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The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children:The ActiveBrains project

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Journal of Sport and Health Science 2023年第2期12卷 175-185页

作者： María Rodriguez-Ayllon Abel Plaza-Florido andrea Mendez-Gutierrez Signe Altmäe Patricio Solis-Urra Concepción M.Aguilera Andrés Catena Francisco B.Ortega Irene Esteban-Cornejo PROFITH“PROmoting FITness and Health through physical activity”research group Sport and Health University Research Institute(iMUDS)Department of Physical and Sports EducationFaculty of Sport SciencesUniversity of GranadaGranada 18071Spain Department of Epidemiology Erasmus University Medical CenterRotterdam 3015 GDthe Netherlands Department of Biochemistry and Molecular Biology Ⅱ School of PharmacyUniversity of GranadaGranada 18071Spain Department of Biochemistry and Molecular Biology Faculty of SciencesUniversity of GranadaGranada 18071Spain Nuclear Medicine Services Virgen de Las Nieves University HospitalGranada 18014Spain Faculty of Education and Social Sciences Universidad Andres BelloViña del Mar 2531015Chile Department of Experimental Psychology School of PsychologyUniversity of GranadaGranada 18011Spain Faculty of Sport and Health Sciences University of JyväskyläJyväskylä40014Finland Department of Bioscience and Nutrition Karolinska InstitutetHuddingeSE 14157Sweden

Background:Emerging research supports the idea that exercise positively affects ***,the mechanisms linking exercise with brain health are largely *** aimed to investigate the effect of exercise on(a)blood biomarkers selected based on previous evidence(brainderived neurotrophic factor,β-hydroxybutyrate(BHB),cathepsin B(CTSB),kynurenine,fibroblast growth factor 21(FGF21),soluble vascular cell adhesion molecule-1(sVCAM-1));and(b)a panel of 92 neurology-related proteins(discovery analysis).We also investigated whether changes in these biomarkers mediate the effects of exercise on brain health(hippocampal structure and function,cognitive performance,and mental health).Methods:We randomized 81 overweight/obese children(10.1±1.1 years,41%girls)into 2 groups:either 20 weeks of aerobic plus resistance exercise or *** biomarkers were assessed using enzyme-linked immunosorbent assay(ELISA)for kynurenine,FGF21,and CTSB;colorimetry forβ-hydroxybutyrate;and XMap for brain-derived neurotrophic factor and soluble vascular cell adhesion ***92 neurology-related proteins were analyzed by an antibody-based proteomic ***:Our intervention had no significant effect on candidate biomarkers(all p>0.05).In the discovery analysis,a reduction in circulating macrophage scavenger receptor type-I was observed(standardized differences between groups=-0.3,p=0.001).This effect was validated using ELISA methods(standardized difference=-0.3,p=0.01).None of the biomarkers mediated the effects of exercise on brain ***:Our study does not support a chronic effect of exercise on candidate *** observed that while chronic exercise reduced the levels of macrophage scavenger receptor type-Ⅰ,it did not mediate the effects of exercise on brain *** studies should explore the implications of this novel biomarker for overall health.

关键词： Brain development Childhood MRI Physical activity Proteomic

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changes in culm surface temperature with maturity of the bamboo species Guadua angustifolia

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Journal of Forestry Research 2016年第2期27卷 419-425页

作者： Nils Nolke Juan Carlos Camargo Garcia Christoph Klein andrea Polle Chair of Forest Inventory and Remote Sensing Universitat GottingenBusgenweg 537077 GottingenGermany Faculty of Environmental Sciences Technological Universityof PereiraLa JulitaPereiraColombia Department of Forest Botany and Tree Physiology Universiat GottingenBiJsgenweg 237077 GottingenGermany

We used thermal images of bamboo culms of Guadua angustifolia Kunth to analyze the relationship between culm surface temperature and maturity, driven by the hypothesis that young culms may exhibit lower surface temperatures than old ones. The culm surface temperature shows small but constant differences between three age classes of 1, 2, and 3 years. Our findings indicate that surface temperature may be applied as an additional indi- cator to support the determination of maturity of guadua culms besides the visual assessment of the culms.

