检索结果-南通市图书馆

analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical analysis 2017年第5期7卷 324-331页

作者： Gema M.durán Tomás E.Benavidez ana M.Contento Angel Ríos Carlos D.García Department of analytical Chemistry and Food Technology University of Castilla-La Mancha IRICA (Regional Institute of Applied Scientific Research) Department of Chemistry Clemson University219 Hunter Laboratories

A simple methodology was developed to quantify penicillamine(PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots(Cu-GQDs). The proposed strategy combines the advantages of carbon dots(over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response(in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.

关键词： Graphene quantum dots One-step synthesis Fluorescence quenching Penicillamine Pharmaceutical preparations

Age-adjusted NT-proBNP could help in the early identification and follow-up of children at risk for severe multisystem inflammatory syndrome associated with COVID-19(MIS-C)

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第29期10卷 10435-10450页

作者： Moises Rodriguez-Gonzalez ana Castellano-Martinez Division of Pediatric Cardiology Puerta del Mar University HospitalCadiz 11009Spain Division of Pediatric Nephrology Puerta del Mar University HospitalCadiz 11009Spain

BACKGROUND Multisystem inflammatory syndrome in children(MIS-C) has emerged as a new disease associated with COVID-19 that presents in acute critically ill children with acute cardiovascular *** To determine whether the age-adjusted N-terminal pro-brain natriuretic peptide(NT-proBNP) value(Z-log-NT-proBNP) is associated with severe MIS-C and myocardial *** A retrospective study was conducted which included children with MIS-C managed at our institution between April 1,2020,and February 28,*** divided the population into groups depending on severity based on pediatric intensive care unit(PICU) *** compared Z-log-NT-proBNP values across these groups and analyzed Z-log-NT-proBNP dynamics during the onemonth *** We included 17 participants [median age 3(2-9) years] and seven(41%) required PICU ***(100%) of these cases presented very high(Z-log > 4) levels of NT-proBNP at the time of admission compared to only 5(50%) patients with non-severe MIS-C(P = 0.025).NT-proBNP was significantly correlated with highsensitive Troponin I levels(P = 0.045),Ross modified score(P = 0.003) and left ventricle ejection fraction(P = 0.021).CONCLUSION Raised NT-proBNP,specifically very high values(Z-log-NT-proBNP > 4) could help in the early identification of MIS-C patients with myocardial dysfunction requiring inotropic support and PICU admission.

关键词： Multisystem inflammatory syndrome associated with COVID-19 COVID-19 SARS-CoV-2 NT-proBNP Echocardiography Myocardial dysfunction Children

Interpreting Morphologically Homogeneous(Paleo-)Populations as Ecological Species Enables Comparison of Living and Fossil Organism Groups,Exemplified by Nummulitid Foraminifera

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2022年第6期33卷 1362-1377页

作者： Johann Hohenegger ana Ivis Torres-Silva Wolfgang Eder Institute for Paleontology University of Vienna1090ViennaAustria

Morphologically homogeneous groups,either living populations or fossil paleo-populations,must be regarded as ecological species,independent of their molecular genetic resemblance in living *** is always expressed during development by structure genes initiated from a network of regulator genes acting at different times and intensities,additionally being subjected to epigenetic ***,homogeneous populations influenced by the environment represent species better than the reproduction(biological species)or molecular-genetic approach using ancestral sequences like *** and fossil representatives of nummulitid foraminifera were chosen to demonstrate complete reconstruction of morphology using metrical growth-invariant and growth-independent *** these characters,6 models were established to define ecological species in living and fossil ***,a distinction between evolutionary and environmental effects in fossil forms was possible using discriminant analysis showing characters that are responsible for differentiating between evolutionary and environmental trends.

