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Antiproliferative role of Indig ofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats

Asian Pacific Journal of Tropical Biomedicine 2012年第12期2卷 966-974页

作者： Sivagnanam Selva Kumar Mudiganti Ram krishna Rao Maruthaiveeran Periyasamy Balasubramanian Department of Industrial Biotechnology Bharath University Department of Pharmacology and Environmental Toxicology Dr.A.L.M.Post graduate Institute of Basic Medical SciencesUniversity of Madras

Objective:To find out the anticancer effect of indigofera aspalathoides(***)on20-methylcholanthrene induced fibrosarcoma in ***:Fibrosarcoma was induced in Wistar strain male albino rats by ***(i.p.)administration of250 mg/kg body weight/day of aqueous extract of *** for 30 d effectively suppressed chemically induced *** such as body weight,liver and kidney weight,tumor weight,mean survival time,behavioral changes,blood glucose,blood glycogen and marker enzymes such as alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),acid phosphatase(ACP)and 5'-nucleiotidase(5'-NT)in serum,liver and kidney and lipid profiles such as total cholesterel,phospholipids,free fatty acids in liver and kidney of control and experimental animals were ***:Fibrosarcoma bearing animals were ferocious and *** mean survival time was found to increase after the *** body weights were significantly decreased(P<0.001)in groupⅡfibrosarcoma animals which steadily increased after the treatment with *** liver and kidney weights were significantly increased whereas the tumor weights decreased as compared to the weights in untreated fibrosarcoma bearing *** blood glucose and the liver and kidney glycogen levels were found to decrease significantly(P<0.001)in groupⅡ*** activities of marker enzymes were observed in serum,liver and kidney of fibrosarcoma bearing GroupⅡanimals which were normalize after *** *** the liver and kidney of GroupⅡanimals the total cholesterol increased whereas the pbospbolipids and free fatty acid levels decreased(P<0.001)which were normalized after ***:The treatment by *** on fihrosarcoma bearing rats has improved the levels of various parameters indicating its antiproliferative and anticancer activity.

关键词： Chemoprevention Tumor weight Mean survival time Glucose Glycogen Marker enzymes

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Υ射线照射过的菜豆胚轴切片的线粒体蛋白质定性和定量变化

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核农学通报 1986年第1期 17-18页

作者： krishna U.Pai 谭敏

研究电离辐射对线粒体结构与功能的影响十分必要,这些细胞器构成了细胞中的“动力厂”。电离辐射对线粒体的氧化磷酸化、膨胀和收缩以及离子吸收等的效应已经清楚。所有这些效应直接取决于一些与电子传递和结构成分(如蛋白质和脂肪)有... 详细信息

研究电离辐射对线粒体结构与功能的影响十分必要,这些细胞器构成了细胞中的“动力厂”。电离辐射对线粒体的氧化磷酸化、膨胀和收缩以及离子吸收等的效应已经清楚。所有这些效应直接取决于一些与电子传递和结构成分(如蛋白质和脂肪)有关的酶的作用。在以前的研究中,我们认为是辐射对脂代酶的效应造成脂肪含量特别是磷脂显著减少。目前的研究说明,辐射可能使另一个主要的(60%)线粒体成分即蛋白质发生变化。

关键词：线粒体电离辐射粒线体电磁辐射细胞色素蛋白质细胞器蛋白水解酶蛋白酶酶活度芸扁豆豆类蔬菜菜豆胚轴

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Recovery of Sillimanite from Beach Sands--An Operator＇s Nightmare？

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Journal of Earth Science and Engineering 2013年第4期3卷 270-281页

作者： Chivukula Venkata Gopala krishna Murty Leon Rademeyer Natarajan JaiSankar Patruni Bhavya Manjeera Prasana-sampath Challa Venkata Ramachandra Murthy Trimex Sands Private Limited Srikakulam Chinavatsavalasa 532404 Andhra Pradesh India Department of Chemical Engineering Andhra University College of Engineering (A) Visakhapatnam 530003 India