关键词： Bamboo culms Thermal images Bamboowood quality

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Studies on Differential Nuclear Translocation Mechanism and Assembly of the Three Subunits of the Arabidopsis thaliana Transcription Factor NF-y

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Molecular Plant 2012年第4期5卷 876-888页

作者： Dieter Hackenberg yanfang Wu andrea Voigt Robert Adams Peter Schramm Bernhard GrimmI Institute of Biology/Plant Physiology Humboldt University Philippstr. 13 Building 12 10115 Berlin Germany

The eukaryotic transcription factor NF-y consists of three subunits （A, B, and C）, which are encoded in Ara- bidopsis thaliana in multigene families consisting of 10, 13, and 13 genes, respectively. In principle, all potential combi- nations of the subunits are possible for the assembly of the heterotrimeric complex. We aimed at assessing the probability of each subunit to participate in the assembly of NF-y. The evaluation of physical interactions among all members of the NF-y subunit families indicate a strong requirement for NF-yB/NF-yC heterodimerization before the entire complex can be accomplished. By means of a modified yeast two-hybrid system assembly of all three subunits to a heterotrimeric complex was demonstrated. Using GFP fusion constructs, NF-yA and NF-yC localization in the nucleus was demonstrated, while NF- yB is solely imported into the nucleus as a NF-yC-associated heterodimer NF-yC. This piggyback transport of the two Arabidopsis subunits differs from the import of the NF-y heterotrimer of heterotrophic organisms. Based on a peptide structure model of the histone-fold-motifs, disulfide bonding among intramolecular conserved cysteine residues of NF-yB, which is responsible for the redox-regulated assembly of NF-yB and NF-yC in human and Aspergillus nidulans, can be excluded for Arabidopsis NF-yB.

关键词： gene expression transcriptional control and transcription factors nuclear translocation protein-proteininteraction.

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Evidence on antimicrobial activity of essential oils and herbal extracts against yersinia enterocolitica - A review

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Food Bioscience 2022年第3期47卷 132-144页

作者： andrea Durofil Naga Raju Maddela Reinier Abreu Naranjo Matteo Radice Area de Botánica Del Departamento de Biología y Producción de los Vegetales Facultad de CienciasUniversidad de ExtremaduraBadajozSpain Departamento de Ciencias Biológicas Facultad la Ciencias de la SaludUniversidad Técnica de ManabíPortoviejoEcuador Instituto de Investigación Universidad Técnica de ManabíPortoviejoEcuador Universidad Estatal Amazónica Km 2 ½ Vía Puyo-TenaPuyoEcuador

yersinia enterocolitica is a very common food-borne pathogen which causes gastrointestinal infections (yersiniosis) in humans and a wide array of animals (***,deer,pigs,and birds).Due to the increasing interest in innovative plant-based substances as common food preservatives,several essential oils and herbal extracts have been investigated deeply that resulted in the emergence of novel anti-yersinia *** reviewed relevant work done by 53 researchers covering literature from the year 2002 to till *** species such as Origanum vulgare ,Rosmarinus officinalis ,Thymus vulgaris ,Ocimum basilicum have been extensively investigated and identified that 1,8-cineole,linalool and γ-terpinene as compounds found in the essential oils of these plants have anti-yersinia activity active food packaging *** the same direction,some promising results have been mentioned about the herbal extracts of Murrya koenigii ,Tanacetum vulgare and Tanacetum balsamita,but further investigations are needed for their sustainable *** to hierarchical cluster analysis,we found that Lamiaceae and Lauracea as the most significant families with anti-yersinia *** the end,we proposed new research trends in order to enhance a global knowledge about the use of natural products against *** .

关键词： Food-borne pathogens Plant-based alternatives Food preservation Active packaging

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Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair

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Cellular & Molecular Immunology 2022年第11期19卷 1251-1262页

作者： Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher Department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA Department of Microbiology and Immunology University of MichiganAnn ArborMIUSA Department of Medicinal Chemistry University of MichiganAnn ArborMIUSA Department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA Department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

Macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.

关键词： wound healing epigenetics diabetes JMJD3 STING

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[y(dbm)_(3)(H_(2)O)]:Synthesis,thermal behavior and spin-coating precursor for y_(2)O_(3)layer formation

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Journal of Rare Earths 2017年第12期35卷 1248-1254页

作者： Elaheh Pousaneh andrea Preuβ Khaybar Assim Julian Noll Alexander Jakob Tobias Rüffer Heinrich Lang Technische Universitat Chemnitz Faculty of Natural SciencesInstitute of ChemistryInorganic Chemistry

