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In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica Sinica B 2021年第4期11卷 989-1002页

作者： ana lMartínez-lópez Carlos JGonzález-Navarro Paula Aranaz JosélVizmanos Juan MIrache NANO-VAC research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health research(IdiSNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of *** nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/*** intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium *** therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose *** this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in *** finding was associated with a signifcant reduction in the formation of reactive oxygen species(rOS)as well as an important decrease in the glucose and fat content in *** effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： Nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans rOS

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rare complication of percutaneous endoscopic gastrostomy: Ostomy metastasis of esophageal carcinoma

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World Journal of Gastrointestinal Oncology 2013年第11期5卷 204-206页

作者： ana lúcia Sousa Diamantino Sousa Francisco Velasco Francisco Aucena ana lopes Horácio Guerreiro Department of Gastroenterology Hospital de Faro E.P.E. Department of Internal Medicine Hospital de Faro E.P.E.

The authors present the case of a 55-year-old male with a stage Ⅲ(T4N1M0) squamous-cell esophageal carcinoma, who underwent percutaneous endoscopic gastrostomy(PEG). The pull method of tube placement was used. Five months after the procedure, the patient was referred to the hospital with a hard palpable tumour at the ostomy site. The hystologic exam revealed an abdominal wall metastasis of the esophageal cancer. The authors present this case because of the rarity of metastasis in ostomy after placement of PEG in patients with tumours located in the head and neck. In this particular context and judging by the rarity of situation, the clinical impact of this phenomenom is limited. Nevertheless, metastasis in ostomy site could be prevented by the push method, laparoscopy or laparotomy.

关键词： Enteral nutrition Gastrostomy Esophageal neoplasms Neoplasm metastasis Ostomy

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3D Printed Gelatin Scaffold with Improved Shape Fidelity and Cytocompatibility by Using Antheraea pernyi Silk Fibroin Nanofibers

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Advanced Fiber Materials 2022年第4期4卷 758-773页

作者： Shengzhi Zou Suna Fan ana l.Oliveira Xiang Yao Yaopeng Zhang Huili Shao State Key laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China CBQF‑Centro de Biotecnologia e Quimica Fina‑laboratorio Associado Escola Superior de BiotecnologiaUniversidade Catolica PortuguesaRua Diogo Botelho 13274169‑005 PortoPortugal

Gelatin(G)is a commonly used natural biomaterial owing to its good biocompatibility and easy ***,using pure gelatin as a bioink can barely achieve an ideal shape fidelity in 3D *** this study,Antheraea pernyi silk fibroin nanofibers(ASFNFs)with arginine-glycine-aspartic acid(rGD)peptide and partial natural silk structure are extracted and combined with pure gelatin bioink to simultaneously improve the shape fidelity and cytocompatibility of corresponding 3D printed *** show that the optimum printing temperature is 30℃ for these *** printed filaments using 16G/4ASFNFs bioink(16wt%gelatin and 4wt%ASFNFs)demonstrate better morphology and larger pore size than those printed by pure gelatin bioink(20G,20wt%gelatin),thus successfully improve the shape fidelity and porosity of the 3D printed *** 16G/4ASFNFs scaffold also demonstrate higher swelling ratio and faster degradation rate than the pure gelatin ***,the cell viability and proliferation ability of Schwann cells cultured on the 16G/4ASFNFs scaffold are significantly superior than those cultured on the pure 20G *** ASFNFs enhanced 16G/4ASFNFs scaffold reported here are expected to be a candidate with excellent potential for biomedical applications.

