ingala Martini andres Franco Abache Glen Abdo Department of Orthopedic Surgery Clínica Universidad de los AndesSantiago 7620157Chile Department of Orthopedic Surgery Hospital IVSS Dr.Luis OrtegaPorlamar 6301Venezuela Department of Orthopedic Surgery Hospital Clinicas del EsteLos Robles 6301Venezuela Department of Orthopedic Surgery Hospital de Especialidades Guayaquil MSPGuayaquil 090101Ecuador Department of Graduate Medical Education Internal Medicine Residence ProgramNew York Medical College at St.Mary’s and St.Clare’sPassaicNJ 07055United States

Shoulder pain is a common musculoskeletal complaint,and rotator cuff(RC)pathologies are one of the main *** RC undergoes various tendinopathic and avascular changes during the aging *** degenerative changes affecting its healing potential make it an appealing target for biological ***-rich plasma(PRP)has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators,and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle,ligaments,and tendinous *** review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical *** to the different characteristics and conflicting outcomes,clinicians should use PRP with moderate expectations until more consistent evidence is ***,it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate *** autologous origin makes it a safe treatment,and its characteristics make it a promising option for treating RC tendinopathy,but the efficacy has yet to be established.

关键词： Rotator cuff Tendinopathy Platelet-rich plasma Shoulder pain Nonoperative treatment Injectables

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Effect of Pressure on Cesium Iodide Band Gap

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物理化学学报 2018年第2期34卷 208-212页

作者： CEDILLO andres CORTONA Pietro Departamento de Quimica Universidad Autonoma Metropolitana-Iztapalapa San Rafael Atlixco 186 09340 Mexico DF Mexico Laboratoire Structures Proprietes et Modelisation des Solides CNRS UMR 8580 Universite Paris-Saclay CentraleSupelec GrandeV

The evolution of cesium iodide band gap as a function of pressure is studied in the range from 0 to 60 GPa. Within this range, two structural phase transitions occurred, and the band gap was affected by the compression pressure and structural rearrangement. The band gap estimation under pressure, as obtained by the density functional theory methods, successfully reproduced the experimental trend of the optical gap and electrical resistivity, namely, a general decreasing tendency, an early maximum, and a discontinuous peak around 40 GPa.

关键词：密度泛函理论光学科学研究工作物理学

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Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: Current evidence

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World Journal of Diabetes 2019年第5期10卷 291-303页

作者： Leonardo Pozo Fatimah Bello andres Suarez Francisco E Ochoa-martinez Yamely Mendez Chelsea H Chang Salim Surani University of Texas Rio Grande Valley-Doctors Hospital at Renaissance Internal Medicine Residency Program Faculty of Medicine Universidad Autonoma de Nuevo LeonUniversity Hospital "Dr. José Eleuterio González" Faculty of Medicine "Dr. Alberto Romo Caballero" Universidad Autonoma de Tamaulipas Medical Critical Care Services Christus Spohn Hospitals-Corpus Christi

Cardiovascular diseases(CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus(T2DM)suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration(FDA) established new expectations for the evaluation of new antidiabetic agents, advising for pre and,in some cases, post-marketing data on major cardiovascular events. As a direct consequence, there has been a paradigm shift in new antidiabetic agents that has given birth to the recently published American Diabetes Association/European Association for the Study of Diabetes consensus statement recommending sodium-glucose cotransporter-2 inhibitors(SGLT2i) and glucagon like peptide-1 receptor agonists(GLP-1RA) in patients with T2DM and established CVD. As a result of over a decade of randomized placebo controlled cardiovascular outcome trials, the aforementioned drugs have received FDA approval for risk reduction of cardiovascular(CV) events in patients with T2DM and established CV ***2i have been shown to have a stronger benefit in patients with congestiveheart failure and diabetic kidney disease when compared to their GLP-1RA counterparts. These benefits are not withstanding additional considerations such as cost and the multiple FDA Black Box warnings. This topic is currently an emerging research area and this mini-review paper examines the role of these two novel classes of drugs in patients with T2DM with both confirmed, and at risk for, CVD.

