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Celiac disease markers in patients with liver diseases: A single center large scale screening study

World Journal of Gastroenterology 2012年第43期18卷 6255-6262页

作者： Pavel Drastich Eva Honsová Alena Lodererová Marcela Jaresová Aneta Pekáriková Iva Hoffmanová Ludmila Tuková Helena Tlaskalová-Hogenová Julius piák Daniel Sánchez Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Clinical and Transplant Pathology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic Department of Immunology Institute of Microbiology Academy of Sciences of the Czech Republic 14220 Prague Czech Republic 2nd Department of Internal Medicine 3rd Faculty of Medicine Charles University 10034 Prague Czech Republic

AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver ***:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy. RESULTS:We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients:4 with autoimmune hepatitis type Ⅰ, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non-alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type Ⅰ. COnCLUSIOn:We suggest that screening for celiac disease may be beneficial not only in patients with associated liver diseases, but also in patients with Wilson's disease.

关键词： Tissue transglutaminase Anti-tissue transglutaminase antibodies Autoimmune liver diseases Wilson's disease Celiac disease Liver transplantation

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Progression of Cognitive Deficit in Older People with Mild Cognitive Impairment Treated with Cerebrolysin

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Health 2014年第19期6卷 2581-2591页

作者： Irina S. Boksha Svetlana I. Gavrilova Igor V. Kolykhalov Iana B. Fedorova Iaroslav B. Kalyn natalia D. Selezneva andrei V. Samorodov Serge n. Miasoedov Elizabeta B. Mukaetova-Ladinska Laboratory of neurochemistry Moscow Russia Department of Alzheimer’s Disease and Related Disorders Moscow Russia Department of Bioengineering and Medical Equipment and Systems Moscow State Technical University Moscow Russia Laboratory of Biostatistics and Evidence Based Medicine Mental Health Research Center of Russian Academy of Medical Sciences Moscow Russia Institute of neurocience Newcastle University Institute for Ageing Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK

Objectives: Although people with amnestic mild cognitive impairment (aMCI) benefit from cerebrolysin treatment, some still develop dementia. The aim of the current study was to identify most informative clinical assessment tests to predict the therapy efficacy in aMCI subjects treated with cerebrolysin. Methods: We studied patients with amnestic mild cognitive impairment (aMCI;n = 53) who had regular neurocognitive and clinical psychiatric assessments and were treated with cerebrolysin i.v. infusions 20 × 30 ml twice a year over three years period. Data were analyzed using non-parametric statistics, cluster and linear discriminant analyses. Results: Combined mathematical modeling enabled to predict cognitive decline from aMCI to dementia in the cerebrolysin-treated patients based on their initial neurocognitive assessment scores. We identified a “dementia risk group” with fast cognitive decline (i.e. low efficacy of the treatment). Lower baseline scores in the Mattis Dementia Rating Scale Memory subtest, Mini-Mental State Examination (MMSE), 10 word list immediate recall, and Frontal Assessment Battery tests when accompanied by higher depression score (Hamilton Depression Rating Scale) suggest poor prognosis for aMCI patients treated with cerebrolysin. Changes in scores on the MMSE, Boston naming test, Digit span forward, and Wechsler scale subtest “Categorical associations” during the treatment course are more characteristic for patients who convert to dementia than their initial scores. Conclusions: aMCI subjects treated with cerebrolysin with lower baseline cognitive functioning and subclinical depression have poor prognosis in terms of converting to dementia. Changes in the MMSE, Boston naming test, Digit span forward, and Wechsler scale subtest “Categorical associations” scores during the treatment course are more informative to identify patients who will develop dementia than their initial scores.

关键词： Mild Cognitive Impairment Cerebrolysin Dementia Cluster Analysis Linear Discriminant Analysis

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中捷父母在家庭体育活动中培养幼儿体育素养的角色对比与反思

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乐山师范学院学报 2019年第1期34卷 113-118页

作者：段丽琼梁孟姣 Milu?e Ra?ková Dominika Provázková Stolinská 四川师范大学教育科学学院四川成都610068 Palacky University Faculty of Education

父母参与幼儿家庭体育活动的角色对幼儿体育素养的培养起重要的作用。中捷父母在幼儿家庭体育活动中存在三大角色差异:旁观者-参与者、支持者-引领者、提醒者-指导者。父母积极定位自己在幼儿家庭体育活动中的角色,为幼儿提供充足的运... 详细信息

父母参与幼儿家庭体育活动的角色对幼儿体育素养的培养起重要的作用。中捷父母在幼儿家庭体育活动中存在三大角色差异:旁观者-参与者、支持者-引领者、提醒者-指导者。父母积极定位自己在幼儿家庭体育活动中的角色,为幼儿提供充足的运动时间、多样的运动环境、积极的情感支持能有效地促进幼儿体育素养的发展。

