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synthetic gauge fields for ultracold atoms

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National science Review 2016年第2期3卷 166-167页

作者： ana Maria rey JILA NIST and Department of PhysicsUniversity of Colorado

Ultracold gases are remarkably versatile and controllable systems with untapped potential to emulate a variety of quantum phenomena[1].Atoms are,however,electrically neutral and therefore it is highly desirable to make them behave as charged *** capability has recently been demonstrated in a series of recent experiments[2-4].Although many challenges remain ahead,

关键词： synthetic gauge fields for ultracold atoms

Downed logs improve soil properties in old-growth temperate forests of northern Iran

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Pedosphere 2020年第3期30卷 378-389页

作者： Negar MOGHIMIAN seyed Gholamali JALALI Yahya KOOCH ana rey Faculty of Natural Resources&Marine sciences Tarbiat Modares UniversityNoor 46417-76489Iran Department of Biogeography and Global Change National Museum of Natural History(MNCN)Spanish Scientific Council(CSIC)C/Serrano 115bisMadrid 28006(Spain

Dead trees, particularly downed logs, play an important role in the dynamics of forest ecosystem. Contribution of decaying wood to C and nutrient pools of forest soils depends on the tree species and degree of wood decay. However, the extent to which the downed logs affect the soil properties of temperate forests has rarely been evaluated. In this study, a mixed beech forest was selected in Liresar region of Mazandaran Province, northern Iran, to investigate if and how the presence of downed logs affected soil quality and function by comparing soils underneath degraded logs and nearby soils of the two dominant tree species(beech and hornbeam). We then explored how these effects occurred as downed logs decomposed by comparing the woods of both tree species at four degrees of decomposition. Degree of decay of downed logs was classified into four classes(DC1–DC4). Eight dead trees of each tree species were selected at the center of each sample plot. Three composite soil samples underneath each decaying log and 100 cm away from a decaying log were collected at two soil depths(0–15 and 15–30 cm) to analyze soil main physicochemical properties and microbial activity. The results revealed that downed logs affected soil physical(5% wetter than control soils), chemical(2% lower pH, 100% increase in organic C and total N in the case of hornbeam, and 2% increase in P), and biological characteristics(soil microbial respiration enhanced by 10%, and microbial biomass C 620 and 351.5 mg kg-1 and microbial biomass N 66.47 and 32.18 mg kg-1, respectively, in the cases of beech and hornbeam), thus resulting in significantly different soil microsites from those without downed logs. Presence of downed logs increased soil microbial activity and soil fertility as wood decayed. Thus, the presence of downed logs is an important factor influencing forest soils and should be taken into consideration in forest management practices.

关键词： beech course woody debris dead tree decay degree hornbeam soil microbial activity soil physicochemical properties

Kinetic and morphology study of alginate-vineyard pruning waste biocomposite vs. non modified vineyard pruning waste for dye removal

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Journal of Environmental sciences 2015年第12期27卷 158-167页

作者： Xanel Vecino Rosa Devesa-rey salvador Villagrasa Jose M.Cruz ana B.Moldes Chemical Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende Defense University Center Naval AcademyUniversity of Vigo Materials Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende

In this work a comparative bioadsorption study between a biocomposite consisting of hydrolysed vineyard pruning waste entrapped in calcium alginate spheres and non entrapped vineyard residue was carried *** have demonstrated that the biocomposite based on lignocellulose-calcium alginate spheres removed 77.3% of dyes,while non entrapped lignocellulose eliminated only removed 27.8% of colour *** experimental data were fitted to several kinetic models（pseudo-first order,pseudo-second order,Chien-Clayton model,intraparticle diffusion model and Bangham model）; being pseudo-second order the kinetic model that better described the adsorption of dyes onto both *** addition,a morphological study（roughness and shape） of alginate-vineyard biocomposite was established under extreme conditions,observing significant differences between hydrated and dehydrated alginate-vineyard *** techniques used to carry out this morphological study consisted of scanning electron microscopy（sEM）,perfilometry and 3D surface analysis.

