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Chronic stress sensitizes rats to pancreatitis induced by cerulein:Role of TNF-α

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World Journal of Gastroenterology 2010年第44期16卷 5565-5581页

作者： Marcelo G Binker andres A Binker-Cosen Daniel Richards Herbert Y Gaisano Rodica H de Cosen Laura I Cosen-Binker CBRHC Research Health Center Department of Medicine and Physiology University of Toronto

AIM:To investigate chronic stress as a susceptibility factor for developing pancreatitis,as well as tumor necrosis factor-α (TNF-α) as a putative ***:Rat pancreatic acini were used to analyze the influence of TNF-α on submaximal (50 pmol/L) cholecystokinin (CCK) *** restraint (4 h every day for 21 d) was used to evaluate the effects of submaximal (0.2 μg/kg per hour) cerulein stimulation on chronically stressed ***:In vitro exposure of pancreatic acini toTNF-α disorganized the actin *** was further increased by TNF-α/CCK treatment,which additionally reduced amylase secretion,and increased trypsin and nuclear factor-κB activities in a protein-kinase-C δ and ε-dependent ***-α/CCK also enhanced caspases' activity and lactate dehydrogenase release,induced ATP loss,and augmented the ADP/ATP *** vivo,rats under chronic restraint exhibited elevated serum and pancreatic TNF-α ***,pancreatic,and lung inflammatory parameters,as well as caspases' activity in pancreatic and lung tissue,were substantially enhanced in stressed/cerulein-treated rats,which also experienced tissues' ATP loss and greater ADP/ATP *** examination revealed that stressed/cerulein-treated animals developed abundant pancreatic and lung edema,hemorrhage and leukocyte infiltrate,and pancreatic *** severity was greatly decreased by treating animals with an anti-TNF-αantibody,which diminished all inflammatory parameters,histopathological scores,and apoptotic/necrotic markers in stressed/cerulein-treated ***:In rats,chronic stress increases susceptibility for developing pancreatitis,which involves TNF-α sensitization of pancreatic acinar cells to undergo injury by physiological cerulein stimulation.

关键词： Pancreatitis Stress Tumor necrosis factor-α

Smart Cities to Wise Cities

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China Today 2019年第7期68卷 14-15页

作者： andres PASTRANA 不详

ACCORDING to the United Nations, half of the world’s population already lives in cities, with that proportion estimated to increase to 66 percent by 2050. If we are to progress, we must manage our cities both efficiently and humanely. Smart cities are defined by the use of data captured by cameras, sensors, and other devices, and then analyzed by artificial intelligence to provide real time information to decision makers and citizens.

关键词： ACCORDING to the United Nations the world’s population decision makers and citizens

Strain-induced band gap engineering in layered TiS3

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Nano Research 2018年第1期11卷 225-232页

作者： Robert Biele Eduardo Flores Jose Ramon Ares Carlos Sanchez Isabel J. Ferrer Gabino Rubio-Bollinger andres Castellanos-Gomezs Roberto D'Agosta Nano-Bio Spectroscopy Group and European Theoretical Spectroscopy Facility (EFSF) Universidad del Pals Vasco 20018 San Sebastidn Spain Materials of Interest in Renewable Energies Group (MIRE Group) Dpto. de Fisica de Materiales Universidad Aut6noma de Madrid 28049 Madrid Spain Instituto de Ciencia de Materiales "Nicolds Cabrera" Campus de Cantoblanco 28049 Madrid Spain Dpto. de Ffsica de la Materia Condensada Condensed Matter Physics Center (IFIMAC) Universidad Aut6noma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto de Ciencia de los Materiales de Madrid (ICMM-CSIC) Cantoblanco 28049 Madrid Spain IKERBASQUE Basque Foundation for Science 48013 Bilbao Spain

By combining ab initio calculations and experiments, we demonstrate how the band gap of the transition metal trichalcogenide TiS3 can be modified by inducing tensile or compressive strain. In addition, using our calculations, we predicted that the material would exhibit a transition from a direct to an indirect band gap upon application of a compressive strain in the direction of easy electrical transport. The ability to control the band gap and its nature could have a significant impact on the use of TiS3 for optical applications. We go on to verify our prediction via optical absorption experiments that demonstrate a band gap increase of up to 9% （from 0.99 to 1.08 eV） upon application of tensile stress along the easy transport direction.

