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American Journal of Plant Sciences 2013年第9期4卷 1863-1871页

作者： ana carla feio ana Cristina Andrade de Aguiar-Dias Raimunda Conceicao de Vilhena Potiguara Doctoral Student in Botany Universidade Federal de Vicosa—UFVVicosaBrazil Instituto de Ciencias Biológicas Universidade Federal do Pará—UFPABelémBrazil Museu Paraense Emílio Goeldi—MPEG Coordenacao de BotanicaBelémBrazil

This study describes the anatomy of sterile leaves of Elaphoglossum discolor (Kuhn) C. Chr., E. flaccidum (Fée) T. Moore and E. laminarioides (Bory ex Fée) T. Moore, the most representative species of the genus in the Ecological Park of Gunma in Pará State. It reports the main diagnostic characters and provides new systematic data for the group. In addition, it locates the production and accumulation sites of bioactive compounds to determine possible adaptive strategies of these species in the Amazon rainforest environment. Diagnostic structural features include stoma typology, central veins and margin forms, type of mesophyll, and the presence of schlerenchymatous sheaths in the cortex, among others. Among the bioactive compounds related to defense adaptation are phenolic compounds, which occur in all three species, and alkaloids and mucilage, which are exclusive to E. laminarioides. Of the three species studied, E. laminarioides has features that make it the best suited to the rainforest environment.

关键词： Fern Ombrophilous Forest Epiphytes Comparative anatomy Secondary Metabolites

Evaluation of Novel 3D Architectures Based on Knitting Technologies for Engineering Biological Tissues

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Journal of Donghua University(English Edition) 2013年第5期30卷 421-426页

作者： RIBEIRO Viviana Pinto RIBEIRO ana Soares SILVA carla Joana DURES Nelson feio BONIFCIO Graa CORRELO Vitor Manuel MARQUES Alexandra Pinto SOUSA Rui Amandi OLIVEIRA ana Leite REIS Rui Luís 3B's Research G roup-Biomaterials Biodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine ICVS /3B's-PT G overnment Associated Laboratory University of Minho CeNTI Centre for Nanotechnology and Smart MaterialsV. N. CITEVE Technological Centre for Textile and Clothing IndustryV. N. CBQF-School of Biotechnology Portuguese Catholic University

Textile-based technologies are considered as potential routes for the production of 3D porous architectures for tissue engineering( TE) applications. We describe the use of two polymers,namely polybutylene succinate( PBS) and silk fibroin(SF) to produce fiber-based finely tuned porous architectures by weft and warp knittings. The obtained knitted constructs are described in terms of their morphology, mechanical properties,swelling ability,degradation behaviour,and cytotoxicity. Each type of polymer fibers allows for the processing of a very reproducible intra-architectural scaffold geometry,with distinct characteristics in terms of the surface physicochemistry,mechanical performance,and degradation capability,which has an impact on the resulting cell behaviour at the surface of the respective biotextiles. Preliminary cytotoxicity screening shows that both materials can support cell adhesion and proliferation. Furthermore, different surface modifications were performed( acid /alkaline treatment, UV radiation,and plasma) for modulating cell behavior. An increase of cell-material interactions were observed,indicating the important role of materials surface in the first hours of culturing. Human adipose-derived stem cells( hASCs) became an emerging possibility for regenerative medicine and tissue replacement therapies. The potential of the recently developed silk-based biotextile structures to promote hASCs adhesion,proliferation,and differentiation is also evaluated. The obtained results validate the developed constructs as viable matrices for TE applications. Given the processing efficacy and versatility of the knitting technology, and the interesting structural and surface properties of the proposed polymer fibers,it is foreseen that our developed systems can be attractive for the functional engineering of tissues such as bone,skin,ligaments or cartilage and also for develop more complex systems for further industrialization of TE products.

