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Stressful life events,psychosocial health and general health in preschool children before age 4

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World Journal of Pediatrics 2023年第3期19卷 243-250页

作者： Jie Luo amy van Grieken Shuang Zhou Yuan Fang Hein Raat Department of Public Health Erasmus MCDr.Molewaterplein 403015 GD RotterdamThe Netherlands Department of Maternal and Child Health School of Public HealthPeking UniversityBeijingChina

Background The impact of stressful life events(SLEs)in early childhood is often *** aimed to examine longitudinal associations between SLEs and psychosocial and general health in preschool *** Twelve SLEs occurring before the age of 24 months were assessed and categorized by frequency(no events,1-2 SLEs,and>2 SLEs)and overall tension(no events,low,and high)(n=1431).Psychosocial and general health were meas-ured three times at the age of 24,36 and 45 *** associations were examined by logistic regression models using generalized estimating equations to handle repeated *** Half(48.4%)of the families experienced SLEs,and 23.8%perceived high-tension SLEs before the children were aged 24 *** differences were observed in the association between SLEs and psychosocial *** to girls without SLEs,girls who experienced>2 SLEs[OR=3.31,95%confidence interval(CI)2.05-5.35]or high-tension SLEs(OR=3.01,95%CI 2.07-4.39)had higher odds of psychosocial problems from 24 to 45 *** odds ratios in boys were 2.10(95%CI 1.36-3.24)and 1.47(95%CI 1.06-2.03),***,only girls'risk of psychosocial problems increased after experiencing 1-2 SLEs(OR=2.15,95%CI 1.54-3.00)or low-tension SLEs(OR=1.90,95%CI 1.31-2.74).Regarding general health,children who experienced>2 SLEs(OR=1.96,95%CI 1.21-3.18)and high-tension SLEs(OR=1.60,95%CI 1.12-2.28)had higher odds of poor general health from 24 to 45 *** The findings emphasized that young children's psychosocial and general health can be impacted by experienc-ing SLEs in early *** and adequate support for families experiencing SLEs are needed to minimize the potential negative effect of SLEs on child health,particularly in girls.

关键词： Child health Preschool children Stressful life event

Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants

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Journal of Pharmaceutical Analysis 2022年第1期12卷 58-64页

作者： Deepa Raghu Pamela Hamill Arpitha Banaji amy McLaren Yu-Ting Hsu Product Characterization MilliporeSigmaRockvilleMD20850USA Product Characterization MilliporeSigmaStirlingFK94NFUK Process and Analytical Development MilliporeSigmaSt.LouisMO63118USA

Severe acute respiratory syndrome-associated coronavirus 2 is a major global health issue and is driving the need for new *** surface spike protein,which plays a central role in virus infection,is currently the target for vaccines and neutralizing *** emergence of novel variants with multiple mutations in the spike protein may reduce the effectiveness of neutralizing antibodies by altering the binding activity of the protein with angiotensin-converting enzyme 2(ACE2).To understand the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody(mAb)therapies,the binding activities of the original spike protein receptor binding domain(RBD)sequence and the reported spike protein variants were investigated using surface plasmon *** addition,the interactions of the ACE2 receptor,an antispike mAb(mAb1),a neutralizing mAb(mAb2),the original spike RBD sequence,and mutants D614G,N501Y,N439K,Y453F,and E484K were *** to the original RBD,the Y453F and N501Y mutants displayed a significant increase in ACE2 binding affinity,whereas D614G had a substantial reduction in binding *** mAb-RBD mutant proteins displayed a reduction in binding affinities relative to the original RBD,except for the E484K-mAb1 *** potential neutralizing capability of mAb1 and mAb2 was ***,mAb1 failed to inhibit the ACE2-RBD interaction while mAb2 inhibited the ACE2-RBD interactions for all RBD mutants,except mutant E484K,which only displayed partial blocking.

关键词： Surface plasmon resonance SARS-CoV-2 Monoclonal antibody RBD ACE2

Neurovascular unit in diabetic retinopathy:pathophysiological roles and potential therapeutical targets

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Eye and Vision 2021年第3期8卷 135-153页

作者： Shen Nian amy C.Y.Lo Yajing Mi Kai Ren Di Yang Department of Pathology Xi’an Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong KongHong Kong Institute of Basic Medicine Science Xi’an Medical UniversityXi’anShaanxi ProvinceChina Department of Biochemistry and Molecular Biology Xi’an Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming Medical UniversityKunmingYunnan ProvinceChina

Diabetic retinopathy(DR),one of the common complications of diabetes,is the leading cause of visual loss in working-age individuals in many industrialized *** has been traditionally regarded as a purely microvascular disease in the ***,an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the *** of neural retina could precede microvascular abnormalities in the DR,leading to microvascular ***,disruption of interactions among neurons,vascular cells,glia and local immune cells,which collectively form the neurovascular unit,is considered to be associated with the progression of DR early on in the ***,it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration,neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage ***,we present current perspectives on the pathophysiology of DR as a neurovascular disease,especially at the early *** novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well.

