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Fibrin sealant for esophageal anastomosis:A phase II study

World Journal of Gastrointestinal Oncology 2020年第6期12卷 651-662页

作者： Yao-Bin Lin Jian-Hua Fu Yan Huang Yi-Huai Hu Kong-Jia Luo Ke-Xi Wang amoséla bella Dong-Rong Situ Ji-Yang Chen Ting Lin Xavier B D’Journo Nuria M Novoa Alessandro Brunelli Hiran C Fernando Robert J Cerfolio Mahmoud Ismail Hong Yang 无 Department of Thoracic Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Thoracic Surgery Avicenne HospitalBobigny 93000France Department of Surgery and Specialties Faculty of Medicine and Biomedical SciencesUniversity of YaoundéIYaoundéCameroon Department of Surgery Royal Darwin HospitalNorthern Territory 0811Australia Department of Thoracic Surgery and Diseases of Esophagus Aix-Marseille UniversityHôpital NordMarseille 13915France Thoracic Surgery Service University Hospital of SalamancaSalamanca 37007Spain Department of Thoracic Surgery St James's University HospitalLeeds LS97TFUnited Kingdom Section of Thoracic Surgery Inova Fairfax Medical CenterInova Schar Cancer InstituteFalls ChurchVA 22042United States Department of Cardiothoracic Surgery New York University Langone HealthNew YorkNY 10016United States Department of Thoracic Surgery Academic Hospital of the Charité–UniversitätsmedizinHumboldt University BerlinBerlin 10117Germany the AME Thoracic Surgery Collaborative Group

BACKGROUND Esophagectomy is a pivotal curative modality for localized esophageal or esophagogastric junction cancer(EC or EJC).Postoperative anastomotic leakage(AL)remains *** use of fibrin sealant(FS)may improve the strength of esophageal anastomosis and reduce the incidence of *** To assess the efficacy and safety of applying FS to prevent AL in patients with EC or *** In this single-arm,phase II trial(*** identifier:NCT03529266),we recruited patients aged 18-80 years with resectable EC or EJC clinically staged as *** open or minimally invasive McKeown esophagectomy was performed with a circular stapled *** performing the anastomosis,2.5 mL of porcine FS was applied *** primary endpoint was the proportion of patients with AL within 3 *** From June 4,2018,to December 29,2018,57 patients were *** the data cutoff date(June 30,2019),three(5.3%)of the 57 patients had developed AL,including two(3.5%)with esophagogastric AL and one(1.8%)with gastric *** incidence of anastomotic stricture and other major postoperative complications was 1.8%and 17.5%,*** median time needed to resume oral feeding after operation was 8 d(Interquartile range:7.0-9.0 d).No adverse events related to FS were *** deaths occurred within 90 d after *** Perioperative sealing with porcine FS appears safe and may prevent AL after esophagectomy in patients with resectable EC or *** phase III studies are warranted.

关键词： Esophageal cancer McKeown esophagectomy Fibrin sealant Anastomotic leakage Postoperative complications Prevention

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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia la Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

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Caspase-3 expression in metastatic lymph nodes of esophageal squamous cell carcinoma is prognostic of survival

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World Journal of Gastroenterology 2014年第15期20卷 4414-4420页

作者： Xiu-Shen Wang Kong-Jia Luo amos Ela bella Shan-Shan Bu Jing Wen Shui-Shen Zhang Yi Hu Department of Radiation Oncology Cancer Hospital of Zhengzhou University State Key laboratory of Oncology in South China Cancer CenterSun Yat-sen University Department of Thoracic Oncology Cancer CenterSun Yatsen University Guangdong Esophageal Cancer Research Institute

AIM: To assess whether differential expression of caspase-3 in paired metastatic lymph nodes (LNs) is prognostic of survival in patients with resectable esophageal squamous cell carcinoma (ESCC).

