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Effects of Environmental Water Contamination in the Reproductive System of Mice

Journal of Environmental Protection 2013年第7期4卷 121-125页

作者： Paulo Augusto Amador Pereira ana julia lichtenfels Luiz Alberto Amador Pereira Olaf Malm Paulo Hilario Nascimento Saldiva Alfesio Luis Ferreira Braga Chin An Lin Environmental Epidemiology Study Group Laboratory of Experimental Air PollutionUniversity of Sao Paulo Faculty of Medical SciencesSao PauloBrazil Environmental Risk and Exposure Assessment Group Collective Health Post-Graduation ProgramCatholic University of SantosSantosBrazil Program of Environmental Biophysics and Biotechnology Institute of Biophysics Carlos Chagas FilhoFederal University of Rio de JaneiroRio de JaneiroBrazil Medical Clinics Department University of Sao Paulo Faculty of Medical SciencesSao PauloBrazil

This study investigated the effects on the reproductive system of balb-c mice exposed to water collected from different sources near to a deactivated fertilizer waste depositary. Eighty male mice were separated in four groups: Group A (mineral water);Group B (water from the water treatment station);Group C (water from Cubatao city);Group D (water from the waste depositary region). They were exposed to water since they were weaned until they reached sexual maturity, then they were coupled with females in reproductive age and after this mating time they were sacrificed. The evaluated parameters were testicle weight, sperm analysis, pregnancy rate, sex ratio of the offspring and Sertoli cell count. The analysis of the water did not show presence of pollutants in the Group “A” and Group “C” water. Group “B” showed low level of cadmium, 3.58 ± 0.50 μg/L. Group “D” showed the presence of PAH’s and high levels of lead (221 ± 16 μg/L), cadmiun (12.6 ± 1.2 μg/L) and mercury (5.3 ± 1.1 μg/L). The tests of Levene and Kolmogorov-Smirnov were employed to verify the homogeneity of the variances and the tack to the normal curve, respectively. ANOVA was used for parametric tests and Kruskall-Wallis was used for non-parametric tests, while Turkey tests were employed for multiple comparisons. There were no differences between groups in testicle weight, sperm analysis, pregnancy rate and Sertoli cell count. There was a significant reduction in sex-ratio of the offspring in Group B. This alteration cannot be explained by the cadmium levels in Group B water. In the present study we cannot associate the exposition to contaminated water from the waste depositary and reproductive alterations.

关键词： Pollution Reproduction Metals Organic Pollutants Mice

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Up-regulation of tumor necrosis factor-a pathway survival genes and of the receptor TNFR2 in gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 281-294页

作者： ana Flavia Teixeira Rossi julia Cocenzo Contiero Fernanda da Silva Manoel-Caetano Fabio Eduardo Severino ana Elizabete Silva Department of Biology Sao Paulo State University–UNESP Department of Surgery and Orthopedics Faculty of Medicine Sao Paulo State University–UNESP

BACKGROUND Gastric carcinogenesis can be induced by chronic inflammation triggered by Helicobacter pylori(H. pylori) infection. Tumor necrosis factor(TNF)-α and its receptors(TNFR1 and TNFR2) regulate important cellular processes, such as apoptosis and cell survival, and the disruption of which can lead to cancer. This signaling pathway is also modulated by microRNAs(miRNAs), altering gene *** To evaluate the mRNA and miRNAs expression involved in the TNF-α signaling pathway in gastric cancer(GC) tissues and its *** Quantitative polymerase chain reaction(qPCR) by TaqMan? assay was used to quantify the RNA transcript levels of TNF-α signaling pathway(TNF, TNFR1,TNFR2, TRADD, TRAF2, CFLIP, NFKB1, NFKB2, CASP8, CASP3) and miRNAs that targets genes from this pathway(miR-19 a, miR-34 a, miR-103 a, miR-130 a,miR-181 c) in 30 GC fresh tissue samples. Molecular diagnosis of H. pylori was performed by nested PCR for gene HSP60. A miRNA:mRNA interaction network was construct using Cytoscape v3.1.1 from the in silico analysis performed using public *** Up-regulation of cellular survival genes as TNF, TNFR2, TRADD, TRAF2, CFLIP,and NFKB2, besides CASP8 and miR-34 a was observed in GC tissues, whereas mediators of apoptosis such as TNFR1 and CASP3 were down-regulated. When the samples were stratified by histological type, the expression of miR-103 a and miR-130 a was significantly increased in the diffuse-type of GC compared to the intestinal-type. However, no influence of H. pylori infection was observed on the expression levels of mRNA and miRNAs analyzed. Moreover, the miRNA:mRNA interaction network showed several interrelations between the miRNAs and their target genes, highlighting miR-19 a and miR-103 a, which has as predicted or validated target a large number of genes in the TNF-α pathway,including TNF, TNFR1, TNFR2, CFLIP, TRADD, CASP3 and *** Our findings show that cell survival genes mediated by TNF/TNFR2 binding