关键词： Diabetic retinopathy Neurovascular unit Neurodegeneration Gliosis Inflammation treatment

Hodgkin's lymphoma coexisting with liver failure secondary to acute on chronic hepatitis B

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World Journal of Clinical Cases 2013年第1期1卷 37-40页

作者： Renee Palta amy McClune Karl Esrason Division of Gastrointestinal and Liver Disease Department of Transplant Hepatology Kaiser Permanente Los Angeles Medical Center Los Angeles CA 90027 United States Division of Hepatology University of California Los Angeles CA 94607 United States

Acute on chronic liver failure(ACLF) is rarely the initial manifestation of a malignant process or precipitated by the initiation of anti-viral treatment with a nucleoside or nucleotide agent. We report an unusual case of ACLF temporally associated with initiation of Entecavir for treatment of chronic hepatitis B. Early Hodgkin's lymphoma(HL) was unmasked with initiation of the antiviral treatment which may have exacerbated ACLF. To the best of our knowledge, this has not been described in the literature. In reviewing our patients clinical course and liver autopsy, he developed a severe acute exacerbation of his chronic hepatitis B virus coinciding with the institution of antiviral therapy and the underlying HL perhaps modulating the overall degree of hepatic injury.

关键词： Entecavir Hepatic flare Fulminant hepatic failure Chronic hepatitis Acute liver failure Hodgkin’s lymphoma

RE-ENGINEERING TRANSFORMER MAINTENANCE PROCESSES TO IMPROVE CUSTOMIZED SERVICE DELIVERY

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Journal of Systems Science and Systems Engineering 2011年第3期20卷 323-345页

作者： amy J.C. TRAPPEY Yong SUN Charles V. TRAPPEY Lin MA Department of Industrial Engineering and Engineering Management National Tsing Hua University Taiwan China Department of Industrial Engineering and Management National Taipei University of Technology Taiwan China School of Engineering Systems Queensland University of Technology Australia Department of Management Science National Chiao Tung University Taiwan China

The outage of a transformer in a power generation system will generally result in a shutdown of the entire system. Consequentially, large amounts of revenue are lost to the plant owner with a substantial negative impact on the civil community and industrial customers. This paper analyzes the current maintenance practices （i.e., an as-is process model） of a transformer manufacturing company, which provides maintenance services to power generation plants and reports the major weaknesses in current business practices. The maintenance weaknesses include isolated processes and paper based information communication. These inefficient processes result in service delays, cost increases, and inappropriate responses to customers＇ specific requests and complaints. To improve the efficiency and flexibility of the entire transformer maintenance service system, an e-integration approach is implemented with three key tasks. First, the current business processes are re-engineered to provide an improved （to-be） business model. Then, we replace paper based documentation methods with an electronic filing system for efficient and cost-effective information exchange. Afterward, the improved process model is implemented as an Internet based system to enhance the interactions among the transformer manufacturer, end-users, and service contractors for customized maintenance services. The case study demonstrates that implementing the e-integration approach increases the efficiency and effectiveness of the customized maintenance services.

关键词： Business Processes Reengineering (BPR) asset maintenance power industry after-sales services transformers engineering

Lipid reserves and immune defense in healthy and diseased migrating monarchs Danaus plexippus

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Current Zoology 2013年第3期59卷 393-402页

作者： Dara A. SATTERFIELD amy E. WRIGHT Sonia ALTIZER Odum School of Ecology University of Georgia Athens GA 30602 USA

Recent studies suggest that the energetic demands of long-distance migration might lower the pool of resources available for costly immune defenses. Moreover, migration could amplify the costs of parasitism if animals suffering from para- site-induced damage or depleted energy reserves are less able to migrate long distances. We investigated relationships between long-distance migration, infection, and immunity in wild fall-migrating monarch butterflies Danaus plexippus. Monarchs migrate annually from eastern North America to central Mexico, accumulating lipids essential for migration and winter survival as they travel southward. Monarchs are commonly infected by the debilitating protozoan parasite Ophryocystis elektroscirrha （OE）. We collected data on lipid reserves, parasite loads, and two immune measures （hemocyte concentration and phenoloxidase activity） from wild monarchs migrating through north GA （USA） to ask whether （1） parasite infection negatively affects lipid reserves, and （2） greater investment in lipid reserves is associated with lower immune measures. Results showed that monarchs sampled later in the fall migration had lower but not significantly different immune measures and significantly higher lipid reserves than those sampled earlier. Lipid measures correlated negatively but only nearly significantly with one measure of immune defense （phenoloxidase activity） in both healthy and infected monarchs, but did not depend on monarch infection status or parasite load. These results provide weak support for a trade-off between energy reserves and immune defense in migrants, and suggest that previously-demonstrated costs of OE infection for monarch migration are not caused by depleted lipid reserves .

