检索结果-南通市图书馆

Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering

在线全文

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第1期7卷 57-73页

作者： amit Kumar singh Krishna Pramanik amit Biswas Centre of Excellence in Tissue Engineering Department of Biotechnology and Medical EngineeringNational Institute of TechnologyRourkela 769008India

Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering *** present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue *** experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and *** resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)*** studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural *** scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue *** tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of *** enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue *** vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold *** addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its pote

关键词： Scaffold Biomaterial Sodium alginate Chitosan Gelatin 3D printing Tissue engineering

Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第4期18卷 784-789页

作者： Catherine Yeates Prajakta Deshpande Madhuri Kango-singh amit singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

The pathology of Alzheimer’s disease involves a long preclinical period,where the characteristic clinical symptoms of the changes in the brain are *** the preclinical period,homeostatic mechanisms may help prevent widespread cell *** has pointed towards selective cell death of diseased neurons playing a potentially protective *** the disease progresses,dysregulation of signaling pathways that govern cell death contributes to *** activation of the c-Jun N-terminal kinase pathway has been established in human and animal models of Alzheimer’s disease caused by amyloid-beta 42-or tau-mediated *** mosaic studies in Drosophila that examine amyloid-beta 42 in a subset of neurons suggest complex interplay between amyloid-beta 42-expressing and wild-type *** review examines the role of c-Jun N-terminal kinase signaling in the context of cell competition and short-range signaling interactions between amyloid-beta 42-expressing and wild-type *** competition is a conserved phenomenon regulating tissue integrity by assessing the fitness of cells relative to their neighbors and eliminating suboptimal *** clones of amyloid-beta 42 that juxtapose genetically distinct neuronal cell populations show promise for studying *** genetic mosaics with labeled clones of amyloid-beta 42-or tau-expressing and wild-type neurons will allow us to understand how short-range signaling alterations trigger cell death in neurons and thereby contribute to the progression of Alzheimer’s *** approaches have the potential to uncover biomarkers for early Alzheimer’s disease detection and new therapeutic targets for intervention.

关键词： Alzheimer’s disease amyloid-beta 42 mediated neurodegeneration cell competition Drosophila c-Jun N-terminal kinase signaling suboptimal cell super competition super competitor cell two clone-approach wild type cell

Exploring the efficacy of natural products in alleviating Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第8期14卷 1321-1329页

作者： Prajakta Deshpande Neha Gogia amit singh Department of Biology University of Dayton Dayton OH USA Premedical Program University of Dayton Dayton OH USA Center for Tissue Regeneration and Engineering at Dayton (TREND) University of Dayton Dayton OH USA The Integrative Science and Engineering Center University of Dayton Dayton OH USA Center for Genomic Advocacy (TCGA) Indiana State University Terre Haute IN USA

Alzheimer’s disease(hereafter AD) is a progressive neurodegenerative disorder that affects the central nervous system. There are multiple factors that cause AD, viz., accumulation of extracellular Amyloid-beta 42 plaques, intracellular hyper-phosphorylated Tau tangles, generation of reactive oxygen species due to mitochondrial dysfunction and genetic mutations. The plaques and tau tangles trigger aberrant signaling, which eventually cause cell death of the neurons. As a result, there is shrinkage of brain, cognitive defects, behavioral and psychological problems. To date, there is no direct cure for AD. Thus, scientists have been testing various strategies like screening for the small inhibitor molecule library or natural products that may block or prevent onset of AD. Historically, natural products have been used in many cultures for the treatment of various diseases. The research on natural products have gained importance as the active compounds extracted from them have medicinal values with reduced side effects, and they are bioavailable. The natural products may target the proteins or members of signaling pathways that get altered in specific diseases. Many natural products are being tested in various animal model systems for their role as a potential therapeutic target for AD, and to address questions about how these natural products can rescue AD or other neurodegenerative disorders. Some of these products are in clinical trials and results are promising because of their neuroprotective, anti-inflammatory, antioxidant, anti-amyloidogenic, anticholinesterase activities and easy availability. This review summarizes the use of animal model systems to identify natural products, which may serve as potential therapeutic targets for AD.