关键词： Antheraea pernyi silk fibroin nanofiber 3D printed scaffold Shape fidelity Cytocompatibility Gelatin

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length–mass allometries in amphibians

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Integrative Zoology 2018年第1期13卷 36-45页

作者： luca SANTINI ana BENÍTEZ-lÓPEZ Gentile Francesco FICETOlA Mark A.J.HUIJBrEGTS Department of Environmental Science Institute for Wetland and Water ResearchFaculty of ScienceRadboud UniversityNijmegenthe Netherlands Department of Bioscience University of MilanMilanItaly Alpine Ecology laboratory Grenoble Alpes UniversityGrenobleFrance PBl Netherlands Environmental Assessment Agency The Haguethe Netherlands

Body mass is rarely recorded in amphibians,and other body measurements(*** to vent length,SVl)are generally collected ***,length measurements,when used as proxies of body mass in comparative analyses,are problematic if different taxa and morphotypes are *** developed allometric relationships to derive body mass from SVl *** fitted phylogenetic generalized least square models for frogs(Anura)and salamanders(Caudata)and for several families *** tested whether allometric relationships differed between species with different habitat preferences and between morphs in *** were fitted with SVl-mass measurements for 88 frog and 42 salamander *** assessed the predictive performance of the models by ***,the models showed high explained variance and low forecasting *** differed among semi-aquatic,terrestrial and arboreal frogs,and between paedomorphic and non-paedomorphic *** mass estimates derived from our models allow for comparability of studies on multiple taxa and can be used for testing theories built upon evolutionary and ecological processes which are directly related to body mass.

关键词： Anura body size body weight Caudata SVl

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Impact of high-fat diet and vitamin D_3 supplementation on aortic stenosis establishment in waved-2 epidermal growth factor receptor mutant mice

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Journal of Integrative Medicine 2019年第2期17卷 107-114页

作者： Bérénice Colleville Nicolas Perzo Guillaume Avinée ana?s Dumesnil Frederic Ziegler Paul Billoir Hélène Eltchaninoff Vincent richard Eric Durand Department of Biology Institut National de la Santé et de la Recherche Médicale U1096 (Endothélium Valvulopathies et Insuffisance Cardiaque) Normandie University Fédération Hospitalo-Universitaire rEMODeling in Valvulopathy and Heart Failure Department of Cardiology Rouen University Hospital Department of Biology Institut National de la Santé et de la Recherche Médicale U1073 (Nutrition Inflammation et Dysfonction de l’axe Intestin-Cerveau) Normandie University Institute for Clinical Biology-General Biochemistry Unit Rouen University Hospital Department of Vascular Hemostasis Rouen University Hospital

Objective: The use of animal models of aortic stenosis(AS) remains essential to further elucidate its pathophysiology and to evaluate new therapeutic strategies. The waved-2 mouse AS model has been proposed;data have indicated that while aortic regurgitation(Ar) is effectively induced, development of AS is *** aimed to evaluate the effect of high-fat diet(HFD) and vitamin D_3 supplementation in this ***: HFD and subcutaneous vitamin D_3 injections were initiated at the age of 6 weeks until the age of 6(n = 16, 6-month treatment group) and 9(n = 11, 9-month treatment group) months. Twelve waved-2 mice without supplementation were used as control. Echocardiography was performed at 3, 6 and 9 months. Blood serum analysis(calcium, 1,25(OH)_2D_3 and cholesterol), histology and immunohistochemistry(CD-31, CD-68 and osteopontin) were evaluated at the end of the experiment(6 or 9 months).results: Total cholesterol and 1,25(OH)_2D_3 were significantly increased relative to the control group. HFD and vitamin D_3 supplementation did result in improvements to the model, since AS was only detected in 6(15.3%) mice(2 in the 3 groups) and Ar was developed in the remaining animals. Echocardiographic parameters, fibrosis, thickness, inflammation and valvular calcification, were not significantly different between the 6-month treatment and control groups. Similar results were also observed in the 9-month treatment ***: These results suggest that HFD and vitamin D_3 supplementation have no effect in the waved-2 mouse model. This model essentially mimics Ar and rarely AS. Further studies are needed to find a reliable animal model of AS.

