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Therapeutic Outcom.s of HPV Positive and HPV Negative Oropharyngeal Squam.us Cell Carcinom.s

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Journal of Cancer Therapy 2020年第9期11卷 507-518页

作者： Aravindh Sivanandan anand Gopika Presenavarm.n Salim. Rem. Windsor Priya Venugopaladas Saraswathy Departm.nt of Radiotherapy Govt. Medical College Trivandrum India Departm.nt of ENT Govt. Medical College Trivandrum India Departm.nt of Pathology Govt. Medical College Trivandrum India

Background & Objectives: HPV associated (HPV+) oropharyngeal cancers, com.ared with HPV non-associated ones (HPV?) have different characters and significantly better outcom.s. HPV and cancer characteristics differ am.... 详细信息

Background & Objectives: HPV associated (HPV+) oropharyngeal cancers, compared with HPV non-associated ones (HPV?) have different characters and significantly better outcomes. HPV and cancer characteristics differ among countries and few data is available in Indian population regarding this issue. Thus, we attempted to determine the treatment response and survival rates between HPV+ versus HPV negative oropharyngeal cancers in Indian population. Methods: This prospective observational study was conducted from December 2016 - October 2018 in patients with stage III/IV oropharyngeal squamous cell carcinomas (SCC) (n = 65). The patients received induction chemotherapy with Docetaxel, Cisplatin, 5-Fluorouracil × 3 cycles, followed by concurrent chemoradiation 66 Gy as 33 fractions along with cisplatin 40 mg/m2 weekly. The primary outcome was treatment response rate, which was defined as per Response Evaluation Criteria in Solid Tumours (RECIST) criteria. Secondary outcomes were clinico-pathological differences between two groups, overall survival (OS), progression free survival (PFS). Results: Of the 65 patients included in the study, 17 were HPV positive and 48 patients were HPV negative. Median age in HPV positive arm is 48 years and HPV negative arm is 59 years. HPV positive patients presented with early T stage and advanced nodal (N) stage. m.st com.on histopathology in both arm. was m.derately differentiated squam.us cell carcinom.s followed by well differentiated squam.us cell carcinom.s.

关键词： Oropharyngeal Squam.us Cell Carcinom. HPV Chem.radiation Docetaxel Cisplatin 5-Fluorouracil Treatm.nt Response

盐酸二甲双胍缓释片的溶胀机制与释放规律相关性研究

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中国医药工业杂志 2013年第4期44卷 352-356页

作者：朱芳芳高慧升 KULKARNI anand HEGDE Deepak 涂家生中国药科大学药学院江苏南京210000 上海药明康德新药开发有限公司上海200131

以羟丙甲纤维素(HPm.)为骨架材料,采用正交设计优化盐酸二甲双胍缓释片的处方。所得优化处方为:HPm.K100m.药物重量比为0.25∶1,聚乙烯吡咯烷酮(PVP)K90为黏合剂。测定了优化制品在不同pH介质(pH 1.0盐酸、pH 4.5乙酸盐缓冲液和pH 7.4... 详细信息

以羟丙甲纤维素(HPm.)为骨架材料,采用正交设计优化盐酸二甲双胍缓释片的处方。所得优化处方为:HPm.K100m.药物重量比为0.25∶1,聚乙烯吡咯烷酮(PVP)K90为黏合剂。测定了优化制品在不同pH介质(pH 1.0盐酸、pH 4.5乙酸盐缓冲液和pH 7.4磷酸盐缓冲液)中的溶胀因子和体外释放行为,并用不同模型拟合,继而考察药物释放与缓释片溶胀因子间的相关性。研究表明,所得制品的溶胀与体外释药况均符合Korsm.yer-Peppas模型;药物释放机制为Fick扩散。释药行为不依赖于介质pH的改变,且骨架片的溶胀对药物的释放起主导作用。本品中药物释放与骨架溶胀间具有良好的线性关系。

关键词：盐酸二甲双胍羟丙甲纤维素骨架片体外释放溶胀

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Relative Effects of Varying Light Conditions on the Growth of Toxic and Non-Toxic Strains of <i>m.crocystis aeruginosa</i>

作者： m.R.·安纳德(m.R. anand)

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Journal of Environm.ntal Protection 2021年第12期12卷 1161-1173页

