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Horticulture Research 2021年第1期8卷 2404-2415页

作者： Greg S.Goralogia Glenn T.Howe amy m.brunner Emily Helliwell michael F.Nagle Cathleen ma Haiwei Lu Amanda L.Goddard Anna C.magnuson amy L.Klocko Steven H.Strauss Department of Forest Ecosystems and Society Oregon State UniversityCorvallisORUSA Department of Forest Resources and Environmental Conservation Virginia TechBlacksburgVAUSA Department of Biology University of Colorado Colorado SpringsColorado SpringsCOUSA

The spread of transgenes and exotic germplasm from planted crops into wild or feral species is a difficult problem for public and regulatory acceptance of genetically engineered plants,particularly for wind-pollinated trees such as *** report that overexpression of a poplar homolog of the floral repressor SHORT VEGETATIVE PHASE-LIKE(SVL),a homolog of the Arabidopsis mADS-box repressor SHORT VEGETATIVE PHASE(SVP),delayed the onset of flowering several years in three genotypes of field-grown transgenic *** expression of SVL correlated with a delay in flowering onset and lower floral abundance,and did not cause morphologically obvious or statistically significant effects on leaf characteristics,tree form,or stem *** effects on reproductive and vegetative phenology in spring was modest and *** results suggest that use of SVL and related floral repressors can be useful tools to enable a high level of containment for vegetatively propagated short-rotation woody energy or pulp crops.

关键词： field planted crops

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中草药 2024年第1期55卷 181-189页

作者：崔高畅 amy Yi Hsan Saik 张新慧马玉玮杨早东姑阿都拉曼大学m.Kandiah医学与健康科学学院雪兰莪加影43000 宁夏医科大学药学院宁夏银川750004

目的利用生物信息学方法筛选湿性年龄相关性黄斑变性(wet age-related macular degeneration,w AmD)的氧化应激相关差异表达基因及靶向中药,以期为wAmD的预防和治疗提供新思路。方法从GEO数据库中筛选数据集,利用R软件limma包筛选差异基... 详细信息

目的利用生物信息学方法筛选湿性年龄相关性黄斑变性(wet age-related macular degeneration,w AmD)的氧化应激相关差异表达基因及靶向中药,以期为wAmD的预防和治疗提供新思路。方法从GEO数据库中筛选数据集,利用R软件limma包筛选差异基因,从Genecard数据库筛选氧化应激差异基因,并利用韦恩图得到共有基因。应用metascape对氧化应激差异基因进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)分析,并通过String数据库构建蛋白质相互作用(protein-protein interaction,PPI)网络,再通过Cytoscape软件筛选出wAmD中氧化应激的关键(Hub)基因。采用GSE103060数据集验证Hub基因的差异表达。利用Coremine medical预测靶向中药。结果经筛选共得到差异表达基因1874个,其中上调基因747个,下调基因1127个。KEGG富集分析表明,差异表达基因主要富集于细胞外基质受体相互作用、黏附斑激酶通路、河马(Hippo)信号通路、晚期糖基化终末产物-晚期糖基化终末产物受体(advanced glycation end products-receptor for advanced glycation end products,AGE-RAGE)信号通路、钙信号通路和磷脂酰肌醇-3-羟激酶(phosphatidylinositol-3-hydroxykinase,PI3K)/蛋白激酶B(protein kinase B,Akt)信号通路。通过PPI网络筛选得到与w AmD氧化应激密切相关的8个Hub基因,分别为IL6、EGFR、HIF1A、APOE、FN1、PPARG、EDN1和NGF。最后在GSE103060数据集中验证了以上Hub基因的显著差异表达。利用Coremine medical预测人参、黄芪、枸杞子、丹参、银杏叶等可作为预防或治疗wAmD的靶向中药。结论通过对w AmD芯片的挖掘和生物信息分析,差异基因主要富集于氧化应激的相关通路与wAmD的氧化应激相关基因引起的。防治wAmD的首选中药为人参、黄芪、枸杞子、丹参和银杏叶等26种。这将对理解和探索wAmD的中医药防治策略有重要意义。

关键词：生物信息学湿性年龄相关性黄斑变性氧化应激中药筛选人参黄芪枸杞子丹参银杏叶

Impower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang amy Cai Lilian Bu Jane Shi Jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: Impower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: Impower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

Natural regeneration responses to thinning and burning treatments in ponderosa pine forests and implications for restoration

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Journal of Forestry Research 2022年第3期33卷 741-753页

作者： Tzeidle N.Wasserman amy E.m.Waltz John Paul Roccaforte Judith D.Springer Joseph E.Crouse Ecological Restoration Institute Northern Arizona UniversityP.O.Box 15017FlagstaffAZ86011-5017USA

Understanding naturally occurring pine regeneration dynamics in response to thinning and burning treatments is necessary not only to measure the longevity of the restoration or fuels treatment,but also to assess how well regeneration meets forest sustainability guidelines and whether natural regeneration is sufficient for maintaining a sustainable forest structure and composition.A synthesis review was carried out on the effects of mechanical thinning and prescribed burn treatments on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United *** focus was on site-specific variability in pine regeneration dynamics,temporal trends in regeneration presence and abundance,and response to treatment as described in the current literature using 29 studies that met our evidence-based review *** showed that the effects of thinning and burning treatments on regeneration depended on time since *** thinning,prescribed burning,and thinning plus burn treatments all increased seedling density,but there was high variability among sites and *** were mixed results in the short-term(m studies(>20 years)concluded that stands can return to pre-treatment densities in terms of total trees per hectare and forest floor duff levels when there are no maintenance treatments *** studies showed the average ponderosa pine seedling presence,survival and growth found in today’s forests to be at a high density;this combined with missed fire cycles could contribute to future fire risk and reduce the efficacy of maintaining fuel reduction goals.

