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Genes & Diseases 2023年第4期10卷 1180-1182页

作者： J.Bargiela-iparraguirre J.M.Herrero N.Pajuelo-Lozano M.Perez R.Perona A.G.Quiroga C.Calés i.Sanchez-Perez Dpto.de Bioquímica.Fac.Medicina UAMMadrid 28029Spain Biomedical Research institute of Madrid CSIC/UAMMadrid 28029Spain Cancer Stem Cell and Fibroinflammatory Microenvironment Group Chronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid 28034Spain Unidad Asociada de Biomedicina UCLM-CSiC Madrid 28029 Spain CiBER for Rare Diseases(CiBERER) instituto de Salud CarlosⅢ Madrid 28029Spain Dpto.de Anatomía Histología y Neurociencia.Fac.Medicina UAMMadrid 28029Spain g Dpto.de Química Inorgánica Fac.Ciencias UAMMadrid 28049Spain

Gastric cancer(GC)is worldwide the sixth most diagnosed and third leading cause of cancer deaths,with poor and late prognosis,probably due to post-surgery adjuvant treatment resistance and lack of a thorough panel of prognostic *** have previously shown that mitotic arrest deficient 2(MAD2,encoded by MAD2L1),a key protein of the spindle assembly checkpoint,is relevant in GC cells;its interference impairs migration and growth,while its overexpression cor-relates with tumorigenesis.

关键词： MAD2 tumorigenesis Gastric

Crystal and Molecular Structure of 4-Benzoyl-1,5-diphenyl-1H-pyrazole-3-carbonitrile

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Crystal Structure Theory and Applications 2012年第1期1卷 1-8页

作者： E.Korkusuz E.Sahin i.Yildirim Kayseri Vocational Colage Erciyes UniversityKayseriTurkey Department of Chemistry Faculty of SciencesAtaturk UniversityErzurumTurkey Department of Chemistry Faculty of SciencesErciyes UniversityKayseriTurkey

The crystal structure of potential active 4-benzoyl-1,5-diphenyl-1H*-pyrazole-3-carbonitrile (C23H15N3O) (i) has been determined from single crystal X-ray diffraction data. Also iR, Uv-vis and NMR spectral data were determined. The title compound crystallizes in the monoclinic space group P* 21/c, with a* = 9.3167(2), b* = 20.6677(3), c* = 10.6143(3) ?, β* = 112.665(3)°, V* = 1886.00(8) ?3, Dcalc* = 1.23g cm-3, Z* = 4. in the structure, intermolecular H*-bonds lead to the formation of a centrosymmetric dimmer of the molecule. Furthermore, the compound has a wide transmission window (300 to 1100 nm) with a transparency of nearly 100% and the UV cut-off wavelength occurs at 242 nm.

关键词： Pyrazole-3-Carbonitrile 2,3-Furandione Single Crystal Structure X-Ray Diffraction iR NMR Spectra

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透岩浆流体作用与矿田构造

地质力学学报 2015年第1期21卷 1-12页

作者：黑慧欣罗照华 Vikentyev i V 郭晶中国地质大学地质过程与矿产资源国家重点实验室北京100083 institute of Geology of Ore Deposits PetrographyMineralogy and Geochemistry of Russian Academy of Sciences ( IGEM RAS)

从透岩浆流体成矿理论的角度对矿田构造进行了重新认识,提出矿田构造系统是一种复杂性动力系统的观点。根据这个模型,矿田构造是近场应力场与远场应力场强烈相互作用的产物。近场应力场由岩浆成矿系统而不是远场应力场派生,因而不能由... 详细信息

从透岩浆流体成矿理论的角度对矿田构造进行了重新认识,提出矿田构造系统是一种复杂性动力系统的观点。根据这个模型,矿田构造是近场应力场与远场应力场强烈相互作用的产物。近场应力场由岩浆成矿系统而不是远场应力场派生,因而不能由矿田构造反演区域构造,但可以从区域构造限定矿田构造。矿田构造常有岩脉和热液脉充填,因而是可识别的。利用构造统计学方法,可以根据岩脉和/或热液脉的分布密度图(或等值线图)预测找矿靶区。

关键词：矿田构造近场应力场岩浆成矿系统透岩浆流体找矿靶区预测

Study of blasting vibrations in Sarcheshmeh copper mine

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Acta Seismologica Sinica(English Edition) 2002年第6期15卷 683-690页

作者： K. Najm1) A. Javaherian2) H. B. Amnieh1) 1) Department of Mining, Metallurgy and Petroleum Engineering, Amirkabir University, Tehran, i R iran 2) institute of Geophysics, Tehran University, Tehran, i R iran Department of Mining Metallurgy and Petroleum Engineering Amirkabir University Tehran I R Iran institute of Geophysics Tehran University Tehran I R Iran

Ground vibration is one of the side effects of blasting, in which way considerable amount of explosive energy is exhausted, and causes decrease in production and even decline in mine development workings. in this study, 57 recorded 3-C seismograms from 11 blasts in Sarcheshmeh copper mine, Kerman, iran, are processed and analyzed. These data were recorded by digital seismograph PDAS-100 and analyzed by DADiSP software. Finally, blasting parameters, such as explosive weight and type, distance between the structures and blasting site, blasting delays, affecting ground vibration are reviewed and their influence on peak particle velocity (PPV) are studied. Based on this study, suitable detonation delays and explosive type is determined. Considering these data, a graph of PPV versus scaled distance for Sarcheshmeh copper mine is prepared, by the help of which, safe distance for structures and accordingly explosive quantity could be determined.