关键词： Type 2 diabetes mellitus Glucagon-like-peptide 1 agonists Sodium-glucose cotransporter-2 inhibitor Cardiovascular disease Major adverse cardiovascular event

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Revealing the complexity of vampire bat rabies "spillover transmission"

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Infectious Diseases of Poverty 2023年第1期12卷 102-110页

作者： Luis E.Escobar andres Velasco-Villa Panayampalli S.Satheshkumar Yoshinori Nakazawa Paige Van de Vuurst Department of Fish and Wildlife Conservation Virginia TechBlacksburgVAUSA Virginia Tech Graduate School Translational BiologyMedicineand Health ProgramBlacksburgVAUSA Global Change Center Virginia TechBlacksburgVAUSA Center for Emerging Zoonotic and Arthropod‑Borne Pathogens Virginia TechBlacksburgVAUSA Facultad de Ciencias Agropecuarias Universidad de La SalleBogotáColombia Poxvirus and Rabies Branch Centers for Disease Control and Prevention1600 Clifton Rd.NEAtlantaGA 30333USA

Background The term virus'spillover’embodies a highly complex phenomenon and is often used to refer to viral transmission from a primary reservoir host to a new,naïve yet susceptible and permissive host *** transmission can result in a virus becoming pathogenic,causing disease and death to the new host if successful infection and transmission takes *** text The scientific literature across diverse disciplines has used the terms virus spillover,spillover transmission,cross-species transmission,and host shift almost indistinctly to imply the complex process of establishment of a virus from an original host(source/donor)to a naïve host(recipient),which have close or distant taxonomic or evolutionary *** transmission may result in unsuccessful onward transmission,if the virus dies off before ***,successful viral establishment in the new host can occur if subsequent secondary transmission among individuals of the same novel species and among other sympatric susceptible species *** such,virus spillover transmission is a common yet highly complex phenomenon that encompasses multiple subtle stages that can be deconstructed to be studied separately to better understand the drivers of disease *** virus(RABV)is a well-documented viral pathogen which still inflicts heavy impact on humans,companion animals,wildlife,and livestock throughout Latin America due substantial spatial temporal and ecological—natural and expansional—overlap with several virus reservoir ***,the rabies disease system represents a robust avenue through which the drivers and uncertainties surrounding spillover transmission can be unravel at its different subtle stages to better understand how they may be affected by coarse,medium,and fine scale *** The continued study of viral spillover transmission necessitates the elucidation of its complexities to better assess the cross-scale impacts of ecological force

关键词： Bat-borne diseases Rabies Spillover Transmission

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Two titans fin ally meet each other under nitrogen deficiencies:FERONIA-TORC1 activation promotes plant growth

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Molecular Plant 2022年第7期15卷 1095-1097页

作者： Javier martinez Pacheco Jose M.Estevez Fundación Instituto Leloir and IIBBA-CONICET.Av.Patricias Argentinas 435 Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile ANID-Millennium Science Initiative Program-Millennium Nucleus for the Development of Super Adaptable Plants(MN-SAP) SantiagoChile

Plant growth is determined by well-defined developmental processes that integrate cell-intrinsic factors and external environmental cues,and it is largely dependent on the assimilation of macro-and micro-nutrients from the *** the macro-nutrients,the inorganic nitrogen(e.g.,nitrate and ammonium)and amino acids are essential for plant survival and *** acting as macro-nutrients and structural components of macro-molecules,these nitrogen-containing molecules could also act as signaling molecules to orchestrate diverse genetic programs(Wang et al.,2018).

关键词： activation inorganic nitrate

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Fetkin-hydro,a new thermo-hydrological algorithm for low-temperature thermochronological modeling

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Geoscience Frontiers 2021年第3期12卷 186-200页

作者： Francisco Sánchez andres Barrea Federico M.Dávila andres Mora Centro de Investigaciones en Ciencias de la Tierra(CICTERRA) CONICET-UNCFCEFyNCiudad UniversitariaAv.Vélez Sarsfield 16115000 CórdobaArgentina Facultad de Matemática AstronomíaFísica y Computación(FAMAF)Ciudad UniversitariaAv.Medida Allende 21445000 CórdobaArgentina Ecopetrol BotafogoRio de JaneiroBrazil

