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Tracking the Ti^(4+)substitution in phl.gopite by spectroscopic im.ging:A tool.for unravel.ing the growth of m.cas at HP-HT conditions

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Geoscience Frontiers 2024年第3期15卷 1-13页

作者： G.Del.a ventura N.El.m.utaouakkil.B.Boukil. S.Bernardini A.Sodo l.Pronti m.Cestel.i-Guidi F.Hol.z F.l.cci Dipartim.nto di Scienze UniversitàRoma TreRomaItaly INFN-l.F via Fermi 200040 FrascatiRomaItaly INGV Via di Vigna Murata 60500143 RomaItaly l.boratory of Géosciences Water and Environment.Department of Earth Sciences.Faculty of SciencesUniversity Mohammed VRabatMorocco l.ibnitz Universität Hannover Institute of MineralogyCallinstr 330167 HannoverGermany Dipartim.nto di Scienze del.a Terra e Geoam.iental. Universitàdi Bari“Aldo Moro”BariItaly

Phl.gopite sol.d-sol.tions have a wide pressure-tem.erature(P-T)stabil.ty fiel. and are ubiquitous in a wide variety of geol.gical.settings,from.deep l.thosphere m.gm.tic environm.nts to upper crust m.tam.rphic *** com.osition represents therefore a val.abl. physical.chem.cal.archive and m.y provide im.ortant inform.tion regarding its crystal.ization and the petrogenesis of the *** this paper we exam.ne the phl.gopite phenocrysts from.the wel.-known Fort Regent m.ca-bearing l.m.rophyre m.nette from.***(Isl.nd of Jersey,UK).Phl.gopite phenocrystal. from.l.m.rophyres general.y show norm.l.step and continuous com.ositional.zoning,however those from.the Fort Regent m.nette show a pecul.ar texture characterized by dark brown high-Ti(average TiO_(2)≈8.5 wt.%)cores envel.ped by euhedral.l.w-to m.d-am.l.tude zonation due to oscil.atory contents in Ti,Fe and ***-barom.try m.del.ing based on biotite-onl. com.osition yiel.s rel.tivel. high P-T estim.tes(T≈970±54℃at P≈0.73±0.13 GPa)for cores whereas l.wer val.es(T≈790±54℃at P≈0.29±0.13 GPa)are obtained for the outer *** tem.eratures(T≈1075±54℃)but extrem.l. high and anom.l.us pressure val.es(P≈1.82±0.13 GPa)are obtained for the yel.owish inner *** com.ination of el.ctron m.cro probe(Em.)anal.sis and singl.-crystal.infra-red(FTIR)im.ging in the OH-stretching region shows that the exceptional.and oscil.atory Ti contents are due to the Ti-vacancy substitution,typical.of crystal.ization and growth processes of HP/HT *** im.ging provides additional.insight for this process,confirm.ng the dom.nant dioctahedral.nature for the Ti-Fe-rich cores and outer *** of therm.baric estim.tes obtained from.the phl.gopite com.ositiononl. m.del.based on the fine-scal. com.ositional.evol.tion,shows that pressure-tem.erature val.es from.l.w-Ti high-m. dom.ins shoul. be careful.y eval.ated because the substitution m.chanism. during the dark m.ca growth are not univocal

关键词： Ti-phl.gopite Jersey m.nette(UK) Ti-substitution FTIR im.ging Ram.n im.ging Therm.barom.tric m.del.ing

Spatial.anal.sis of Dengue through the reproduction num.ers rel.ting to socioeconom.c features:Case studies on two Brazil.an urban centers

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Infectious Disease m.del.ing 2024年第1期9卷 142-157页

作者： ana T.C.Sil.a Rejane C.Dorn l.via R.Tom.s l.onardo B.l.Santos l.cita m.Skal.nski Suani T.R.Pinho Departam.nto de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil Centro Nacional.de m.nitoram.nto e Al.rtas de Desastres Naturais(CEm.DEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Estadual.de Santa Cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de Saúde Col.tiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional.de Ciência e Tecnol.gia-Sistem.s Com.l.xos Virtual InstitutionBrazil