关键词： Gastric cancer Tumor necrosis factor-a signaling TNFR1 TNFR2 Cellular survival MicroRNAs

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Advancing 5G Network Applications Lifecycle Security:An ML-Driven Approach

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1447-1471页

作者： ana Hermosilla Jorge Gallego-Madrid Pedro Martinez-julia Jordi Ortiz Ved P.Kafle Antonio Skarmeta Information and Communications Engineering Department University of MurciaMurcia30100Spain Research&Development Department Odin Solutions S.L.Murcia30007Spain Network Architecture Laboratory Network Research InstituteNational Institute of Information and CommunicationsTokyo184-8795Japan Engineering and Applied Techniques Department University Center of Defense at the Spanish Air Force AcademyMurcia30729Spain

As 5th Generation(5G)and Beyond 5G(B5G)networks become increasingly prevalent,ensuring not only networksecurity but also the security and reliability of the applications,the so-called network applications,becomesof paramount *** paper introduces a novel integrated model architecture,combining a networkapplication validation framework with an AI-driven reactive system to enhance security in *** proposedmodel leverages machine learning(ML)and artificial intelligence(AI)to dynamically monitor and respond tosecurity threats,effectively mitigating potential risks before they impact the network *** dualapproach not only validates the functionality and performance of network applications before their real deploymentbut also enhances the network’s ability to adapt and respond to threats as they *** implementation ofthis model,in the shape of an architecture deployed in two distinct sites,demonstrates its practical viability *** application validation with proactive threat detection and response,the proposed modeladdresses critical security challenges unique to 5G *** paper details the model,architecture’sdesign,implementation,and evaluation of this solution,illustrating its potential to improve network securitymanagement in 5G environments *** findings highlight the architecture’s capability to ensure boththe operational integrity of network applications and the security of the underlying infrastructure,presenting asignificant advancement in network security.

关键词： Network application network function virtualization machine learning security 5G

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Does drought stress modify the effects of plant-growth promoting rhizobacteria on an aboveground chewing herbivore？

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Insect Science 2017年第6期24卷 1034-1044页

作者： Maite Fernandez de Bobadilla julia Friman Nurmi Pangesti Marcel Dicke Joop J.A. van Loon ana Pineda Laboratory of Entomology Wageningen University Wageningen The Netherlands Netherlands Institute of Ecology (NIOO-KNA W) Department of Terrestrial Ecology Wageningen The Netherlands

Soil microbes have important effects on the interactions of plants with their environment, by promoting plant growth, inducing resistance to pests or by conferring tolerance to abiotic stress. However, their effects are variable and the factors responsible for this variation are mainly unknown. Our aim was to assess how drought stress modifies the effect of the nonpathogenic rhizobacterium Pseudomonas simiae WCS417r on plant growth and resistance against the generalist leaf-chewing caterpillar Mamestra brassicae. We studied Arabidopsis tha/iana Col-0 plants, as well as mutants altered in the biosyn- thesis of the phytohormones jasmonic acid （JA） and abscisic acid （ABA）. Caterpillars did not prefer rhizobacteria-treated plants, independently of drought stress. Rhizobacteria colonization had a variable effect on caterpillar performance, which ranged from positive in one experiment to neutral in a second one. Drought had a consistent negative effect on herbivore performance; however, it did not modify the effect of rhizobacteria on herbivore performance. The effect of drought on herbivore performance was JA-mediated （confirmed with the use of the dde2-2 mutant）, but it was still present in the ABA-deficient mutant aba2-1. Plant biomass was reduced by both drought and herbivory but it was enhanced by rhizobacterial colonization. Pseudomonas simiae WCS417r is able to promote plant growth even when plants are suffering herbivory. Nevertheless, the microbial effect on the herbivore is variable, independently of drought stress. To get the best possible outcome from the rhizobacteria-plant mutualism it is important to understand which other factors may be responsible for its context-dependency.

