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Nicotine enhances migration and invasion of human esophageal squamous carcinoma cells which is inhibited by nimesulide

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World Journal of Gastroenterology 2009年第20期15卷 2500-2505页

作者： Ye Zong shu-tian zhang Sheng-Tao Zhu Department of Gastroenterology Beijing Friendship Hospital Affiliated to the Capital Medical University Beijing Digestive Disease Center Beijing 100050 China

AIM： To study the effect of nicotine on the migration and invasion of human esophageal squamous carcinoma cells and to investigate whether nimesulide can inhibit the effect of ***： The esophageal squamous carcinoma cell line （TE-13） was treated with different concentrations of nicotine （100 μg/mL and 200 μg/mL） or 200 μg/mL nicotine plus 100 μmol/L nimesulide. Cell migration and invasion were measured using migration and invasion chamber systems. COX-2 expression was determined by Western blotting. Matrix metalloproteinase-2 （MMP-2） was analyzed by zymography and ***： Nicotine （100 μg/mL, 200 μg/mL） enhanced TE-13 cells migration and invasion, and increased the protein expression of COX-2 and the activity of MMP-2. Nicotine （200 μ/mL） stimulated TE-13 cells migration and invasion which were partly blocked by nimesulide. This was associated with decreased protein expression of COX-2 and decreased activity and protein expression of MMP-2. CONCLUSION： Nicotine enhances the migration and invasion of the esophageal squamous carcinoma cell line, and nimesulide partly blocks the effect ofnicotine-enhanced esophageal squamous carcinoma cell migration and invasion.

关键词： Carcinoma Cyclooxygenase 2 inhibitors Esophagus Nicotine Squamous cell

Knowledge Graph and Knowledge Reasoning:A Systematic Review

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Journal of Electronic Science and Technology 2022年第2期20卷 159-186页

作者： Ling tian Xue Zhou Yan-Ping Wu Wang-Tao Zhou Jin-Hao zhang tian-shu zhang Kashi Institute of Electronics and Information Industry Kashi 844099 Shenzhen Institute of Information Technology Shenzhen 518172 the School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054 the School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu 610054

The knowledge graph(KG) that represents structural relations among entities has become an increasingly important research field for knowledge-driven artificial intelligence. In this survey, a comprehensive review of KG and KG reasoning is provided. It introduces an overview of KGs, including representation, storage, and essential technologies. Specifically, it summarizes several types of knowledge reasoning approaches, including logic rules-based, representation-based, and neural network-based methods. Moreover, this paper analyzes the representation methods of knowledge hypergraphs. To effectively model hyper-relational data and improve the performance of knowledge reasoning, a three-layer knowledge hypergraph model is proposed. Finally, it analyzes the advantages of three-layer knowledge hypergraphs through reasoning and update algorithms which could facilitate future research.

关键词： methods. representation reasoning

Successful endoscopic removal of a giant upper esophageal inflammatory fi brous polyp

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World Journal of Gastroenterology 2009年第41期15卷 5236-5238页

作者： Jie zhang Jian-Yu Hao Simon Wing Heng Li shu-tian zhang Department of Gastroenterology Beijing Chaoyang Hospital Affiliated to Capital Medical University Baijiazhuang Road 8 Chaoyang District Beijing 100020 China Department of Medicine Pamela Youde Nethersole Eastern Hospital Hong Kong China Department of Gastroenterology Beijing Friendship Hospital Affiliated to Capital Medical University Yongan Road 95 Xuanwu District Beijing 100050 China

Giant esophageal inflammatory fibrous polyp （espedally 〉 17 cm in size） is seen rarely. Endoscopic removal has been reported rarely because the procedure is technically demanding and the hemostasis is difficult to ascertain. Here, we describe a case of a giant upper esophageal inflammatory fibrous polyp that was resected successfully by endoscopy.