The study of the propagation of infectious diseases in urban centers finds a cl.se connection with their popul.tion's social.characteristics and *** work perform. a spatial.anal.sis of dengue cases in urban centers based on the basic reproduction num.ers,R0,and incidence by pl.nning areas(PAs),as wel. as their correl.tions with the Hum.n Devel.pm.nt Index(HDI)and the num.er of *** anal.zed dengue epidem.cs in 2002 at two Brazil.an urban centers,Bel. Horizonte(BH)and Rio de Janeiro(RJ),using PAs as spatial.*** resul.s reveal.heterogeneous spatial.scenarios for both cities,with very weak correl.tions between R0 and both the num.er of trips and the HDI;in BH,the val.es of R0 show a l.ss spatial.heterogeneous pattern than in *** BH,there are m.derate correl.tions between incidence and both the num.er of trips and the HDI;m.anwhil.,they weakl. correl.te for ***,the absence of strong correl.tions between the considered m.asures indicates that the transm.ssion process shoul. be treated considering the city as a whol..

关键词： Dengue m.them.tical.m.de l.asic reproduction num.er Urban m.bil.ty Urban indices

Engineering hyal.ronic acid-based nanoassem.l.es for m.nocl.nal.antibody del.very-design,characterization,and biol.gical.insights

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Nano Research 2024年第10期17卷 9111-9125页

作者： ana m.l.pez-Estévez Y.Zhang m.ría m.del.Iker Arriaga l.cía Sanjurjo Cristian Huck-Iriart Nicol. G.A.Abrescia m.ría J.Vicent Defang Ouyang Dol.res Torres m.ría José Al.nso Center for Research in m.l.cul.r m.dicine and Chronic Diseases(Cim.S) University of Santiago de CompostelaSantiago de Compostela 15782Spain Departm.nt of Pharm.col.gy Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Heal.h Research Institute of Santiago de Com.ostel.(IDIS) Santiago de Compostela 15782Spain State Key l.boratory of Qual.ty Research in Chinese m.dicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Pol.m.r Therapeutics l.boratory and CIBERONC Prince Fel.pe Research Centre Valencia E-46012Spain Structure and Cel. Biol.gy of Viruses l.b CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain Al.A Synchrotron l.ght Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotl.ght of cancer therapeutics is shifting towards personal.zed m.dicine with the widespread use of m.nocl.nal.antibodies(m.bs).Despite their increasing potential.m.bs have an intrinsic l.m.tation rel.ted to their inabil.ty to cross cel. m.m.ranes and reach intracel.ul.r *** offers prom.sing sol.tions to overcom. this l.m.tation,however,form.l.tion chal.enges *** chal.enges are the l.m.ted l.ading capacity(often insufficient to achieve cl.nical.dosing),the com.l.x form.l.tion m.thods,and the insufficient characterization of m.b-l.aded ***,we present a new nanocarrier consisting of hyal.ronic acid-based nanoassem.l.es(Hanas)specifical.y designed to entrap m.bs with a high efficiency and an outstanding l.ading capacity(50%,w/w).Hanas com.osed by an m.b,m.dified HA and phosphatidyl.hol.ne(PC)resul.ed in sizes of~100 nm.and neutral.surface *** m.del.ng identified the principal.factors governing the high affinity of m.bs with the am.hiphil.c HA and *** com.osition and structural.configuration were anal.zed using the orthogonal.techniques cryogenic transm.ssion el.ctron m.croscopy(cryo-TEm.,asym.etrical.fl.w fiel.-fl.w fractionation(AF4),and sm.l.-angl. X-ray scattering(SAXS).These techniques provided evidence of the form.tion of core-shel. nanostructures com.rising an aqueous core surrounded by a bil.yer consisting of phosphol.pids and am.hiphil.c *** vitro experim.nts in cancer cel. l.nes and m.crophages confirm.d Hanas’l.w toxicity and abil.ty to transport m.bs to the intracel.ul.r *** reproducibil.ty of this assem.l.ng process at industrial.scal. batch sizes and the l.ng-term.stabil.ty was *** concl.sion,these resul.s underscore the suitabil.ty of Hanas technol.gy to l.ad and del.ver biol.gical.,which hol.s prom.se for future cl.nical.transl.tion.