关键词： ecological species growth-invariant metrical characters morphology homogeneity nummulitids

PBL联合情景模拟教学法在胃肠外科护理带教中的应用效果

在线全文

学校读者我要写书评

暂无评论

中国医药指南 2024年第7期22卷 186-188页

作者：谢巧珍庄丽红郭阿娜泉州市第一医院胃肠外科泉州362000

目的探讨PBL教学法联合情景模拟教学法在胃肠外科临床护理带教中的应用效果。方法选取2021年12月至2022年11月在泉州市第一医院胃肠外科接受护理带教的实习护生80名,随机分为对照组和试验组,两组均为40名。对照组采用传统教学方式进... 详细信息

目的探讨PBL教学法联合情景模拟教学法在胃肠外科临床护理带教中的应用效果。方法选取2021年12月至2022年11月在泉州市第一医院胃肠外科接受护理带教的实习护生80名,随机分为对照组和试验组,两组均为40名。对照组采用传统教学方式进行教学,试验组采用PBL教学法联合情景模拟教学法进行教学,对比两组实习护生理论考核成绩、技能考核成绩、教学满意度及批判性思维能力。结果试验组的理论考核成绩、操作考核成绩、教学满意度及批判性思维能力测量得分均高于对照组(P <0.05)。结论 PBL教学法与情景模拟教学法相结合应用于胃肠外科护理教学,其效果显著,大大提升了实习护生的理论知识水平及临床操作能力,同时提高了带教满意度、发展了实习护生的批判性思维能力。

关键词：以问题为导向的教学法情景模拟胃肠外科护理教学

Nanofluid based on 1-dodecylpyridinium chloride for enhanced oil recovery

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2023年第1期20卷 600-610页

作者： Akram Al-Asadi Alba Somoza Alberto Arce Eva Rodil ana Soto CRETUS.Department of Chemical Engineering Universidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain Chemical and Petrochemical Techniques Eng.Department Basra Engineering Technical CollegeSothern Technical UniversityMinistry of Higher Education and Scientific ResearchIraq School of Engineering Universidade de A CorunaE-15403FerrolSpain

The use of nanoparticles is considered promising for enhanced oil recovery(EOR),especially when they are combined with ***,the combination of nano-sized material with surface-active ionic liquids(SAILs)is an unexplored EOR *** this work,the advantages of mixing Al2O3 nanoparticles with the SAIL 1-dodecylpyridinium chloride were *** nanofluids in brine could only be achieved using the polymer polyvinylpyrrolidone(PVP)as a stabilizing *** was found that the addition of nanoparticles(and PVP)to the surfactant formulation helped to:slightly increase its viscosity,enhance its water-oil interfacial tension(IFT)reduction capacity,and reduce the adsorption on carbonate rocks(adsorption on sandstone was found to be excessive).IFT was selected as target property to minimize for the design of EOR *** flooding tests were carried out with surfactant(0.5 wt%[C_(12)py]Cl),surfactant-polymer(0.5 wt%[C_(12)py]Cl,1.0 wt%PVP)and nanofluid(0.05 wt%Al_(2)O_(3),1.0 wt%PVP,0.5 wt%[C12py]Cl)formulations in brine(0.5 wt%NaCl).Additional oil recoveries of 3.4%,7.4%and 12.0%OOIP were achieved,respectively,the nanofluid formulation being the most promising for the ***,it was found capable of changing the wettability of carbonate rocks from oilwet to *** significance of this work lies in showing the new possibilities resulting from the combination of SAILs and nanoparticles for EOR,specifically the combination of[C_(12)py]Cl with Al_(2)O_(3).

关键词： Nanofluid Viscosity Interfacial tension Adsorption Wettability EOR

Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy anais R.Briant Etienne Javouhey Sophie Breinig Julia Dina Marion Caseris Francois Angoulvant Stephane Leteurtre Morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine Research Center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the pediatric intensive care unit(PICU).Secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive SARS-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental SARS-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French PICU registry(PICURe)between September 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SARS-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to SARS-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SARS-CoV-2 mortality in the French pediatric population was *** though the imputability of SARS-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit SARS-CoV-2

Impact of common gastrointestinal disorders in elderly on in vitro meat protein digestibility and related properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Bioscience 2022年第2期46卷 439-449页

作者： Ever Hern´andez-Olivas Sara Mu˜noz-Pina Jorge García-Hern´andez ana Andr´es ana Heredia Instituto Universitario de Ingeniería de Alimentos para el Desarrollo(IUIAD-UPV).Universitat Polit`ecnica de Val`encia Camino de Vera s/nC.P.46022ValenciaSpain Centro Avanzado de Microbiología de Alimentos(CAMA) Universitat Polit`ecnica de Val`enciaCamino de Vera s/nC.P46022ValenciaSpain