关键词： Alzheimer’s disease amyloid-beta 42 natural products Lunasin neuroprotective anti-inflammation antioxidant Drosophila cell death neurodegeneration

Hippo signaling:bridging the gap between cancer and neurodegenerative disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第4期16卷 643-652页

作者： Neha Gogia Anuradha Venkatakrishnan Chimata Prajakta Deshpande Aditi singh amit singh Department of Biology University of DaytonDaytonOHUSA Medical Candidate University of Toledo College of Medicine and Life SciencesToledoOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

During development,regulation of organ size requires a balance between cell proliferation,growth and cell *** of these fundamental processes can cause a variety of *** cell proliferation results in cancer whereas excessive cell death results in neurodegenerative *** signaling pathways known-to-date have a role in growth *** them,evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and ***,a complex process of progressive death of neuronal population,results in fatal disorders with no available cure to *** normal development,cell death is required for sculpting of an ***,aberrant cell death in neuronal cell population can result in neurodegenerative *** pathway has gathered major attention for its role in growth regulation and cancer,however,other functions like its role in neurodegeneration are also emerging *** review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo *** Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future.

关键词： animal models cell death mechanisms cell-signaling chemical inhibitors Drosophila eye Hippo pathway neurodegeneration neurological diseases therapeutic targets

CADSE： communication aware design space exploration for efficient run-time MPSoC management

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2013年第3期7卷 416-430页

作者： amit Kumar singh Akash KUMAR Jigang WU Thambipillai SRIKANTHAN Department of Electrical and Computer Engineering National University of Singapore Singapore 119077 Singapore School of Computer Science and Software Engineering Tianjin Polytechnic University Tianjin 300160 China School of Computer Engineering Nanyang Technological University Singapore 639798 Singapore

Real-time multi-media applications are increasingly mapped on modern embedded systems based on multiprocessor systems-on-chip （MPSoC）. Tasks of the applications need to be mapped on the MPSoC resources efficiently in order to satisity their performance constraints. Exploring all the possible mappings, i.e., tasks to resources combinations exhaustively may take days or weeks. Additionally, the exploration is performed at design-time, which cannot handle dynamism in applications and resources＇ status. A runtime mapping technique can cater for the dynamism but cannot guarantee for strict timing deadlines due to large computations involved at run-time. Thus, an approach performing feasible compute intensive exploration at design-time and using the explored results at run-time is required. This paper presents a solution in the same direction. Communicationaware design space exploration （CADSE） techniques have been proposed to explore different mapping options to be selected at run-time subject to desired performance and available MPSoC resources. Experiments show that the proposed techniques for exploration are faster over an exhaustive exploration and provides almost the same quality of results.

关键词： multiprocessor systems-on-chip design space exploration run-time mapping synchronous dataflow graphs throughput

Deep Learning-Assisted OFDM Detection with Hardware Impairments

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Communications and Information Networks 2023年第4期8卷 378-388页

作者： amit singh Sanjeev Sharma Kuntal Deka Vimal Bhatia Indian Institute of Technology(IIT)BHU Varanasi Varanasi 221005India Indian Institute of Technology(IIT)Guwahati Guwahati 781039India Indian Institute of Technology(IIT)Indore Indore 452020India

This paper introduces a deep learning(DL)algorithm for estimating doubly-selective fading channel and detecting signals in orthogonal frequency division multiplexing(OFDM)communication systems affected by hardware impairments(HIs).In practice,hardware imperfections are present at the transceivers,which are modeled as direct current(DC)offset,carrier frequency offset(CFO),and in-phase and quadrature-phase(IQ)imbalance at the transmitter and the receiver in OFDM *** HIs,the explicit system model could not be mathematically derived,which limits the performance of conventional least square(LS)or minimum mean square error(MMSE)***,we consider time-frequency response of a channel as a 2D image,and unknown values of the channel response are derived using known values at the pilot locations with DL-based image super-resolution,and image restoration ***,a deep neural network(DNN)is designed to fit the mapping between the received signal and transmit symbols,where the number of outputs equals to the size of the modulation *** show that there are no significant effects of HIs on channel estimation and signal detection in the proposed DL-assisted *** proposed DL-assisted detection improves the OFDM performance as compared to the conventional LS/MMSE under severe Hls.

关键词： OFDM DL HIs channel estimation signal detection

Depillaring of total thickness of a thick coal seam in single lift using cable bolts：A case study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2016年第2期26卷 223-233页

作者： Kumar Rakesh Mishra Arvind Kumar singh Arun Kumar singh amit Kumar Ram Sahendr singh Rajendr Central Institute of Mining and Fuel Research (under CSIR) Dhanbad 826015 India Indian School of Mines Dhanbad 826004 India

Explaining fundamentals of application of cable bolting for a thick seam depillaring,this paper summarizes the results of field studies conducted during adoption of this approach in more than fifteen panels of Madhusudanpur 7 pit and incline *** 7.0 m thick Kajora top coal seam of this mine is developed on pillars along the floor horizon to an average height of 3.0 m,leaving a coal band of around 4.0 m along the *** of procured core samples showed that roof strata are easily caveable with a caveability index value of around 2000 *** caveable overlying strata and shallow depth of cover alleviated most of the expected strata mechanics problems of the thick seam ***,extraction of total thickness at shallow cover caused differential-subsidence and cracks on the *** manifestations were immediately tackled to avoid creation of a breathing path for spontaneous heating in the extracted area.

