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mesenchymal.stem cel.-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model.of Al.heimer’s disease

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Neural.Regeneration Research 2019年第9期14卷 1626-1634页

作者： Edwin E. Reza-Zal.ivar mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-mercado Sergio Sandoval.ávil. Ul.ses Gomez-Pinedo ana l. márquez-aguirre Estefanía Vázquez-méndez Eduardo Padil.a-Camberos Al.jandro A. Canal.s-aguirre Unidad de Eval.ation Precl.nica Unidad de Biotecnologia Medica y FarmaceuticaCentro de Investigation y Asistencia en Tecnologia y Diseno del Estado de JaliscoGuadalajaraMexico Regenerative medicine Unit Neuroscience InstituteDepartment of Neurosurgery and NeurologyIdlSSC Health Research Institute of the Hospital Clinico San CarlosMadridSpain

Studies have shown that mesenchymal.stem cel.-derived exosomes can enhance neural.pl.sticity and improve cognitive *** purpose of this study was to investigate the effects of mesenchymal.stem cel.-derived exosomes on neurogenesis and cognitive capacity in a mouse model.of Al.heimer’s ***’s disease mouse model. were establ.shed by injection of beta amyl.id 1?42 aggregates into dentate gyrus *** water maze and novel.object recognition tests were performed to eval.ate mouse cognitive deficits at 14 and 28 days after ***,neurogenesis in the subventricul.r zone was determined by immunofl.orescence using doubl.cortin and PSA-NCAm *** showed that mesenchymal.stem cel.s-derived exosomes stimul.ted neurogenesis in the subventricul.r zone and al.eviated beta amyl.id 1?42-induced cognitive impairment,and these effects are simil.r to those shown in the mesenchymal.stem *** findings provide evidence to val.date the possibil.ty of devel.ping cel.-free therapeutic strategies for Al.heimer’s *** procedures and experiments were approved by Institutional.Animal.Care and Use Committee(CICUAl.(approval.*** 2016-011)on April.25,2016.

关键词： Al.heimer’s disease neurodegenerative disease cognitive impairment memory Al.heimer’s disease mouse model mesenchymal stem cel. exosomes neurogenesis cognitive improvement cel.-free therapy neural regeneration

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Evol.tionary Genomics of Weedy Rice in the USA

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Journal.of Integrative Pl.nt Biol.gy 2007年第6期49卷 811-816页

作者： Kenneth m. Ol.en ana l. Caicedo Yul.n Jia Department of Biol.gy Washington University St Louis MO 63130 USA Department of Biol.gy University of Massachusetts Amherst MA 01003 USA USDA-ARS Dal. Bumpers National.Rice Research Center Stuttgart AR 72160 USA

Red rice Is an Interfertl.e, weedy form of cul.ivated rice （Oryza sativa l.） that competes aggressivel. with the crop In the southern US, reducing yiel.s and contaminating harvests. No wil. Oryza species occur In North America and the weed has been proposed to have evol.ed through mul.ipl. mechanisms, Incl.ding ＂de-domestication＂ of US crop cul.l.ars, accidental.introduction of Asian weeds, and hybridization between US crops and Asian wil./weedy Oryza strains. The phenotype of US red rice ranges from ＂crop mimics＂, which share some domestication traits with the crop, to strains cl.sel. resembl.ng Asian wil. Oryza species. Assessments of genetic diversity have Indicated that many weed strains are cl.sel. rel.ted to Asian taxa （Incl.ding indica and aus rice varieties, which have never been cul.ivated In the US, and the Asian crop progenitor O. rufl.ogon）, whereas others show genetic simil.rity to the tropical.Japonica varieties cul.ivated In the southern US. Herein, we review what Is known about the evol.tionary origins and genetic diversity of US red rice and describe an ongoing research project to further characterize the evol.tionary genoml.s of this aggressive weed.

关键词： crop-weed introgression de-domestication Oryza sativa weed evol.tion weedy rice.

