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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos caroline Tianeze de castro Marcel silva Luz Gabriel Reis Rocha Gabriel Lima correa santos Luís Guilherme de Oliveira silva Mariana santos calmon cláudio Lima souza Ana carla Zarpelon-schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de saúde coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BAcKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13c-UBT and 14c-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBAsE,and cochrane central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)c-UBT or ^(14)c-UBT)against a reference *** used the QUADAs-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted spearman correlation analysis,and we generated summary receiver operating characteristic(sROc)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)c-UBT has been found to outperform the ^(14)c-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted cell survival Factor that Drives Metabolic Disease

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Engineering 2023年第1期20卷 9-18页

作者： Tamana Yousof Jae Hyun Byun Jack chen Richard c.Austin Department of Medicine Division of NephrologyMcMaster UniversityThe Research Institute of St.Joe’s Hamilton and the Hamilton Centre for Kidney ResearchHamiltonOntarioL8N 4A6Canada

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular protein belonging to the evolutionarily conserved pleckstrin homology-related domain family. Its murine homologue, T-cell death-associated 51 (TDAG51) gene, was initially discovered for its role in activation-induced apoptosis in T-cell hybridomas. In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence also supports its role in endoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell proliferation. In this review, the current knowledge of PHLDA1 gene and protein regulation, localization, and function is summarized. This review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of metabolic diseases.

关键词： ER-stress Metabolism Apoptosis cell survival PHLDA1

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Parkinson's disease, heart disease and propolis consumption

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Journal of Integrative Medicine 2021年第5期19卷 467-468页

作者： Fulvio A.scorza Antonio-carlos G.de Almeida carla A.scorza Ana c.Fiorini Josef Finsterer Disciplina de Neurociência Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP 04021-001Brazil centro de Neurociências e saúde da Mulher Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Departamento de Engenharia de Biossistemas Universidade Federal de Sao Joao del-Rei(UFSJ)Sao Joao del-ReiMG36307-352Brazil Departamento de Fonoaudiologia Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Brazil-Programa de Estudos Pós-Graduado em Fonoaudiologia Pontifícia Universidade Católica de Sao Paulo(PUC-SP)Sao PauloSP04021-001Brazil Klinikum Landstrasse Messerli InstituteVienna 1210Austria

It is reported that neurodegeneration is a process that is implicated in both neuropharmacological disorders and brain aging [1].Research has shown that natural products have a wide range of pharmacological and biolog... 详细信息

关键词： Parkinson’s disease heart disease and propolis consumption

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自我监测血压和自我调整药物对合并高危心血管疾病的高血压患者收缩压的影响--脑卒中和高危人群血压控制目标和自我管理随机临床试验

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中华高血压杂志 2014年第11期22卷 1087-1088页

作者： McManus RJ Mant J Haque Ms Bray EP Bryan s Greenfield sM Jones MI Jowett s Little P Penaloza c schwartz c shackleford H shovelton c Varghese J Williams B Hobbs FD 练桂丽叶鹏 unknown

血压升高是全球疾病负担的主要危险因素。虽然在过去10年中得到了改善,但是血压控制率仍然很低。修订后的美国高血压预防、检测、评估与治疗联合委员会（the joint national committee on prevention,detection,evaluation,and treatmen... 详细信息

血压升高是全球疾病负担的主要危险因素。虽然在过去10年中得到了改善,但是血压控制率仍然很低。修订后的美国高血压预防、检测、评估与治疗联合委员会（the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure,JNc）专家组成员第8次报告（JNc8）2014年高血压循证管理指南提出≥60岁的老年人,糖尿病和慢性肾脏病患者血压的控制目标可以放宽。目前接受高血压治疗的美国人达到血压控制目标的比例,

关键词：血压控制目标高血压患者高危心血管疾病随机临床试验自我管理高危人群自我调整 prevention

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典型特大城市下垫面空气动力学特征参数的计算与分析研究

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热带气象学报 2016年第4期32卷 503-514页

作者：唐玉琪谈建国 GRIMMOND c s B 常远勇敖翔宇上海市气象科学研究所(上海市卫星气象遥感应用中心) 上海200030 上海市气象与健康重点实验室上海200030 Department of Meteorology University of Reading