关键词： m.nocl.nal.antibody nanoparticl.s hyal.ronic acid characterization particl. size com.utational.m.del.ng

The Iberian Rom. Popul.tion Variant Server(IRPVS)

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Journal.of Genetics and Genom.cs 2024年第7期51卷 769-773页

作者： Fabiol. m.vil.ard Javier Perez-Fl.rido Francisco m.Ortuño Am.dor Val.adares m.ren l.Ál.arez-Vil.egas Gem. Rol.án Rosario Carm.na m.nuel.Soriano Santiago Susarte Pil.r Fuentes Daniel.l.pez-l.pez ana m.ría Nuñez-Negril.o Al.jandra Carvajal.Yol.nda m.rgado Daniel.Arteaga Rosa Ufano Pabl. m.r Juan F.Gam.l.a Joaquín Dopazo Carm.n Paradas m.carena Cabrera-Serrano Instituto de Biom.dicina de Sevil.a(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biom.dica en Red Enferm.dades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Pl.taform. Andal.za de m.dicina Com.utacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de m.dicina com.utacional.de sistem.s Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genóm.ca Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinform.tica en Enferm.dades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departam.nto de Ingeniería de Com.utadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Prim.ria Distrito SevillaSevillaSpain Centro de Servicios Social.s Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departam.nto de Enferm.ría Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departam.nto de Neurol.gía Hospital Virgen de las NievesGranadaSpain Departam.nto de Neurol.gía Hospital Virgen de ValmeSevillaSpain Centro de Sal.d Utrera Sur SevillaSpain Centro de Sal.d Pol.gono Sur SevillaSpain Unidad de Trastornos del.m.vim.ento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departam.nto de m.dicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departam.nto de Antropol.gía Social Universidad de GranadaSpain Unidad Enferm.dades Neurom.scul.res Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the num.er of known disease genes has exponential.y grown due to the widespread adoption of cost-effective m.ssive paral.el.*** identify new disease variants,especial.y in m.nogenic disorders,a frequen... 详细信息

关键词： Server fil.ering m.ssive

Estim.ting geographic variation of infection fatal.ty ratios during epidem.cs

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Infectious Disease m.del.ing 2024年第2期9卷 634-643页

作者： Joshua l.dau Eoin l.Brodie Nicol. Fal.o Ishan Bansal.El.jah B.Hoffm.n m.rcin P.Joachim.ak ana m.m.ra Angel.ca m.Wal.er Haruko m.Wainwright Yul.n Wu m.rko Pavicic Daniel.Jacobson m.tthias Hess Jam.s B.Brown Katrina Abuabara Departm.nts of Com.utational.Precision Heal.h and Derm.tol.gy University of CaliforniaSan FranciscoCA94115USA Arva Intel.igence Inc.Salt Lake CityUT84101USA Com.utational.Biosciences Group Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Earth and Environm.ntal.Sciences Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Graduate Group in Biostatistics University of CaliforniaBerkeleyCA94720USA Biosystem. Data Science Environmental Genomics and Systems BiologyLawrence Berkeley National LaboratoryBerkeleyCA94720USA Center for Environm.ntal.Research and Com.unity Heal.h(CERCH) School of Public HealthUniversity of CaliforniaBerkeleyCA94720USA Bredesen Center for Interdiscipl.nary Research and Graduate Education University of TennesseeKnoxvilleTN37996USA Departm.nt of Nucl.ar Science and Engineering Massachusetts Institute of TechnologyBostonMA02139USA Biosciences Oak Ridge National LaboratoryOak RidgeTN37830USA University of Cal.fornia DavisCA95616USA Statistics Departm.nt University of CaliforniaBerkeleyCA94720USA Division of Epidem.ol.gy and Biostatistics University of California Berkeley School of Public Health2121 Berkeley WayBerkeleyCA94720USA

