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The transient receptor potential melastatin 2:a new therapeutical target for Parkinson's disease?

Neural Regeneration Research 2023年第8期18卷 1652-1656页

作者： ana Flávia F.Ferreira Luiz Roberto G.Britto Department of Physiology and Biophysics Institute of Biomedical SciencesUniversity of São PauloSão PauloBrazil

The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating mechanism is dependent on reactive oxygen species. In pathological conditions, transient receptor potential melastatin 2 is overactivated, leading to a Ca~(2+) influx that alters cell homeostasis and promotes cell death. The role of transient receptor potential melastatin 2 in neurodegenerative diseases, including Alzheimer's disease and ischemia, has already been described and reviewed. However, data on transient receptor potential melastatin 2 involvement in Parkinson's disease pathology has emerged only in recent years and the issue lacks review studies that focus specifically on this topic. The present review aims to elucidate the role of the transient receptor potential melastatin 2 channel in Parkinson's disease by reviewing, summarizing, and discussing the in vitro, in vivo, and human studies published until August 2022. Here we describe fourteen studies that evaluated the transient receptor potential melastatin 2 channel in Parkinson's disease. The Parkinson's disease model used, transient receptor potential melastatin 2 antagonist and genetic approaches, and the main outcomes reported were discussed. The studies described transient receptor potential melastatin 2 activation and enhanced expression in different Parkinson's disease models. They also evidenced protective and restorative effects when using transient receptor potential melastatin 2 antagonists, knockout, or silencing. This review provides a literature overview and suggests where there is a need for more research. As a perspective point, this review shows evidence that supports transient receptor potential melastatin 2 as a pharmacological target for Parkinson's disease in the future.

关键词： 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine(MPTP) 1-methyl-4-phenylpyridinium(MPP+) 6-hydroxydopamine AG490 clotrimazole flufenamic acid N-(p-amylcinnamoyl)anthranilic acid Parkinson's disease poly-ADPR polymerase type 1(PARP1) rotenone paraquat transient receptor potential melastatin 2(TRPM2)

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加夫列尔·加西亚·马尔克斯图书馆,巴塞罗那,西班牙

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世界建筑 2024年第5期 76-81页

作者：无 Elena Orte Guillermo Sevillano Marta Romero Jesús Lopez Luis Sierra ana Patricia Minguito Pablo Corroto María Abellán Sara Contreras RitaÁlvarez Tabio MiguelÁngel Maure Jesús Granada(摄影) SUMA建筑设计事务所不详

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计... 详细信息

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计成一座雕塑式实体建筑,让人联想到堆叠的书籍及其折叠的书页。该馆坐落在一处高架广场上,方便周围行人来往。同时,它又在空地上悬挑而出,门廊由现有的树木环绕,形成了一座城市大厅。不同大小及结构的开口定义了其不同立面与周围环境的关系。

关键词：巴塞罗那普罗旺斯周围环境加布里埃尔加西亚·马尔克斯图书馆关联式西班牙

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Impact of simulated in vitro gastrointestinal digestion on bioactive compounds,bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder

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Food Bioscience 2022年第3期47卷 1358-1367页

作者： Ricardo Gómez-García ana A.Vilas-Boas Manuela Machado Débora A.Campos Cristóbal N.Aguilar ana R.Madureira Manuela Pintado Universidade Católica Portuguesa CBQF-Centro de Biotecnologia e Química Fina – Laboratório AssociadoEscola Superior de BiotecnologiaRua Diogo Botelho 13274169-005PortoPortugal BBG-DIA.Bioprocesses and Bioproducts Group.Food Research Department School of ChemistryAutonomous University of CoahuilaSaltilloCoahuilaMexico

The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products,considering (i) the recovery and accessibility indexes,(ii) the changes on antioxidant activity,and (iii) the prebiotic *** exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were ***,these both parameters exhibited stable accessibility,accounting with 81.89%,76.55%,and 54.07% for TPC,ABTS and DPPH,*** gastrointestinal digestion,the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and Lactobacillus strains,possibly associated with the high content of simple sugar (glucose and fructose).This fraction also showed to be safe on Caco-2 intestinal *** findings suggest that MPJ might be used as a potential food functional ingredient.