关键词： band gap engineering titanium trisulfide 2-D materials strain

Two titans fin ally meet each other under nitrogen deficiencies:FERONIA-TORC1 activation promotes plant growth

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Molecular Plant 2022年第7期15卷 1095-1097页

作者： Javier martinez Pacheco Jose M.Estevez Fundación Instituto Leloir and IIBBA-CONICET.Av.Patricias Argentinas 435 Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile ANID-Millennium Science Initiative Program-Millennium Nucleus for the Development of Super Adaptable Plants(MN-SAP) SantiagoChile

Plant growth is determined by well-defined developmental processes that integrate cell-intrinsic factors and external environmental cues,and it is largely dependent on the assimilation of macro-and micro-nutrients from the *** the macro-nutrients,the inorganic nitrogen(e.g.,nitrate and ammonium)and amino acids are essential for plant survival and *** acting as macro-nutrients and structural components of macro-molecules,these nitrogen-containing molecules could also act as signaling molecules to orchestrate diverse genetic programs(Wang et al.,2018).

关键词： activation inorganic nitrate

Influence of V(C,N) Precipitates on Microstructure and Mechanical Properties of Continuous Cooled C-Mn-V

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Journal of Iron and Steel Research International 2011年第S1期18卷 266-270页

作者： Carlos Garcia-Mateo Carlos Capdevila Juan Cornide Jesus Chao Francisca G Caballero Carlos Garcia de andres Materalia Research Group Department of Physical Metallurgy Centro Nacional de Investigaciones Metalúrgicas (CENIM-CSIC)Avda.Gregorio del Amo8 E-28040 MadridSpain

The effect of chemical composition and processing parameters on the formation of acicular ferrite and/or bainite has been *** particular,this paper deals with the influence that N through its combination with V,as V(C,N) precipitates,has on the decomposition of ***,the intragranular nucleation potency of V(C,N) precipitates is analyzed through the continuous cooling transformation diagrams (CCT) of two C-Mn-V steels with different contents of *** reported in this work allow us to conclude that acicular ferrite can only be achieved alloying with vanadium and nitrogen,meanwhile bainite is promoted in steels with a low level of *** is concluded that higher strength values are obtained in acicular ferrite than in bainitic steel but a similar brittle-ductile transition temperature (BDT),and lower values of impact absorbed energy (KV) has been recorded in nitrogen-rich steel.

关键词： acicular ferrite bainite vanadium precipitates mechanical properties

细胞因子对膀胱平滑肌细胞内诱导性一氧化氮合酶的激活作用(英文)

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中国药理学与毒理学杂志 2001年第6期15卷 408-412页

作者：徐新云 andres MALAVE 深圳市卫生防疫站广东深圳518020 Department of Pharmaceutical Sciences

探讨肿瘤坏死因子α (TNFα)和γ干扰素(INFγ)对大鼠膀胱平滑肌细胞诱导性一氧化氮合酶(iNOS )的影响 .将TNFα (1nmol·L- 1)或INFγ(5 0kU·L- 1)分别或同时加入膀胱平滑肌细胞培养液 ,2 4h后测定细胞培养液中一氧化氮 (NO)水平 ,并... 详细信息

探讨肿瘤坏死因子α (TNFα)和γ干扰素(INFγ)对大鼠膀胱平滑肌细胞诱导性一氧化氮合酶(iNOS )的影响 .将TNFα (1nmol·L- 1)或INFγ(5 0kU·L- 1)分别或同时加入膀胱平滑肌细胞培养液 ,2 4h后测定细胞培养液中一氧化氮 (NO)水平 ,并用Western印迹方法检测iNOS的表达 .结果显示 ,TNFα或INFγ单独不能诱导iNOS表达 ,也不能引起NO水平显著提高 .但当TNFα和INFγ联合诱导细胞 2 4h ,则细胞培养液中NO水平明显升高 ,用Western印迹分析可见iNOS表达 ,说明TNFα和INFγ具有协同诱导作用 .在TNFα和INFγ加入膀胱平滑肌细胞前 30min ,加入NOS抑制剂L 氮精氨酸甲酯 (L NAME) ,可显著抑制TNFα和INFγ对NO的生成诱导 .结果提示 ,TNFα和INFγ联合应用可激活膀胱平滑肌细胞iNOS .

