SARS-CoV-2 consequences for mental health:Neuroinflammatory pathways linking COVID-19 to anxiety and depression

作     者：Anna Julie de Mello Morgana Moretti Ana Lúcia S Rodrigues 

作者机构：Department of BiochemistryUniversidade Federal de Santa CatarinaFlorianópolis 88040-200Brazil 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2022年第12卷第7期

页      面：874-883页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：Conselho Nacional de Desenvolvimento Científico e Tecnológico  No. 312215/2021-5 

主　　题：Anxiety disorders COVID-19 pandemic Depression Mental health Neuroinflammation Stress 

摘      要：The coronavirus disease 2019(COVID-19)pandemic has been linked to an increased prevalence of mental health disorders,particularly anxiety and ***,the COVID-19 pandemic has caused stress in people worldwide due to several factors,including fear of infection;social isolation;difficulty in adapting to new routines;lack of coping methods;high exposure to social media,misinformation,and fake reports;economic impact of the measures implemented to slow the contagion and concerns regarding the disease ***-19 patients have elevated levels of pro-inflammatory cytokines,such as interleukin(IL)-1β,IL-6,and tumor necrosis factor-α,and other inflammation-related ***,invasion of the central nervous system by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)may potentially contribute to neuroinflammatory alterations in infected ***,a consequence of psychological stress due to the COVID-19 pandemic,may also play a role in the development of anxiety and depressive symptoms in the general *** that neuroinflammation plays a significant role in the pathophysiology of depression and anxiety,this study investigated the effects of SARS-CoV-2 on mental health and focused on the impact of the COVID-19 pandemic on the neuroinflammatory pathways.