关键词： Melon by-products Functional ingredients Phenolic antioxidants Simulated digestion Prebiotic effect

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Trends in the treatment of undescended testes:a pediatric tertiary care center experience from Croatia

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World Journal of Pediatric Surgery 2022年第4期5卷 261-266页

作者： Marko Bašković Luca Zaninović Ivona Sansović ana Maria Meašić ana KatušićBojanac Davor Ježek Scientific Centre of Excellence for Reproductive and Regenerative Medicine University of ZagrebSchool of MedicineZagrebCroatia Department of Pediatric Surgery Children's Hospital ZagrebZagrebCroatia Department of Medical Genetics and Reproductive Health Children's Hospital ZagrebZagrebCroatia Department of Medical Biology University of ZagrebSchool of MedicineZagrebCroatia Department of Histology and Embryology University of ZagrebSchool of MedicineZagrebCroatia Department of Transfusion Medicine and Transplantation Biology University Hospital Centre ZagrebZagrebCroatia

Objective Undescended testes(UDT)is the most common anomaly of the male genitourinary *** guidelines suggest that orchidopexy in congenitally UDT should be performed between 6 months and 18 months of age,while in acquired UDT,orchidopexy should be performed before *** in treatment increases the risk of cancer and *** main aim of this study was to determine whether we meet international standards in the treatment of *** The present study included all boys who underwent orchidopexy either due to congenital or acquired UDT in 2019(from January 1 to December 31).For each group,laterality,location,associated anomalies,premature birth and in how many cases ultrasound was applied were ***,for each group,the types of surgery,the number of necessary reoperations,and in how many cases atrophy occurred were ***,ages of referral,of clinical examination,and of orchidopexy were *** during this period,198 patients with 263 UDT underwent *** median time of orchidopexy for the congenital group was 30 months,while that for the acquired group was 99 *** the congenital group up to 18 months of age,orchidopexy was performed in 16(16%)boys,while in the acquired group up to 13 years of age,orchidopexy was performed in 95(96.94%)*** Given the well-known risks of late treatment of UDT,orchidopexy needs to be performed much earlier,especially in the congenital group.

关键词： congenital treatment urinary

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Spatiotemporal assessment of particulate matter(PM_(10) and PM_(2.5)) and ozone in a Caribbean urban coastal city

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Geoscience Frontiers 2022年第1期13卷 437-445页

作者： ana L.Duarte Ismael L.Schneider Paulo Artaxo Marcos L.S.Oliveira Department of Civil and Environmental Universidad de la CostaCalle 58#55-66080002 BarranquillaAtlánticoColombia Instituto de Física Universidade de São PauloSão PauloBrazil Universidad de Lima Avenida Javier Prado Este 4600Santiago de Surco 1503Peru

Air pollution has become a critical issue in urban areas,so a broad understanding of its spatiotemporal characteristics is important to develop public *** study analyzes the spatiotemporal variation of atmospheric particulate matter(PM_(10) and PM_(2.5))and ozone(O_(3))in Barranquilla,Colombia from March 2018 to June 2019 in three monitoring *** average concentrations observed for the Móvil,Policía,and Tres Avemarías stations,respectively,for PM_(10):46.4,51.4,and 39.7μg/m^(3);for PM_(2.5):16.1,18.1,and 15.1μg/m^(3) and for O_(3):35.0,26.6,and 33.6μg/m^(3).The results indicated spatial and temporal variations between the stations and the pollutants *** highest PM concentrations were observed in the southern part of the city,while for ozone,higher concentrations were observed in the *** variations are mainly associated with the influence of local sources in the environment of each site evaluated as well as the meteorological conditions and transport patterns of the study *** study also verified the existence of differences in the concentrations of the studied pollutants between the dry and rainy seasons and the contribution of local sources as biomass burnings from the Isla Salamanca Natural Park and long-range transport of dust particles from the Sahara *** study provides a scientific baseline for understanding air quality in the city,which enables policy makers to adopt efficient measures that jointly prevent and control pollution.

