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Stroke care during the COVID-19 outbreak in Spain: the experience of Spanish stroke units

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Stroke & Vascular Neurology 2021年第2期6卷 267-273页

作者： Maria Alonso de Lecinana Mar Castellanos Oscar Ayo-Martin ana morales the Stroke Group-Spanish Society of Neurology Department of Neurology and Stroke Center Hospital La Paz Institute for Health Research-IdiPAZ.La Paz University Hospital.Universidad Autonoma de MadridMadridSpain Department of Neurology Complexo Hospitalario Universitario A Coruna.Biomedical Research Institute of A CorunaA CorunaSpain Department of Neurology Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Department of Neurology University Clinic Hospital Virgen de la ArrixacaMurciaSpain 不详

Background and purpose Spain has been heavily affected by *** of resources for managing the outbreak might have caused a disruption in stroke *** study analyses the impact on stroke care of reorganising the healthcare system in response to the first COVID-19 outbreak peak in Spain and the strategies adopted by Spanish stroke units to deal with this *** and methods We obtained data from a structured survey sent to the responsible of stroke units across the *** recorded the number of strokes,stroke code activations,intravenous thrombolysis treatments and mechanical thrombectomies during February and March 2019 and *** also collected information on the impact on workflow metrics and on the availability of specialised neurological care and rehabilitation treatments,the characteristics of stroke care for patients with SARS-CoV-2 infection and the impact on human *** compared the activity data between 2019 and 2020 and the information on activity and impact on stroke care between regions classified according to the disease incidence *** Fifty-seven(75%)of all stroke units in Spain responded to the *** was an overall reduction in admissions for all stroke types during the outbreak’s peak and in the number of stroke code activations and intravenous thrombolysis treatments,results that were independent of the COVID-19 incidence *** reported a delay in workflow metrics and a reduction of admissions to stroke units,outpatient clinics and rehabilitation *** pathways and protocols for managing stroke patients with SARS-CoV-2 infection have been *** The COVID-19 outbreak has jeopardised all phases of stroke *** a consequence,some patients with stroke did not receive adequate treatment.

关键词： Spanish consequence outbreak

Potential anti neuro-inflammatory effect of BioCen-128 in animal models of dementia

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Animal Models and Experimental Medicine 2022年第4期5卷 369-376页

作者： Nashelly Esquivel Yenela García Roberto Menéndez Teidy EGarcía ana Rmorales Claudio Rodríguez National Center for Bioproducts(BIOCEN) BejucalCuba Center for Neurosciences(CNEURO) PlayaCuba Department of Pharmacology Institute of Marine Sciences(ICIMAR)HavanaCuba

Background:BioCen-128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide *** results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging,immunosenescence and Alzheimer’s disease(AD),where the inflammation plays an important *** of the anti-i nflammatory potential of BioCen-128,the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular(ICV)administration of streptozotocin(STZ).Method:The experiment was carried out using male OF-1mice weighing 20±2 ***:Mice administered BioCen-128 in via the IP route at 5,10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma,providing evidence of a systemic anti-i nflammatory *** the ICV model of STZ,the administration of BioCen-128 improved cognitive ***:These responses suggested an anti-neuroinflammatory effect explainable by the action of thymosinβ4 and thymosin alfa *** results suggested that BioCen-128 could be used in the prevention and treatment of some diseases,for example AD,where neuroinflammation is one of the biological events that take place.

关键词： BioCen-128 cotton pellet mice neuroinflammation

Chitosan Nanoparticles as Biostimulant in Lettuce (Lactuca sativa L.) Plants

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 777-787页

作者： Silvia C.Ramírez-Rodríguez Pablo Preciado-Rangel Marcelino Cabrera-De La Fuente Susana González-morales Hortensia Ortega-Ortiz Tecnológico Nacional de México Instituto Tecnológico de TorreónEjido AnaTorreónCoahuila27170México Departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Departamento de Materiales Avanzados Centro de Investigación en Química AplicadaSaltilloCoahuila25294México

Biodegradable nanoparticles such as chitosan nanoparticles (CSNPs) are used in sustainable agriculture since theyavoid damage to the environment;CSNPs have positive effects such as the accumulation of bioactive compoundsand increased productivity in plants. This study aimed to investigate the impact of applying CSNPs on lettuce,specifically focusing on enzymatic activity, bioactive compounds, and yield. The trial was conducted using a completelyrandomized design, incorporating CSNPs: 0, 0.05, 0.1, 0.2, 0.4, and 0.8 mg mL−1. The doses of 0.4 mg mL−1improve yields up to 24.6% increases and 0.1 mg mL−1 of CSNPs increases total phenols by 31.2% and antioxidantcapacity by 34.6%. In addition, when low concentrations of CSNPs (0.05 and 0.1 mg L−1) were applied, anincrease in catalase was determined. The CSNPs represent a good alternative to be used as a biostimulant in sustainableagriculture because they improve the yield and quality of lettuce by increasing the bioactive compounds.