关键词： Experimental model Epidermal growth factor receptor Vitamin D3 High-fat diet Aortic stenosis Aortic regurgitation

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Convenient model of hard tissue simulation for dental radiographic research and instruction

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World Journal of Methodology 2024年第1期14卷 80-86页

作者： Etiene Andrade Munhoz Claudio roberto Gaiao Xavier roberto Ponce Salles ana lúcia Alvares Capelozza Augusto Vanni Bodanezi Department of Dentistry Health Science CentreFederal University of Santa CatarinaFlorianopolis 88040-379Brazil Department of Stomatology Radiology and Oral SurgerySchool of DentistryUniversity of São PauloBauru 17012-901Brazil

BACKGrOUND The authors describe a technique for building an alternative jawbone phantom using dental gypsum and rice for research and dental radiology *** To investigate the potential of an alternative phantom to simulate the trabecular bone aspect of the human maxilla in periapical *** Half-maxillary phantoms built from gypsum-ground rice were exposed to X-rays,and the resulting images(experimental group)were compared to standardized radiographic images produced from dry human maxillary bone(control group)(n=7).The images were blindly assessed according to strict criteria by three examiners for the usual trabecular aspects of the surrounding bone,and significant differences between groups and in assessment reliability were compared using Fisher’s exact and kappa tests(α=0.05).rESUlTS The differences in the trabecular aspects between groups were not statistically *** addition,interobserver agreement among observers was 0.43 and 0.51 for the control and experimental groups,respectively,whereas intraobserver agreement was 0.71 and 0.73,*** The tested phantom seemed to demonstrate potential for trabecular bone image Munhoz EA et *** of hard tissue simulation for dental radiography WJM https://*** 2 March 20,2024 Volume 14 Issue 1 simulation on maxillary periapical radiographs.

关键词： Phantom radiology Education Endodontic treatment Bone trabecular

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Cutaneous leishmaniasis in an indigenous infant with Down’s syndrome: A case report

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Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 574-576页

作者： Fernanda Fresneda Villibor Geracina Marchesini ana lúcia roselino ribeiro renataOliveira Guaré Centro Universitário Tocantinense Presidente Antonio Carlos AraguaínaTocantinsBrasil Programa de Pós Graduacao em Odontologia Universidade Cruzeiro do SulSao PauloSao PauloBrasil Hospital de Doencas Tropicais AraguaínaTocantinsBrasil Faculdade de Ciencias do Tocantins AraguaínaTocantinsBrasil

rationale: leishmaniasis, caused by the protozoan leishmania and transmitted by sandflies, is endemic to the tropical and subtropical areas of Brazil. It is one of the neglected tropical diseases in the world. Patient concerns: A 20-month-old indigenous infant with severe malnutrition and Down’s syndrome presented with a facial ulcer for 5 months. Diagnosis: Giemsa staining of scraped ulcer tissues indicated the presence of the amastigote form of leishmania sp., and positive Montenegro’s intradermal test helped in diagnosing the condition as cutaneous leishmaniasis. Interventions: The child was hospitalized and received intravenous treatment for cutaneous leishmaniasis(1 mg/kg/day of amphotericin B). Outcomes: The condition was cured with amphotericin B(1 mg/kg/day for 14 d). lessons: Because of infanticide practices in indigenous cultures, indigenous infants with Down’s syndrome rarely survive. Thus, no similar case has been reported in the literature.

关键词： Cutaneous leishmaniasis Indigenous Down’s syndrome Immune deficiencies

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SArS-CoV-2 consequences for mental health:Neuroinflammatory pathways linking COVID-19 to anxiety and depression

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World Journal of Psychiatry 2022年第7期12卷 874-883页

作者： Anna Julie de Mello Morgana Moretti ana lúcia S rodrigues Department of Biochemistry Universidade Federal de Santa CatarinaFlorianópolis 88040-200Brazil