关键词： Immobilized alginate-vineyard Dyes Kinetic studies Roughness spherical shape

Precision medicine in pantothenate kinase-associated neurodegeneration

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Neural Regeneration Research 2019年第7期14卷 1177-1185页

作者： Mónica álvarez-Córdoba Marina Villanueva-Paz Irene Villalón-García suleva Povea-Cabello Juan M.suárez-Rivero Marta Talaverón-rey Javier Abril-Jaramillo ana Belén Vintimilla-Tosi José A.sánchez-Alcázar Centro Andaluz de Biología del Desarrollo(CABD-CsIC-Universidad Pablo de Olavide) and Centro de Investigación Biomédica en Red:Enfermedades RarasInstituto de Salud Carlos Ⅲ Centro de Neurología Avanzada Centro Civet

Neurodegeneration with brain iron accumulation is a broad term that describes a heterogeneous group of progressive and invalidating neurologic disorders in which iron deposits in certain brain areas,mainly the basal *** predominant clinical symptoms include spasticity,progressive dystonia,Parkinson's disease-like symptoms,neuropsychiatric alterations,and retinal *** the neurodegeneration with brain iron accumulation disorders,the most frequent subtype is pantothenate kinase-associated neurodegeneration(PKAN) caused by defects in the gene encoding the enzyme pantothenate kinase 2(PANK2)which catalyzed the first reaction of the coenzyme A biosynthesis *** there is no effective treatment to prevent the inexorable course of these *** aim of this review is to open up a discussion on the utility of using cellular models derived from patients as a valuable tool for the development of precision medicine in ***,we have described that dermal fibroblasts obtained from PKAN patients can manifest the main pathological changes of the disease such as intracellular iron accumulation accompanied by large amounts of lipofuscin granules,mitochondrial dysfunction and a pronounced increase of markers of oxidative *** addition,PKAN fibroblasts showed a morphological senescence-like ***,pantothenate supplementation,the substrate of the PANK2 enzyme,corrected all pathophysiological alterations in responder PKAN fibroblasts with low/residual PANK2 enzyme ***,pantothenate treatment had no favourable effect on PKAN fibroblasts harbouring mutations associated with the expression of a truncated/incomplete *** correction of pathological alterations by pantothenate in individual mutations was also verified in induced neurons obtained by direct reprograming of PKAN *** observations indicate that pantothenate supplementation can increase/stabilize the expression levels of PANK2 in s

关键词： neurodegeneration with brain iron accumulation pantothenate kinase-associated neurodegeneration pantothenate kinase 2 pantothenate induced neurons precision medicine induced neuron fibroblast

A common metabolomic signature is observed upon inoculation of rice roots with various rhizobacteria

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Journal of Integrative Plant Biology 2020年第2期62卷 228-246页

作者： Marine Valette Marjolaine rey Florence Gerin Gilles Comte Florence Wisniewski-Dyé Universite de Lyon Universite Lyon1Ecologie MicrobienneCNRS UMR-5557INRA UMR-1418VetAgroSup43 boulevard du 11 novembre 191869622 VilleurbanneFrance

Plant growth-promoting rhizobacteria(PGPR),whose growth is stimulated by root exudates,are able to improve plant growth and *** those,bacteria of the genus Azospirillum were shown to affect root secondary metabolite content in rice and maize,sometimes without visible effects on root *** studies also revealed that expression of several genes involved in stress and plant defense was affected,albeit with fewer genes when a strain was inoculated onto its original host ***,we investigated,via a metabolic profiling approach,whether rice roots responded differently and with gradual intensity to various PGPR,isolated from rice or not.A common metabolomic signature of nine compounds was highlighted,with the reduced accumulation of three alkylresorcinols and increased accumulation of two hydroxycinnamic acid amides(HCAA),identified as N-p-coumaroylputrescine and *** was accompanied by the increased transcription of two genes involved in the N-feruloylputrescine biosynthetic ***,exposure to a rice bacterial pathogen triggered a reduced accumulation of these HCAA in roots,a result contrasting with previous reports of increased HCAA content in leaves upon pathogen *** of HCAA,that are potential antimicrobial compounds,might be considered as a primary reaction of plant to bacterial perception.