The synthesis,structure and thermal behavior of [y（dbm）3（H2 O）]（3）（dbm = 1,3-diphenyl-1,3-propandionate） and its use as a spin-coating precursor for y2 O3 deposition is reported. Complex 3 was prepared by the reaction of [y（NO3）3·6 H2 O]（1） with 3 equiv of Hdbm（2） in presence of NaOH. The molecular structure of 3 in the solid-state was determined by single X-ray crystal diffraction. Both C1 symmetric crystallographically independent species of 3 possess a yO7 coordination setup with minor deviation from an ideal capped octahedron coordination geometry（∧ enantiomer）. Complex 3 forms a1 D chain, due to intermolecular hydrogen bonds between the coordinated H2 O molecule and the 0 atom of the dbm ligand, respectively. The thermal decomposition behavior of 3 was investigated by thermogravimetric studies in the temperature range of 40-800 ℃ and 40-1300 ℃ under an oxygen and argon atmosphere, respectively. Powder X-ray diffraction（PXRD） measurements of the residues confirmed the formation of y2 O3. Complex 3 was applied as a spin-coating precursor for yttrium oxide film formation on either Si wafers with a continuous 100 nm thick SiO2 film, or with a native oxide *** as-deposited y2 O3 layers are smooth, conformal, dense and transparent and are of a thickness of 27 and 30 nm, respectively.

关键词： yttrium β-Diketonate yttrium oxide Spin-coating Solid-state structure Vapor pressure

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Small renal masses in kidney transplantation:Overview of clinical impact and management in donors and recipients

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Asian Journal of Urology 2022年第3期9卷 208-214页

作者： Alberto Piana Iulia Andras Pietro Diana Paolo Verri andrea Gallioli Riccardo Campi Thomas Prudhomme Vital Hevia Romain Boissier Alberto Breda Angelo Territo Department of Urology Fundacio PuigvertAutonoma University of BarcelonaSpain Department of Urology San Luigi Gonzaga HospitalUniversity of TurinOrbassanoTurinItaly Urology Department Iuliu Hatieganu University of Medicine and Pharmacy and Municipal HospitalCluj-NapocaRomania Unit of Urological Robotic Surgery and Renal Transplantation University of FlorenceCareggi HospitalFlorenceItaly Department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Department of Urology and Kidney Transplantation Toulouse University HospitalToulouseFrance Hospital Universitario Ramon y Cajal.Alcala University Instituto Ramon y Cajal de Investigacion Sanitaria(IRYCIS)MadridSpain Aix-Marseille universite service de chirurgie urologique et de transplantation renaleCHU ConceptionAP-HMMarseilleFrance

Kidney transplantation is the best replacement treatment for the end-stage renal ***,the imbalance between the number of patients on a transplant list and the number of organs available constitutes the crucial limitation of this *** expand the pool of organs amenable for transplantation,kidneys coming from older patients have been employed;however,the combination of these organs in conjunction with the chronic use of immunosuppressive therapy increases the risk of incidence of graft small renal *** narrative review aims to provide the state of the art on the clinical impact and management of incidentally diagnosed small renal tumors in either donors or *** to the most updated evidence,the use of grafts with a small renal mass,after bench table tumor excision,may be considered a safe option for high-risk patients in *** the other hand,an early small renal mass finding on periodic ultrasound-evaluation in the graft should allow to perform a conservative treatment in order to preserve renal ***,in case of a renal tumor in native kidney,a radical nephrectomy is usually recommended.

关键词： Small renal mass Renal cancer Kidney transplantation Nephron-sparing treatment

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Second generation biorefining in Ecuador:Circular bioeconomy,zero waste technology,environment and sustainable development:The nexus

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Journal of Bioresources and Bioproducts 2021年第2期6卷 83-107页

作者： Lourdes M.Orejuela-Escobar andrea C.Landázuri Barry Goodell Universidad San Francisco de Quito USFQ Colegio de Ciencias e IngenieríasInstituto de Ingeniería CircularEngineeringApplied Sciences&Simulation Group(GICAS)Chemical Engineering DepartmentDiego de Robles y Vía InteroceánicaP.O.Box 17-0901QuitoEcuador Universidad San Francisco de Quito USFQ Instituto de Investigaciones Biológicas y Ambientales BIÓSFERADiego de Robles y Vía InteroceánicaP.O.Box 17-0901QuitoEcuador University of Massachusetts Department of MicrobiologyAmherstMA 01003United States