关键词： Butterfly Hemocytes Migration Neogregarine Infection Energy reserves

Nidogen:A matrix protein with potential roles in musculoskeletal tissue regeneration

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Genes & Diseases 2022年第3期9卷 598-609页

作者： Sheng Zhou Song Chen Yixuan amy Pei Ming Pei Stem Cell and Tissue Engineering Laboratory Department of OrthopaedicsWest Virginia UniversityMorgantownWV 26506USA Department of Orthopaedics The GeneraLHospital of Western Theater CommandChengduSichuan 610083PR China WVU Cancer Institute Robert C.Byrd Health Sciences CenterWest Virginia UniversityMorgantownWV 26506USA

Basement membrane proteins are known to guide cell structures,differentiation,and tissue *** there is a wealth of knowledge on the functions of laminins,per-lecan,and type IV collagen in maintaining tissue homeostasis,not much is known about *** a key molecule in the basement membrane,nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific *** this review,the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development;the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration,including but not limited to adipogenesis,angiogenesis,chondrogenesis,myogenesis,and ***,potential mechanisms underlying the role of nidogens in stem cell-based tissue regeneration are also *** concise review is expected to facilitate our existing understanding and utilization of nidogen in tissue engineering and regeneration.

关键词： Adipose Basement membrane Cartilage Differentiation Nerve Nidogens Vessel

Methodology in coronary artery bypass surgery quality assessment

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Journal of Geriatric Cardiology 2022年第11期19卷 867-875页

作者： Zhongmin Li Nicole Shirakawa amy Chen Fu-Hai Ji Hong Liu Department of Anesthesiology and Pain Medicine University of California Davis HealthSacramentoUSA Department of Anesthesiology First Affiliated Hospital of Soochow UniversitySuzhouChina

Coronary artery bypass graft(CABG)is associated with a high risk of mortality and morbidity;thus,assessment of surgery quality is *** this perspective,we will focus on the structure,process,and outcomes measured as quality assessment.A set of 21 evidence-based structure,process,and outcome measures were selected as National Quality *** these,the Society of Thoracic Surgeons ultimately chose 11 individual quality measures grouped them into four domains used to assess the quality of *** four domains consisted of perioperative medical care,operative care,risk-adjusted operative mortality and postoperative risk-adjusted major *** measures have been useful as quality improvement tools in assessing the quality of CABG surgery.

关键词： bypass surgery mortality

Effect of growing media and their constituents on fungus gnat, Bradysia sp, nr, coprophila （Lintner） adults

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Insect Science 2007年第6期14卷 467-475页

作者： RAYMOND A. CLOYD amy DICKINSON RICHARD A. LARSON KAREN A. MARLEY Department of Entomology Kansas State University Manhattan Kansas Division of Biodiversity and Ecological Entomology Illinois Natural History Survey Champaign Illinois University of Illinois Department of Natural Resources and Environmental Sciences Urbana Illinois USA

This study was conducted to determine the attractiveness of two growing media, commonly utilized in greenhouses, to fungus gnat, Bradysia sp. nr. coprophila adults. The constituents of the most attractive growing medium tested were determined by gas chromatography analysis using a steam-distillation procedure. We found that fungus gnat adults were more attracted to the growing medium, SB300 Universal Professional Growing Mix, which contains composted bark, than to another growing medium （Sunshine LC1 Mix） and their components when tested in a series of laboratory experiments using multiple-choice experimental arenas. A higher percentage of fungus gnat adults were attracted to moist SB300 （92%） than SB300 growing medium that had been oven dried （8%）. In addition, fungus gnat adults preferred SB300 although they had been reared on Sunshine LC1 Mix. When comparing the SB300 fresh from the bag to growing medium that had been pasteurized and moistened with water, gas chromatographic-mass spectroscopic data showed there were declines in several terpenoid constituents as well as an increase in fatty acids and cyclosulfur. The results of this study indicate that B. sp. nr. coprophila adults prefer certain growing media, which may assist greenhouse producers in managing fungus gnats in crop production systems.

关键词： Attraction fungus gnats growing medium pest management preference,steam distillation