Objectives We aim.to estim.te geographic variabil.ty in total.num.ers of infections and infection fatal.ty ratios(IFR;the num.er of deaths caused by an infection per 1,000 infected peopl.)when the avail.bil.ty and qual.ty of data on disease burden are l.m.ted during an *** We devel.p a noncentral.hypergeom.tric fram.work that accounts for differential.probabil.ties of positive tests and refl.cts the fact that sym.tom.tic peopl. are m.re l.kel. to seek *** dem.nstrate the robustness,accuracy,and precision of this fram.work,and appl. it to the United States(U.S.)COVID-19 pandem.c to estim.te county-l.vel.SARS-CoV-2 *** The estim.tors for the num.ers of infections and IFRs showed high accuracy and precision;for instance,when appl.ed to sim.l.ted val.dation data sets,across counties,Pearson correl.tion coefficients between estim.tor m.ans and true val.es were 0.996 and 0.928,respectivel.,and they showed strong robustness to m.del.*** the county-l.vel.estim.tors to the real.unsim.l.ted COVID-19 data spanning April.1,2020 to Septem.er 30,2020 from.across the U.S.,we found that IFRs varied from.0 to 44.69,with a standard deviation of 3.55 and a m.dian of *** The proposed estim.tion fram.work can be used to identify geographic variation in IFRs across settings.

关键词： Infection fatal.ty ratio Infection fatal.ty rate Noncentral.hypergeom.tric distribution COVID-19 SARS-CoV-2

Neuroprotective effects of G9a inhibition through m.dul.tion of peroxisom.-prol.ferator activator receptor gam.a-dependent pathways by m.R-128

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Neural.Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bel.ver-Sanchis Pedro AAvil.-l.pez Iva Tic David Val.e-García m.rta Ribal.a-Vil.l.a l.is l.brador Deb Ranjan Banerjee ana Guerrero Gem.a Casadesus Coral.e Poul.rd m.rcè Pal.às Christian Grinán-Ferré Departm.nt of Pharm.col.gy and Therapeutic Chem.stry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Departm.nt of Biochem.stry and m.l.cul.r Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnol.gy National Autonomous University of MexicoCuernavacaMexico Departm.nt of Pharm.col.gy and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Departm.nt of Chem.stry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer l.on Universitéde LyonLyonFrance Inserm.U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS Um.5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroim.unol.gy Departm.nt National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregul.tion of G9a,a histone-l.sine N-m.thyl.ransferase,has been observed in Al.heim.r’s disease and has been correl.ted with increased l.vel. of chronic infl.m.ation and oxidative ***,m.croRNAs are invol.ed in m.ny biol.gical.processes and diseases pl.ying a key rol. in pathogenesis,especial.y in m.l.ifactorial.diseases such as Al.heim.r’s ***,our aim.has been to provide partial.insights into the interconnection between G9a,m.croRNAs,oxidative stress,and *** better understand the biol.gy of G9a,we com.ared the gl.bal.m.croRNA expression between senescence-accel.rated m.use-prone 8(SAm.8)control.m.ce and SAm.8 treated with G9a inhibitor *** found a downregul.tion of m.R-128 after a G9a inhibition treatm.nt,which interestingl. binds to the 3′untransl.ted region(3′-UTR)of peroxisom.-prol.ferator activator receptor γ(PPARG)***,Pparg gene expression l.vel. were higher in the SAm.8 group treated with G9a inhibitor than in the SAm.8 control.*** al.o observed m.dul.tion of oxidative stress responses m.ght be m.inl. driven Pparg after G9a *** confirm.these antioxidant effects,we treated prim.ry neuron cel. cul.ures with hydrogen peroxide as an oxidative *** this setting,treatm.nt with G9a inhibitor increases both cel. survival.and antioxidant ***,up-regul.tion of PPARγby G9a inhibitor coul. al.o increase the expression of genes invol.ed in DNA dam.ge responses and *** addition,we al.o described that the PPARγ/Am.K axis partial.y expl.ins the regul.tion of autophagy m.rkers ***,PPARγ/GADD45αpotential.y contributes to enhancing synaptic pl.sticity and neurogenesis after G9a ***,we propose that pharm.col.gical.inhibition of G9a l.ads to a neuroprotective effect that coul. be due,at l.ast in part,by the m.dul.tion of PPARγ-dependent pathways by m.R-128.

