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Characterization of Rsg2.a3:A new greenbug resistance allele at the Rsg2 locus from wild barley(Hordeum vulgare ***)

The Crop journal 2022年第6期10卷 1727-1732页

作者： Xiangyang Xu Dolores Mornhinweg amy Bernardo Genqiao Li Ruolin Bian Brian j.Steffenson Guihua Bai USDA-ARS Wheat Peanutand Other Field Crop Research UnitStillwaterOK 74075USA USDA-ARS Hard Winter Wheat Genetics Research Unit ManhattanKS 66506USA Department of Plant Pathology Kansas State UniversityManhattanKS 66506USA Department of Plant Pathology University of MinnesotaSt.PaulMN 55108USA

Greenbug(Schizaphis graminum Rondani)is a destructive insect pest that not only damages plants,but also serves as a vector for many *** plant resistance is the preferred strategy for managing *** greenbug resistance genes,Rsg1 and Rsg2,have been reported in *** breed cultivars with effective resistance against various greenbug biotypes,additional resistance genes are urgently needed to sustain barley *** barley accession WBDC053(PI 681777)was previously found to be resistant to several greenbug *** this study,a recombinant inbred line(RIL)population derived from Weskan×WBDC053 was evaluated for response to two greenbug biotypes(E and TX1)and genotyped using genotyping by sequencing(GBS).A set of 3347 high quality GBS-derived single nucleotide polymorphisms(SNPs)were then used to map the greenbug resistance gene in this wild barley *** analysis placed the greenbug resistance gene in a 2.35 Mb interval(0-2,354,645 bp)in the terminal region of the short arm of chromosome *** interval harbors 15 genes with leucine-rich-repeat(LRR)protein *** allelism test indicated that the greenbug resistance gene in WBDC053,designated Rsg2.a3,is likely allelic or closely linked to ***-SNPs 2H_1318811and 2H_1839499 co-segregating with Rsg2.a3 in the RIL population were converted to Kompetitive allele specific PCR(KASP)markers KASP-Rsg2.a3-1 and KASP-Rsg2.a3-2,*** two KASP markers can be used to select Rsg2.a3 and have the potential to tag Rsg2 in barley improvement programs.

关键词： Barley Greenbug resistance gene KASP markers Genotyping by sequencing Linkage mapping

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Adiponectin signalling in bone homeostasis,with age and in disease

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Bone Research 2021年第1期9卷 15-25页

作者： jonathan W.Lewis james R.Edwards amy j.Naylor Helen M.McGettrick Rheumatology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

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Immunostimulation in the era of the metagenome

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Cellular & Molecular Immunology 2011年第3期8卷 213-225页

作者： amy D Proal Paul j Albert Greg P Blaney Inge A Lindseth Chris Benediktsson Trevor G Marshall Murdoch University PerthWAAustralia Weill Cornell Medical College New YorkNYUSA Stillpoint Centre VancouverBCCanada 4M-Klinikken OsloNorway Autoimmunity Research Foundation Thousand OaksCAUSA

Microbes are increasingly being implicated in autoimmune *** calls for a re-evaluation of how these chronic inflammatory illnesses are routinely *** standard of care for autoimmune disease remains the use of medications that slow the immune response,while treatments aimed at eradicating microbes seek the exact opposite-stimulation of the innate immune *** is complicated by a cascade of sequelae,including exacerbated inflammation,which occurs in response to microbial *** the past 8 years,we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory *** intervention,designed to stimulate the innate immune response,has required a reevaluation of disease progression and *** is the inherent conflict between palliation and microbicidal *** microbicidal activity was experienced as immunopathology-a temporary worsening of *** studies are needed,but they will require careful planning to manage this immunopathology.

关键词： antimicrobial peptides autoimmune disease immune reconstitution inflammatory syndrome immunopathology innate immunity metagenomics

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Do introduced honeybees affect seed set and seed quality in a plant adapted for bird pollination?