关键词： Regeneration Ponderosa pine Frequent-fire Treatments Thinning Burning

Formation potential and analysis of 32 regulated and unregulated disinfection by-products: Two new simplified methods

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Journal of Environmental Sciences 2022年第7期34卷 209-221页

作者： Jillian N.murakami Xu Zhang Joanne Ye amy m.macDonald Jorge Perez David W.Kinniburgh Susana Y.Kimura Department of Chemistry University of CalgaryCalgaryAlbertaT2N 1N4Canada Alberta Centre for Toxicology University of CalgaryCalgaryAlbertaT2N 4N1Canada

Water disinfection is an essential process that provides safe water by inactivating pathogens that cause waterborne diseases. However, disinfectants react with organic matter naturally present in water, leading to the formation of disinfection by-products(DBPs). multi-analyte methods based on mass spectrometry(mS) are preferred to quantify multiple DBP classes at once however, most require extensive sample pre-treatment and significant resources. In this study, two analytical methods were developed for the quantification of 32 regulated and unregulated DBPs. A purge and trap(P&T) coupled with gas chromatography mass spectrometry(GC-mS) method was optimized that automated sample pre-treatment and analyzed volatile and semi-volatile compounds, including trihalomethanes(THms), iodinated trihalomethanes(I-THms), haloacetonitriles(HANs), haloketones(HKTs) and halonitromethanes(HNms). LOQs were between 0.02-0.4 μg/L for most DBPs except for 8 analytes that were in the low μg/L range. A second method with liquid chromatography(LC) tandem mass spectrometry(mS/mS) was developed for the quantification of 10 haloacetic acids(HAAs) with a simple clean-up and direct injection. The LC-mS/mS direct injection method has the lowest detection limits reported(0.2-0.5 μg/L). Both methods have a simple sample pre-treatment, which make it possible for routine analysis. Hyperchlorination and uniform formation conditions(UFC) formation potential tests with chlorine were evaluated with water samples containing high and low TOC. Hyperchlorination formation potential test maximized THms and HAAs while UFC maximized HANs. Ascorbic acid was found to be an appropriate quencher for both analytical methods. Disinfected drinking water from four water utilities in Alberta, Canada were also evaluated.

关键词： Disinfection byproducts Purge and trap LC-mS/mS Drinking water DBP formation potential HAAs HANs

Quiet in the nest:The nest environment attenuates song in a grassland songbird

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Avian Research 2023年第4期14卷 623-629页

作者： Sarah L.Dobney mikayla m.K.Bornais D.Ryan Norris amy E.m.Newman Heather Williams Stéphanie m.Doucet Daniel J.mennill Department of Integrative Biology University of WindsorWindsorOntarioN9B 3P4Canada Department of Integrative Biology University of GuelphGuelphOntarioN1G 2W1Canada Biology Department Williams CollegeWilliamstownMA01267USA

The nest environment may limit the ability of nest-bound birds to hear sounds from the outside *** vocal learning species,such as humans and songbirds,it is vital for young animals to hear the voices of conspecific animals early in *** songbirds,nest structure varies considerably across species,and the resulting impact on sound transmission may have consequences for vocal learning in *** this study,we tested the hypothesis that the nest environment attenuates song of Savannah Sparrows(Passerculus sandwichensis),grassland songbirds that build nests on the ground under cover of dense *** recorded live Savannah Sparrows singing at variable distances from 21 *** recorded songs using one microphone inside the nest(the typical position of a nestling)and another placed 1 m directly above the nest(a typical position of an adult).We found a substantial reduction in signal-to-noise ratio,where songs recorded inside the nest were an average of 11 dB lower than songs recorded directly above the *** estimate that the attenuation imposed by the nest reduced the maximum acoustic environment from 117.7 m(for recordings above the nest),to 78.6 m(for recordings within the nest),which is analogous to listening from a position 39.1 m farther away from the *** research estimated that song transmits up to 100 m in this species,so any adult male within 100 m of a young bird was previously considered a potential vocal *** reducing the nestling acoustic environment from 100 m to 78.6 m,the number of male tutors available to nestlings is reduced by an average of 27%.Given the growing evidence that song learning begins very early in life,future research on vocal development should account for how the structural properties of the natal environment affect the songs that nestlings hear.