The projection of world population growth with concurrent generation of large volumes of agroindustrial waste that negatively affect the environment is of great ***,this review article describes the nexus between concepts of Circular Bioeconomy,Zero Waste Technology,Sustainable Development,Biorefineries,and alternatives and research efforts to generate less environmental impact.A brief analysis of the Ecuadorian industry and exports is described,emphasizing the fact that,to improve the Ecuadorian trade balance,it is necessary to increase industrial *** is important to have emerging technologies and innovation in order to promote the replacement of fossil-derived raw materials with renewable raw materials and develop more environmentally friendly processes and *** paper analyses the state of biomass research and its transformation in Ecuador,together with current pretreatment research on biomass to obtain bioproducts and biofuels in a biorefinery that promotes clean production for the extraction of phytochemicals using green solvents,such as deep eutectic solvents;and technologies to recover high-value added materials with enhanced *** conclusion,the need to develop technologies and markets to commercialize high value-added products coming from biorefineries is highlighted,as this will increase the income both in rural and urban areas and will strengthen the productivity and profitability of the Ecuadorian *** goal through this analysis is to improve Ecuador’s trade balance while also contributing to the circular bioeconomy that promotes sustainable development.

关键词： Biorefinery Circular bioeconomy Agro-industrial by-products High-added-value products Sustainable development

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The interplay of nurse and target plant traits influences magnitude and direction of facilitative interactions under different combinations of stress and disturbance intensities in Andean dry grassland

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Journal of Plant Ecology 2016年第3期9卷 296-310页

作者： andrea Catorci Luca Malatesta Jose Luis Velasquez Federico Maria Tardella Horacio Zeballos School of Biosciences and Veterinary Medicine University of Camerinovia Pontoni 5CamerinoMCItaly School of Advanced Studies PhD Course in Environmental Sciences and Public Health University of Camerinovia Lili 55CamerinoMCItaly Centro de Estudios y Promoción del Desarrollo(Desco) Málaga Grenet 678ArequipaPeru Instituto de Ciencias de la Naturaleza Territorio Yenergia RenovablesPontificia Universidad Católica del Perù.Av.Universitaria 1801San Miguel 32LimaPerù

Aims Facilitation is a key process in vegetation dynamics,driving the response to natural and anthropogenic *** harsh-grazed systems,palatable plants mainly survive when nested under unpalatable tussocks and *** magnitude and direction of positive interactions are driven by resource availability,extent of herbivory and type of nurse *** hypothesized that different combinations of disturbance and environmental stress affect community composition in the dry Puna(southern Peruvian Andes)by modifying nurse types and plant interactions in magnitude and specific *** investigated whether different combinations of stress and disturbance influence species richness,type and frequency of occurrence of nurse and beneficiary species and magnitude and patterns of plant interactions;whether nurse species influence these interactions and target species change their interactions under different combinations of stress and disturbance and whether plant functional traits differ in the studied communities and influence the pattern of spatial *** We selected three plant communities subject to different precipitation and management regimes:in each we laid a number of transects proportional to its *** collected include species presence/absence,type of spatial interactions with nurse species and functional *** calculated species richness and rarefaction patterns,described the patterns of plant-plant spatial interactions and investigated the associations between nurse and other species in the three communities using indicator species analysis(ISA).We performed ISA and correlation analysis to investigate whether plant functional traits influenced facilitative *** Findings We found that different combinations of stress and disturbance shaped a complex set of responses,including changes in the nurse species *** composition influenced magnitude and direction of plant interactions under different stress

关键词： dry Puna facilitation functional traits nurse and beneficiary species species-specific interaction stress-gradient hypothesis

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Water oxidation electrocatalysis with iron oxide nanoparticles prepared via laser ablation

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Journal of Energy Chemistry 2016年第2期25卷 244-248页

作者： Erica Pizzolato Stefano Scaramuzza Francesco Carraro Alessia Sartori Stefano Agnoli Vincenzo Amendola Marcella Bonchio andrea Sartorel Department of Chemical Sciences University of Padova Institute on Membrane Technology unit of Padova

Iron oxide nanoparticles（FeOx NPs, 5–30 nm size） prepared via laser ablation in liquid were supported onto Indium Tin Oxide conductive glass slides by magnetophoretic deposition（MD） technique. The resulting Fe O x@ITO electrodes are characterized by a low amount of iron coverage of 16–50 nmol/cm^2,and show electrocatalytic activity towards water oxidation in neutral phosphate buffer pH 7 with 0.58 V overpotential and quantitative Faradaic efficiency towards oxygen production. XPS analysis on the oxygen region of the FeOx films reveals a substantial hydration of the surface after catalysis, recognized as a crucial step to access reactivity.

关键词： Water oxidation Electrocatalysis Iron oxide Laser ablation Nanoparticles

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