关键词： ground vibration peak particle velocity blasting

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“武陵夜雨”的气候特征及资源价值分析

重庆师范大学学报（自然科学版） 2017年第2期34卷 113-119页

作者：武仙竹马江波 N i Drozdov 重庆师范大学科技考古实验室重庆师范大学中俄科技考古研究所重庆401331

【目的】武陵山区气候及生态条件特殊,是中国最大夜雨(当日20:00至次日8:00之间自然降落的雨水)分布区。研究"武陵夜雨"气候特点及资源价值,促进扶贫攻坚区武陵山区的经济发展和生态文明建设。【方法】通过国内外典型夜雨区比较分析,并... 详细信息

【目的】武陵山区气候及生态条件特殊,是中国最大夜雨(当日20:00至次日8:00之间自然降落的雨水)分布区。研究"武陵夜雨"气候特点及资源价值,促进扶贫攻坚区武陵山区的经济发展和生态文明建设。【方法】通过国内外典型夜雨区比较分析,并综合考察武陵山区降雨机制、昼雨量及夜雨量。【结果】因中国西南气候锋移动路线与武陵山脉走向重合、南北气候锋交遇区与武陵山分布范围重合,再加上该地区山(峰)谷(河谷)高差形成显著"山谷风",共同促成了中国大面积夜雨区"武陵夜雨"的形成。【结论】武陵夜雨是武陵山区优良生态环境和丰富资源条件的坚实基础,有提高空气质量、提升农作物产量和品质、涵养优质旅游资源、促进传统经济发展等作用。重视武陵夜雨的研究和利用,应视为是发展中国西部经济和加强该地区生态文明建设的工作任务之一。

关键词：武陵夜雨气候特征资源价值

On-chip generation of hybrid polarization-frequency entangled biphoton states

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Photonics Research 2023年第2期11卷 270-278页

作者： S.FRANCESCONi A.RAYMOND R.DUHAMEL P.FiLLOUX A.LEMAiTRE P.MiLMAN M.i.AMANTi F.BABOUX S.DUCCi Université Paris Cité CNRSLaboratoire Matériaux et Phénomènes Quantiques75013 ParisFrance Université Paris-Saclay CNRSCentre de Nanosciences et de Nanotechnologies91120 PalaiseauFrance

We demonstrate a chip-integrated semiconductor source that combines polarization and frequency entanglement,allowing the generation of entangled biphoton states in a hybrid degree of freedom without *** Al Ga As device is based on type-Ⅱ spontaneous parametric downconversion in a counterpropagating phasematching scheme in which the modal birefringence lifts the degeneracy between the two possible nonlinear interactions. This allows the direct generation of polarization–frequency entangled photons at room temperature and telecom wavelength, and in two distinct spatial modes, offering enhanced flexibility for quantum information protocols. The state entanglement is quantified by a combined measurement of the joint spectrum and Hong–Ou–Mandel interference(raw visibility 70.1% ± 1.1%) of the biphotons, allowing to reconstruct a restricted density matrix in the hybrid polarization–frequency space.

关键词： space. matching restricted

X-Ray Radiation Characteristics of Nested-Wire Array implosion in Sino-Russian Joint Z-pinch Experiments on Angara-5-1

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Chinese Physics Letters 2005年第2期22卷 413-415页

作者：徐荣昆李正宏宁佳敏郭存许泽平杨建伦李林波夏广新毕欣生丁宁刘强顾元朝 E.V.Grabovsky G.M.Oleynic S.L.Nedoseev V.V.Alexandrov K.N.Mitrofanov M.V.Zurin G.S.Volkov i.A.Porofeev i.N.Frolov V.P.Smirnov ChinaAcademyofEngineeringPhysics POBox919-212Mianyang621900 TroitskinstituteforinnovationandThermonuclearResearches Troitsk142190Russia

We report and discuss the results of x-ray radiation measurements in the Sino-Russian joint Z-Pinch experiments on Angara-5-1 facility with a load current of 2.5--3.6MA. The measurements were conducted by using an x-ray power meter (XRPM) and a time-resolved one-dimensional x-ray imaging system developed in China Academy of Engineering Physics. The experimental results indicate that an x-ray power-platform prior to a main peak and a less intensive sub-peak after the main peak in the waveform exist for the nested-wire array implosions, and the radiation process is relatively faster than that in the case of the single array. Laser shadowgraph of the imploding plasma suggests that the prior power-platform is a result of the collision of the inner-outer plasma layers. The faster radiation process of nested array implosion can be explained by analysing the corresponding result of the time-resolved one-dimensional imaging system, which demonstrates a better axial imploding uniformity and synchronization. in comparison with x-ray diode, the XRPM yields a higher height of x-ray power-platform due to its flat energy response. The sub-peak after the main peak is proposed to be a result of the later-time additional implosion of plasma.