基于2012年12月—2013年11月上海徐家汇气象铁塔风和湍流观测资料及铁塔周边500m半径范围（平均建筑高度为39.5m）下垫面信息,分别利用温度方差方法、风速标准差方法、涡度相关法和形态学方法计算典型特大城市下垫面零平面位移和动力学... 详细信息

基于2012年12月—2013年11月上海徐家汇气象铁塔风和湍流观测资料及铁塔周边500m半径范围（平均建筑高度为39.5m）下垫面信息,分别利用温度方差方法、风速标准差方法、涡度相关法和形态学方法计算典型特大城市下垫面零平面位移和动力学粗糙度。结果表明,温度脉动方差法计算的零平面位移与建筑物高度分布存在差异,但在58-208°方向与建筑顶面积系数呈现正相关（相关系数0.73）,计算公式的经验参数、稳定度阈值和风速对计算结果影响较为显著;涡度相关方法和风速标准差方法计算的动力学粗糙度随风向分布趋势相似（相关系数0.94）,并与零平面位移呈负相关关系。形态学方法与动力学方法之间数值和随风向的变化趋势均存在差异,风温观测仪器源区和形态学方法分析区域具有显著影响。

关键词：空气动力学参数特大城市动力学方法形态学方法影响因素

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中国19个狂犬病病毒街毒分离株N基因的序列分析

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病毒学报 2002年第1期18卷 48-51页

作者：徐葛林 Li Ku 吴杰 c.A.De Mattos 郑新雄薛经刚胡巧玲刘锦彦朱家鸿 c.c.De Mattos J s.smith 武汉生物制品研究所湖北武汉430060 美国疾病控制中心

测定了 30年来从不同动物中分离的 19个中国狂犬病病毒街毒株N基因的部分核酸序列 ,并对其核苷酸差异做了比较分析。可将中国狂犬病病毒街毒株分为 4个组群 ,各组间的同源性为 83 45 %～ 88 6 2 %。除广西地区分离的狂犬病病毒街毒株彼... 详细信息

测定了 30年来从不同动物中分离的 19个中国狂犬病病毒街毒株N基因的部分核酸序列 ,并对其核苷酸差异做了比较分析。可将中国狂犬病病毒街毒株分为 4个组群 ,各组间的同源性为 83 45 %～ 88 6 2 %。除广西地区分离的狂犬病病毒街毒株彼此差异较大外 ,其余街毒株的地理分布与其N基因核酸序列差异的距离是密切相关的 ,基本上可按其地理分布分为东。

关键词：狂犬病病毒街毒株 N基因核苷酸序列分析中国

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Early prediction of severe acute pancreatitis by urinary trypsinogen activation peptide

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Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 285-289页

作者： Liu Z.-s. Jiang c.-Q. Qian Q. sun Q. Fan L.-F. Ai Z.-L. Department of General surgery Zhongnan Hospital Wuhan University Wuhan 430071 China

Objective: To investigate the value of urinary trypsi-nogen activation peptide (TAP) in the early predic-tion of severe acute pancreatitis and to compare itwith acute physiology and chronic health evaluationⅡ (APAcHE Ⅱ).Methods: We assessed the predictive value of urinaryTAP concentrations measured by a competitive en-zyme-linked immunosorbent assay. Urine sampleswere collected for detecting TAP concentrations atadmission, and 24, 48, and 72 h from 41 patientswith acute pancreatitis (12 with severe disease, 29with mild disease) who presented within 48 h the on-set of symptoms and from 11 control patients, whileAPAcHE Ⅱ scores were recorded at 48 h after ***: The peak median urinary TAP concentrationwas seen at admission. The median urinary TAPconcentration at admission for severe pancreatitis (95nmol/L) was significantly higher than the medianfor patients with mild pancreatitis (20 nmol/L, Pcontrols (15 nmol/L, Pconcentrations were significantly higher in patientswith severe acute pancreatitis than the median in pa-tients with mild pancreatitis (Pcontrols(Ps 2 to 3. The median APAcHE Ⅱscores of severe patients were significantly differentfrom those of mild patients (10.5 vs 6.0, Psensitivity, specificity, positive predictive, andnegative predictive values of an admission urinaryTAP≥35 nmol/L for severe pancreatitis were91.7%, 89.7%, 78.6% and 96.3%, whereas 48 hafter admission the values for APAcHE Ⅱ scores(≥9) were 75.0%, 72.7%, 52.9% and 87.5%. Inprediction of disease severity, the urine TAP concen-tration was much better than APAcHE Ⅱ at 48 ***: Urinary TAP obtained at the first 48 hof the onset of symptoms can predict severe acutepancreatitis. In prediction of disease severity, theurinary TAP is much better than APAcHE Ⅱ score.