关键词： Particulate matter Ozone Colombian Caribbean Coastal urban area

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3D Printed Gelatin Scaffold with Improved Shape Fidelity and Cytocompatibility by Using Antheraea pernyi Silk Fibroin Nanofibers

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Advanced Fiber Materials 2022年第4期4卷 758-773页

作者： Shengzhi Zou Suna Fan ana L.Oliveira Xiang Yao Yaopeng Zhang Huili Shao State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China CBQF‑Centro de Biotecnologia e Quimica Fina‑Laboratorio Associado Escola Superior de BiotecnologiaUniversidade Catolica PortuguesaRua Diogo Botelho 13274169‑005 PortoPortugal

Gelatin(G)is a commonly used natural biomaterial owing to its good biocompatibility and easy ***,using pure gelatin as a bioink can barely achieve an ideal shape fidelity in 3D *** this study,Antheraea pernyi silk fibroin nanofibers(ASFNFs)with arginine-glycine-aspartic acid(RGD)peptide and partial natural silk structure are extracted and combined with pure gelatin bioink to simultaneously improve the shape fidelity and cytocompatibility of corresponding 3D printed *** show that the optimum printing temperature is 30℃ for these *** printed filaments using 16G/4ASFNFs bioink(16wt%gelatin and 4wt%ASFNFs)demonstrate better morphology and larger pore size than those printed by pure gelatin bioink(20G,20wt%gelatin),thus successfully improve the shape fidelity and porosity of the 3D printed *** 16G/4ASFNFs scaffold also demonstrate higher swelling ratio and faster degradation rate than the pure gelatin ***,the cell viability and proliferation ability of Schwann cells cultured on the 16G/4ASFNFs scaffold are significantly superior than those cultured on the pure 20G *** ASFNFs enhanced 16G/4ASFNFs scaffold reported here are expected to be a candidate with excellent potential for biomedical applications.

关键词： Antheraea pernyi silk fibroin nanofiber 3D printed scaffold Shape fidelity Cytocompatibility Gelatin

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Differential diagnosis between autism spectrum disorder and other developmental disorders with emphasis on the preschool period

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世界儿科杂志:英文版 2023年第8期19卷 715-726页

作者： Taynara Amancio de Lima Patricia Aparecida Zuanetti Marina Estima Neiva Nunes ana Paula Andrade Hamad Department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical SchoolUniversity of São PauloAv.Bandeirantes3900Monte AlegreRibeirão PretoSP14049-900Brazil University Hospital Ribeirão Preto Medical SchoolUniversity of São Paulo(HCFMRP-USP)Ribeirão PretoSPBrazil

Background Neurodevelopmental disorders are a heterogeneous group of conditions that manifest as delays or deviations in the acquisition of expected developmental milestones and behavioral *** spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in communication and social interaction and by repetitive and restricted patterns of behavior,interests and *** aim of this review is to discuss the clinical features of the differential diagnoses of ASD that are prevalent among preschoolers,focusing on their similarities and *** sources The international medical literature search was conducted using PubMed and was revised regarding the subject using single and/or combined keywords as follows:differential diagnosis,preschoolers,diagnostic challenge,attention deficit hyperactivity disorder,intellectual disability,high abilities/giftedness,childhood apraxia of speech,social communication disorder,Landau–Kleffner syndrome,stereotyped movement disorder and excessive screen *** We describe conditions commonly found in clinical practice,taking ASD as a *** addressed converging and divergent aspects of behavior,cognition,communication,language,speech,socialization,and stereotypes for the diagnosis of ASD and other disorders identified as potential differential or comorbid *** The ranking and characterization of symptoms appear to be essential for better understanding the underlying common ground between children with developmental disorders and children with ASD,thus properly diagnosing and directing social,professional,or medication *** detailed discussion adds to the literature since,although ASD differential diagnoses are frequently mentioned and discussed in textbooks and journal articles,they rarely occupy a prominent place as we aimed herein.