关键词： Biostimulant bioactive compounds enzymatic activity

Polyorchidism： the case in a young male and review of the literature

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Asian Journal of Andrology 2015年第3期17卷 511-512页

作者： ana Avargues Ramon Rogel Enrique Broseta Saturnino Lujan Jesus A Betancourt Gonzalo morales Francisco Boronat Department of Urology University and Polytechnic Hospital La Fe Valencia 46026 Spain

Dear Editor, Polyorchidism refers to the presence of more than two testicles. Blasius described it for the first time in 1670 as an incidental finding in an autopsy, while Lane was the one who performed the first histological description of a supernumerary testis in 1895.1,2 Before imaging diagnosis techniques, this condition could only be verified under surgical exploration. Nowadays, current imaging techniques have increased the number of diagnosis of this anatomical variation. On the other hand, there is still a certain group of physicians who use histological analysis as the unioue way to diagnosis.

关键词： ManaGEMENT

In Vitro Propagation, Isolation and Expression Studies of Suaeda edulis Genes Involved in the Osmoprotectants Biosynthesis

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 715-726页

作者： Gloria Viviana Cerrillo-Rojas Mariana Tiscareno-Andrade ana Erika Ochoa-Alfaro Eugenio Perez-Molphe Balch Ruth Elena Soria-Guerra Jose Francisco morales-Dominguez Departamento de Quimica Universidad Autonoma de AguascalientesCentro de Ciencias BasicasCiudad UniversitariaAguascalientes20131Mexico Facultad de Quimica Universidad Autonoma de San Luis PotosiZona UniversitariaSan Luis Potosi78210Mexico

Halophytes are an excellent choice for the study of genes conferring salt tolerance to salt-sensitive plants and,they are suitable for reclamation and remediation of saline *** develop an in vitro plant propagation protocol and studies of genes involved with GB and Pro biosynthesis in Suaeda *** buds were used as explants and cultured in different treatments on Murashige and Skoog(MS)medium supplemented with different concentrations and combinations of plant growth *** highest number of multiple shoots was on MS medium containing 1 mg/L Benzyladenine(BA)and/or 2 g/L activated carbon with 5.5±06 shoots per *** identification and expression analysis of genes involved in glycine betaine(GB)biosynthesis were S-adenosyl-methionine synthetase(SAMS),choline monooxygenase(CMO)and betaine alde-hyde dehydrogenase(BADH),and for proline(Pro)was pyrroline 5-carboxylate synthetase(P5CS).These sequences shared 90–95%of identity with others plant homologous in public *** amino acids sequence analysis showed that all these peptides contain some of the conserved motifs of those kinds of *** qRT-PCR analysis revealed a higher expression of SeBADH,SeCMO,and,SeP5CS genes in the roots and leaves from plants collected in the field in contrast with from in vitro ***,the expression level of SeSAMS was higher only in the leaves of plants collected in the field when com-pared to those cultivated in vitro.

关键词： Axillary buds halophyte proline glycine betaine salt-resistant

Comparison of the Ability of Myricetin and Quercetin to Modulate the Oxidative DNA Damage Induced by Heterocyclic Amines

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Food and Nutrition Sciences 2011年第4期2卷 356-365页

作者： ana Isabel Haza Angel Lui Coto Paloma morales 不详

The aim of the present study was to compare the ability of the myricetin and quercetin to modulate the oxidative DNA damage induced by 2-amino-3, 8- dimethylimidazo [4,5-f] quinoxaline (8-MeIQx), 2-amino- 3, 4, 8- trimethylimidazo [4, 5-f]-quinoxaline (4,8-diMeIQx) and 2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP), in human hepatoma cells. DNA damage (strand breaks and oxidized purines/pyrimidines) was evaluated by the alkaline single-cell gel electrophoresis or comet assay. None of the myricetin and quercetin concentrations tested protected against 8-MeIQx, 4, 8-diMeIQx and PhIP-induced DNA strand breaks. The oxidized pyrimidines induced by 4, 8-diMeIQx and PhIP were reduced by myricetin but not by quercetin. Quercetin reduced the oxidized purines induced by 8-MeIQx and PhIP, while myricetin also reduced the induced by 4, 8-diMeIQx. One feasible mechanism by which myricetin and quercetin exert their protective effect towards HCAs-induced oxidative DNA could be related in part to the reduction of human CYP1A1. Another mechanism claimed to be responsible for the protective effect of myricetin and quercetin is the induction of phase II metabolizing enzymes such as UDP-glucuronyltrasferase (UGT). The ethoxyresorufin O-deethylation (CYP1A1) activity was moderately inhibited by myricetin, while little effect was observed by quercetin. On the contrary, quercetin showed the greatest increase on UDP-glucuronyltransferase activity. However, these are not the only mechanisms by which myricetin and quercetin exert their protective effect, other mechanisms such as stimulation of the repair of carcinogen-induced DNA damage and or the free radical scavenging efficiency have been also implicated. In conclusion, our results clearly indicate that myricetin was more efficient than quercetin to prevent DNA damage (oxidized purines and pyrimidines) induced by the three HCAs evaluated. This protective effect depends on the chemical structure of flavonoid and the mutagen stud

