Neurovascular unit in diabetic retinopathy:pathophysiological roles and potential therapeutical targets

作     者：Shen Nian Amy C.Y.Lo Yajing Mi Kai Ren Di Yang Shen Nian;Amy C.Y.Lo;Yajing Mi;Kai Ren;Di Yang

作者机构：Department of PathologyXi’an Medical UniversityXi’anShaanxi ProvinceChina Department of OphthalmologyLKS Faculty of MedicineThe University of Hong KongHong KongHong Kong Institute of Basic Medicine ScienceXi’an Medical UniversityXi’anShaanxi ProvinceChina Department of Biochemistry and Molecular BiologyXi’an Medical UniversityXi’anShaanxi ProvinceChina Department of OphthalmologyFirst Affiliated Hospital of Kunming Medical UniversityKunming Medical UniversityKunmingYunnan ProvinceChina 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2021年第8卷第3期

页      面：135-153页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100212[医学-眼科学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81873740,81860174) Natural Science Basic Research Plan of Shaanxi Province(2020JM-612) Applied Basic Research Program of Yunnan Province(2017FE468(-143)) National Fund Cultivation Project in Xi’an Medical University(2017GJFY29) 

主　　题：Diabetic retinopathy Neurovascular unit Neurodegeneration Gliosis Inflammation treatment 

摘      要：Diabetic retinopathy(DR),one of the common complications of diabetes,is the leading cause of visual loss in working-age individuals in many industrialized *** has been traditionally regarded as a purely microvascular disease in the ***,an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the *** of neural retina could precede microvascular abnormalities in the DR,leading to microvascular ***,disruption of interactions among neurons,vascular cells,glia and local immune cells,which collectively form the neurovascular unit,is considered to be associated with the progression of DR early on in the ***,it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration,neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage ***,we present current perspectives on the pathophysiology of DR as a neurovascular disease,especially at the early *** novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well.