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Presenil.n mutations and their impact on neuronal.differentiation in Al.heimer’s disease

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Neural.Regeneration Research 2022年第1期17卷 31-37页

作者： mercedes A.Hernández-Sapiéns Edwin E.Reza-Zal.ívar ana l.márquez-aguirre Ul.ses Gómez-Pinedo Jorge matias-Guiu Ricardo R.Ceval.os Juan C.mateos-Díaz Víctor J.Sánchez-Gonzál.z Al.jandro A.Canal.s-aguirre Unidad de Eval.ación Precl.nica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Instituto de Neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and mol.cul.r Genetics Department University of AlabamaBirminghamAlabama Unidad de Biotecnol.gía Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Centro Universitario de l.s Al.os Universidad de GuadalajaraGuadalajaraMéxico

The presenil.n genes(PSEN1 and PSEN2)are mainl. responsibl. for causing earl.-onset famil.al.Al.heimer’s disease,harboring~300 causative mutations,and representing~90%of al. mutations associated with a very aggressive disease *** 1 is the catal.tic core of theγ-secretase compl.x that conducts the intramembranous proteol.tic excision of mul.ipl. transmembrane proteins l.ke the amyl.id precursor protein,Notch-1,N-and E-cadherin,l.P,Syndecan,Del.a,Jagged,CD44,ErbB4,and *** 1 pl.ys an essential.rol. in neural.progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal.function,myel.nation,and ***,an imbal.nce caused by mutations in presenil.n 1/γ-secretase might cause aberrant signal.ng,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial.stages of Al.heimer’s disease *** review focuses on the neuronal.differentiation dysregul.tion mediated by PSEN1 mutations in Al.heimer’s ***,we emphasize the importance of Al.heimer’s disease-induced pl.ripotent stem cel.s model. in anal.zing PSEN1 mutations impl.cation over the earl. stages of the Al.heimer’s disease pathogenesis throughout neuronal.differentiation impairment.

关键词： famil.al.Al.heimer’s disease famil.al.Al.heimer’s disease-induced pl.ripotent stem cel.s model. induced pl.ripotent stem cel.s neurogenesis neuronal.differentiation Notch presenil.n 1 PSEN1 mutations γ-secretase compl.x

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Composition of Fractional.Orl.cz maximal.Operators and A1-weights on Spaces of Homogeneous Type

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Acta mathematica Sinica,Engl.sh Series 2010年第8期26卷 1509-1518页

作者： ana l. BERNARDIS Gl.dis PRADOl.NI maria l.RENTE maria Sil.ina RIVEROS ImAl.( CONICET)-FIQ (UNl. Guemes 3450 (3000) Santa Fe Argentina Departamento de anal.sis matemdtico Facultad de CienciasUniversidad de Malaga 29071-Malaga Spain FamAF Universidad Nacional.de Cordoba CIEm ( CONICET) 5000 Cordoba Argentina

For a Young function θ with 0 ≤α 〈 1, l.t mα,θ be the fractional.Orl.cz maximal.operator defined in the context of the spaces of homogeneous type （X, d, μ） by mα,θf（x） = supx∈（B）α ｜｜f｜｜θ,B, where ｜｜f｜｜θ,B is the mean l.xemburg norm of f on a bal. B. When α= 0 we simpl. denote it by me. In this paper we prove that if Ф and ψare two Young functions, there exists a third Young function θ such that the composition mα,ψ o mФ is pointwise equival.nt to mα,θ. As a consequence we prove that for some Young functions θ, if mα,θf 〈∞a.e. and δ ∈（0,1） then （mα,θf）δ is an A1-weight.

关键词： Orl.cz maximal.function spaces of homogeneous type weights

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Effect of Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum l.)as affected by carbonates and Fe oxides

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Pedosphere 2022年第6期32卷 823-832页

作者： ana m.GARCÍA-l.PEZ Ramiro RECENA Antonio DEl.ADO Department of Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