关键词： Digestive system endoscopic surgery Polyps Endosonography Esophageal neoplasms Hemostasis, Endoscopic Middle aged

The sedimentological characteristics of microbialites of the Cambrian in the vicinity of Beijing,China

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Journal of Palaeogeography 2017年第2期6卷 117-131页

作者： Yin- Ye Wu tian-shu zhang Jia-Lei Lü Yan Liu Department of Petroleum Geology Research Institute of Petroleum Exploration and DevelopmentPetroChinaBeijing 100083China School of Earth Sciences Zhejiang UniversityHangzhou 310027Zhejiang ProvinceChina

With oil and gas exploration transferring to deeper and more ancient marine strata,more researches have been conducted about the Meso—Neoproterozoic and Cambrian microbial carbonate rocks by petroleum *** Cambrian deposits experienced the first transgression of the Paleozoic,with shallow marine facies depositing in most areas,which are favorable for different kinds of biological *** Lower Cambrian in Beijing area is lithologically dominated by purple red shales interbedded with limestones,the Middle Cambrian is mainly composed of thick oolitic limestones,and the Upper Cambrian consists of thin limestones and flat-pebble *** beds of microbial carbonate rocks were discovered in the Cambrian outcrops in the vicinity of *** is from the zhangxia Formation of Middle Cambrian,and the other is from the Gushan Formation of Upper *** microbialites are characterized by combination of multiple stromatolites forming different *** bioherms are mostly in oval shape and with different sizes,which are 3-4 m long,and 1-3 m *** surrounding strata beneath the bioherms are oolitic limestones.A central core of flat-pebble conglomerates occurred within each *** or columnar stromatolites grow on the basis of flat-pebble conglomerates,with dentate erosional *** bioherm carbonate rocks are interpreted as products from a deep ramp sedimentary environment where potential oil and gas reservoirs can be *** analysis of sedimentological characteristics of bioherm carbonate rocks and its lithofacies palaeogeography has significant implication for petroleum *** on geological record of microbialites is beneficial to investigating the Earth evolution,biodiversity,palaeoenvironment and palaeoclimate change,as well as biological extinction event during geological *** also gives warning to human beings of modern biological crisis.

关键词： Cambrian Stromatolite Bioherm Microbialite Oil and gas reservoir Marine sedimentary environment Beijing

Gold Self-Relay Catalysis Enabling[3,3]-Sigmatropic Rearrange-ment/Nazarov Cyclization and Allylic Alkylation Cascade for Constructing All-Carbon Quaternary Stereocenters

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Chinese Journal of Chemistry 2022年第6期40卷 687-692页

作者： Fan-Tao Meng Xiao-Yan Qin Jing Li tian-shu zhang shu-Jiang Tu Bo Jiang Wen-Juan Hao School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhouJiangsu 221116China School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhouJiangsu 221018China

Molecular scaffolds endowed with all-carbon quaternary stereocenter are ubiquitous in natural products and significant bioactive ***,efficient construction of this type of structure units is full of challenge due to their congested chemical ***,we report a new gold(Ⅰ)self-relay catalysis merging[3,3]-sigmatropic rearrangement/Nazarov cyclization with al-lylic alkylation starting from 1,3-enyne acetates and allylic alcohols,producing a wide range of synthetically important allyl cyclo-pentenones with an all-carbon quaternary stereocenter in good yields under mild *** protocol demonstrates the precise control of regioselectivity,high functional group tolerance of substrates and the low loading of gold catalyst without inert atmos-phere protection,providing a catalytic and efficient entry to all-carbon quaternary stereocenters.

关键词： Allylation Domino reactions Carbocycles Gold self-relay catalysis 1,3-Enynes

Aberrant methylation of the 3q25 tumor suppressor gene PTX3 in human esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2011年第37期17卷 4225-4230页

作者： Jun-Xiong Wang Yuan-Long He Sheng-Tao Zhu shuo Yang shu-tian zhang Beijing Friendship Hospital Affiliated to the Capital Medical University Beijing 100050 China Department of Gastroenterology Qingdao Municipal Hospital Qingdao 266071 Shandong Province China Department of Gastroenterology Beijing Friendship Hospital Affiliated to the Capital Medical University Beijing 100050 China shuo Yang Laboratory Medicine Department Peking University Third Hospital Beijing 100050 China

AIM:To identify the novel methylation-silenced gene pentraxin 3(PTX3) in esophageal squamous cell carcinoma(ESCC).METHODS:PTX3 mRNA expression was examined in six human ESCC cell lines,one human immortalized normal esophageal epithelial cell line,primary ESCC tumor tissue,and paired adjacent nontumor tissue using reverse transcription polymerase chain reaction(RTPCR).Semi-quantitative immunohistochemistry was used to examine cellular localisation and protein *** specific PCR and bisulphite genomic sequencing were employed to investigate the methylation of the candidate ***:In the majority of ESCC cell lines,we found that PTX3 expression was down-regulated due to gene promoter hypermethylation,which was further confirmed by bisulphite genomic *** treatment with 5-aza-2'-deoxycytidine restored PTX3 mRNA expression in ESCC cell *** was more common in tumor tissues(85%) than in adjacent nontumor tissues(25%)(P < 0.01).CONCLUSION:PTX3 is down-regulated through promoter hypermethylation in ESCC,and could potentially serve as a biomarker of ESCC.

