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Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD

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Genes & Diseases 2024年第3期11卷 34-38页

作者： mj mahesh Kumar shailendra Arindkar masum saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2Dm)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

Impact of microstructural and surface modifications on the Ti-45Nb Alloy’s Response to Bio-Environment

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Acta metallurgica sinica(English Letters) 2024年第7期37卷 1215-1230页

作者： Ivana Cvijović-Alagić slađana Laketić milošmomčilović Jovan Ciganović Jelena Bajat Vesna Kojić Vinča Institute of Nuclear sciences-National Institute of the Republic of serbia University of BelgradeMike Petrovića Alasa 12-1411000BelgradeSerbia Faculty of Technology and metallurgy University of BelgradeKarnegijeva 411000BelgradeSerbia Oncology Institute of Vojvodina Faculty of MedicineUniversity of Novi SadPut Doktora Goldmana 4Sremska Kamenica21204Sremska KamenicaSerbia

The Ti-45Nb (mass%) alloy’s corrosive and biocompatible response in simulated physiological conditions was investigated before and after its additional high-pressure torsion (HPT) and laser irradiation processing. The grain size reduction from 2.76 µm to ~ 200 nm and the appearance of laser-induced morphologically altered and highly oxidized surface led to the significant improvement of alloy corrosion resistance and cell–implant interaction. moreover, an additional increase of the laser pulse energy from 5 to 15 mj during the alloy irradiation in the air led to an increase in the surface oxygen content from 13.64 to 23.89% accompanied by an increase of excellent cell viability from 127.18 to 134.42%. As a result of the controlled alloy microstructural and surface modifications, the formation of protective bi-modal mixed Ti- and Nb-oxide external scale was enabled. The presence of this surface oxide scale enhanced the alloy’s resistance to corrosion deterioration and simultaneously boosted cell viability and proliferation.

关键词： Ti-45Nb alloy High-pressure torsion Laser surface scanning Corrosion resistance Biocompatible properties

Development of an experimental method for well-controlled blast induced traumatic limb fracture in rats

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Defence Technology（防务技术） 2024年第4期34卷 168-176页

作者： Luyang Xu Xiancheng Yu Clement DFavier Ibidumo Igah Thuy-Tien Nguyen Warren macdonald Anthony mj.Bull Centre for Blast Injury studies Imperial College LondonLondonUnited Kingdom Department of Bioengineering Imperial College LondonLondonUnited Kingdom Dyson school of Design Engineering Imperial College LondonLondonUnited Kingdom Department of Trauma and Orthopaedics Royal Free London National Health Service Foundation TrustLondonUnited Kingdom

Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated ***,the mechanisms behind blast-induced HO remain *** models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an *** studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact ***,these models are limited by the survivability of the animal and repeatability of the *** this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast *** platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's *** obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and ***,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled *** further conducted parametric studies by varying the features of the design of the *** factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting *** platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast *** addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.

关键词： Blast injury Biomechanics Heterotopic ossification Limb fracture Blast wave Animal model

Development of an ultrathin liquid sheet target for laser ion acceleration at high repetition rates in the kilohertz range

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High Power Laser science and Engineering 2024年第3期12卷 134-145页

作者： m.Füle A.P.Kovács T.Gilinger m.Karnok P.Gaál s.Figul G.marowsky K.Osvay National Laser-Initiated Transmutation Laboratory University of SzegedSzegedHungary Department of Experimental Physics University of SzegedSzegedHungary ELI ALPs ELI-HU Non-Profit Ltd.SzegedHungary Department of Optics and Quantum Electronics University of SzegedSzegedHungary Advanced microfluidic systems GmbH GöttingenGermany

A colliding microjet liquid sheet target system was developed and tested for pairs of round nozzles of 10,11 and 18μm in *** sheet's position stability was found to be better than a few *** interaction with 50 mj laser pulses,the 18μm jet has a resonance amplitude of 16μm at a repetition rate of 33 Hz,while towards 100 Hz it converges to 10μm for all nozzles.A white-light interferometric system was developed to measure the liquid sheet thickness in the target chamber both in air and in vacuum,with a measurement range of 182 nm±1μm and an accuracy of±3%.The overall shape and 3D shape of the sheet follow the Hasson±Peck model in *** vacuum versus air,the sheet gradually loses 10%of its thickness,so the thinnest sheet achieved was below 200 nm at a vacuum level of 10±4mbar,and remained stable for several hours of operation.