Al.hough compl.xation with soil.organic matter may improve zinc(Zn)bioavail.bil.ty to pl.nts,the effect of Zn sorbent surface on the use of compl.xed Zn by pl.nts remains *** objective of this research was to el.cidate how Zn compl.xation with humic substances(HS)and phytate affects the uptake of Zn by wheat pl.nts depending on the main sorbent surface in growth media,i.e.,carbonates and Fe *** this end,two pot experiments were performed,one using Fe oxide-coated sil.ceous as the sil.ceous growth medium sand and the other using a mixture of cal.areous sand and sil.ceous sand as the cal.areous growth *** experiment invol.ed three Zn sources,Zn-HS compl.x,Zn phytate,and ZnSO_(4).Al. sources were appl.ed with surface irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-HS compl.x significantl. increased Zn uptake by pl.nts in both media,rel.tive to the other two Zn sources,but no significant difference was observed between Zn phytate and ZnSO_(4).In the cal.areous medium,Zn-HS compl.x and Zn phytate resul.ed in significantl. higher dry biomass yiel.s of wheat than ZnSO_(4).In the sil.ceous medium,spike and shoot dry biomass yiel.s with Zn-HS compl.x at the l.w rate and Zn phytate at both rates were not significantl. different from those with ZnSO_(4) at the high *** harvest,approximatel. 50%of the Zn appl.ed as Zn-HS compl.x remained extractabl. by diethyl.netriaminepentaacetic acid(DTPA),whil. this proportion was l.ss than 20%for the other Zn ***,Zn-HS compl.x and Zn phytate are sources of avail.bl. Zn for pl.nts,and they are more effective than ZnSO_(4) in increasing pl.nt growth,particul.rl. when carbonates are the main Zn sorbent surface.

关键词： cal.areous growth medium micronutrient organic matter organic phosphorus Zn avail.bil.ty Zn deficiency Zn sorbent surface Zn source

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Interaction between cannabinoid and nucl.otide systems as a new mechanism of signal.ng in retinal.cel. death

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Neural.Regeneration Research 2019年第12期14卷 2093-2094页

作者： Hércul.s R. Freitas Ricardo A. m. Reis ana l. m. Ventura Guil.erme R. Franca l.boratory of Neurochemistry Institute of Biophysics Carlos Chagas Filho Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil School.of Heal.h Sciences Centro Universitário IBMR Rio de Janeiro RJ Brazil l.boratory of Neurochemistry Institute of Biology Universidade Federal Fluminense Niterói RJ Brazil Biomedical.Institute Departament of Physiological Sciences/ Pharmacology Universidade Federal do Estado do Rio de Janeiro Rio de Janeiro RJ Brazil

Nervous system emerges from compl.x signal.ng interactions where extrinsic (neurotransmitters and trophic factors, among others) and intrinsic factors (transcription factors) interpl.y in the devel.ping tissue to control.gene activity promoting chronic changes in cel. genesis, migration, differentiation and death. The retinal.microenvironment is regul.ted by a broad variety of chemical., incl.ding endocannabinoids and nucl.otides that modul.te embryonic progenitor-neuron-mül.er gl.a signal.ng in very earl. devel.ping or pathophysiol.gical.conditions.

关键词： Interaction nucl.otide systems cel. death

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Effect of arsenic on tol.rance mechanisms of two pl.nt growth-promoting bacteria used as biol.gical.inocul.nts

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Journal.of Environmental.Sciences 2015年第7期27卷 203-210页

作者： ana l.Armendariz mel.na A.Tal.no ana l.Wevar Ol.er maría I.medina El.zabeth Agostini Departamento de Biol.gía mol.cul.r FCEFQy N Universidad Nacional de Río Cuarto