关键词： Acoustic environment Nest environment Songbird Sound attenuation Vocal learning

Nidogen:A matrix protein with potential roles in musculoskeletal tissue regeneration

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Genes & Diseases 2022年第3期9卷 598-609页

作者： Sheng Zhou Song Chen Yixuan amy Pei ming Pei Stem Cell and Tissue Engineering Laboratory Department of OrthopaedicsWest Virginia UniversityMorgantownWV 26506USA Department of Orthopaedics The GeneraLHospital of Western Theater CommandChengduSichuan 610083PR China WVU Cancer Institute Robert C.Byrd Health Sciences CenterWest Virginia UniversityMorgantownWV 26506USA

Basement membrane proteins are known to guide cell structures,differentiation,and tissue *** there is a wealth of knowledge on the functions of laminins,per-lecan,and type IV collagen in maintaining tissue homeostasis,not much is known about *** a key molecule in the basement membrane,nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific *** this review,the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development;the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration,including but not limited to adipogenesis,angiogenesis,chondrogenesis,myogenesis,and ***,potential mechanisms underlying the role of nidogens in stem cell-based tissue regeneration are also *** concise review is expected to facilitate our existing understanding and utilization of nidogen in tissue engineering and regeneration.

关键词： Adipose Basement membrane Cartilage Differentiation Nerve Nidogens Vessel

Length-based separation of Bacillus subtilis bacterial populations by viscoelastic microfluidics

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microsystems & Nanoengineering 2022年第1期8卷 149-159页

作者： Ping Liu Hangrui Liu Lucie Semenec Dan Yuan Sheng Yan amy K.Cain ming Li Suqian University Suqian 223800China School of Engineering Macquarie UniversitySydneyNSW 2109Australia Department of Physics and Astronomy Macquarie UniversitySydneyNSW 2109Australia ARC Centre of Excellence in Synthetic Biology Department of Molecular ScienceMacquarie UniversitySydneyNSW 2109Australia Centre for Regional and Rural Futures Deakin UniversityGeelongVIC 3216Australia Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Biomolecular Discovery Research Centre Macquarie UniversitySydneyNSW 2109Australia

In this study,we demonstrated the label-free continuous separation and enrichment of Bacillus subtilis populations based on length using viscoelastic ***,a gram-positive,rod-shaped bacterium,has been widely used as a model organism and an industrial *** can be arranged in different morphological forms,such as single rods,chains,and clumps,which reflect differences in cell types,phases of growth,genetic variation,and changing environmental *** ability to prepare *** populations with a uniform length is important for basic biological studies and efficient industrial ***,we systematically investigated how flow rate ratio,poly(ethylene oxide)(PEO)concentration,and channel length affected the length-based separation of *** *** lateral positions of *** cells with varying morphologies in a straight rectangular microchannel were found to be dependent on cell length under the co-flow of viscoelastic and Newtonian ***,we evaluated the ability of the viscoelastic microfluidic device to separate the two groups of *** cells by length(i.e.,1-5μm and>5μm)in terms of extraction purity(EP),extraction yield(EY),and enrichment factor(EF)and confirmed that the device could separate heterogeneous populations of bacteria using elasto-inertial effects.

关键词： viscoelastic separation straight

Preparation and characterization of Pd-Ag alloy composite membrane with magnetron sputtering

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Science China Chemistry 1999年第6期42卷 581-588页

作者：赵宏宾熊国兴 N.Stroh H.brunner Fraunhofer Institute of Interfacial Engineering and Biotechnology Nobelstrasse 12 D-70569 Stuttgart Germany Germany

A Pd-Ag （24 wt%） alloy composite membrane was prepared by the magnetron sputtering. A γ-Al2O3 membrane was synthesized by the sol-gel method and used as substrate of the Pd-Ag alloy film. The process parameters of the magnetron sputtering were optimized as a function of the compactness of the Pd-Ag alloy film. The best membrane with a thickness of 1 μm was produced with a sputtering pressure of 2.7 Pa and a substrate temperature of 400℃. The membrane had an H2/N2 permselectivity of 51.5--1000 and an H2 permeation rate of 0.036--1.17×10-5cm3/cm2·s· Pa, depending on operating conditions.

关键词： Pd-Ag membrane Al2o3 membrane sol-gel sputtering H2 separation.

SPECIAL ISSUE EDITORIAL ON mASS CUSTOmIZATION AND SUSTAINABLE VALUE SYSTEmS

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Journal of Systems Science and Systems Engineering 2011年第3期20卷 257-259页

作者： amy J.C.TRAPPEY P.m.WOGNUm Charles V.TRAPPEY Department of Industrial Engineering and Engineering management National Tsing Hua University Department of Social Sciences Wageningen UniversityThe Netherlands Department of management Science National Chiao Tung University

Today, new products or services must be designed to satisfy ever changing consumer demand by companies to remain competitive. mass customization, personalized services, and integration of information and decision processes are needed to produce an increasingly diverse range of products and services. At the same time efficiency as well as flexibility of design and production processes need to be improved.

关键词： SPECIAL ISSUE EDITORIAL ON mASS CUSTOmIZATION AND SUSTAINABLE VALUE SYSTEmS