关键词： diagnostics laser ion acceleration nanometric liquid sheet targets vacuum test

Laser processing effects on Ti−45Nb alloy surface,corrosive and biocompatible properties

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Transactions of Nonferrous metals society of China 2024年第8期34卷 2533-2551页

作者： I.CVIJOVIĆ-ALAGIĆ s.LAKETIĆ m.mOmČILOVIĆ J.CIGANOVIĆ Đ.VELJOVIĆ J.BAJAT V.KOJIĆ m.RAKIN Vinča Institute of Nuclear sciences-National Institute of the Republic of serbia University of BelgradeP.O.Box 52211001 BelgradeSerbia Faculty of Technology and metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Oncology Institute of Vojvodina Faculty of MedicineUniversity of Novi SadPut Dr Goldmana 421204 Sremska KamenicaSerbia

The Ti−45Nb(wt.%)alloy properties were investigated in relation to its potential biomedical *** surface modification was utilized to improve its performance in biological *** a result of the laser treatment,(Ti,Nb)O scale was formed and various morphological features appeared on the alloy *** electrochemical behavior of Ti−45Nb alloy in simulated body conditions was evaluated and showed that the alloy was highly resistant to corrosion deterioration regardless of additional laser surface modification ***,the improved corrosion resistance after laser treatment was evident(the corrosion current density of the alloy before laser irradiation was 2.84×10^(−8)A/cm^(2),while that after laser treatment with 5 mj was 0.65×10^(−8)A/cm^(2))and ascribed to the rapid formation of a complex and passivating bi-modal surface oxide *** cytotoxicity and effects of the Ti−45Nb alloy laser surface modification on the mRC-5 cell viability,morphology,and proliferation were also *** Ti−45Nb alloy showed no cytotoxic ***,cells showed improved viability and adherence to the alloy surface after the laser irradiation *** highest average cell viability of 115.37%was attained for the alloy laser-irradiated with 15 *** showed that the laser surface modification can be successfully utilized to significantly improve alloy performance in a biological environment.

关键词： Ti−45Nb alloy laser surface scanning electrochemical properties biocompatibility cell morphology

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Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells:A systematic review

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World Journal of methodology 2024年第2期14卷 134-144页

作者： Vamsi Krishna mundluru mj Naidu Ravi Teja mundluru Naveen Jeyaraman sathish muthu swaminathan Ramasubramanian madhan Jeyaraman Department of Orthopaedics MJ Naidu Super Speciality HospitalVijayawada 520002Andhra PradeshIndia Department of Regenerative medicine StemC ClinicsVijayawada 520002Andhra PradeshIndia Department of Orthopaedics ACS Medical College and HospitalDr.MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

BACKGROUND Adipose-derived stem cells(ADsCs)and the stromal vascular fraction(sVF)have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of *** enzymatic methods for isolating these cells face challenges such as high costs,lengthy processing time,and regulatory *** This systematic review aimed to assess the efficacy and practicality of nonenzymatic,mechanical methods for isolating sVF and ADsCs,comparing these to conventional enzymatic *** Following the Preferred Reporting Items for systematic Reviews and meta-analyses guidelines,a comprehensive literature search was conducted across multiple *** were selected based on inclusion criteria focused on non-enzymatic isolation methods for sVF and ADsCs from adipose *** risk of bias was assessed,and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included *** Nineteen studies met the inclusion criteria,highlighting various mechanical techniques such as centrifugation,vortexing,and ultrasonic *** review identified significant variability in cell yield and viability,and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic *** some advantages of mechanical methods,including reduced processing time and avoidance of enzymatic reagents,the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic *** Non-enzymatic,mechanical methods offer a promising alternative to enzymatic isolation of sVF and ADsCs,potentially simplifying the isolation process and reducing regulatory ***,further research is necessary to standardize these techniques and ensure consistent,high-quality cell yields for clinical *** development of efficient,safe,and reproducible non-enzymatic isolation methods could signi