关键词： acute pancreatitis trypsinogen activation peptide APAcHE Ⅱ

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Persistence of Anti-sARs-coV-2 IgM Antibody up to 8 Months Post-cOVID-19

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case Reports in clinical Medicine 2021年第9期10卷 227-231页

作者： carlos David A. Bichara Ednelza s. G. Amoras Gergiane L. Vaz cléa N. c. Bichara Isabella P. c. Amaral Amaral Antonio c. R. Vallinoto Laboratório de Virologia Instituto de Ciências Biológicas Universidade Federal do Pará (UFPA) Belém Brasil Amaral costa Medicina Diagnóstica Belém Brasil Faculdade de Medicina Centro de Ciências Biológicas e da Saúde Universidade do Estado do Pará (UEPA) Belém Brasil Programa de Pós-Gradua&ccedil ã o em Biologia de Agentes Infecciosos e Parasitários Instituto de Ciências Biológicas Universidade Federal do Pará (UFPA) Belém Brasil

Here, we present a longitudinal analysis of two patients who recovered from cOVID-19 more than 8 months prior but showed persistent serological detection of anti-sARs-coV-2 IgM. We still do not know the exact reason for this prolonged persistence of IgM in these patients. To our knowledge, these are the first reports of IgM persistence in the context of sARs-coV-2 infection and point to the need for no longer using IgM as a diagnostic criterion for acute or recent cOVID-19. One should opt for gold standard molecular methodologies due to their high sensitivity and specificity.

关键词： cOVID-19 sARs-coV-2 Antibodies IgM Persistence

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Qualifying the suitability of living donor livers for pediatric liver transplantation:are we doing the right thing?

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Hepatobiliary surgery and Nutrition 2023年第3期12卷 462-464页

作者： Henkjan J.Verkade Frans c.J.cuperus Aad P.van den Berg Division of Pediatric Gastroenterology and Hepatology Department of PediatricsUniversity of GroningenBeatrix Children’s HospitalUniversity Medical Center GroningenGroningenThe Netherlands Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands

Over the last decades,liver transplantation has become the standard care for many forms of end-stage liver disease,both in adults and in *** prognosis after pediatric liver transplantation(pLT)has steadily increased up to a patient survival at 5 years of 85%and an estimated graft half life of 31 years(1,2).In the early days of pLT,the transplanted organ originated from deceased *** 1990,adult-to-child living donor liver transplantation(LDLT)programs have developed,which rapidly gained popularity,particularly in Europe and Asia(2,3).A major stimulus for LDLT has been the limited availability of deceased *** indications for liver transplantation have expanded,particularly for adult patients,at a higher rate than the availability of donor ***,the quality of donor organs has steadily declined,resulting in a decreased utilization of livers from deceased donors for transplantation(4).The limited availability of qualified deceased donor livers has further stimulated LDLT:in Europe,for example,the percentage of living donor organs used for pLT increased from 7%before 2000 to 40%since 2010(1).

关键词： steatosis graft survival pediatric liver transplantation(pLT) patient survival

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Bromatological characteristics of sugarcane silages inoculated with Lactobacillus buchneri

Bromatological characteristics of sugarcane silages inoculat...

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ⅩⅪ International Grassland congress and the Ⅷ International Rangeland congress

作者： J.c.Pinto c.L.s.Avila H.c.P.Figueiredo A.R.Morais O.G.Pereira R.F.schwan Universidade Federal de Lavras Minus Gerais Brazil Universidade Federal de Vicosa Minas GeraisBrazil

＜正＞Introduction The intense alcoholic fermentation by yeasts during sugarcane ensiling results into high rates of DM losses. Inoculants containing the species *** have proved effective in inhibiting the growth of yeasts（Pedroso et al.,2005）. The objective of this work was to evaluate the effect of the addition of two strains of ***,one from a commercial inoculant and the other isolated from sugarcane silage,upon the fermentation profile of this forage plant.

关键词： crude protein dry matter fermentation profile fiber inoculants saccharumspp

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