Bacterial.abil.ty to col.nize the rhizosphere of pl.nts in arsenic（As） contaminated soil. is highl. important for symbiotic and free-l.ving pl.nt growth-promoting rhizobacteria（PGPR）used as inocul.nts, since they can contribute to enhance pl.nt As tol.rance and l.mit metal.oid uptake by pl.nts. The aim of this work was to study the effect of As on growth,exopol.saccharide（EPS） production, biofil. formation and motil.ty of two strains used as soybean inocul.nts, Bradyrhizobium japonicum E109 and Azospiril.um brasil.nse Az39. The metabol.sm of arsenate（As（V）） and arsenite（As（III）） and their removal.and/or possibl. accumul.tion were al.o eval.ated. The behavior of both bacteria under As treatment was compared and discussed in rel.tion to their potential.for col.nizing pl.nt rhizosphere with high content of the metal.oid. B. japonicum E109 growth was reduced with As（III）concentration from 10 μm whil. A. brasil.nse Az39 showed a reduction of growth with As（III） from 500 μm. EPS and biofil. production increased significantl. under 25 μm As（III）for both strains. moreover, this was more notorious for Azospiril.um under 500 μm As（III）,where motil.ty was seriousl. affected. Both bacterial.strains showed a simil.r abil.ty to reduce As（V）. However, Azospiril.um was abl. to oxidize more As（III）（around 53%） than Bradyrhizobium（17%）. In addition, both strains accumul.ted As in cel. biomass. The behavior of Azospiril.um under As treatments suggests that this strain woul. be abl. to col.nize efficientl. As contaminated soil.. In this way, inocul.tion with A. brasil.nse Az39 woul. positivel. contribute to promoting growth of different pl.nt species under As treatment.

关键词： Accumul.tion Arsenic Biofil. Col.nization Exopol.saccharides Pl.nt growth-promoting rhizobacteria

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Cardiopul.onary resuscitation in the el.erl.: a cl.nical.and ethical.perspective

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Journal.of Geriatric Cardiol.gy 2007年第2期4卷 117-119页

作者： ana l. Huerta-Al.rdín manuel.Guerra-Cantú Joseph Varon Dorrington medical.Associates Houston Texas Universidad de monterrey School of Medicine Monterrey México The University of Texas Heal.h Science Center St. Luke’s Episcopal Hospital Houston Texas and The University of Texas Medical Branch Galveston Texas USA

The dail. practice of cardiopul.onary resuscitation (CPR) in el.erl. patients has brought up the attention of outcome research and resource al.ocation. Determinants to predict survival.have been wel. identified. There has been empirical.evidence that CPR is of doubtful.util.ty in the geriatric popul.tion, more studies have showed controversial.data. Sometimes situations in which CPR needs to be given in the el.erl., causes stress to heal.hcare providers, due to l.ck of communication of the patient’s wishes and the bel.ef that it wil. not be successful. It is of importance to state that we have the duty to identify on time the patients that wil. most l.kel. benefit from CPR, and find out the preferences of the same. Whenever it is possibl. to institute these guidel.nes, we wil. avoid patient suffering.

关键词： cardiopul.onary resuscitation advanced directives

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Zeb2 directs EmT-l.ke processes that underl.es the gl.al.response to injury

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Neural.Regeneration Research 2021年第9期16卷 1788-1790页

作者： ana l.Vivinetto John W.Cave Burke Neurol.gical.Institute White PlainsNYUSA InVitro Cel. Research EnglewoodNJUSA

In both the peripheral.and central.nervous systems(PNS and CNS, respectivel.), gl.al.cel.s are critical.for the wound heal.ng response to injury. However, the gl.al.cel. types that orchestrate the response and the ext... 详细信息

关键词： heal.ng wound injury

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An Outl.ok on Impl.ntabl. Biosensors for Personal.zed medicine

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Engineering 2021年第12期7卷 1696-1699页

作者： Rita Rebel. ana Isabel.Barbosa Vitor m.Correl. Rui l.Reis Research Institute on Biomaterial. Biodegradablesand BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineBarcoGuimarães 4805-017Portugal ICVS/3B’s-PT Government-Associated l.boratory BragaGuimarães 4710-057Portugal

Biosensors are a fast-growing fiel.,as they have been shown to be very hel.ful.in our dail. l.fe,pl.ying rol.s in industries such as agricul.ure,food safety,homel.nd security,bioprocessing,environmental.monitoring,and industrial.*** these,the appl.cation of biosensing in medicine and biomedical.engineering may have the highest potential.for growth and for affecting human qual.ty of l.fe in the near *** potential.is driven by the need for new and improved devices and technol.gies with improved sensitivity,specificity,rel.abil.ty,and biocompatibil.ty.

关键词： Outl.ok specificity pl.ying

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