Sillimanite, chemically named aluminum silicate, 3Al2O3SiO2 is one of the three forms of alumino silicate polymorphs and commonly encountered in aluminous metamorphic, plutonic and volcanic rocks and their weathering products. Traditionally in India, sillimanite is upgraded by froth floatation technique using oleic acid as a collector cum frother, sodium silicate as depressant and soda ash as pH regulator. At TSPL （Trimex Sands Pvt Ltd）, conventional mechanical float cells are installed to float sillimanite. In addition to the usual problems associated with conventional cells, poor flow ability of the sillimanite concentrate is experienced in dry circuit due to the presence of sodium oleate. Fine garnet in the sillimanite concentrate contributes to high iron content in the final product, making sillimanite separation a nightmare for operators （lower recoveries coupled with inferior grades）. Various efforts were made to improve the performance of the circuit such as introduction of additional frother like MIBC （methyl ISO butyl carbinol）, optimizing the operating parameters such as pulp density, collector dosage, depressant dosage, air flow rate, pH etc., use of collector aids, stage wise addition of reagents etc.. The challenges faced to produce a sillimanite product with stringent quality norms and the efforts made to improve the grade and recovery are described in this paper.

关键词： Sillimanite froth flotation conventional mechanical cell.

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Magnetic and Electrical Properties of Gd Doped Ni-Cu-Zn-Fe<sub>2</sub>O<sub>4</sub>

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Advances in Materials Physics and Chemistry 2018年第10期8卷 401-410页

作者： P. Venkata Srinivasa Rao T. Anjaneyulu D. V. krishna Reddy M. Rami Reddy Department of Physics Acharya Nagarjuna University Guntur India Department of Physics S. S. & N. College Guntur India Department of Physics Narasaraopeta Engineering College Guntur India

Ni0.5Cu0.25Zn0.25GdxFe2-xO4 (x = 0.0, 0.025, 0.05, 0.075, 0.1) ferrites were synthesized using an oxalic-based precursor method. The TC for all the Ni0.5Cu0.25Zn0.25GdxFe2-xO4 (x = 0.0, 0.025, 0.05, 0.075, 0.1) samples was measured by using one of the double coil susceptibility setup. In all the samples it is observed that, at a certain temperature, susceptibility falls to zero indicating the Curie temperature (TC) and ferrimagnetic samples are converted into paramagnetic sample at that temperature. The electrical properties were investigated for these samples. Dielectric properties and ρdc properties were observed to decrease with the increase in the frequency for all the Gd doped ferrite samples.

关键词： Ni-Cu-Zn-Gd Nanoferrites Magnetic Properties Electrical Properties

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A Multiplex Autoantibody Panel for Early Detection of Autoimmune Disease Activity

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Open Journal of Rheumatology and Autoimmune Diseases 2018年第2期8卷 43-52页

作者： Yuanyuan Yang Karthik krishna Vinodh Ranganathan Vasanth Jayaraman Tianhao Wang Kang Bei Hari krishnamurthy John J. Rajasekaran Vibrant America LLC San Carlos CA USA

Background: Detection of autoantibodies has played a consolidate role in diagnosis of systemic autoimmune disorders. A cascade autoantibody testing is usually performed by employing antinuclear antibodies (ANA) test as a first screening test and the other tests as second level determinations. Here, we present that supplementing extractable nuclear antigens (ENA) tests to the ANA test may capture more autoimmunity and provide critical medical information at an early stage. In this study, we?evaluated the clinical significance of a multiplex ANA + ENA panel. Methods: A cohort of 110 subjects, identified as ANA negative but ENA positive, were followed up for two years. The detection of their ANA and anti-ENA autoantibodies was assessed with a multiplex ANA + ENA panel at Vibrant America Clinical Laboratory. Results: During two years of multi-visit follow-up, 23 out of 110 subjects (20.9%) were found to become ANA positive within an average of 385 (±144) days. Histone (50/110, 45.5%) and Chromatin (25/110, 22.7%) antibodies were the most frequently found antibodies at their first visits. The subjects who were positive for RNP (5/8, 62.5%) and SSA (Ro) (10/22, 45.5%) have the highest ratio of conversion to positive ANA. No significant correlation was observed between the conversion frequency and the number of anti-ENA antibodies being carried. Conclusion: This study, which followed up on the subjects who had disparate ANA and ENA test results, showed that anti-ENA antibodies may exist years earlier than ANA. Combining ENA tests with ANA screening may reduce false negatives and improve sensitivity.