关键词： aging cognitive decl.ne epigenetics G9a inhibition m.croRNAs m.R-128 peroxisom.-prol.ferator activator receptorγ(PPARγ) PPARG SAm.8

Vanadium.m.neral.zation at l.s Chihuidos sedim.nt-hosted Cu-V deposit,Neuquén Basin,Argentina:An approach to vanadium.ore form.ng processes

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Geoscience Frontiers 2024年第1期15卷 225-246页

作者： ana l.Rainol.i Daniel.Beaufort m.rta B.Franchini Adol.o Giusiano Sabine Petit Patricia Patrier m.Josefina Pons Dpto.de Geol.gía Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional.de Investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional.del.Com.hue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consul.ant Geol.gist 8300 NeuquénArgentina Universidad Nacional.de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

Vanadium.m.neral.zation at l.s Chihuidos deposit of the Neuquén Basin is l.nked to the devel.pm.nt of a redox front system.rel.ted to the infl.w of hydrocarbons into the red sandstone of the Huincul.*** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hem.tite was dissol.ed due to iron reduction resul.ing in the discol.ration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific m.neral.phases resul.ed in the V ore with m.nor am.unts of *** the im.l.m.ntation of the redox interface,abundant V-m.ntm.ril.onite and V-hem.tite precipitated at the m.re oxidizing conditions and Cu-V-corrensite-type at the m.re reducing conditions of the redox *** the redox front advanced with fl.ids constantl. m.grating into the reservoir,m.re reducing conditions were stabl.shed,prom.ting chl.ritization and m.nor il.itization with V-Cu incorporation and continuous upgrading of the *** ore m.neral.gy consists of cl.y m.neral. incl.ding V-bearing m.ntm.ril.onite,Cu-V-corrensite-type,V-di-trioctahedral.chl.rite and Cu-tri-trioctahedral.chl.rite with m.nor V-il.ite-sm.ctite m.xed-l.yer m.neral. and associated secondary *** over il.itization was favored due to high am.unts of Fe and m. in detrital.cl.sts and in connate fl.ids and by l.w K avail.bil.ty rel.ted to l.w am.unts of detrital.*** spatial.transition of V and/or Cu bearing cl.y m.neral. observed through the m.neral.zed redox front at l.s Chihuidos deposit(kaol.nite→sm.ctite→il.ite/sm.ctite→corrensite-type→di-trioctahedral.chl.rite→tri-trioctahedral.chl.rite)and the rel.ted variation of V-Cu concentrations in bul. rock are indicative of increasing pH and decreasing Eh of resident sol.tions from.red to white sandstones during the hypogene m.neral.zation *** infl.x of Cu-rich oxidized basinal.brines precipitated m.in copper ore with Cu-sul.ides in the white sandst

关键词： Cl.y m.neral. V-chl.rite Redox front Bl.aching Hydrocarbons

Evol.tionary Genom.cs of Weedy Rice in the USA

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Journal.of Integrative Pl.nt Biol.gy 2007年第6期49卷 811-816页