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journal of Plant Ecology 2017年第4期10卷 721-729页

作者： amy-Marie Gilpin justin C.Collette Andrew j.Denham Mark K.j.Ooi David j.Ayre Centre for Sustainable Ecosystem Solutions School of Biological SciencesUniversity of WollongongNorthfields AvenueWollongongNSW 2522Australia NSW Department of Premier and Cabinet Office of Environment and HeritagePO Box 1967HurstvilleNSW 2220Australia Centre for Ecosystem Science School of BiologicalEarth and Environmental SciencesUniversity of New South WalesSydneyNSW 2052Australia

Aims Worldwide,evidence suggests that exotic pollinators can disrupt plant mating ***,few studies have determined if pol-lination by the honeybee Apis mellifera(the world’s most widely introduced pollinator)reduces offspring quality when compared with pollination by native *** Australian Proteaceae provides an excellent opportunity to test the impact of honeybees in pol-lination systems that are adapted to birds and non-flying *** We compared the frequency of flower visitation and foraging behav-iour of birds and insects within seven populations of Banksia *** ericifolia is hermaphroditic and has large nectar-rich,orange inflorescences typical of bird and mammal pollinated *** a subset of the study populations,we compared the qual-ity of seed produced via an exclusion treatment(that only allowed invertebrates to access flowers)with an open-pollination treatment(potentially visited by mammals,birds and invertebrates),by meas-uring seed weight,germination rates(T50),percent germination,seedling height after 14 days since the emergence of the cotyledon and time to emergence of the *** Findings Apis mellifera was the only apparent insect pollinator and the most frequent flower visitor,while the open treatment inflorescences were also frequently visited by avian pollinators,primarily hone-yeater *** foraging behaviour of honeybees and honeyeat-ers showed striking differences that potentially affect patterns of pollen *** made significantly greater proportions of within *** plant movements and only 30%(n=48)of honeybees foraged for pollen(nectar foragers carried no pollen)whilst all birds were observed to contact both stigmas and anthers when foraging for *** these fundamental differences in behaviour,there was little effect of treatment on seed set or *** data show that while honeybees appear to alter patterns of pollen transfer within *** popu

关键词： Apis mellifera Banksia ericifolia Proteaceae seedling performance seed vigour

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Moving beyond Wastewater:Perspectives on Environmental Surveillance of Infectious Diseases for Public Health Action in Low-Resource Settings

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Environment & Health 2024年第10期2卷 684-687页

作者： jeseth Delgado Vela Sarah E.Philo joe Brown Mami Taniuchi Molly Cantrell Alexandra Kossik Maya Ramaswamy Sitara SR Ajjampur Fatma Z.Guerfali Rochelle H.Holm john Scott Meschke Maria Catherine B.Otero amy j.Pickering Mahbubur Rahman Alexander G.Shaw Abhilasha Shrestha Kwanrawee Sirikanchana Vivi Maketa Tevuzula Rolf U.Halden Alexandria B.Boehm Kyle Bibby Department of Civil and Environmental Engineering Duke UniversityDurhamNorth Carolina 27710United States Department of Civil and Environmental Engineering and Earth Sciences University of Notre DameSouth BendIndiana 46556United States Department of Civil and Environmental Engineering University of Southern California Los AngelesCA 90007USA Department of Environmental Sciences and Engineering University of North Carolina at Chapel HillChapel HillNorth Carolina 27599United States Division of Infectious Diseases and International Health University of VirginiaCharlottesvilleVirginia 22903United States Waterborne Disease Prevention Branch U.S.Centers for Disease ControlAtlantaGeorgia 30329United States The Wellcome Trust Research Laboratory Christian Medical CollegeVellore 632004India Laboratory of Transmission Control and Immunobiology of Infections(LTCII)Institut Pasteur de TunisTunis-Belvédère 1002Tunisia UniversitéTunis El Manar Tunis 1002Tunisia Christina Lee Brown Envirome Institute School of MedicineUniversity of LouisvilleLouisvilleKentucky 40202United States Department of Environmental and Occupational Health Sciences School of Public HealthUniversity of WashingtonSeattleWashington 98195United States College of Medicine University of the Philippines ManilaManila 2801Philippines Department of Civil and Environmental Engineering University of CaliforniaBerkeleyBerkeleyCalifornia 94720United States Institute of Epidemiology Disease Control and Research(IEDCR)Dhaka 1212Bangladesh Department of Infectious Disease Epidemiology Imperial College LondonLondon SW72AZU.K. Division of Environmental and Occupational Health Sciences University of Illinois Chicago School of Public HealthChicagoIllinois 60612United States Research Laboratory of Biotechnology Chulabhorn Research InstituteBangkok 10210Thailand Department of Tropical Medicine University of KinshasaKinshasa/DR 63090201Congo School of Sustainable Engineering and the Built Environment Arizona State UniversityTempe