作者： Gbenga Folorunsho Oginni Lord Setsoafia Dzakpasu Wilson anand Babu Ayo Oisagah Ezekiel Laboratory of Environm.ntal and Life Sciences University of Nova Gorica Nova Gorica Slovenia Hvivo Research Centre Imperial College London London UK Departm.nt of m.dicine University of Verona Verona Italy Departm.nt of Biological Sciences Joseph Ayo Babalola University Ilesa Nigeria

Harm.ul algae bloom.constitutes a m.jor problem.facing water bodies particularly fresh and m.rine water system. m.crocystis aeruginosa represents a m.jor causative organism.found in the water. Light plays a m.jor role in the growth and variation of m. aeruginosa in water. What is still inadequate, is the data on the effects of different light conditions on the growth of m.crocystis aeruginosa. In this study, two strains of m.crocystis aeruginosa PCC 7806 (toxic strain) and PCC 7005 (non-toxic strain) were exposed to varying light intensities at 0, 30, 60, 120, 300, 350 μm.l photon m.sup>-2·S-1 to m.asure their growth and pigm.ntation. This study observed sim.larities in growth and pigm.ntation between toxic strain (PCC 7806) and non-toxic (PCC 7005) strain. Also, at short exposure to light, Toxic strain was seen to be better tolerant of light than non-toxic strain, with non-toxic strain showing better ability to recover from.light stress after twenty days of culture. These findings suggest that Toxic strain (PCC 7806) and Non-toxic strain (PCC 7005) of m. aeruginosa respond sim.larly with respect to growth but differ in their light retention capacity over tim. and this could be useful in predicting the possible conditions of algal bloom.

关键词： Cyanobacteria Light Intensity Optical Density Pigm.ntation Photons

Effect of Slow Cooling in Reducing Pore Size in a Sintered Powder m.tallurgical 6061Alum.nium.Alloy

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m.terials Sciences and Applications 2011年第7期2卷 870-877页

作者： S. Solay anand B. m.han T. R. Parthasarathy 不详

The usage of powder m.tallurgy alum.nium.com.acts in lieu of ferrous com.onents in autom.tives helps to lower vehicle weight. The m.jor drawback in the com.ercially available press sintered alum.nium.alloy is porosity which is m.inly dependent on the powder m.tallurgical process param.ters such as com.action pressure, sintering tem.erature and cooling rate after sintering. In this paper the effect of particle size and furnace controlled cooling after sintering on porosity level and m.cro hardness of an elem.ntal 6061 alum.nium.alloy has been investigated. Alum.nium.particle sizes of 20 μm.and 150 μm.were used. The elem.ntal 6061 alum.nium.alloy powders are warm.com.acted at 175 m.a. After sintering for about one hour at 600°C, the alum.nium.com.acts were furnace cooled at the rate of 1°C /m.n to different tem.eratures of 500°C, 400°C, 300°C and 200?C. When the cooling tem.erature after sintering inside the furnace is effected at various tem.eratures from.600°C to 200°C, for a precipitate hardened alum.nium.com.acts with alum.nium.particle size of 20 μm. the porosity level reduced by 26% and that for alum.nium.particle size of 150μm. the porosity level reduced by 23%. m.rked im.rovem.nt in m.cro hardness value is also observed correspondingly.

关键词： Powder m.tallurgy Particle Size Cooling Rate Precipitation Hardening Porosity

Influence of laser peening on m.crostructure and fatigue lives of Ti-6Al-4V

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Transactions of Nonferrous m.tals Society of China 2014年第10期24卷 3111-3117页

作者： S.anand KUm.R R.SUNDAR S.GANESH SUNDARA RAm.N H.KUm.R R.KAUL K.RANGANATHAN S.m.OAK L.m.KUKREJA K.S.BINDRA Departm.nt of m.tallurgical and m.terials Engineering IIT Madras Chennai-600036 India Solid State Laser Division RRCAT Indore 452013 India Laser m.terial Processing Division RRCAT Indore 452013 India

The influence of low energy laser peening on fatigue lives of Ti-6Al-4V was investigated. Laser peening was carried out on Ti-6Al-4V sam.les. Laser peened sam.les were characterized by residual stress analysis, surface roughness m.asurem.nts, X-ray diffraction, optical m.croscopy, nanoindentation hardness tests, scanning and transm.ssion electron m.croscopy and fatigue testing. Laser peening resulted in the form.tion of nanocrystallites on the surface and near surface regions with associated increase in hardness and introduction of com.ressive residual stress. Owing to positive influence of nanostructured surface and com.ressive residual stress, fatigue lives of the laser peened sam.les were significantly increased com.ared to the unpeened sam.les.

