Angiogenesis in gastrointestinal stromal tumors:From bench to bedside

作     者：Stavros P Papadakos Christos Tsagkaris Marios Papadakis Andreas S Papazoglou Dimitrios V Moysidis Constantinos G Zografos Stamatios Theocharis 

作者机构：First Department of PathologySchool of MedicineNational and Kapodistrian University of AthensAthens 10679Greece Faculty of MedicineUniversity of CreteHeraklion 71003Greece University Hospital Witten-HerdeckeUniversity of Witten-HerdeckeWuppertal 42283Germany First Department of CardiologyAHEPA University HospitalAristotle University of ThessalonikiThessaloniki 54636Greece First Department of SurgeryAthens Medical SchoolNational and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece First Department of PathologyMedical SchoolUniversity of AthensAthens 11527Greece 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第8期

页      面：1469-1477页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastrointestinal stromal tumor Cancer Oncology Angiogenesis Gastrointestinal oncology Stromal tumors 

摘      要：Gastrointestinal stromal tumors(GISTs)are rare neoplasms with an estimated incidence from 0.78 to 1-1.5 patients per *** most commonly occur in the elderly during the eighth decade of life affecting predominantly the stomach,but also the small intestine,the omentum,mesentery and *** available treatments for GIST are associated with a significant rate of recurrent disease and adverse *** understanding of GIST’s pathophysiology and translation of this knowledge into novel regimens or drug repurposing is essential to counter this *** present review summarizes the existing evidence about the role of angiogenesis in GIST’s development and progression and discusses its clinical underpinnings.