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Computer-aided clinical image analysis as a predictor of sentinel lymph node positivity in cutaneous melanoma

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World Journal of Clinical Oncology 2022年第8期13卷 702-711页

作者： Marios Papadakis Alexandros Paschos andreas s papazoglou andreas Manios Hubert Zirngibl Georgios Manios Dimitra Koumaki Department of surgery Ⅱ University of Witten-HerdeckeWuppertal 42283Germany Department of Dermatology Helios St.Elisabeth Hospital OberhausenOberhausen 46045Germany Faculty of Medicine Aristotle University of ThessalonikiThessaloniki 54124Greece Department of surgical Oncology University Hospital of HeraklionHeraklion 71110Greece Department of Computer science and Biomedical Informatics University of ThessalyLamia 35131Greece Department of Dermatology University Hospital of HeraklionHeraklion 71110Greece

BACKGROUND Delays in sentinel lymph node(sLN)biopsy may affect the positivity of *** these reasons,effort is being directed at obtaining reliable information regarding sLN positivity prior to surgical ***,the existing tools,e.g.,dermoscopy,do not recognize statistically significant predictive criteria for sLN positivity in *** To investigate the possible association of computer-assisted objectively obtained color,color texture,sharpness and geometry variables with sLN *** We retrospectively reviewed and analyzed the computerized medical records of all patients diagnosed with cutaneous melanoma in a tertiary hospital in Germany during a 3-year *** study included patients with histologically confirmed melanomas with Breslow>0.75 mm who underwent lesion excision and sLN biopsy during the study period and who had clinical images shot with a digital camera and a handheld ruler aligned beside the *** Ninety-nine patients with an equal number of lesions met the inclusion criteria and were included in the *** mean(±standard deviation)age was 66(15)*** study group consisted of 20 patients with tumor-positive sLN(sLN+)biopsy,who were compared to 79 patients with tumor-negative sLN biopsy specimen(control group).The two groups differed significantly in terms of age(61 years vs 68 years)and histological subtype,with the sLN+patients being younger and presenting more often with nodular or secondary nodular tumors(Pstudy group patients showed significantly higher eccentricity(*** between color and geometrical midpoint)as well as higher sharpness(*** lesions were more discrete from the surrounding normal skin,Ps,sLN+patients demonstrated higher range in all four color intensities(gray,red,green,blue)and significantly higher skewness in three color intensities(gray,red,blue),Ps,***,were comparable in both

关键词： Melanoma skin cancer Image processing sentinel lymph node Presurgical

Hepatomusculoskeletal disorders:Coining a new term might improve the management of the musculoskeletal manifestations of chronic liver disease

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World Journal of Gastrointestinal Pathophysiology 2022年第4期13卷 124-127页

作者： Christos Tsagkaris stavros P Papadakos Dimitrios V Moysidis andreas s papazoglou Alexandra Koutsogianni Marios Papadakis Public Health and Policy Working Group Stg European Student Think TankAmsterdamNetherlands Laiko General Hospital of Athens National and Kapodistrian University of AthensAthens 18233Greece Hippokration University Hospital Aristotle University of ThessalonikiThessaloniki 54642Greece Athens Naval Hospital Athens 18233Greece Department of surgery II University Hospital Witten-HerdeckeUniversity of Witten-HerdeckeWuppertal 42283Germany

Chronic liver disease can affect many body systems including the musculoskeletal *** pathogenetic crosstalk between the liver and organs such as the brain and the kidneys has already been described with compound terms merging the organs affected by the pathology,such as the hepatorenal ***,the musculoskeletal manifestations of chronic liver disease have not been coined with such a term to *** of this shortage,documenting the musculoskeletal implications of chronic liver disease in both research and clinical practice is *** fill this gap,the authors propose the term hepatomusculoskeletal disorders,a compound term of Greek origin that encompasses all the body structures involved in the aforementioned pathologic crosstalk.

关键词： Chronic liver disease Hepatomusculoskeletal disorders Musculoskeletal system Hepatology Pathophysiology Osteodystrophy

Dependence of impact regime boundaries on the initial temperatures of projectiles and targets

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Defence Technology（防务技术） 2024年第1期31卷 49-57页

作者： stefano signetti andreas Heine Fraunhofer-Institut für Kurzzeitdynamik Ernst-Mach-InstitutEMIErnst-Zermelo-Str.479104 Freiburg im BreisgauGermany

Towards higher impact velocities,ballistic events are increasingly determined by the material *** effects might range from moderate thermal softening to full phase *** particular,it is of great interest to quantify the conditions for incipient or full melting of metals during impact interactions,which result in a transition from still strength-affected to hydrodynamic material *** this work,we investigate to which extent the respective melting thresholds are also dependent on the initial,and generally elevated,temperatures of projectiles and targets before *** is studied through the application of a model developed recently by the authors to characterize the transition regime between high-velocity and hypervelocity impact,for which the melting thresholds of materials were used as the defining *** obtained results are expected to be of general interest for ballistic application cases where projectiles or targets are *** conditions might result,for example,from aerodynamic forces acting onto a projectile during atmospheric flight,explosive shapedcharge-jet formation or armor exposure to environmental *** performed analyses also broaden the scientific understanding of the relevance of temperature in penetration events,generally known since the 1960s,but often not considered thoroughly in impact studies.