关键词：捷克家庭体育活动体育素养父母角色

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Synthesis of novel Low-band-Gap Thiophene-based Oligomers and Copolymers

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复旦学报（自然科学版） 2007年第5期46卷 799-页

作者： I.Kmínek V.Cimrová D.Vyprachicky P.Pavlaková Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic Heyrovského nám.2CZ-162 06 Praha 6 Czech Republic

1 Results In this contribution,the synthesis and characterization of low-band-gap oligothiophenes and copolymers based on fluorene and thiophene units are ***,5,5′-dibromo derivative of 1 was synthesised and used as a building block for synthesis of quinquethiophene and septithiophene analogues of 1 and the synthesis of a novel low band-gap polymer - soluble alternating copolymer 3,which was prepared by the Suzuki coupling of 5,5′-dibromo derivative of 1 with bis(propane-1,3-diyl) 9,9-bis(2-...

关键词： di(2-thienyl)thienothiadiazole oligothiophene low band-gap polymers

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Synthesis and Properties of novel Copolymers Based on Fluorene and Thiophene

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复旦学报（自然科学版） 2007年第5期46卷 806-页

作者： P.Pavlaková V.Cimrová D.Vyprachicky I.Kmínek Institute of Macromolecular Chemistry Academy of Sciences of the Czech RepublicHeyrovského nám. 2CZ-162 06 Praha 6 Czech Republic

1 Results In this contribution we present the synthesis and characterization of novel copolymers based on fluorene and thiophene (see Scheme 1).They were synthesized by the Pd-catalyzed Suzuki coupling reaction of 9,9-dihexylfluorene-2,7-diboronic acid bis(1,3-propanediol) ester and 3-substituted (R=3-methylbutyl,hexyl,2-(pyren-1-yl)vinyl) 2,5-dibromothiophenes and characterized by GPC,IR and nMR ***-vis absorption,photoluminescence (PL) and electrochemical behavior of these polymers were also...

关键词： fluorene-thiophene copolymers synthesis photoluminescence electrochemical properties

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Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi Balázs rdg Zoltán Rakonczai Jr Tamás Takács János Lonovics Annamária Szabolcs Réka Sári András Tóth Julius G Papp András Varró Mária K kovács Mike A Gray Barry E Argent Zsolt Boldogki First Department of Medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and Molecular Biosciences

AIM： To examine the effect of acute infection caused by herpesvirus （pseudorabies virus, PRV） on pancreatic ductal secretion. METHODS： The virulent Ba-DupGreen （BDG） and non- virulent Ka-RREp01acgfp （KEG） genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein （GFP）. Small intra/ interlobular ducts were infected with BDG virus （10^7 PFU/mL for 6 h） or with KEG virus （10^10 PFU/mL for 6 h）, while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h. The rate of HCO3 secretion [base efflux -λ（B）] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification （1） after sudden blockage of basolateral base loaders with dihydro-4,4,- diisothiocyanatostilbene-2,2,-disulfonic acid （500 μmol/L） and amiloride （200 μmol/L）, and （2） after alkali loading the ducts by exposure to nH4Cl. All the experiments were performed in HCO3-buffered Ringer solution at 37 ℃ （n = 5 ducts for each experimental condition）. Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.RESULTS： The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral anUgens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -λB-） 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -λB-）. After alkali loading the ducts, -λB-） was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group. COnCLUSIOn： Incubation with the BDG or KEG strains of PRV results in an effective i

关键词： Pancreas Hypersecretion Ductal cells Infection Pseudorabies virus

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景观别墅

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现代装饰 2021年第12期 16-25页

作者： Marek Jan ?těpán Franti?ek Brychta Luká? Svoboda Tomá? Jurák Hana Arletová Hana My?ková BoysPlaynica 郭映琴

"我希望创造一种内部空间情绪,人们可以在其间自由走动,就像鱼儿在水中自由游动那般。这种轻松的生活方式会让你在潜意识里对未来的生活有所憧憬。日光的自然流动是最重要的,光线穿梭于大窗户与屋顶的圆形开口之间。当我第一次参观这个...