关键词： abiotic stress abscisic acid crosstalk induced systemic resistance jasmonic acid Pseudomonas simiae

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Bioaccessibility of phenolic compounds from Brazilian grape juices using a digestion model with intestinal barrier passage

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Food Bioscience 2023年第2期52卷 1343-1351页

作者： Maria da Conceicao Prudencio Dutra ana Beatriz Martins da Silva Ederlan de Souza Ferreira ana julia de Brito Araujo Carvalho Marcos dos Santos Lima Aline Camarao Telles Biasoto Graduate Program in Food Science Faculty of PharmacyFederal University of BahiaSalvadorBahiaBrazil Federal Institute of Education Science and Technology of Sertao PernambucanoLiquid Chromatography LaboratoryCampus IndustrialPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa Semi-arid RegionPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa EnvironmentJaguariunaSao PauloBrazil

Grape juices are rich in bioactive compounds;however,for these compounds to exert their functionality,they must be ***,the present study evaluated a simulated digestion process on the main bioactive compounds of monovarietal grape juices of five Brazilian hybrid cultivars(*** x ***).Characterization of the chemical profiles in liquid chromatography(HPLC-DAD-RID),behaviour of phenolics in the stages of digestion and bioaccessibility through the INFOGEST protocol plus intestinal barrier passage were carried *** the 24 polyphenols identified in the grape juice samples,11 were bioaccessible,with emphasis on the class of *** B2(101-426%),(+)-catechin(169-370%)and gallic acid(61-230%)stood out in all juices,showing that these compounds are key to the functionality of these *** were observed to differ between juices,demonstrating that factors such as the cultivar should be explored more extensively in studies on functional *** study also suggests that quality components such as sugars and organic acids influence the bioaccessibility of beverages.

关键词： Grape cultivars Functional beverages Phytochemicals Digestion simulation Bioactivity

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Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： Juan Martínez-Milla Marcelino Cortés García julia Anna Palfy Mikel Taibo Urquía Marta López Castillo ana Devesa Arbiol ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón Department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain Department of Cardiology Hospital Central de Asturias Department of Cardiology Hospital Universitario Ruber-Quirónsalud Department of Cardiology Hospital Universitario Infanta Leonor Department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving *** median follow-up was28.04(IR:19.41-36.67)*** the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?

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World Journal of Pediatrics 2017年第1期13卷 76-83页

作者： Hoi Yan Tong Nicolás Medrano Alberto Manuel Borobia JoséAntonio Ruiz ana María Martínez julia Martín Manuel Quintana Santos Garcfa Antonio Jos6 Carcas Elena Ramirez Department of Clinical Pharmacology Hospital Universitario La PazIdiPAZSchool of MedicineUniversidad Autónoma de MadridMadridSpain Pediatric Emergency Department Hospital Universitario La PazIdiPAZMadridSpain General Emergency Department Hospital Universitario La PazIdiPAZMadridSpain

Background:There are few data Oll hepatotoxicity induced by acute or chronic paracetamol poisoning in the pediatric *** poisoning data can reveal the weakn嗍ofparacetamol poisoning management ***:We retrospectively studied the patients of less than 18 years old with measurable paracetamol levels,who were brought to the emergency department(ED)of La Paz University Hospital,Madrid,Spain,for suspected paracetamol overdoses between 2005 and 2010.

关键词： acute liver failure hepatotoxicity paracetamol poisoning

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The role of natural killer cells in the uterine microenvironment during pregnancy

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Cellular & Molecular Immunology 2018年第11期15卷 941-943页

作者： julia P.Andreotti ana E.Paiva Pedro H.D.M.Prazeres Daniel A.P.Guerra Walison N.Silva Rogerio S.Vaz Akiva Mintz Alexander Birbrair Department of Pathology Federal University of Minas GeraisBelo HorizonteMGBrazil Department of Biotechnology and Bioprocess Engineering Federal University of ParanaCuritibaPRBrazil Department of Radiology Columbia University Medical CenterNew YorkNYUSA

Pregnancy is a choreographed physiological phenomenon that involves maternal-fetal *** the cellular and molecular mechanisms involved in this communication will allow us to develop therapies for gestational *** is known about the role of natural killer(NK)cells in the uterine *** a recent study,Fu et al.(2017)used state-of-art technologies and showed that NK cells stimulate fetal growth via growth-promoting factors.