Although testing wastewater for public health surveillance has recently received significant attention in the United States,researchers and public health professionals have long realized the tremendous promise of environmental surveillance(ES),defined as tracking pathogens of interest in fecally contaminated surface waters,soil,or fomites,in low-resource settings for public health action.1,2 The power of ES in lowresource settings is most clearly illustrated with the over 30 years of well-established and standardized polio *** part of the Global Polio Eradication Initiative,the World Health Organization(WHO)has accredited 146 laboratories within the Global Polio Lab Network(GPLN).These facilities across 92 countries process over 8,000 wastewater or fecally contaminated surface water samples per year,in addition to over 220,000 stool samples annually.3 The data generated from the GPLN are closely linked to clear public health action related to targeted vaccination *** investment and adoption of ES for polio eradication efforts serves as a use-case for other targets of *** explore the current state of the field,the National Science Foundation-funded Research Coordination Network(RCN)on Wastewater Based Epidemiology for SARS-CoV-2 and Emerging Public Health Threats held a workshop in December 2023 to discuss the opportunities and challenges for ES in low-resource settings(Figure 1).Discussions during the workshop highlighted knowledge gaps,best-practices,target selection,academic/government/private partnerships and overall public health action and sustainability of these programs.

关键词： wastewater Wastewater annually

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A ONE-STOP LOGISTIC SERVICES FRAMEWORK SUPPORTING GLOBAL SUPPLY CHAIN COLLABORATION

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journal of Systems Science and Systems Engineering 2016年第2期25卷 229-253页

作者： amy j.C. Trappey Charles V. Trappey Sandy W.C. Chang W.T. Lee Tun Nien Hsu Department of Industrial Engineering and Engineering Management National Tsing Hua University Hsinchu Taiwan China Department of Management Science National Chiao Tung University Taiwan China Technology Center for Service Industries Industrial Technology Research Institute Taiwan China

A global enterprise must continuously improve the efficiency of logistic operations between supply chain collaborators. Integrating logistic services, resources, and necessary information flows in the supply chain to ensure efficiency and efficacy is critically important to these companies. Global logistic service companies face challenges from their clients to provide logistic services that are cost effective, accurate, and seamlessly integrate material, information and cash flows. In this research, an improved framework for one-stop logistic services is systematically designed, analyzed, and evaluated. The one-stop logistic service framework, defmed in four models, is developed to provide enterprises with integrated and comprehensive services within the global supply chain context. The levels of service importance are assessed using a four categories questionnaire. This research provides a case study of the implementation of one-stop logistic services in the distribution industry and demonstrates the framework operating under different demand conditions. Finally, system dynamics causal evaluation is used to evaluate the advantages of the logistic service framework.