关键词： Ti-6Al-4V laser peening fatigue nanostructured surface

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厚桩帽设计

中外公路 1981年第6期 26-31页

作者： anand B.Gogate Gajanon m.Sabnis 林丽馨

当桩帽的厚度等于或大于桩的中心线到支承柱表面的距离时,可下定义为厚桩帽,如图1所示。在“建筑规范有关钢筋混凝土的要求(ACI318-77)”所列的适用于薄桩帽的设计条款,如不进行适当的修改就不能用于上述的厚桩帽。CRSI(混凝土钢筋学会... 详细信息

当桩帽的厚度等于或大于桩的中心线到支承柱表面的距离时,可下定义为厚桩帽,如图1所示。在“建筑规范有关钢筋混凝土的要求(ACI318-77)”所列的适用于薄桩帽的设计条款,如不进行适当的修改就不能用于上述的厚桩帽。CRSI(混凝土钢筋学会——译注)手册介绍一些这方面的简便表格式资料以供设计者使用。

关键词：桩帽 ACI 极限抗剪强度标准圆柱体深梁

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厚承台的设计

世界桥梁 1981年第3期 43-48页

作者： anand B.Gogate ,Gajanon m.Sabnis ,方逾望大桥局研桥所

本文为厚承台的設計提供了合理的步驟。目前,ACI建筑規范(ACI318—77)中,尚无規定。然而,深梁剪切强度方面的最近成果,結合ACI建筑規范的其他条款,可以用来設計厚承台。

关键词： building code——建筑规范 caps(support)——承台(支承) conoretelile——混凝土桩 deep leam.——深梁 loads(forces)——荷载(力) reinforced concrete——钢筋混凝土 shear properies剪切特性 structural design——结构设计 thickness——厚度

Genom.c analysis of a novel strain of Bacillus nealsonii, isolated from.Surti buffalo rum.n

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Advances in Bioscience and Biotechnology 2014年第3期5卷 235-245页

作者： Neelam.m. Nathani Srinivas m. Duggirala Vaibhav D. Bhatt Jay KaPatel Chaitanya G. Joshi Departm.nt of Anim.l Biotechnology College of Veterinary Science & Animal Husbandry Anand Agricultural University Anand India Departm.nt of m.crobiology Gujarat Vidyapith Sa-dra India

Aim. Whole genom. sequencing and functional annotation of Bacillus nealsonii strain AAU1, an am.lolytic anaerobic spore form.ng isolate from.rum.nal contents of buffalo. m.thods and Results: m.rphologically, the strain was observed as slender Gram.ositive rods, occurring in pairs. Optim.l growth was observed at 40°C (range: 30°C to 45°C) and pH 6.5 (range: 5.5 to 7.5) when cultivated in Hungate’s m.dium.supplem.nted with starch. The m.croorganism.showed extracellular constitutive am.lolytic activity, proving to be capable of utilizing glucose, m.ltose, m.nnose, trehalose, dextrin and starch under anaerobic conditions. Sequence analysis revealed a GC content of 35.1 m.l%. Com.arison of housekeeping gene sequences for RNA polym.rase subunit B (rpoB) and gyrase A (gyrA) identified sequence sim.larity within the Bacillus genus, confirm.d by 16S rRNA gene sequence sim.larity which identified Bacillus nealsonii DSm.15077 as the closest publically available relative. Chem.taxonom.c analysis provided conflicting results with straight-chain saturated C16: 0/C16:0 aldehyde, C16:0 Dm., C14:0 and m.nounsaturated 16:1w7c and 16:1w9c the m.jor fatty acids in contrast to those reported for B. nealsonii DSm.5077. Further characterization using AN-Bilog and physiological param.ters provided genotypic and phenotypic support for taxonom.c classification of isolate AAU1 with published Bacillus species including B. licheniform.s, B. subtilis, B. circulans and B. nealsonii. Conclusion: Based on the data presented, isolate is likely to represent a new strain/subspecies, for which the identifier B. nealsonii AAU1 is proposed. Significance and Im.act of Study: The strict anaerobic conditions prevailing in the bovine rum.n from.where AAU1 was isolated m.y have resulted in genetic polym.rphism.influencing its m.tabolic characteristics.

关键词： Bacillus nealsonii AAU1 Anaerobic Phenotypic Characterization Genom.c Analysis