关键词： killer fetal uterine

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Perioperative management and early complications after intestinal resection with ileocolonic anastomosis in Crohn’s disease:analysis from the PRACTICROHN study

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Gastroenterology Report 2019年第3期7卷 168-175,I0001,I0002页

作者： ana Gutierrez Montserrat Rivero Maria Dolores Martin-Arranz Valle Garcia Sanchez Manuel Castro Jesus Barrio Ruth de Francisco Manuel Barreiro-de Acosta Berta julia Luis Cea-Calvo Cristina Romero Natalia Borruel Sainz Eugeni Domenech Gastroenterology Department General University Hospital of Alicante and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd)CarlosⅢHealth InstituteMadridSpain Gastroenterology Department Marques de Valdecilla General University HospitalSantanderSpain Gastroenterology Department La Paz General University HospitalInstituto de Investigacion Biomedica La Paz(IdiPaz)MadridSpain Clinical Management of Gastrointestinal Tract Diseases Unit Reina Sofia University HospitalMaimonides Institute of Biomedical Research of Cordoba(IMIBIC)Cordoba UniversityCordobaSpain Gastroenterology Department Valme University HospitalSevillaSpain Gastroenterology Department University HospitalRio HortegaValladolidSpain Gastroenterology Department University Hospital Central de AsturiasOviedoSpain Gastroenterology Department Inflammatory Bowel Disease UnitUniversity Hospital Complex of Santiago de CompostelaSantiago de CompostelaSpain Medical Department Merck Sharp and DohmeMadridSpain Crohn-Colitis Care Unit(UACC) Digestive Tract ServiceHospital Universitari Vall d’HebronBarcelonaSpain Gastroenterology Department Germans Trias i Pujol University Hospital and CIBERehdBadalonaSpain

Background:This study is aimed at describing the prevalence of and risk factors associated with early post-operative complications after Crohn’s disease-related intestinal ***:This was a retrospective analysis of data from the PRACTICROHN *** Crohn’s disease patients who underwent ileocolonic resection with ileocolonic anastomosis between January 2007 and December 2010 were *** complications evaluated included death,ileus,anastomotic leak,abscess,wound infection,catheter-related infection,digestive bleeding and other extra-abdominal infections that occurred in the 30 days after ***:A total of 364 patients(median age at surgery 38 years and 50%men)were *** for surgery was:stricturing disease(46.4%),penetrating disease(31.3%),penetrating and stricturing disease(14.0%)or resistance to medical treatment(5.8%).Early complications were recorded in 100(27.5%)patients,with wound infection,intra-abdominal abscess and anastomotic leakage being the most frequent *** hospitalization duration was 16 days for patients with complications vs.9 days without complications(P<0.001).Complications were more common among patients with penetrating disease(36/114,31.6%)and those refractory to treatment(9/21,42.9%)compared with stricturing disease(45/169,26.6%)or stricturingtpenetrating disease(6/51,11.8%)(P=0.040).The rate of complications was higher among patients with diagnosis made at the time of surgery(15/31,48.4%)compared with the rest(85/331,25.7%)(P=0.013).Medication received at the time of surgery did not affect the rate of ***:Almost a quarter of patients developed early complications after intestinal *** disease and urgent surgery were associated with an increased risk of complications.

关键词： Ileocolonic resection Crohn’s disease post-operative complications risk factors

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Contralateral axillary metastasis:is surgical treatment the best option?

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 26-30页

作者： María julia Giménez Jesús Manuel Patrón Giovanni Vento ana Bayón Vincenzo Maisto Isidro Bolumar Rosa Ferrer Josep Asensi Joaquin Gavila Rafael Estevan Department of Surgery Fundación Instituto Valenciano de Oncología(IVO)Valencia 46007Espana

Contralateral axillary metastasis (CAM) is a rare entity normally treated as a systemic disease. Recent publications have proposed aggressive surgical treatment with benefits to the patients in terms of survival. We present a case of a 74-year-old patient with a history of unilateral breast cancer, recurrence on the ipsilateral breast and then development of a CAM. The patient was treated with aggressive surgical treatment, but she developed an early recurrence of the disease with distant metastasis. There is limited evidence of the correct management of CAM, although proposed to treat it as a loco regional disease, individualized and multidisciplinary management is the best option for these patients.

关键词： Breast cancer contralateral axillary metastasis lymphatic routes blockage

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