关键词： Autoantibody ANA ENA Autoimmunity Connective Tissue Disorder

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Leelamine suppresses cMyc expression in prostate cancer cells in vitro and inhibits prostate carcinogenesis in vivo

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 242-253页

作者： krishna B.Singh Eun-Ryeong Hahm Shivendra V.Singh Department of Pharmacology&Chemical Biology University of Pittsburgh School of MedicinePittsburghPennsylvaniaPA15261USA UPMC Hillman Cancer Center University of Pittsburgh School of MedicinePittsburghPennsylvaniaPA 15213USA

Aim:Leelamine(LLM)inhibits the growth of human prostate cancer cells but the underlying mechanism is not fully *** present study was undertaken to determine the effect of LLM on cMyc,which is overexpressed in a subset of human prostate ***:The effect of LLM on cMyc expression and activity was determined by western blotting/confocal microscopy and luciferase reporter assay,respectively.A transgenic mouse model of prostate cancer(Hi-Myc)was used to determine the chemopreventive efficacy of ***:Exposure of androgen-sensitive(LNCaP)and castration-resistant(22Rv1)human prostate cancer cells to LLM resulted in downregulation of protein and mRNA levels of *** of cMyc partially attenuated LLM-mediated inhibition of colony formation,cell viability,and cell migration in 22Rv1 and/or PC-3 *** treatment decreased protein levels of cMyc targets(e.g.,lactate dehydrogenase),however,overexpression of cMyc did not attenuate these effects.A trend for a decrease in the expression level of cMyc protein was discernible in 22Rv1 xenografts from LLM-treated mice compared with control *** treatment(10 mg/kg body weight,5 times/week)was well-tolerated by Hi-Myc transgenic *** incidence of high-grade prostatic intraepithelial neoplasia,adenocarcinoma in situ,and microinvasion were lower in LLM-treated Hi-Myc mice but the difference was not statistically ***:The present study reveals that LLM inhibits cMyc expression in human prostate cancer cells in vitro but concentrations higher than 10 mg/kg may be required to achieve chemoprevention of prostate cancer.

关键词： Prostate cancer cMyc leelamine chemoprevention

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大脑髓静脉磁敏感加权像评估急性缺血性脑卒中的研究

大脑髓静脉磁敏感加权像评估急性缺血性脑卒中的研究

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作者：科瑞仕纳（krishna Shrestha）内蒙古民族大学

学位级别：硕士

目的:利用核磁共振磁敏感加权成像(susceptibility weighted imaging,SWI)技术分析脑梗死患者的大脑髓质静脉不对称征与脑梗死严重程度的相关性,为临床急性脑梗死诊断、治疗提供影像参考。方法:将2018年12月至2019年12月,内蒙古民族大... 详细信息

目的:利用核磁共振磁敏感加权成像(susceptibility weighted imaging,SWI)技术分析脑梗死患者的大脑髓质静脉不对称征与脑梗死严重程度的相关性,为临床急性脑梗死诊断、治疗提供影像参考。方法:将2018年12月至2019年12月,内蒙古民族大学附属医院收治的急性缺血性脑卒中患者纳入本研究,其中共收录86例急性大脑中动脉(MCA)卒中患者的磁敏感加权成像。将两侧大脑半球分别采用0(无可见DMV)到3(非常显著DMV)的评分系统进行评测,同侧和对侧之间的得分差异被定义为不对称(AMV+)。AMV+的发生与美国国立卫生研究院卒中量表(NIHSS)的入院和出院评分以及改良Rankin量表(mRS)的出院评分相关。采用序贯回归分析评价NIHSS和mRS对脑卒中严重程度的预测作用。结果:55例患者显示不对称征(AMV+组),31例患者未显示不对称征(AMV-组)。AMV+组入院时 NIHSS 中位数为 17(11-21),AMV-组为 9(5-15)(p=0.001)。出院时,AMV+患者NIHSS中位数为11(5-20),AMV患者NIHSS中位数为5(2-14)(p=0.005)。AMV+组出院时 mRS 中位数为 4(3-5),AMV-组为 3(1-4)(p=0.001)。AMV+获得高于 AMV-的 mRS 的优势比为 3.19(95%CI:1.24-8.21)(p=0.016)。结论:DMV在SWI上的不对称表现,与脑梗死的严重程度有很强的相关性,可作为急性缺血性脑卒中患者的一个重要影像学指标。