关键词： textile-based technologies silk polybutylene succinate(PBS) surface modifications human adipose-derived stem cells(hASCs) tissue engineering(TE)

Microbiological assessment of street foods at the point of sale in Maputo(Mozambique)

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Food Quality and Safety 2021年第1期5卷 22-30页

作者： Acacio Salamandaneu ana carla Silva Luisa Brito Manuel Malfeito-Ferreira Linking Landscape EnvironmentAgriculture and Food(LEAF)Research CentreInstituto Superior de AgronomiaUniversity of LisbonLisbonPortugal Faculdade de Ciencias de Saude Universidade LurioBairro de MarrereNampulaMozambique

Objectives:The aim of this study was to assess the microbiological quality and safety of street food sold in the main streets and informal markets of Maputo,the capital of *** and Methods:From 83 different vendors selling different types of foods,83 samples of ready-to-eat(RTE)street food were ***,Escherichia coli and total coliforms were used as quality and hygiene *** monocytogenes(***)Salmonella and coagulase-positive staphylococc were used as food safety ***:High proportions of unsatisfactory food samples were found in both traditional hot(76.7%)and cold(75%)*** and Salmonella were tested negative in this ***,when coagulase-positive staphylococci was used as a food safety indicator,approximately 25%(23/83)of the food samples analyzed were classified as unsatisfactory/potentially ***:These results,showing that street food sold in Maputo clearly requires adequate sanitary conditions for its preparation and sale,contribute to the development of good manufacturing practices(GMP)for street food in Maputo,*** is the first report on the microbiological quality and safety of street food in Mozambique.

关键词： ready-to-eat street food Escherichia coli coagulase-positive staphylococcr good manufacturing practices good hygiene practices

Assessment of Cancer-Related Fatigue Expression:Comparing the Expression of Fatigue in Patients with a History of Cancer,Patients with Other Chronic Diseases,and Healthy Individuals

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Psycho-Oncologie 2024年第1期18卷 49-57页

作者： Maria Inês Clara Maria Cristina Canavarro ana Severina Susana Ramos carla Rafael ana Allen Gomes Chronopsychology and Cognitive Systems Lab(ChronCog) University of CoimbraCoimbra3000-115Portugal Center for Research in Neuropsychology and Cognitive and Behavioral Intervention(CINEICC) University of CoimbraCoimbra3000-115Portugal Faculty of Psychology and Educational Sciences University of CoimbraCoimbra3000-115Portugal Oncology Department Centro Hospitalar do Médio Tejo(CHMT)Torres Novas2350-754Portugal

Aims:We aimed to compare cancer survivors’fatigue expression with that of the general population and examine psychobiological factors associated with ***:In this quantitative,transversal study,we analyzed clinical and sociodemographic indicators of 389 participants(68.38%females):148 cancer survivors on active treatment,55 disease-free survivors,75 patients with another chronic disease,and 111 healthy ***:Fatigue was expressed dissimilarly in patients with a previous history of cancer and participants without a history of *** on active treatment reported significantly higher levels of fatigue than the other clinical status ***,some level of cancer-related fatigue persisted,in a similar pattern,after active treatment into the survivorship ***-free survivors showed significantly lower vigor levels when compared to patients with other chronic *** distress and daytime sleepiness emerged as transdiagnostic factors associated with ***:Cancer-related fatigue may have a unique pattern,characterized by reduced endurance and muscle *** the present study,psychological distress and daytime sleepiness are associated with cancer-related *** findings suggest the pertinence of future studies examining whether interventions targeting those factors may help manage this burdensome complaint.

关键词： Fatigue cancer patients cancer burden psychological distress cancer survivors neoplasms

Effect of Lepidium meyenii(maca)roots on spermatogenesis of male rats

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Asian Journal of Andrology 2001年第3期3卷 231-233页

作者： Gustavo F.Gonzales ana Ruiz carla Gonzales León Villegas Amanda Cordova Department of Physiological Sciences Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura.Universidad Peruana Cayetano Heredia.Postal Office 1843.LimaPeru

Aim:To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii(maca)on spermatogenesis in adult male ***;Male rats received an aqueous extract of the root(66.7 mg in onemL)twice a day for 14 consecutive ***:Treatment with Lepidium meyenii resulted in an increase in theweights of testis and epididymis but not the seminal vesicle *** length and frequency of stages IX-XIV seminif-erous tubules,where mitosis occurred,were increased and stages I-VI were reduced in rats treated with ***;The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initialstages(IX-XIV).