关键词： Adipose-derived stem cells stromal vascular fraction Regenerative medicine Non-enzymatic isolation mechanical separation techniques

ON sEVERAL NEW mETHODs TO POLAR DECOmPOsITION COmPUTATION

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Acta mechanica solida sinica 1998年第4期11卷 329-340页

作者： Huang, mj Li, m Fu, mF Nanchang Univ Inst Engn Mech Nanchang 330029 Peoples R China

In this paper, the polar decomposition of a deformation gradient tensor is analyzed in detail. The four new methods for polar decompositioncomputation are given: (1) the iterated method, (2) the principal invariant's method, (3) the principal rotation axis' s method, (4) the coordinate transformation's method. The iterated method makes it possible to establish the nonlinear finite element method based on polar decomposition. Furthermore, the material time derivatives of the stretch tensor and the rotation tensor are obtained by explicit and simple expressions.

关键词： polar decomposition deformation gradient stretch tensor rotation tensor large deformation and large rotation

Optimization of the fuel rod＇s arrangement cooled by turbulentnanofluids flow in pressurized water reactor (PWR)

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Chinese Journal of Chemical Engineering 2017年第6期25卷 722-731页

作者： m. Hatami mj.Z. Ganfi I. sohrabiasl D. Jing International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'anJiaotong University Xi'an 710049 China Department of mechanical Engineering Esfarayen University of Technology Esfarayen North Khorasan lran Department of Renewable Energies Engineering Faculty of New Sdences & Technologies University of Tehran Tehran lran Department of mechanical Engineering Babol University of Technology Babol lran

In this paper, response surface methodology(Rsm) based on central composite design(CCD) is applied to obtain an optimization design for the fuel rod's diameter and distance cooled by turbulent Al_2O_3–water nanofluid for a typical pressurized water reactor(PWR). Fuel rods and nanofluid flow between them are simulated 3D using computational fluid dynamics(CFD) by ANsYs-FLUNET package software. The RNG k–ε model is used to simulate turbulent nanofluid flow between the rods. The effect of different nanoparticles concentration is also investigated on the Nusselt number from heat transfer efficiency view point. Results reveal that when distance parameter(a) is in the minimum level and diameter parameter(r) is in the maximum possible level, cooling the rods will be better due to higher Nusselt number in this situation. Also, using the different nanoparticles on the cooling process confirms that Al_2O_3 averagely 17% and TiO_2 10% improve the Nusselt numbers.

关键词： Optimization Fuel rods Nanofluid Pressurized water reactor

Compressive property and energy absorption characteristic of interconnected porous mg-Zn-Y alloys with adjusting Y addition

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Journal of magnesium and Alloys 2024年第1期12卷 171-185页

作者： J.A.Liu s.J.Liu B.Wang W.B.sun X.J.Liu Z.W.Han College of materials science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of Bionic Engineering(ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China Weihai Institute for Bionics-Jilin University Weihai 264205PR China

In this study,interconnected porous mg-2Zn-xY alloys with different phase compositions were prepared by various Y additions(x=0.4,3,and 6 wt.%)to adjust the compressive properties and energy absorption *** characterization methods were then applied to identify the microstructure of the porous mg-Zn-Y and describe the details of the second *** tests were performed at room temperature(RT),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results showed that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different mg-Zn-Y ternary phases appear:I-phase(mg_(3)Zn_(6)Y),W-phase(mg_(3)Zn_(3)Y_(2)),and LPsO phase(mg_(12)ZnY).When the Y content ranges between 0.4%and 6%,the compressive strength increases from 6.30mPa to 9.23 mPa,and the energy absorption capacity increases from 7.33 mj/m^(3)to 10.97 mj/m^(3)at RT,which is mainly attributed to the phase composition and volume fraction of the second ***,the average energy absorption efficiency is independent of the Y *** addition,the compressive deformation behaviors of the porous mg-Zn-Y are altered by the testing *** compressive strength and energy absorption capacity of the porous mg-Zn-Y decrease due to the softening effect of the high temperature on the *** deformation behaviors at different temperatures are finally observed to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements microstructure Compressive behavior Energy absorption characteristic