关键词： One-stop logistic services logistic management supply chain management system dynamics modeling

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Protease supplementation reduced the heat increment of feed and improved energy and nitrogen partitioning in broilers fed maize-based diets with supplemental phytase and xylanase

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Animal Nutrition 2022年第3期10卷 19-25页

作者： Klint W.McCafferty Mingan Choct Sosthene Musigwa Natalie K.Morgan Aaron j.Cowieson amy F.Moss USDA-ARS Poultry Research Unit School of Environmental and Rural SciencesMississippi State39762United States University of New England ArmidaleNSW2351Australia DSM Nutritional Products Kaiseraugst4303Switzerland

An experiment was conducted to explore the effects of digestible amino acid(dAA)concentrations and supplemental protease on live performance and energy partitioning in *** 308 male broilers(n?288)were distributed into 24 floor pens and offered 1 of 4 dietary treatments with 6 replicates from 1 to 35 d of *** treatments consisted of a 2×2 factorial arrangement with dAA concentrations(standard and reduced[34 g/kg below standard])and supplemental protease(without or with)as the main *** 1,15,28,and 35 d of age,feed and broilerswereweighed to determine live ***20 to 23 d of age,a total of 32 birds(2 birds/chamber,4 replicates)were placed in closed-calorimeter chambers to determine respiratory exchange(heat production,HP),apparent metabolisable energy(AME),retained energy(RE),and net energy(NE).From 29 to 35 d of age,supplemental protease in the reduced-dAA diet decreased broiler feed conversion ratio(FCR)by 5.6 points,whereas protease supplementation in the standard-dAA diet increased FCR by 5.8 *** indirect calorimetry assay revealed that supplemental protease decreased(Pj/***,from 20 to 23 d of age,broilers offered the reduced-dAA diet with supplemental protease had a higher daily body weight gain(BWG)(t10.4%),N intake(t7.1%),and N retention(t8.2%)than those offered the standard-dAA with supplemental *** offered the reduced-dAA without supplemental protease exhibited a 3.6%higher AME-to-crude protein(CP)ratio than those offered other *** supplementation in the standard-and reduced-dAA diets resulted in 2.7%and 5.6%lower AME intake-to-N retention ratios,respectively,compared with the unsupplemented ***-dAA increased(P<0.05)AME intake(t4.8%),RE(t9.8%),NE intake(t5.8%),NE intake-to-CP ratio(t3.0%),and RE fat-to-RE ratio(t8.6%).Protease supplementation increased(P<0.05)respiratory quotient(t1.2%)and N retention-to-N intake ratio(t2.2%),

关键词： Exogenous enzyme Mono-component protease Net energy Amino acid

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Incidence and consequences of varicella in children treated for cancer in Guatemala

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世界儿科杂志:英文版 2016年第3期12卷 320-326页

作者： amy E.Caruso Brown Edwin j.Asturias Mario Melgar Federico A.Antillon-Klussmann Pamela Mettler Myron j.Levin Center for Bioethics and Humanities and Department of Pediatrics SUNY Upstate Medical University Center for Global Health and Department of Epidemiology Colorado School of Public HealthAuroraColoradoUSA National Unit of Pediatric Oncology Guatemala CityGuatemala Department of Biostatistics and Informatics Colorado Biostatistics ConsortiumColorado School of Public HealthAuroraColoradoUSA Section of Pediatric Infectious Diseases Department of PediatricsUniversity of Colorado Denver Anschutz Medical CampusAuroraColoradoUSA

Background:Varicella-zoster virus infection is associated with significant morbidity and mortality in immune-compromised children,despite treatment with antiviral *** varicella vaccine programs have significantly decreased this risk in many highincome countries,but in most low-income and middleincome countries,the burden of varicella in children treated for malignancy is poorly defi ***:We retrospectively reviewed records of children at the National Unit of Pediatric Oncology(UNOP)in Guatemala diagnosed with varicella between january 2009 and March 2013 in order to calculate incidence of varicella and evaluate morbidity,mortality,treatment interruption,and ***:Fifty-nine cases of varicella were *** was 23.4 cases per 1000 person-years(p-y).66.1%of cases occurred in children with leukemia(median age 5.2 years;interquantile range 3.4-7 years)and 41.0%of these occurred during maintenance *** of exposure was identified for 14/59(23.7%)*** were hospitalized(71.2%)and given intravenous acyclovir(64.4%).Eight(13.6%)children required critical care,and two(3.4%)died from disseminated varicella with multiorgan *** was delayed or omitted due to varicella in 50%.No signifi cant differences in outcomes based on nutritional and immunologic status were *** minimum average cost of treatment per episode was 598.75 ***:Varicella is a significant problem in children treated for cancer in Guatemala,where effective post-exposure prophylaxis is *** the absence of universal varicella vaccination,strategies to improve recognition of exposure and the future use of novel inactivated vaccines currently under investigation in clinical trials could mitigate this burden.