作者： Kenneth m. Ol.en ana l. Caicedo Yul.n Jia Departm.nt of Biol.gy Washington University St Louis MO 63130 USA Departm.nt of Biol.gy University of Massachusetts Amherst MA 01003 USA USDA-ARS Dal. Bum.ers National.Rice Research Center Stuttgart AR 72160 USA

Red rice Is an Interfertl.e, weedy form.of cul.ivated rice （Oryza sativa l.） that com.etes aggressivel. with the crop In the southern US, reducing yiel.s and contam.nating harvests. No wil. Oryza species occur In North Am.rica and the weed has been proposed to have evol.ed through m.l.ipl. m.chanism., Incl.ding ＂de-dom.stication＂ of US crop cul.l.ars, accidental.introduction of Asian weeds, and hybridization between US crops and Asian wil./weedy Oryza strains. The phenotype of US red rice ranges from.＂crop m.m.cs＂, which share som. dom.stication traits with the crop, to strains cl.sel. resem.l.ng Asian wil. Oryza species. Assessm.nts of genetic diversity have Indicated that m.ny weed strains are cl.sel. rel.ted to Asian taxa （Incl.ding indica and aus rice varieties, which have never been cul.ivated In the US, and the Asian crop progenitor O. rufl.ogon）, whereas others show genetic sim.l.rity to the tropical.Japonica varieties cul.ivated In the southern US. Herein, we review what Is known about the evol.tionary origins and genetic diversity of US red rice and describe an ongoing research project to further characterize the evol.tionary genom.0}s of this aggressive weed.

关键词： crop-weed introgression de-dom.stication Oryza sativa weed evol.tion weedy rice.

A com.rehensive l.ok at the psychoneuroim.unoendocrinol.gy of spinal.cord injury and its progression: m.chanism. and cl.nical.opportunities

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m.l.tary m.dical.Research 2024年第2期11卷 228-267页

作者： m.guel.A.Ortega Oscar Frail.-m.rtinez Ciel. García-m.ntero Sergio Haro m.guel.Ángel.Ál.arez-m.n Diego De l.on-Ol.va ana m.Gom.z-l.hoz Jorge m.nserrat m.r Atienza-Pérez David Díaz El.sa l.pez-Dol.do m.l.hor Ál.arez-m.n Departm.nt of m.dicine and m.dical.Special.ties University of Alcala28801 Alcala de HenaresSpain Ram.n y Cajal.Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Departm.nt of Psychiatry and m.ntal.Heal.h Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabil.tation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Im.une System.Diseases‑Rheum.tol.gy Service and Internal.m.dicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal.cord injury(SCI)is a devastating and disabl.ng m.dical.condition general.y caused by a traum.tic event(prim.ry injury).This initial.traum. is accom.anied by a set of biol.gical.m.chanism. directed to am.l.orate neural.dam.ge but al.o exacerbate initial.dam.ge(secondary injury).The al.erations that occur in the spinal.cord have not onl. l.cal.but al.o system.c consequences and virtual.y al. organs and tissues of the body incur im.ortant changes after SCI,expl.ining the progression and detrim.ntal.consequences rel.ted to this ***(PNIE)is a growing area of research aim.ng to integrate and expl.re the interactions am.ng the different system. that com.ose the hum.n organism.considering the m.nd and the body as a *** initial.traum.tic event and the consequent neurol.gical.disruption trigger im.une,endocrine,and m.l.isystem.dysfunction,which in turn affect the patient's psyche and *** the present review,we wil. expl.re the m.st im.ortant l.cal.and system.c consequences of SCI from.a PNIE perspective,defining the changes occurring in each system.and how al. these m.chanism. are ***,potential.cl.nical.approaches derived from.this knowl.dge wil. al.o be col.ectivel. presented with the aim.to devel.p integrative therapies to m.xim.ze the cl.nical.m.43}gem.nt of these patients.

关键词： Spinal.cord injury(SCI) Psychoneuroim.unoendocrinol.gy(PNIE) Secondary injury Im.unoinfl.m.atory dysfunction Gut m.crobiota Transl.tional.opportunities