关键词： Esophageal squamous cell carcinoma Caspase-3 protein Prognosis Lymph node

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Truth and consequences:the bioinvasion of the Mediterranean Sea

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Integrative Zoology 2012年第3期7卷 299-311页

作者： bella Sarah GALIL National Institute of Oceanography Israel Oceanographic and Limnological ResearchHaifaIsrael

Over 660 alien marine multicellular species have been recorded in the Mediterranean Sea,with many establishing viable populations and subsequently dispersing from their points of entry.A brief overview is presented of the current state of knowledge of bioinvasions in the Mediterranean Sea,with particular attention paid to gelatinous invasive species.A database of alien species records was used to characterize their identity,pattern of expansion and native region,and to discuss the relative importance of different taxa and vectors in the various regions of the *** temporal and spatial spread of 4 alien scyphozoans and 2 alien ctenophores is *** thermophilic species constitute the majority of Mediterranean aliens,Erythrean aliens are predominant in the east,with shipping and mariculture being mainly responsible for introductions in the *** propagule pressure driving the Erythrean invasion is powerful in the establishment and spread of alien species in the eastern *** implications of the enlargement of the Suez Canal,reflecting patterns in global trade and economy,are briefly ***,as alien species inventories play a pivotal role in informing regional policy and management decisions and identifying resource priorities,the scientific community is called upon to pay particular attention to their accuracy and veracity.

关键词： alien gelatinous inventories Mediterranean Sea trends vectors

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A stable Cenozoic geologic time scale is indispensable

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Episodes 2006年第1期29卷 43-45页

作者： amos Salvador Department of Geological Sciences University of Texas at Austin Austin Texas 78712 USA.

A stable, standard geologic time scale is indispensable for the clear and precise communication among geologists; it is a basic tool of geologic work. Considerable progress has been made to achieve such a stable time scale. However, during the last few years several proposals have been made to modify the Cenozoic section of the geologic time scale that threaten to destabilize it. Seven articles published in Episodes since 2000 that could contribute to this destabilization are discussed. They provide excellent examples of the profusion of different terminologies, hierarchies, and stratigraphic relationships that have been proposed： to eliminate the Tertiary and the Quaternary or to raise their rank to suberathems; to extend the Neogene to the present; to make the Quaternary a formal subsystem of the Neogene, or consider it an informal stratigraphic unit; to eliminate the Holocene, and to decouple the base of the Pleistocene from the base of the Quaternary. If adopted, these proposals would cause nothing but great confusion and controversy. They disregard the clear preferences of geologists the world over as reflected by the terminology they have been using for many decades. Common sense would dictate the continued use of this terminology in its current, widely accepted form.

关键词：新生代地质时间比例尺地质工作

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A Double Assessment of Privacy Risks Aboard Top‑Selling Cars

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Automotive Innovation 2023年第2期6卷 146-163页

作者： Giampaolo bella Pietro Biondi Giuseppe Tudisco Dipartimento di Matematica e Informatica Universitàdegli Studi di CataniaCataniaItaly Osservatorio Astrofisico di Catania Istituto Nazionale di AstrofisicaCataniaItaly

The advanced and personalised experience that modern cars offer makes them more and more *** example,the cabin preferences of the possible drivers must be recorded and associated to some identity,while such data could be exploited to deduce sensitive information about the driver’s ***,drivers’privacy must be taken seriously,requiring a dedicated risk assessment framework,as presented in this paper through a double assessment combining the asset-oriented ISO approach with the threat-oriented STRIDE *** framework is tailored to the level of specific car brand and demonstrated on the ten top-selling brands as well as,due to its innovative character,*** two approaches yield different,but complementary findings,demonstrating the additional insights gained through their parallel adoption.

关键词： Automotive Cyber physical systems Risk management ISO 27005 STRIDE

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Relativistic treatment of the spin-zero particles subject to the second Pschl Teller-like potential

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Chinese Physics B 2013年第10期22卷 101-106页

作者： Ekele V.Aguda amos S.Idowu Department of Mathematics Ahmadu Bello University ZariaNigeria Department of Mathematics University of IlorinNigeria

The three-dimensional Klein-Gordon equation is solved for the case of equal vector and scalar second Poschl-Teller potential by proper approximation of the centrifugal term within the framework of the asymptotic iteration method. Energy eigenvalues and the corresponding wave function are obtained analytically. Eigenvalues are computed numerically for some values of n and It is found that the results are in good agreement with the findings of other methods for short-range potential.