关键词： cancer developing countries immunocompromised host oncology varicella

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Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

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Translational Neurodegeneration 2015年第1期4卷 205-208页

作者： Gonzalo j.Revuelta Aaron Embry jordan j.Elm Chris Gregory amy Delambo Steve Kautz Vanessa K.Hinson Movement Disorders Division Department of NeurologyCollege of MedicineMedical University of South Carolina208B Rutledge AvenueMSC 108CharlestonSC 29425USA Department of Health Sciences and Research Center for Rehabilitation Research in Neurological ConditionsCollege of Health ProfessionsMedical University of South CarolinaCharlestonSCUSA Department of Public Health Sciences College of MedicineMedical University of South CarolinaCharlestonSC 29425USA Ralph H.johnson VA Medical Center CharlestonSCUSA

Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic *** pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for objective gait ***:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot *** included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual ***,and subjective assessments of gait,quality of life,and safety were also *** primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary *** gait analysis protocol correlated well with clinical scales,but not with subjective *** patients were more likely to increase gait velocity(p=0.033),and improved in other clinical ***:Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subjective *** findings can inform future trials in this population.

关键词： Parkinson’s disease Freezing of gait Noradrenaline Atomoxetine Dopa-response

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Delayed gastric emptying following pancreaticoduodenectomy:Incidence,risk factors,and healthcare utilization

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World journal of Gastrointestinal Surgery 2017年第3期9卷 73-81页

作者： Somala Mohammed George Van Buren II amy Mc Elhany Eric j Silberfein William E Fisher Elkins Pancreas Center Michael E DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030United States

AIM To characterize incidence and risk factors for delayed gastric emptying(DGE) following pancreaticoduodenectomy and examine its implications on healthcare utilization. METHODS A prospectively-maintained database was reviewed. DGE was classified using International Study Group of Pancreatic Surgery criteria. Patients who developed DGE and those who did not were compared. RESULTS Two hundred and seventy-six patients underwent pancreaticoduodenectomy(PD)(> 80% pyloruspreserving, antecolic-reconstruction). DGE developed in 49 patients(17.8%): 5.1% grade B, 3.6% grade C. Demographic, clinical, and operative variables were similar between patients with DGE and those without. DGE patients were more likely to present multiplecomplications(32.6% vs 4.4%, ≥ 3 complications, P < 0.001), including postoperative pancreatic fistula(POPF)(42.9% vs 18.9%, P = 0.001) and intra-abdominal abscess(IAA)(16.3% vs 4.0%, P = 0.012). Patients with DGE had longer hospital stay(median, 12 d vs 7 d, P < 0.001) and were more likely to require transitional care upon discharge(24.5% vs 6.6%, P < 0.001). On multivariate analysis, predictors for DGE included POPF [OR = 3.39(1.35-8.52), P = 0.009] and IAA [OR = 1.51(1.03-2.22), P = 0.035].CONCLUSION Although DGE occurred in < 20% of patients after PD, it was associated with increased healthcare utilization. Patients with POPF and IAA were at risk for DGE. Anticipating DGE can help individualize care and allocate resources to high-risk patients.

关键词： Delayed gastric emptying Pancreaticoduodenectomy Post-operative pancreatic fistula

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