关键词：磁敏感加权成像深髓静脉征急性脑梗死前循环 rtPA

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木白蚁的品级分化

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白蚁科技 1988年第S1期 41-42页

作者： krishna Weesner 袁舜姜广东省昆虫研究所

关于木白蚁的品级分化现象,早期的研究认为:“木白蚁正常发育到翅膀完全期的不同时期内,可能出现发育上的越轨现象,这些现象可以使补充繁殖蚁或兵蚁的形成……。”一个群体的王或后失去达24～28小时时,少量的补充繁殖蚁将会发生;但是仅有

关键词：繁殖蚁翅芽白蚁兵蚁若蚁品级

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人类病毒组——预测莫测之事,识别真正之敌

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实用临床医药杂志 2020年第15期24卷 1-7页

作者： Tamoghna Ghosh Pankaj krishna Prakash Singh Bisen 印度医药城Avantor性能材料公司研发诊断中心印度德拉敦248011 斋浦尔国立大学医学科学和研究中心研究所印度斋浦尔302017 瓜廖尔大学生物技术研究学院印度瓜廖尔474011

人和动物的基因组有很大部分由各种内源性病毒组成,它们快速复制和突变,并呈现出时间和空间的变化性,导致或者不导致疾病。但是人类对于其组成、复杂性和动态变化了解不足。迄今为止,高通量基因组学、转录组学和蛋白质组学研究对病毒组... 详细信息

人和动物的基因组有很大部分由各种内源性病毒组成,它们快速复制和突变,并呈现出时间和空间的变化性,导致或者不导致疾病。但是人类对于其组成、复杂性和动态变化了解不足。迄今为止,高通量基因组学、转录组学和蛋白质组学研究对病毒组-微生物组-人类行为三者之间的相互作用有了一些重要的发现,结果表明其相互作用极大地影响着人体的生理和内稳态。大量的内源性病毒为宿主提供了益处,也带来不良的免疫调节和继发感染。很多寄宿于人体的病毒来源于哺乳动物和鸟类的跨物种传播,这种传播往往导致致死性高的流行病。理解病毒分类以及病毒蛋白质组中负责与宿主病毒组相互作用的元素和因子会帮助我们制订应对未来病毒爆发的策略。本文对病毒宏基因组学研究中与人类健康和疾病相关的一些关键内容进行了综述。

关键词：动物基因组高通量基因组病毒蛋白质组学病毒基因组人类病毒组内稳态宿主

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印度泰米尔纳德邦二化性与多化性家蚕品种的蚕茧缫折影响因素分析(英文)

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蚕业科学 2014年第2期40卷 358-362页

作者： KADHAR Mohammed Abdul MAHESH Madigal Gurulingappa RAMESHBABU Vijay krishna GHOSH Malai Kumar BASU Arindam 蚕丝技术研究中心蚕丝检验与测试室印度康契普拉姆区631502 蚕丝中央委员会蚕茧测试中心印度达尔马布里孔巴托市641018 蚕丝中央委员会蚕丝技术研究中心印度班加罗尔市560068

印度泰米尔纳德邦蚕区饲养二化性和多化性家蚕品种。依据该地区蚕茧市场蚕茧检测中心2006—2010年对蚕茧缫折及相关指标的测试数据进行统计分析,比较影响二化性品种和多化性品种蚕茧缫折的主要因素。统计分析显示,多化性家蚕品种蚕茧的... 详细信息

印度泰米尔纳德邦蚕区饲养二化性和多化性家蚕品种。依据该地区蚕茧市场蚕茧检测中心2006—2010年对蚕茧缫折及相关指标的测试数据进行统计分析,比较影响二化性品种和多化性品种蚕茧缫折的主要因素。统计分析显示,多化性家蚕品种蚕茧的缫折较高,主要是受次茧率的显著影响;尽管近年来二化性家蚕品种的次茧率也明显增加,但高次茧率对其缫折的影响并不显著,这是因为对缫折有明显影响的茧层率在过去的5年里得到显著提高。结果提示,泰米尔纳德邦饲养的二化性家蚕品种具有高茧层率和低缫折的优势。

关键词：家蚕二化性多化性缫折次茧率茧层率

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