The coronavirus disease 2019(COVID-19)pandemic has been linked to an increased prevalence of mental health disorders,particularly anxiety and ***,the COVID-19 pandemic has caused stress in people worldwide due to several factors,including fear of infection;social isolation;difficulty in adapting to new routines;lack of coping methods;high exposure to social media,misinformation,and fake reports;economic impact of the measures implemented to slow the contagion and concerns regarding the disease ***-19 patients have elevated levels of pro-inflammatory cytokines,such as interleukin(Il)-1β,Il-6,and tumor necrosis factor-α,and other inflammation-related ***,invasion of the central nervous system by the novel severe acute respiratory syndrome coronavirus 2(SArS-CoV-2)may potentially contribute to neuroinflammatory alterations in infected ***,a consequence of psychological stress due to the COVID-19 pandemic,may also play a role in the development of anxiety and depressive symptoms in the general *** that neuroinflammation plays a significant role in the pathophysiology of depression and anxiety,this study investigated the effects of SArS-CoV-2 on mental health and focused on the impact of the COVID-19 pandemic on the neuroinflammatory pathways.

关键词： Anxiety disorders COVID-19 pandemic Depression Mental health Neuroinflammation Stress

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An Outlook on Implantable Biosensors for Personalized Medicine

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Engineering 2021年第12期7卷 1696-1699页

作者： rita rebelo ana Isabel Barbosa Vitor M.Correlo rui l.reis research Institute on Biomaterials Biodegradablesand BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineBarcoGuimarães 4805-017Portugal ICVS/3B’s-PT Government-Associated laboratory BragaGuimarães 4710-057Portugal

Biosensors are a fast-growing field,as they have been shown to be very helpful in our daily life,playing roles in industries such as agriculture,food safety,homeland security,bioprocessing,environmental monitoring,and industrial *** these,the application of biosensing in medicine and biomedical engineering may have the highest potential for growth and for affecting human quality of life in the near *** potential is driven by the need for new and improved devices and technologies with improved sensitivity,specificity,reliability,and biocompatibility.

关键词： Outlook specificity playing

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Native and exotic seed dispersal by the stone marten(Martes foina):implications for the regeneration of a relict climactic forest in central Portugal

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Integrative Zoology 2019年第3期14卷 280-292页

作者： lúcia PErEIrA ana VASQUES Paula MAIA Maria João rAMOS PErEIrA Carlos FONSECA Milena MATOS CESAM-Centre for Environmental and Marine Studies-Wildlife research Unit Department of BiologyUniversity of AveiroAveiroPortugal CESAM-Centre for Environmental and Marine Studies-Department of Environment and Planning University of AveiroAveiroPortugal Erasmus University College Life Sciences DepartmentRotterdamthe Netherlands Institute of Biosciences PPGBANDepartment of ZoologyUniversidade Federal do Rio Grande do SulBrazil Bioliving Association FrossosAlbergaria-a-VelhaPortugal

The stone marten(Martes foina)is a carnivorous mammal that often consumes fleshy fruits,thus potentially promoting seed *** present study was developed in Bussaco National Forest,central Portugal,and aimed to assess the potential role of the stone marten in dispersing native and exotic plants in different forest landscape *** from stone marten scats and fleshy fruits were collected monthly and were thereafter identified and sowed in a nursery,following a randomized experimental *** emergence was monitored *** linear models were used to test for differences in time and success of emergence between seeds from scats and fruits of 3 native species(rubus ulmifolius,Arbutus unedo and Celtis australis)and 1 exotic plant species with invasive behavior(Prunus laurocerasus).Fruit consumption by the stone martens significantly increased and accelerated the germination of the native *** but had no effect on the other 2 native species or on the invasive *** suggested that stone martens contribute to gene flow and forest regeneration by dispersing native plant ***,although the germination was not enhanced in the invasive species,the preference of stone martens for these fruits may potentially contribute to the proliferation of *** study represents a contribution to better understanding the fauna and flora interactions,enabling for a more conscious and effective decision-making in forest management.

关键词： germination invasive species Martes foina Prunus laurocerasus relict climactic forest

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