关键词： Ballistic impact Thermal effects Metallic targets Energy partitioning Homologous temperature

The interaction between a shaped charge jet and a single moving plate

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Defence Technology（防务技术） 2024年第1期31卷 1-13页

作者： andreas Helte Jonas Lundgren Jonas Candle FOI WeaponsProtection and SecuritySE-16490StockholmSweden

Reactive armour is a very efficient add-on armour against shaped charge *** reactive armour consists of one or several plates that are accelerated by an *** but less violent acceleration of plates can also be achieved in a completely inert reactive *** be efficient against elongated jets,the motion of the plates needs to be inclined against the jet such that a sliding contact between the jet and the plates is *** sliding contact causes a deflection and thinning of the *** certain circumstances,the contact will become unstable,leading to severe disturbances on the *** disturbances will drastically reduce the jet penetration performance and it is therefore of interest to study the conditions that leads to an unstable *** studies on the interaction between shaped charge jets and flyer plates have shown that it is mainly the forward moving plate in an explosive reactive armour that is effective in disturbing the *** is usually attributed to the higher plate-to-jet mass flux ratio involved in the collision of the forward moving plate compared to the backward moving *** slow moving plates,as occurs in inert reactive armour,the difference in mass flux for the forward and backward moving plate is much lesser,and it is therefore of interest to study if other factors than the mass flux influences on the protection *** this work,experiments have been performed where a plate is accelerated along its length,interacting with a shaped charge jet that is fired at an oblique angle to the plate’s normal,either against or along the plate’s *** arrangement corresponds to a jet interacting with a flyer plate from a reactive armour,with the exception that the collision velocity is the same for both types of obliquities in these *** experiments show that disturbances on the jet are different in the two cases even though the collision velocities are the *** simulatio

关键词： Reactive armour Flyer plate shaped charge jet

Hospital hygiene,purulent wounds and viral escape attempts:an infectious history of the Comnenean Imperial Dynasty

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History & Philosophy of Medicine 2022年第2期4卷 1-2页

作者： Christos Tsagkaris Dimitrios V.Moysidis andreas s.papazoglou Anna Loudovikou European student Think Tank Public Health and Policy Working GroupAmsterdam 1058The Netherlands Hippokration University Hospital Aristotle University of Thessaloniki(AUTh)Thessaloniki 54124Greece Athens Naval Hospital Athens 15561Greece Aristotle University of Thessaloniki(AUTh) Faculty of PhilosophyThessaloniki 54124Greece

A study published recently by Graumans and colleagues(2021)reported James Bond's exposure to infectious agents across a number of movies[1].The authors took the initiative to use cinema as a source of hygiene literacy,pointing out common flaws and risks for individual and public *** popular sources through the lenses of public health,can become an effective tool of science communication by providing readers with an amusing and simultaneously learning *** latter is a dire need,taking into account the mounting health disinformation amidst the COVID-19 pandemic.

关键词： mount latter Imperial

Would COVID-19 vaccination be mandatory in the Republic of Plato?

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History & Philosophy of Medicine 2022年第1期4卷 1-3页

作者： Christos Tsagkaris Anna Loudovikou Dimitrios V.Moysidis andreas s.papazoglou Konstantinos Kalachanis Faculty of Medicine University of CreteHeraklionGreece school of Philosophy Aristotle University of ThessalonikiThessalonikiGreece Faculty of Medicine Aristotle University of ThessalonikiThessalonikiGreece New York College AthensGreece.

The Republic of Plato is a philosophical treatise describing the ideal city-state,a self-sufficient civil entity in the world of Ideas(Forms)that enables both individuals and the society to *** of the Republic can be tracedwoka in modern ***’s ethical and political philosophy consists of a standpoint of reflection towards contemporary challenges,one of whom is admittedly COVID-19 *** countries have made vaccination obligatory for the whole of the population,while many countries consider making vaccination mandatory for particular high-risk groups and front line *** response to the growing debate on the necessity and the ethical integrity of mandatory vaccination against COVID-19,this paper discusses the matter in the context of Plato’s Republic and provides relevant recommendations.