关键词： Z-箍缩 X-线放射特征测量方法激光投影等离子体

Prevalence and outcomes of pancreatic cystic neoplasms in liver transplant recipients

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World Journal of Gastroenterology 2017年第48期23卷 8526-8532页

作者： Ken Liu Vikram Joshi Louise van Camp Qi-Wei Yang Judith E Baars Simone i Strasser Geoffrey W McCaughan Avik Majumdar Payal Saxena Arthur J Kaffes Sydney Medical School The University of Sydney AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital Department of Radiology Royal Prince Alfred Hospital

AiM To determine the prevalence,characteristics and clinical course of pancreatic cystic neoplasms(PCNs) in liver transplantation(LT) *** We retrospectively studied consecutive patients who underwent LT between January 1998 to April 2016. Clinical and laboratory data were obtained from patient medical records. imaging findings on computed tomography and magnetic resonance cholangiopancreatography were reviewed by two *** During the study period,872 patients underwent cadaveric LT. Pancreatic cysts were identified in 53/872(6.1%) and 31/53(58.5%) were PCNs [28 intraductal papillary mucinous neoplasm(iPMN),2 mucinous cystic neoplasm(MCN),1 serous cystadenoma]. Patients with PCNs exhibited less male predominance(55% vs 73%,P = 0.03) compared to patients without pancreatic cysts. Thirteen patients(42%) were diagnosed with PCN pre-LT while 18 patients(58%) developed PCN post-LT. The median size of PCNs was 13 mm [interquartile range(iQR) 10-20 mm]. All iPMNs were side-branch type. Most PCNs were found in the head and body of pancreas(37% each),followed by the tail(25%). Five patients underwent further evaluation with endoscopic ultrasound. Progress imaging was performed on 81% of patients. PCNs remained stable in size and number in all but 2 patients. During a median follow up of 39 mo(iQR 26-58 mo),the 2(6%) patients with MCN underwent pancreatectomy. No PCN patient developed pancreatic adenocarcinoma,while 5 died from illnesses unrelated to the PCN. Among patients without PCN,1/841(0.1%) developed pancreatic *** The prevalence of PCNs in LT recipients was similar to the general population(3.6%,31/872). Side-branch iPMNs do not appear to have accelerated malignant potential in post-LT patients,indicating the current surveillance guidelines are applicable to this group.

关键词： Pancreatic cystic neoplasm intraductal papillary mucinous neoplasm Mucinous cystic neoplasm Liver transplantation Pancreatic adenocarcinoma immunosuppression

Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 293-303页

作者： Evanthia Zampeli Michalis Gizis Spyros i Siakavellas Giorgos Bamias Gastroenterology Department Alexandra General Hospital Academic Department of Gastroenterology Ethnikon and Kapodistriakon University of Athens Laikon Hospital

Ulcerative colitis(UC) is an immune-mediated, chronic inflammatory disease of the large intestine. its course is characterized by flares of acute inflammation and periods of low-grade chronic inflammatory activity or remission. Monoclonal antibodies against tumor necrosis factor(anti-TNF) are part of the therapeutic armamentarium and are used in cases of moderate to severe UC that is refractory to conventional treatment with corticosteroids and/or immunosuppressants. Therapeutic response to these agents is not uniform and a large percentage of patients either fail to improve(primary non-response) or lose response after a period of improvement(secondary non-response/loss of response). in addition, the use of anti-TNF agents has been related to uncommon but potentially serious adverse effects that preclude their administration or lead to their discontinuation. Finally, use of these medications is associated with a considerable cost for the health system. The identification of parameters thatmay predict response to anti-TNF drugs in UC would help to better select for patients with a high probability to respond and minimize risk and costs for those who will not respond. Analysis of the major clinical trials and the accumulated experience with the use of anti-TNF drugs in UC has resulted to the report of such prognostic factors. included are clinical and epidemiological characteristics, laboratory markers, endoscopic indicators and molecular(immunological/genetic) signatures. Such predictive parameters of long-term outcomes may either be present at the commencement of treatment or determined during the early period of therapy. Validation of these prognostic markers in large cohorts of patients with variable characteristics will facilitate their introduction into clinical practice and the best selection of UC patients who will benefit from anti-TNF therapy.

关键词： Ulcerative colitis infliximab Adalimumab Anti-tumor necrosis factor Predictors of response Personalized treatment