This study aimed to in vitro evaluate the impact of common gastrointestinal(GI)alterations appearing with aging on protein digestibility,and functional related properties,in four different meats(chicken,turkey,pork and beef).Thus,three elderly digestion models were stated as long as altered GI conditions affected at oral(E1),oral and gastric(E2)and oral,gastric and intestinal stages(E3).Healthy adult GI conditions were also mimicked as standard control model(C).A notable trichloroacetic acid(TCA)soluble protein and the free amino acids(FAA)release reduction(p<0.05)were found under intestinal suboptimal conditions(E3),being more accused in beef than in other ***,chicken intake would be more advisable,than other meats,in terms of protein digestibility;while beef would provide a greater net supply of FAA under E3 model *** altered conditions,seem to favor protein ***,while gastric and intestinal suboptimal conditions diminish the angiotensin converting enzyme(ACE)inhibition of meat digesta,their antioxidant activity was only negatively affected by intestinal altered conditions.

关键词： Meats Gastrointestinal digestion Aging Proteolysis ACE inhibition Antioxidant activity

Effect of Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum L.)as affected by carbonates and Fe oxides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2022年第6期32卷 823-832页

作者： ana M.GARCÍA-LÓPEZ Ramiro RECENA Antonio DELGADO Department of Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

Although complexation with soil organic matter may improve zinc(Zn)bioavailability to plants,the effect of Zn sorbent surface on the use of complexed Zn by plants remains *** objective of this research was to elucidate how Zn complexation with humic substances(HS)and phytate affects the uptake of Zn by wheat plants depending on the main sorbent surface in growth media,i.e.,carbonates and Fe *** this end,two pot experiments were performed,one using Fe oxide-coated siliceous as the siliceous growth medium sand and the other using a mixture of calcareous sand and siliceous sand as the calcareous growth *** experiment involved three Zn sources,Zn-HS complex,Zn phytate,and ZnSO_(4).All sources were applied with surface irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-HS complex significantly increased Zn uptake by plants in both media,relative to the other two Zn sources,but no significant difference was observed between Zn phytate and ZnSO_(4).In the calcareous medium,Zn-HS complex and Zn phytate resulted in significantly higher dry biomass yields of wheat than ZnSO_(4).In the siliceous medium,spike and shoot dry biomass yields with Zn-HS complex at the low rate and Zn phytate at both rates were not significantly different from those with ZnSO_(4) at the high *** harvest,approximately 50%of the Zn applied as Zn-HS complex remained extractable by diethylenetriaminepentaacetic acid(DTPA),while this proportion was less than 20%for the other Zn ***,Zn-HS complex and Zn phytate are sources of available Zn for plants,and they are more effective than ZnSO_(4) in increasing plant growth,particularly when carbonates are the main Zn sorbent surface.

关键词： calcareous growth medium micronutrient organic matter organic phosphorus Zn availability Zn deficiency Zn sorbent surface Zn source

Treatment strategies in cervical cancer:treatment of advanced disease

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2022年第1期8卷 221-239页

作者： Augusto Valdivia Juan Francisco Grau-Béjar Carmen García-durán ana Oaknin Gynaecologic Cancer Programme Vall d’Hebron Institute of Oncology(VHIO) Hospital Universitari Vall d’HebronVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain

Cervical cancer is the fourth most common cancer in women worldwide,with a global incidence of 604,127 and an annual death rate of 341,831 in *** with recurrent,persistent,or metastatic disease not amenable to curative therapy represent a patient population with a dismal *** recently,the standard of care for these patients was based on platinum doublet chemotherapy with or without ***,significant advances in the treatment landscape of this disease have recently been achieved with the incorporation,among others,of immunotherapy in the therapeutic *** review summarizes the main treatment approaches developed throughout the past decades,with particular emphasis on immunotherapy and novel targeted therapies.

关键词： Cervical cancer advanced stage chemotherapy immunotherapy antiangiogenic agents targeted therapy