关键词： PGPR various rhizobacteria root exudates

s-adenosyl-L-methionine modifies antioxidant-enzymes,glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells

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World Journal of Gastroenterology 2016年第14期22卷 3746-3757页

作者： sonia Amelia Lozano-sepulveda Eduardo Bautista-Osorio Jose Angel Merino-Mascorro Marta Varela-rey Linda Elsa Munoz-Espinosa Paula Cordero-Perez María Luz Martinez-Chantar ana Maria Rivas-Estilla Department of Biochemistry and Molecular Medicine School of Medicine Autonomous University of Nuevo Leon Monterrey Metabolomic Unit CIC bio GUNE CIBERehd Parque Tecnológico de Bizkaia Liver Unit School of Medicine and Hospital Universitario Autonomous University of Nuevo Leon

AIM: To elucidate the mechanism(s) by which s-adenosyl-L-methionine(sAM) decreases hepatitis C virus(HCV) ***: We examined the effects of sAM on viral expression using an HCV subgenomic replicon cell culture system. Huh7 HCV-replicon cells were treated with 1 mmol/L sAM for different times(24-72 h), then total RNA and proteins were isolated. c DNA was synthesized and real time-PCR was achieved to quantify HCV-RNA, superoxide dismutase 1 and 2(sOD-1, sOD-2) catalase, thioredoxin 1, methionine adenosyltransferase 1A and 2A(MAT1A, MAT2A) expression, and GAPDH and RPs18 as endogenous genes. Expression of cellular and viral protein was evaluated by western-blot analysis using antibodies vs HCV-Ns5 A, sOD-1, sOD-2, catalase, thioredoxin-1, MAT1 A, MAT2 A, GAPDH and actin. Total glutathione levels were measured at different times by Ellman's recycling method(0-24 h). Reactive oxidative species(ROs) levels were quantified by the dichlorofluorescein assay(0-48 h); Pyrrolidin dithiocarbamate(PDTC) was tested as an antioxidant control and H2O2 as a positive oxidant ***: sAM exposition decreased HCV-RNA levels 50%-70% compared to non-treated controls(24-72 h). sAM induced a synergic antiviral effect with standard IFN treatment but it was independent of IFN signaling. In addition, 1 mmol/L sAM exposition did not modify viral RNA stability, but it needs cellular translation machinery in order to decrease HCV expression. Total glutathione levels increased upon sAM treatment in HCV-replicon cells. Transcriptional antioxidant enzyme expression(sOD-1, sOD-2 and thioredoxin-1) was increased at different times but interestingly, there was no significant change in ROs levels upon sAM treatment, contrary to what was detected with PDTC treatment, where an average 40% reduction was observed in exposed cells. There was a turnover from MAT1A/MAT2 A, since MAT1 A expression was increased(2.5 fold-times at 48 h) and MAT2 A was diminished(from 24 h) upon sAM treatment a

关键词： Hepatitis C virus s-adenosyl-L-methionine superoxide dismutase 1 superoxide dismutase 2 Replication Hepatitis C virus-RNA Ns5A Oxidative stress Antioxidants Viral proteins Reactive oxygen species Pyrrolidine dithiocarbamate

Acceptance of living liver donation among medical students: A multicenter stratified study from spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos ana Isabel López-Navas ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar sánchez-Gallegos Pedro Ramón Gutiérrez ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: study type: A sociological, interdisciplinary, multicenter and observational study. study population: Medical students enrolled in spain (n = 34000) in the university academic year 2010-2011. sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOs) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. statistical analysis: student´s t test, χsup>2sup> test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P ssibility of needing a transplant oneself in the future (P sed donation (P segment from a family member if one were needed (P scussed the subject with one’s family (P s (P s opinion about the subject (P s of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P sION: spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables spain

Routine invasive strategy and frailty burden in non-sT-segment elevation acute myocardial infarction

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Journal of Geriatric Cardiology 2024年第10期21卷 954-961页