关键词： spermatogenesis Lepidium meyenii maca transillumination

Measurement of Affect： From Theoretical and Instrumental Perspectives

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Psychology Research 2015年第2期5卷 96-107页

作者： ana carla Crispim Roberto Moraes Cruz Davi Baasch

Cannabinoid Modulation of Monoamine Levels in Mouse Brain:Unveiling Neurochemical Dynamics through an Innovative High‑performance Liquid Chromatography‑Fluorescence Detection Bioanalysis

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Journal of analysis and Testing 2024年第3期8卷 300-314页

作者： Fonseca carla Cunha Susana Ferreira Ricardo Lapo Pais Mariana Goncalves Joana Camins Antoni Ettcheto Miren Barbosa Rui Fortuna ana Laboratory of Pharmacology Faculty of PharmacyUniversity of CoimbraPolo das Ciencias da SaudeAzinhaga de Santa CombaCoimbra 3000‑548Portugal CIBIT/ICNAS-Coimbra Institute for Biomedical Imaging and Translational Research University of CoimbraCoimbra 3000‑548Portugal Department of Pharmacology Toxicology and Therapeutic ChemistryFaculty of Pharmacy and Food ScienceUniversitat de BarcelonaBarcelona 08028Spain Institute of Neurosciences Universitat de BarcelonaBarcelona 08035Spain Faculty of Sciences and Technology Doctoral Program in Biomedical EngineeringUniversity of CoimbraCoimbra 3004‑516Portugal Biomedical Research Networking Centre in Neurodegenerative Diseases(CIBERNED) Carlos Ⅲ Health InstituteMadrid 28031Spain Institut d’Investigacio Sanitaria Pere Virgili(IISPV) Reus 43204Spain CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbra 3004-504Portugal

Homeostasis of monoaminergic pathways is compromised in aging and neurodegenerative/neurological diseases such as Alzheimer’s disease and *** the other hand,their modulation has also been linked to the mechanism of action of several ***,monitoring the levels of noradrenaline(NA),adrenaline(AD),dopamine(DA),and serotonin(5-HT),as well as those of tryptophan(TRYP),the precursor of 5-HT,and DA metabolites,namely 3,4-dihydroxyphenylacetic acid(DOPAC)and homovanillic acid(HVA),is fundamental for assessing disease severity and *** work aimed to develop and validate the first High-Performance Liquid Chromatography(HPLC)coupled with fluorescence detector(FLD)method that simultaneously and accurately quantifies NA,AD,DA,DOPAC,HVA,5-HT and TRYP in mouse brain and prefrontal cortex(PFC)*** sample preparation by protein precipitation was required to extract the *** curves were plotted using the background subtraction approach to reduce the interference of the endogenous *** and inter-day accuracy and precision were within the ranges defined by ICH(The International Council for Harmonisation)guideline for bioanalytical method *** validation,the impact of cannabidiol(CBD),cannabigerol(CBG),and cannabidivarin(CBDV)was explored in mice brains post-administration,revealing significant alterations in specific neurotransmitter levels upon cannabinoid exposure and shedding light on the complex modulation of neurochemical dynamics by *** research highlights the fit-for-purpose of the HPLC-FLD method and provides insights into potential mechanisms underlying phytocannabinoid actions in the central nervous system(CNS).