关键词： Myricetin Quercetin Comet Assay Oxidative DNA Damage Heterocyclic Amines

Apoptosis Induced by N-Nitrosamines in Two Cancer Cell Lines

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Journal of Environmental Protection 2010年第3期1卷 314-323页

作者： Paloma morales Nuria Arranz ana I. Haza 不详

In the present study, we investigated the induction of apoptosis by N-nitrosopyrrolidine (NPYR) and N-nitrosodimethy-lamine (NDMA) in two human cell lines: HL-60 (leukemia) and HepG2 (hepatoma). Apoptotic cells were identified by: 1) chromatin condensation, 2) flow cytometry analysis and 3) poly (ADP-ribose) polymerase cleavage. Both cell lines exhibited morphological changes consistent with apoptotic events following treatment with N-nitrosamines. Flow cytometry analysis showed that both N-nitrosamines induced apoptotic cell death in a concentration and time dependent- manner. NPYR was stronger than NDMA, since it induced a significant apoptotic cell death after 72 h starting from a concentration of 10 mM, whereas NDMA was effective at 27 mM. Furthermore, NPYR and NDMA caused the cleavage of PARP in HL-60 cells whereas no PARP cleavage was detected in HepG2 cells. However, NPYR- and NDMA-induced cell death in HepG2 cells was prevented by specific caspase inhibitors. Caspase-8 mediated main pathway and was responsible for 76% (NPYR) and 64% (NDMA) inhibition of apoptosis. The data demonstrate that NPYR and NDMA induce apoptosis in HL-60 and HepG2 cell lines via caspase-dependent pathway.

关键词： N-nitrosopyrrolidine N-nitrosodimethylamine Apoptosis Caspases HL-60 Cells HepG2 Cells

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni ana Júlio Celestino Santos-Buelga ana M.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.Costa Lima Salette Reis Angela Fernandes Isabel C.F.R.Ferreira Virginia Fernandez-Ruiz Patricia morales Guido Flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for Marine Sciences(CCMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

Solanum lycopersicum: Novelties for Climate Factors and Its Agronomic Management for High Yields

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World Journal of Engineering and Technology 2022年第3期10卷 605-612页

作者： Víctor García-Gaytán Soledad García-morales ana V. Coria-Téllez Fanny Hernández-Mendoza Janet María León-morales El Colegio de Michoacán La Piedad México Profesor Investigador Mejoramiento Integral de Plantas a Través de la Genética y Nutrición Vegetal La Piedad México (CONACYT) Centro de Investigación y Asistencia en Tecnología y Diseñ o del Estado de Jalisco Zapopan México Coordinación Académica Región Altiplano Oeste Universidad Autónoma de San Luis Potosí San Luis Potosí México

The intensive production of vegetables such as tomatoes depends on various strategies to achieve high *** of this manuscript is to provide scientific and technological strategies for the intensive production of tomato or other vegetables in mega-production factories. However, with the advancement of knowledge, new improvements in the strategies will be incorporated. We have carried out research related to growth and yield variables in S. Lycopersicum. From this research we have worked on the intensive production of this noble vegetable at an industrial level. The results obtained are improvements in the production system. The improvements include the selection of the appropriate variety, germination and development of seedlings in a certified nursery. Trans-plantation in soil or hydroponics. The conditions of nutrient applications from the irrigation head system. The ventilation system and monitoring of climatic factors both day and night (temperature and relative humidity). Monitoring of macro- and micronutrients in the plant system, including Ca, K, Fe, and Zn. Soil fertility analyzes should include: primary and secondary macronutrients (ppm), organic matter (OM), EC, pH, bulk density (BD), and cation exchange capacity (CEC). The nutritional diagnosis to confirm ranges of sufficiency. As a tool in plant nutrition programs, foliar application can include biostimulants and growth regulators. The foregoing can be considered strategies for the integral management of the tomato crop.

关键词： Integrated Management Climate Factors Plant Nutrition Growth Regulators