关键词：一氧化氮一氧化氮合酶细胞因子细胞平滑肌膀胱

Enhancing the graphene photocurrent using surface plasmons and a p-n junction

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Light(Science & Applications) 2020年第1期9卷 793-802页

作者： Di Wang andres E.Llacsahuanga Allcca Ting-Fung Chung Alexander V.Kildishev Yong P.Chen Alexandra Boltasseva Vladimir M.Shalaev School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA Birck Nanotechnology Center Purdue UniversityWest LafayetteIN 47907USA Department of Physics and Astronomy Purdue UniversityWest LafayetteIN 47907USA Purdue Quantum Science and Engineering Institute(PQSEI) Purdue UniversityWest LafayetteIN 47907USA

The recently proposed concept of graphene photodetectors offers remarkable properties such as unprecedented compactness,ultrabroadband detection,and an ultrafast response ***,owing to the low optical absorption of pristine monolayer graphene,the intrinsically low responsivity of graphene photodetectors significantly hinders the development of practical *** address this issue,numerous efforts have thus far been made to enhance the light–graphene interaction using plasmonic *** approaches,however,can be significantly advanced by leveraging the other critical aspect of graphene photoresponsivity enhancement-electrical junction *** has been reported that the dominant photocarrier generation mechanism in graphene is the photothermoelectric(PTE)***,the two energy conversion mechanisms involved in the graphene photodetection process are light-to-heat and heat-to-electricity *** this work,we propose a meticulously designed device architecture to simultaneously enhance the two conversion ***,a gap plasmon structure is used to absorb a major portion of the incident light to induce localized heating,and a pair of split gates is used to produce a p-n junction in graphene to augment the PTE current *** gap plasmon structure and the split gates are designed to share common key components so that the proposed device architecture concurrently realizes both optical and electrical *** experimentally demonstrate the dominance of the PTE effect in graphene photocurrent generation and observe a 25-fold increase in the generated photocurrent compared to the un-enhanced *** further photocurrent enhancement can be achieved by applying a DC bias,the proposed device concept shows vast potential for practical applications.

关键词： electrical plasmon hinder

Stochastic modeling,analysis,and simulation of the COVID-19 pandemic with explicit behavioral changes in Bogota:Acase study

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Infectious Disease Modelling 2022年第1期7卷 199-211页

作者： David Nino-Torres andres Ríos-Gutierrez Viswanathan Arunachalam Comfort Ohajunwa Padmanabhan Seshaiyer Department of Statistics Universidad Nacional de ColombiaBogotaColombia George Mason University FairfaxVAUSA

In this paper,a stochastic epidemiological model is presented as an extension of a compartmental SEIR model with random perturbations to analyze the dynamics of the COVID-19 pandemic in the city of Bogota D.C.,*** model incorporates thespread of COVID-19 impacted by social behaviors in the population and allows for projecting the number of infected,recovered,and deceased individuals considering the mitigation measures,namely confinement and partial relaxed ***,the role of randomness using the concept of Brownian motion is emphasized to explain the behavior of the *** experiments for the stochastic model with random perturbations were performed,and the model is validated through numerical simulations for actual data from Bogota D.C.

关键词： Epidemic spread SARS-CoV-2 Compartmental modeling Stochastic perturbations Parameter estimation

Has platelet-rich plasma any role in partial tears of the anterior cruciate ligament?Prospective comparative study

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World Journal of Orthopedics 2021年第6期12卷 423-432页

作者： Juan Pablo Zicaro Ignacio Garcia-Mansilla andres Zuain Carlos Yacuzzi Matias Costa-Paz Knee Division Hospital Italiano de Buenos AiresBuenos Aires 1181Argentina

BACKGROUND Partial tears of the anterior cruciate ligament(ACL)are frequent,and there is still considerable controversy surrounding their diagnosis,natural history and *** To examine patient-reported outcomes,physical examination and magnetic resonance imaging(MRI)findings of partial ACL tears treated with an intraarticular injection of platelet-rich plasma(PRP)compared to a control *** From January 2015 to November 2017,consecutive patients from a single institution with partial ACL tears treated nonoperatively were prospectively *** tears were defined as a positive Lachman test with a clear endpoint,a negative pivot-shift and less than 3 mm of side-to-side difference using the KT1000 *** in group 1 were treated with one intraarticular injection of PRP and specific physical therapy *** group consisted of patients treated only with physical *** analyzed data included physical examination,Tegner activity level and Lysholm and International Knee Documentation Committee *** MRI findings and at 6 mo follow-up were *** was defined as those patients with clinical instability at follow-up that required a subsequent ACL *** A total of 40 patients where included,21 treated with PRP injection with a mean follow-up of 25 mo[standard deviation(SD):3.6]and 19 in the control group with a mean follow-up of 25 mo(SD:5.68).Overall failure rate was 32.0%(n=13).No significant differences were observed between groups regarding subjective outcomes,return to sport and failure *** findings revealed an improvement in the ACL signal in half of the patients of both ***,we did not find a significant relationship between MRI findings and clinical *** Overall,95.0%of patients returned to sports at a mean follow-up of 25 *** time to return to sports was 4 *** of these patients,almost 30.0%in each group had a new episode of instability

关键词： Anterior cruciate ligament Partial tears Platelet-rich plasma Non-operative treatment