关键词： COVID-19 vaccines Plato the Republic philosophy

Erratum to:Tribological behaviour of Ti_(3)C_(2)T_(x)nano-sheets:substrate-dependent tribo-chemical reactions

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Friction 2024年第7期12卷 1618-1619页

作者： Alberto ROTA Nicolas BELLINA Bo WANG andreas ROsENKRANZ Dipartimento di scienze Fisiche Informatiche e MatematicheUniversitàdi Modena e Reggio EmiliaModena 41125Italy CNR-Istituto di Nanoscienze Centro S3Modena 41125Italy Centro Interdipartimentale per la Ricerca Applicata e i servizi nel settore della Meccanica Avanzata e della Motoristica Universitàdi Modena e Reggio EmiliaModena 41125Italy Key Laboratory of Marine New Materials and Related Technology Zhejiang Key Laboratory of Marine Materials and Protection TechnologyNingbo Institute of Material Technology&EngineeringChinese Academy of SciencesNingbo 315201China Department of Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiago 8370456Chile

Erratum to Alberto Rota,Nicolas Bellina,Bo Wang&andreas *** behaviour of Ti_(3)C_(2)T_(x)nano-sheets:substratedependent tribo-chemical *** 11(8):1522–1533(2023).

关键词： Friction behaviour chemical

MXene-Based Elastomer Mimetic stretchablesensors: Design, Properties, and Applications

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Nano-Micro Letters 2024年第7期16卷 295-342页

作者： Poushali Das Parham Khoshbakht Marvi sayan Ganguly Xiaowu(shirley)Tang Bo Wang seshasai srinivasan Amin Reza Rajabzadeh andreas Rosenkranz school of Biomedical Engineering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnology(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W Booth school of Engineering Practice and Technology McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexible sensors based on MXene-polymer composites are highly prospective for next-generation wearable electronics used in human-machine *** of the motivating factors behind the progress of flexible sensors is the steady arrival of new conductive ***,a new family of 2D nanomaterials,have been draw-ing attention since the last decade due to their high electronic conduc-tivity,processability,mechanical robustness and chemical *** this review,we encompass the fabrication of MXene-based polymeric nanocomposites,their structure-property relationship,and applications in the flexible sensor ***,our discussion is not only lim-ited to sensor design,their mechanism,and various modes of sensing platform,but also their future perspective and market throughout the *** our article,we intend to fortify the bond between flexible matrices and MXenes thus promoting the swift advancement of flexible MXene-sensors for wearable technologies.

关键词： Flexible sensor 2D nanomaterials MXene Wearable and conductive Applications

Zeno and the Wrong Understanding of Motion—A Philosophical-Mathematical Inquiry into the Concept of Finitude as a Peculiarity of Infinity

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Journal of Applied Mathematics and Physics 2024年第3期12卷 912-929页

作者： andreas Herberg-Rothe Faculty of social and Cultural studies University of Applied Sciences Fulda Hesse Germany

In contrast to the solutions of applied mathematics to Zeno’s paradoxes, I focus on the concept of motion and show that, by distinguishing two different forms of motion, Zeno’s apparent paradoxes are not paradoxical at all. Zeno’s paradoxes indirectly prove that distances are not composed of extensionless points and, in general, that a higher dimension cannot be completely composed of lower ones. Conversely, lower dimensions can be understood as special cases of higher dimensions. To illustrate this approach, I consider Cantor’s only apparent proof that the real numbers are uncountable. However, his widely accepted indirect proof has the disadvantage that it depends on whether there is another way to make the real numbers countable. Cantor rightly assumes that there can be no smallest number between 0 and 1, and therefore no beginning of counting. For this reason he arbitrarily lists the real numbers in order to show with his diagonal method that this list can never be complete. The situation is different if we start with the largest number between 0 and 1 (0.999…) and use the method of an inverted triangle, which can be understood as a special fractal form. Here we can construct a vertical and a horizontal stratification with which it is actually possible to construct all real numbers between 0 and 1 without exception. Each column is infinite, and each number in that column is the starting point of a new triangle, while each row is finite. Even in a simple sine curve, we experience finiteness with respect to the y-axis and infinity with respect to the x-axis. The first parts of this article show that Zeno’s assumptions contradict the concept of motion as such, so it is not surprising that this misconstruction leads to contradictions. In the last part, I discuss Cantor’s diagonal method and explain the method of an inverted triangle that is internally structured like a fractal by repeating this inverted triangle at each column. The consequence is that we encounter t

关键词： Zeno False Assumptions about Motion Finitude Infinity Cantor’s Diagonal Method Inverted Triangle as a Different Method Vertical and Horizontal Dimensions Quantum Theory Relativity of space and Time Depending on Velocity