关键词： Neurotransmitter HPLC Mice Brain Prefrontal cortex Cannabinoid

Parkinson's disease, heart disease and propolis consumption

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Journal of Integrative Medicine 2021年第5期19卷 467-468页

作者： Fulvio A.Scorza Antonio-Carlos G.de Almeida carla A.Scorza ana C.Fiorini Josef Finsterer Disciplina de Neurociência Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP 04021-001Brazil Centro de Neurociências e Saúde da Mulher Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Departamento de Engenharia de Biossistemas Universidade Federal de Sao Joao del-Rei(UFSJ)Sao Joao del-ReiMG36307-352Brazil Departamento de Fonoaudiologia Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Brazil-Programa de Estudos Pós-Graduado em Fonoaudiologia Pontifícia Universidade Católica de Sao Paulo(PUC-SP)Sao PauloSP04021-001Brazil Klinikum Landstrasse Messerli InstituteVienna 1210Austria

It is reported that neurodegeneration is a process that is implicated in both neuropharmacological disorders and brain aging [1].Research has shown that natural products have a wide range of pharmacological and biolog... 详细信息

关键词： Parkinson’s disease heart disease and propolis consumption

Eosinophilic esophagitis-endoscopic distinguishing findings

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World Journal of Gastroenterology 2012年第31期18卷 4221-4223页

作者： ana Célia Caetano Raquel Goncalves carla Rolanda Department of Gastroenterology Braga Hospital4710243 BragaPortugal Life and Health Sciences Research Institute School of Health SciencesUniversity of Minho4710057 BragaPortugal Life and Health Sciences Research Institute/3Bs-PT Government Associate Laboratory 4710057 BragaPortugal

Eosinophilic esophagitis （EE） is the most frequent con- dition found in a group of gastrointestinal disorders called eosinophilic gastrointestinal diseases. The hypo- thetical pathophysiological mechanism is related to a hypersensitivity reaction. Gastroesophageal reflux dis- ease-like complaints not ameliorated by acid blockade or occasional symptoms of dysphagia or food impac- tion are likely presentations of EE. Due to its unclear pathogenesis and unspecific symptoms, it is difficult to diagnose EE without a strong suspicion. Although histo- togical criteria are necessary to diagnosis EE, there are some characteristic endoscopic features. We present the case of a healthy 55-year-old woman with dyspha- gia and several episodes of esophageal food impaction over the last six months. This case report stresses the most distinguishing endoscopic findings-mucosa rings, white exudative plaques and linear furrows-that can help in the prompt recognition of this condition.

关键词： Distinguishing findings Dysphagia Eosino-philic esophagitis Gastro esophageal reflux disease Histological criteria

Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:Useless or useful?-A literature review

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World Journal of Gastroenterology 2021年第27期27卷 4413-4428页

作者： Diogo Alpuim Costa carla Espiney Amaro ana Nunes Joana Santos Cardoso Pedro Modas Daniel Isabel Rosa João Vieira Branco Department of Haematology and Oncology CUF OncologiaLisboa 1998-018Portugal Centro de Medicina Subaquática e Hiperbárica(CMSH) Portuguese NavyLisboa 1649-020Portugal Centro de Investigação Naval(CINAV) Portuguese NavyBase Naval do AlfeiteAlmada 2810-001Portugal OVA Medical School Faculdade de Ciências MédicasLisboa 1169-056Portugal Department of Otorhinolaryngology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Gastroenterology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Vascular Surgery Centro Hospitalar Universitário de Lisboa CentralHospital de Santa MartaLisboa 1169-024Portugal Department of Intensive Care Unit Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of General Surgery Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal

Radiotherapy(RT)is the backbone of multimodality treatment of more than half of cancer *** new modern RT techniques,late complications may occur such as radiation proctitis(RP).The natural history of RP is *** symptoms may resolve spontaneously or require conservative *** the other hand,for similar and uncomplicated clinical contexts,symptoms may persist and can even be refractory to the progressive increase in treatment *** the last decades,an enormous therapeutic armamentarium has been considered in RP,including hyperbaric oxygen therapy(HBOT).Currently,the evidence regarding the impact of HBOT on RP and its benefits is *** prospective and randomised studies are necessary to validate HBOT’s effectiveness in the‘real world’clinical *** article reviewed the relevant literature on pathophysiology,clinical presentation,different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBOT.

关键词： Radiation proctitis Radiation proctopathy Radiotherapy Radio-induced lesion Late radiation tissue injury Delayed radiation injury Late sequelae Hyperbaric oxygen therapy Hyperbaric oxygen Review