关键词： Cable bolting Thick seam depillaring Extraction height Pillar stability Caveability index

Effects of in ovo delivered xylo-and mannan-oligosaccharides on growth performance,intestinal immunity,cecal short-chain fatty acids,and cecal microbiota of broilers

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第4期13卷 1099-1114页

作者： amit Kumar singh Utsav Prakash Tiwari Birendra Mishra Rajesh Jha Department of Human Nutrition Food and Animal SciencesUniversity of Hawaii at Manoa1955 East-West RdHonoluluHI 96822USA

Background:This study investigated a novel in ovo feeding strategy to determine the prebiotic effects of xylo-and mannan-oligosaccharides(XOS and MOS)differing in the degree of polymerization.A total of 192 fertilized eggs were divided into 6 treatment groups:i)normal saline control(NSC),ii)xylotriose(XOS3),iii)xylotetraose(XOS4),iv)mannotriose(MOS3),v)mannotetraose(MOS4),and vi)no injection control(NIC),each containing 4 replicate trays with 8 eggs per *** d 17 of incubation,3 mg of oligosaccharides(except for controls)dissolved in 0.5 mL of 0.85%normal saline were injected into the amnion of Cobb 500 broilers *** hatch,the chicks were raised for 28 d under standard husbandry practices and were fed a commercial broilers diet ad libitum,and samples were collected ***:The hatchability,growth performance,and relative weights of breast,drumstick,liver,and proventriculus were not different among the treatments(P>0.05).The XOS3 injection increased the total short-chain fatty acid production at d 28 compared with both control groups(P0.05).On the hatch day,the expression level of the CD3 gene(a T cell marker)was increased by XOS3,while the IL-10 gene(a marker of anti-inflammatory cytokine)was reduced by MOS4(P0.05),except XOS4 increased IL-4 compared with NSC(P<0.05).The broilers in the MOS4 group had higher operational taxonomic units(OTUs)and had more differentially abundant taxa,including order Lactobacillales and family Leuconostocaceae(P<0.05)than both controls on d *** predictive functional profiling indicated that the linoleic acid metabolism pathway w

关键词： Broilers Gut health Immunity in ovo Mannanoligosaccharides Microbiota Oligosaccharides Prebiotics Xylooligosaccharides

Long Period Fiber Grating Based Refractive Index Sensor With Enhanced Sensitivity Using Michelson Interferometric Arrangement

在线全文

学校读者我要写书评

暂无评论

Photonic Sensors 2015年第2期5卷 172-179页

作者： amit singh Department of Electronics and Communication Engineering Beant College of Engineering & Technology GurdaspurPunjab India

The long period fiber grating （LPFG） is widely used as a sensor due to its high sensitivity and resolution. However, the broad bandwidth of the attenuation bands formed by the mode coupling between the fundamental core mode and the cladding modes constitutes a difficulty when the device is used as a conventional sensor. To overcome this limitation, a Michelson interferometer-type sensor configuration has been developed, using an LPFG grating pair formed by coating a mirror at the distal end of the LPFG. This sensor configuration is more convenient to use and is able to overcome the limitations of the single LPFG based sensor as the shifts in the attenuation bands being more easily detectable due to the formation of the sharp spectral fringe pattern in the LPFG based Michelson interferometer. In this work, I studied the LPFG based Michelson interferometer as the refractive index sensor and discussed the sensitivity enhancement of the LPFG based Michelson interferometer as a refractive index sensor by employing higher order cladding modes and by reducing the cladding radius. The results demonstrated the HE17 mode with a cladding radius of 62.5 μm, in the range of surrounding refractive index （SRI） of 1 - 1.45, and its resonant peak showed a wavelength shift of 26.99nm/RIU. When the cladding region was further reduced to 24μm, the resonant peak showed a wavelength shift of 569.88 nm/RIU, resulting in a sensitivity enhancement of nearly 21 times. However, as the cladding region was etched further, then the HE17 order cladding mode and higher mode would be cut off. Therefore, the implementation of high sensitivity for SRI sensing with the reduced cladding in the LPFG based Michelson interferometer is dependent on the proper combination of the cladding radius and cladding mode order.

关键词： Long period fiber grating (LPFG) Mach-Zehnder interferometer self-interfering LPFG (SILPFG),Michelson interferometer refractive index (RI) reduced cladding sensitivity