关键词： second P6schl-Teller potential asymptotic iteration eigenvalues eigenfunction

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The contribution of cooperative irrigation scheme to poverty reduction in Tanzania

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Journal of Integrative Agriculture 2021年第4期20卷 953-963页

作者： ZHANG Chuan-hong Wandella amos BENJAMIN WANG Miao College of Humanities and Development Studies China Agricultural UniversityBeijing 100083P.R.China CGCOC Agriculture Development Co. Ltd.Beijing 100101P.R.China

Irrigation system is a scare resource in most of drought-stricken *** to manage and maintain the existing irrigation facilities in Africa is a debatable issue to both policy makers and *** facilities run by farmer cooperatives are considered ineffective,unsuccessful and dysfunctional in Tanzania by many researchers.A cooperative irrigation scheme is a mechanism that features the collective management of rural irrigation facilities by farmers'cooperative with some government intervention and external *** is an increasing emphasis on the roles of cooperative irrigation scheme in the development of the agriculture sector and poverty reduction of smallholder *** this study,the authors investigated the management and services of this scheme and analyzed its contribution to poverty reduction of smallholder rice farmers and community development in Tanzania through both quantitative and qualitative *** results showed that the scheme helped smallholder farmers increase the rice production and brought better market *** farmers'net income was also *** generated from rice farming not only improved the livelihoods of smallholder farmers but also created more employment opportunities in the rural *** research also revealed that the scheme was faced with a number of challenges due to resource and institutional constraints and low-level human capacity for both management and *** research provides a feasible approach to effective management of small-scale agricultural infrastructure for poverty reduction in Africa.

关键词： farmer cooperative irrigation rice production poverty reduction Tanzania

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Transmission dynamics of onchocerciasis with two classes of infection and saturated treatment function

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第5期11卷 184-207页

作者： amos Sesan Idowu Oluwatayo Michael Ogunmiloro Department of Mathematics Faculty of Physical Science University of IlorinIlorinKwara StateNigeria Department of MathematicsFaculty of Science Ekiti State UniversityAdo-EkitiEkiti StateNigeria Oluwatayo Michael

A mathematical model describing the epidemic interactions between humans and blackflies in the transmission of onchocerciasis is *** this model,the onchocerciasis infected human individuals are divided into two classes of infected humans with high and low microfilarial output incorporating saturated treatment function,which caters for high saturation of onchocerciasis *** analyze the model feasible region and obtain the basic reproduction number(R_(hb))using the next generation matrix ***,we obtain the onchocerciasis-free and onchocerciasis endemic equilibrium solutions and show that if R_(hb) is less than unity,the onchocerciasis-free equilibrium is locally and globally asymptotically ***,we employed a Lyapunov function to analyze the global asymptotic stability of the onchocerciasis—endemic equilibrium whenever Rhb is greater than *** addition,data on mass drug distribution of ivermectin drug to combat onchocerciasis prevalence in Ekiti state of Nigeria were fitted to the *** results reveal that consistent annual or bi-annual distribution of ivermectin drug in the region is effective in reducing the disease *** simulations also show that public health control measures are needed to minimize infectious contact between humans and blackflies which leads to onchocerciasis infections and visual blindness.

关键词： Onchocerciasis saturated treatment function basic reproduction number stability analysis

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Combination of Interleaved Single-input Multiple-output DC-DC Converters

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 132-142页

作者： Eladio Dur´an Aranda Salvador P´erez Litr´an Mar´ıa bella Ferrera Prieto Electronic Engineering Computer Systems and Automation DepartmentUniversity of HuelvaHuelvaSpain Electrical and Thermal Engineering Design and Projects DepartmentUniversity of HuelvaHuelvaSpain

This paper analyses,simulates and verifies an experimental prototype of a four-phase interleaved DC-DC *** is based on a SEPIC-Cuk *** developed prototype has been used in single-input multiple-output(SIMO)*** combined converter allows obtaining dual output voltages of the same value,from a single input DC voltage and with only a power *** interleaved DC-DC converters achieve a better dynamic response and low ripple,maintaining their *** converter is connected in parallel,thereby managing their losses by distributing them between more components,which facilitates the thermal management of the multiphase converter and allows handling high power values in small sizes with respect to solutions for a single *** control strategies were applied:synchronous operation mode(SOM)and interleaved operation mode(IOM).The simulation results allow the comparison of both operational modes,verifying that the IOM presents advantages with respect to the ripple at the input and output *** experimental prototype was designed for a distributed power architecture and bipolar DC microgrid(MG).

关键词： Bipolar DC DC-DC converter interleaved

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