关键词： Tumor suppressor gene Pentraxin 3 Microarray DNA methylation Esophageal squamous cell carcinoma

Aortoesophageal fistula:A case misdiagnosed as esophageal polyp

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World Journal of Gastroenterology 2009年第47期15卷 6007-6009页

作者： Yue Jiao Ye Zong Zhong-Lin Yu Yong-Zheng Yu shu-tian zhang Department of Digestive Diseases and Beijing Digestive Disease Center Beijing Friendship Hospital Capital Medical University Beijing 100016 China

Aortoesophageal fistula(AEF)is a rare and fatal disorder. It is also a life-threatening cause of massive upper gastrointestinal *** aortic aneurysm is the most common cause of *** of a patient with this disorder requires rapid diagnosis and immediate intervention,which is considered the best way to save the patient's *** report a case of AEF misdiagnosed as esophageal polyp.

关键词： Aortoesophageal fistula Aortic aneurysm Gastrointestinal bleeding

Microscopic oil occurrence in high-maturity lacustrine shales:Qingshankou Formation,Gulong Sag,Songliao Basin

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Petroleum Science 2023年第5期20卷 2726-2746页

作者： Jing-Ya zhang Ru-Kai Zhu Song-Tao Wu Xiao-Hua Jiang Chang Liu Yi Cai Su-Rong zhang tian-shu zhang Research Institute of Petroleum Exploration and Development PetroChinaBeijing100083China

Occurrence and mobility of shale oil are prerequisites for evaluating shale oil reserves and prioritizing exploration targets,particularly for heterogeneous lacustrine *** Qingshankou Formation in the Gulong Sag,Songliao Basin is a classic lacustrine pure shale reservoir that contains abundant shale oil *** predicted geological reserves of the shale are 1.268×10^(9) *** this study,field emission scanning electron microscope(FE-SEM),the modular automated processing system(MAPS),pyrolysisgas chromatography(Py-GC),low-pressure nitrogen gas adsorption(LPNA),Soxhlet extraction,pyrolysis,and 2-D nuclear magnetic resonance(NMR)were integrated to describe the shale oil components,microscopic occurrence,mobility,and the effective pore size ***,the related controlling factors are *** shale oil in the Qingshankou Fm exists dominantly in the matrix pores of the clay minerals,with small amounts distributed in the intergranular pores of terrigenous clastic grains,intercrystalline pores of pyrite,intragranular pores of ostracod shells,and *** oil is distributed in the pore spaces of variable sizes in different *** clay mineral-laminated shales are characterized by the broadest range of pore size and largest volume of pore spaces with shale oil distribution,while the ostracod-laminated shales have limited pore spaces retaining ***,the proposed integrated analysis evaluates the shale oil molecules existing in two states:movable,and adsorbed oil,*** result illustrates that movable oil takes up 30.6%e79.4%of the total residual ***,mineral composition,and pore structures of the shale joint together to control the states and mobility of the shale *** values are positively correlated with the quantities of shale oil regardless of the state of *** mineral components significantly impact the state of shale *** differences in the states of oil were observed following

关键词： Shale oil content Occurrence states Micro-oil distribution Effective pore spaces Controlling factors Gulong sag

Gold self-relay catalysis for accessing functionalized cyclopentenones bearing an allcarbon quaternary stereocenter

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Organic Chemistry Frontiers 2022年第1期9卷 140-146页

作者： Fan-Tao Meng Jing-Long Chen Xiao-Yan Qin tian-shu zhang shu-Jiang Tu Bo Jiang Wen-Juan Hao School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou221116P.R.China School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou 221018P.R.China

A new gold(I)self-relay catalysis consisting of a 3,3-rearrangement,Nazarov cyclization and Michael addition cascade of 1,3-enyne acetates with aurones and their derived azadienes is reported,and used to produce a series of densely functionalized cyclopentenones bearing a cyclic quaternary stereocenter in moderate to good yields under mild *** tandem protocol demonstrates high regioselectivity,broad substrate flexibility and good functional group tolerance of substrates without inert atmosphere protection,providing a catalytic and convergent approach for creating all-carbon stereoscopic centers.

关键词： catalysis quaternary functional