关键词： Autism spectrum disorder Clinical features Differential diagnosis Neurodevelopmental disorders Preschool

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Predicting Dementia Risk Factors Based on Feature Selection and Neural Networks

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Computers, Materials & Continua 2023年第5期75卷 2491-2508页

作者： Ashir Javeed ana Luiza Dallora Johan Sanmartin Berglund Arif Ali Peter Anderberg Liaqat Ali Aging Research Center Karolinska InstitutetStockholm17165Sweden Department of Health Blekinge Institute of TechnologyKarlskrona37141Sweden School of Health Sciences University of SkövdeSkövdeSE 54128Sweden Department of Computer Science University of Science and Technology BannuBannu28100Pakistan Department of Electrical Engineering University of Science and Technology BannuBannu28100Pakistan

Dementia is a disorder with high societal impact and severe consequences for its patients who suffer from a progressive cognitive decline that leads to increased morbidity,mortality,and *** there is a consensus that dementia is a multifactorial disorder,which portrays changes in the brain of the affected individual as early as 15 years before its onset,prediction models that aim at its early detection and risk identification should consider these *** study aims at presenting a novel method for ten years prediction of dementia using on multifactorial data,which comprised 75 *** are two automated diagnostic systems developed that use genetic algorithms for feature selection,while artificial neural network and deep neural network are used for dementia *** proposed model based on genetic algorithm and deep neural network had achieved the best accuracy of 93.36%,sensitivity of 93.15%,specificity of 91.59%,MCC of 0.4788,and performed superior to other 11 machine learning techniques which were presented in the past for dementia *** identified best predictors were:age,past smoking habit,history of infarct,depression,hip fracture,single leg standing test with right leg,score in the physical component summary and history of TIA/*** identification of risk factors is imperative in the dementia research as an effort to prevent or delay its onset.

关键词： Dementia prediction feature selection genetic algorithm neural networks

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Amyotrophic lateral sclerosis,a neurodegenerative motor neuron disease with retinal involvement

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Neural Regeneration Research 2022年第5期17卷 1011-1012页

作者： ana I.Ramírez Rosa de Hoz Pilar Rojas Juan J.Salazar Instituto de Investigaciones Oftalmológicas Ramón Castroviejo.Universidad Complutense de Madrid MadridSpain Facultad deÓptica y Optometría.Departamento de Inmunología Oftalmología y ORL.Universidad Complutense de MadridMadridSpain Hospital General Universitario Gregorio Marañón Instituto Oftálmico de MadridMadridSpain

Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease that damages the motor neurons,the spinal cord,the cerebellum,and some areas of the ***,more recent studies show that it can also affect the visual syst... 详细信息

关键词： visual problems involvement

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Exocytosis,endocytosis and recycling of secretory vesicles in neuroendocrine cells,and its regulation by cortical actin

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BIOCELL 2022年第8期46卷 1867-1873页

作者： ana M.CÁRDENAS I.GALLO FERNANDO D.MARENGO Centro Interdisciplinario de Neurociencia de Valparaíso Facultad de CienciasUniversidad de ValparaísoValparaíso2360102Chile Instituto de Fisiología Biología Molecular y NeurocienciasCONICET.Departamento de Fisiología y Biología Molecular y CelularFacultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires1428Argentina

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to *** dynamic network of cortical filaments,together with motor myosin partners,adjusts the plasmalemma tension,organizes membrane protein microdomains,remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis,endocytosis and recycling of secretory *** this review,we discuss how these mechanisms work in secretory cells.

关键词： Cortical actin Neuroendocrine cell Chromaffin cell Exocytosis Endocytosis

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