作者： Albert Ariza-solé Juan Andrés Bermeo Francesc Formiga Héctor Bueno Gemma Miñana Oriol Alegre David Martí Manuel Martínez-sellés Laura Domínguez-Pérez Pablo Díez-Villanueva JoséA Barrabés Francisco Marín Adolfo Villa Marcelo sanmartín Cinta Llibre Alessandro sionís Antoni Carol sergio García-Blas María JoséMorales Gallardo Jaime Elízaga Iván Gómez-Blázquez Fernando Alfonso Bruno García del Blanco Julio Núñez Juan sanchis Cardiology Department Hospital Universitari de BellvitgeL’Hospitalet de LlobregatBarcelonaSpain Internal Medicine Department Hospital Universitari de BellvitgeL’Hospitalet de LlobregatBarcelonaSpain Centro Nacional de Investigaciones Cardiovasculares(CNIC) MadridSpain.Cardiology DepartmentHospital 12 de Octubreand Instituto de Investigación Sanitaria Hospital 12 de Octubre(imas12)MadridCIBERCVMadridSpain.Universidad ComplutenseMadridSpain Cardiology Department Hospital Clínico Universitario de ValenciaINCLIVAUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital Central de la DefensaMadridSpain Cardiology Department Hospital Universitario Gregorio MarañónCIBERCVUniversidad ComplutenseUniversidad EuropeaMadridSpain Cardiology Department Hospital Universitario La PrincesaIIS-IPCIBERCVMadridSpain Cardiology Department Hospital Universitari Vall d’HebronCIBERCVBarcelonaSpain Cardiology Department Hospital Virgen de la ArrixacaCIBERCVEl PalmarMurciaSpain Cardiology Department Hospital Universitario del SuresteArganda del ReyMadridSpain Cardiology Department Hospital Ramon y CajalCIBERCVMadridSpain Cardiology Department Hospital Germans Trias i PujolCIBERCVBadalonaBarcelonaSpain Cardiology Department Hospital Sant PauCIBERCVBarcelonaSpain Cardiology Department Hospital Moisés BroggiSant Joan DespíBarcelonaSpain

Objective To assess the prognostic impact of a routine invasive strategy according to the frailty burden in patients with non-sT-segment elevation myocardial infarction(NsTEMI)from the MOsCA-FRAIL clinical *** The MOsCA-FRAIL trial randomized 167 frail patients,defined by a Clinical Frailty scale(CFs)≥4,with NsTEMI to an invasive or conservative *** primary endpoint was the number of days alive and out of hospital(DAOH)one year after *** this subanalysis,we compared the impact of an invasive strategy on the outcomes between vulnerable(CFs=4,n=43)and frail(CFs>4,n=124)*** Compared to vulnerable patients,frail patients presented lower values of DAOH(289.8 vs.320.6,P=0.146),more read-missions(1.03 vs.0.58,P=0.046)and higher number of days spent at the hospital during the first year(10.8 vs.3.8,P=0.014).The cau-ses of readmission were mostly non-cardiac(56%).Among vulnerable patients,DAOH were similar regardless of strategy(invasive ***:325.7 vs.314.7,P=0.684).Among frailest patients,the invasive group tended to have less DAOH(267.7 vs.311.1,P=0.117).Indeed,patients with CFs>4,invasively managed lived 29 days less than their conservative *** contrast,the-re were no differences in the subgroup with CFs=*** Adult patients with frailty and NsTEMI showed different prognosis according to the degree of frailty.A routine in-vasive strategy does not improve outcomes and might be harmful to the frailest patients.

关键词： routine invasive infarction

Prediction of sudden death in elderly patients with heart failure

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Journal of Geriatric Cardiology 2018年第2期15卷 185-192页

作者： ana Ayesta Helena Martinez-sellest Antonio Bayes de Luna Manuel Martinez-selles Cardiology Department Hospital Universitario del Sureste Arganda del Rey Madrid Spain Universidad Complutense Madrid Spain Fundacio lnvestigacio Cardiovascular ICCC Hospital de Sant Pau Barcelona Spain Cardiology Department Hospital General Universitario Gregorio Maranon CIVERCK Universidad Europea Madrid Spain

Most heart failure （HF） related mortality is due to sudden cardiac death （sCD） and worsening HF, particularly in the case of reduced ejection fraction. Predicting and preventing sCD is an important goal but most works include no or few patients with advanced age, and the prevention of sCD in elderly patients with HF is still controversial. A recent reduction in the annual rate of sCD has been recently described but it is not clear if this is also true in advanced age patients. Age is associated with sCD, although physicians frequently have the perception that elderly patients with HF die mainly of pump failure, underestimating the importance of sCD. Other clinical variables that have been associated to sCD are symptoms, New York Heart Association functional class, ischemic cause, and comorbidities （chronic obstructive pulmonary disease, renal dysfunction and diabetes）. some test results that should also be considered are left ventricular ejection fraction and diameters, natriuretic peptides, non-sustained ventricular tachycardias and autonomic abnormalities. The combination of all these markers is probably the best option to predict sCD. Different risk scores have been described and, although there are no specific ones for elderly populations, most include age as a risk predictor and some were developed in populations with mean age 〉 65 years. Finally, it is important to stress that these scores should be able to predict any type of sCD as, although most are due to tachyarrhythmias, bradyarrhythmias also play a role, particularly in the case of the elderly.

关键词： Heart failure Prediction Risk sudden death The elderly