Despite two decades of major advances in the field of thermochronological modeling,state-of-the-art numerical implementations still rely mostly on burial and exhumation processes to explain radiometric *** though such an approach has proved valuable,failing to account for other first-order geological variables has led to misinterpretations and therefore,calls for a *** this study a new version of the Fetkin(finite element temperature kinematics,Ecopetrol)program is *** new algorithm couples time-dependent hydrological and thermal calculations,thus rendering thermochronological ages that,instead of being solely dependent on the kinematical evolution of a system,conditioning by the fluid flow is also *** contrast with previous thermochronological models,this work considers the influence of effective stress on rock properties(porosity and permeability)and therefore,in thermal *** analyses addressing relevant geological questions show not only the versatility of the code but also,new perspectives on forward low-temperature thermochronological *** circulation through pure-sandstone settings produce colder thermal architectures than those obtained in impermeable *** in cooling ages from models with and without fluid circulation are up to 5 Myr.A 4-fold variation in thrusting rates(0.5 km/Myr to 2 km/Myr)produces a 15-Myr difference in cooling ages in models with fluid flow,which contrasts to much lower differences,only 2 Myr,in domains without(or minimal)fluid circulation.2D thermal solutions in fold-bend-fold thrust belts composed of sandstones remain static despite substantial relief development by kinematic folding.A case-study from Western Argentina,in the Andean Precordillera,confirms the plausibility of the numerical algorithm here posed and raises new questions on the first-order thermal controls in settings under deformation.

关键词： Thermochronology Hydrogeology Fluid flow Numerical modeling

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Stochastic modeling,analysis,and simulation of the COVID-19 pandemic with explicit behavioral changes in Bogota:Acase study

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Infectious Disease Modelling 2022年第1期7卷 199-211页

作者： David Nino-Torres andres Ríos-Gutierrez Viswanathan Arunachalam Comfort Ohajunwa Padmanabhan Seshaiyer Department of Statistics Universidad Nacional de ColombiaBogotaColombia George Mason University FairfaxVAUSA

In this paper,a stochastic epidemiological model is presented as an extension of a compartmental SEIR model with random perturbations to analyze the dynamics of the COVID-19 pandemic in the city of Bogota D.C.,*** model incorporates thespread of COVID-19 impacted by social behaviors in the population and allows for projecting the number of infected,recovered,and deceased individuals considering the mitigation measures,namely confinement and partial relaxed ***,the role of randomness using the concept of Brownian motion is emphasized to explain the behavior of the *** experiments for the stochastic model with random perturbations were performed,and the model is validated through numerical simulations for actual data from Bogota D.C.

关键词： Epidemic spread SARS-CoV-2 Compartmental modeling Stochastic perturbations Parameter estimation

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Laser trimming for lithography-free fabrications of MoS_(2)devices

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Nano Research 2023年第4期16卷 5042-5046页

作者： Yong Xie OnurÇakıroğlu Wenshuai Hu Kexin He Sergio Puebla Thomas Pucher Qinghua Zhao Xiaohua Ma Carmen Munuera andres Castellanos-Gomez Key Laboratory of Wide Band-Gap Semiconductor Technology School of Advanced Materials and NanotechnologyXidian UniversityXi’an 710071China Materials Science Factory Instituto de Ciencia de Materiales de MadridConsejo Superior de Investigaciones Científicas28049 MadridSpain

Single-layer MoS_(2)produced by mechanical exfoliation is usually connected to thicker and multilayer *** show a facile laser trimming method to insulate single-layer MoS_(2)regions from thicker *** demonstrate,through electrical characterization,that the laser trimming method can be used to pattern single-layer MoS_(2)channels with regular geometry and electrically disconnected from the thicker *** photocurrent microscope further confirms that in the as-deposited flake(connected to a multilayer area)most of the photocurrent is being generated in the thicker flake *** laser trimming,scanning photocurrent microscopy shows how only the single-layer MoS_(2)region contributes to the photocurrent *** presented method is a direct-write and lithography-free(no need of resist or wet chemicals)alternative to reactive ion etching process to pattern the flakes that can be easily adopted by many research groups fabricating devices with MoS_(2) and similar twodimensional materials.

关键词： 2D materials transition metal dichalcogenides laser trimming differential reflectance

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