"我希望创造一种内部空间情绪,人们可以在其间自由走动,就像鱼儿在水中自由游动那般。这种轻松的生活方式会让你在潜意识里对未来的生活有所憧憬。日光的自然流动是最重要的,光线穿梭于大窗户与屋顶的圆形开口之间。当我第一次参观这个已完成的项目时,我11岁的女儿出乎意料地在那里呆了三天时间,因为她非常喜欢这个空间。"项目的主创设计师Marek?těpán说道。

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经颅多普勒超声（TCD）的实践标准——第2部分：临床适应证和预期结果

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国际脑血管病杂志 2012年第1期20卷 1-11页

作者： andrei V. Alexandrov Michael A. Sloan Charles H. Tegeler David n. newell Alan Lumsden Zsolt Garami Christopher R. Levy Lawrence K.S. Wong Colleen Douville Manfred Kaps 李海峰（译）李宏（译）李展秀（译） From the Comprehensive Stroke Center University of Alabama at Birmingham Birmingham AL 青岛大学医学院附属医院神经内科

引言：经颅多普勒（transcranial Doppler，TCD）已被证实为一种安全有效的生理学超声检查技术。尽管成像设备可以在结构影像的基础上显示颅内血流，但成像性双功能超声或非成像性TCD检查提供的最终结果是通过频谱波形来评价生理学血流... 详细信息

引言：经颅多普勒（transcranial Doppler，TCD）已被证实为一种安全有效的生理学超声检查技术。尽管成像设备可以在结构影像的基础上显示颅内血流，但成像性双功能超声或非成像性TCD检查提供的最终结果是通过频谱波形来评价生理学血流参数。总结概要：多学科专家小组确定的TCD临床适应证包括：镰状细胞病、恼缺血、右向左分流（right—to—left shunt，RLS）、蛛网膜下腔出血、脑死亡以及围手术期或术中监测。TCD检查可常规应用于住院或门诊患者的一些临床实践活动：通过完整或部分TCD检查以检测正常、狭窄或闭塞的颅内血管和侧支循环来判断动脉闭塞位置，并进一步完善颈动脉超声或无创性血管造影结果；通过血管运动反应性检查来识别首发或复发性卒中的高危患者；通过栓子监测对脑栓塞进行实时检查、定位和量化；在怀疑反常性栓塞或考虑分流封堵术治疗的患者中进行RLS检测；对溶栓治疗进行监测以促进血管再通和检测再闭塞；在血管内支架置入术、颈动脉内膜切除术和心脏外科手术中进行监测以发现围手术期栓塞、血栓形成、低灌注或高灌注。结论：通过界定实践范围，这些标准将在TCD检查的申请、检查和评价过程中给开申请单的医生、发报告的医生以及第三方提供帮助。

关键词： TCD 适应证应用结果

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Study of contents of selenium and arsenic in soil—A long-term field experiment

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Chinese Journal Of Geochemistry 2006年第B8期25卷 198-198页

作者： Béla kovács Eva Széles József Prokisch Zoltán Gyori Department of Food Science and Quality Assurance Centre of Agricultural Sciences Debrecen University Debrecen Hungary

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In vitro toxicity of particulate matter emissions from residential pellet combustion

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Journal of Environmental Sciences 2022年第5期34卷 215-226页

作者： Estela D.Vicente Daniela Figueiredo Catia Goncalves Isabel Lopes Helena Oliveira nora kovats Teresa Pinheiro Celia A.Alves Department of Environment and Planning and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Department of Biology and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Centre of natural Environmental Sciences University of PannoniaEgyetem str.108200 VeszpremHungary Instituto de Bioengenharia e Biociencias Departamento de Engenharia e Ciencias NuclearesInstituto Superior TecnicoUniversidade de LisboaAv.Rovisco Pais 11049-001 LisboaPortugal

Particulate matter emissions(PM10)from the combustion,in a residential stove,of two com-mercial brands of certified(Enplus A1)pellets,a non-certified brand and laboratory made pellets of acacia were tested for their ability to induce ecotoxic,cytotoxic,and mutagenic re-sponses in unicellular organisms and a human cell *** was evaluated through the Vibrio fischeri bioluminescence inhibition ***,cytotoxicity was assessed at two time points(24-and 48-hr)through two complementary techniques in order to evaluate the cellular metabolic activity and membrane integrity of human lung epithelial cells *** Ames test using two Salmonella typhimurium strains(TA100 and TA98)was employed to assess the mutagenic potential of the polycyclic aromatic hydrocarbon fraction extracted from the PM10 *** obtained with the bioluminescent bacteria indicated that only particles from the combustion of acacia pellets were *** samples induced im-pairment on the A549 cells metabolic activity,while no significant release of lactate dehy-drogenase was ***10 emissions from acacia pellets were the most cytotoxic,while samples from both certified pellets evoked significant cytotoxicity at lower ***-icity time-dependency was only observed for PM10 from the combustion of acacia pellets and one of the brands of certified *** activity was not detected in both *** murium *** study emphasises the role of the raw material for pellet manu-facturing on the toxicological profile of PM *** raw materials should be deeply investigated before their use in pelletisation and combustion in residential appli-ances.

关键词： Ecotoxicity Cytotoxicity Mutagenicity Fuel quality Pellet combustion PM10 emissions

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