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Comment on:development and external validation of a model to predict overall survival in patients with resected gallbladder cancer

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 136-138页

作者： Sakti Chakrabarti amit mahipal Medical College of Wisconsin MilwaukeeWIUSA Division of Medical Oncology Mayo ClinicRochesterMNUSA

We read the study reported by Lohman et *** interest published recently in the Annals of Surgery(1).The authors have developed a statistical model to predict the overall survival(OS)of patients with resected gall bladder cancer(GBC).Dutch national database was used to create and internally validate the model based on individual-level data(n=380).Subsequently,data from a cohort of Australian patients with resected GBC were used for external validation(n=66).The model was constructed based on the patient and tumor characteristics found to be independent predictors of OS that included age,tumor and node(T/N)classification,resection margin,tumor differentiation grade,and vascular *** concordance index(C-index)in the internal and the external validation cohorts were 0.71[95%confidence interval(CI):0.69-0.72]and 0.75(95%CI:0.69-0.80),respectively,suggesting good discriminatory *** authors also demonstrated that their model outperformed the discriminative capability of the American Joint Committee on Cancer(AJCC)staging system(8th edition)with a C-index of 0.59(95%CI:0.57-0.60).Furthermore,the authors constructed a web application that can predict the OS of a given patient based on a small number of clinicopathologic variables(age,T stage,N stage,resection margin,differentiation grade,and perivascular invasion).

关键词： invasion patients Surgery

Management of borderline resectable pancreatic cancer

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World Journal of Gastrointestinal Oncology 2015年第10期7卷 241-249页

作者： amit mahipal Jessica Frakes Sarah Hoffe Richard Kim Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

Pancreatic cancer is the fourth most common cause of cancer death in the United States. Surgery remains the only curative option; however only 20% of the patients have resectable disease at the time of initialpresentation. The definition of borderline resectable pancreatic cancer is not uniform but generally denotes to regional vessel involvement that makes it unlikely to have negative surgical margins. The accurate staging of pancreatic cancer requires triple phase computed tomography or magnetic resonance imaging of the pancreas. Management of patients with borderline resectable pancreatic cancer remains unclear. The data for treatment of these patients is primarily derived from retrospective single institution experience. The prospective trials have been plagued by small numbers and poor accrual. Neoadjuvant therapy is recommended and typically consists of chemotherapy and radiation therapy. The chemotherapeutic regimens continue to evolve along with type and dose of radiation therapy. Gemcitabine or 5-fluorouracil based chemotherapeutic combinations are administered. The type and dose of radiation vary among different institutions. With neoadjuvant treatment, approximately 50% of the patients are able to undergo surgical resections with negative margins obtained in greater than 80% of the patients. Newer trials are attempting to standardize the definition of borderline resectable pancreatic cancer and treatment regimens. In this review, we outline the definition, imaging requirements and management of patients with borderline resectable pancreatic cancer.

关键词： Pancreatic cancer Surgery Chemotherapy Radiation B

Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 808-832页

作者： Sakti Chakrabarti Carrie Y Peterson Deepika Sriram amit mahipal Division of Hematology/Oncology Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States Division of Medical Oncology Mayo ClinicRochesterMN 55905United States

Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective *** majority of patients with colon cancer are diagnosed at an early stage(stages I to III),which provides an opportunity for *** current treatment paradigm of early stage colon cancer consists of surgery followed by adjuvant chemotherapy in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a *** alone is curative for the vast majority of colon cancer ***,surgery and adjuvant chemotherapy can achieve long term survival in about two-thirds of colon cancer patients with nodal *** chemotherapy is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally established despite several large clinical *** research in early stage colon cancer is focused on minimally invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy,utilization of molecular and clinicopathologic information to personalize therapy and exploration of new therapies exploiting the evolving knowledge of tumor *** this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely help improve patient selection and personalization of therapy leading to superior outcomes.

关键词： Adjuvant Circulating tumor DNA Immunoscore Minimally invasive Neoadjuvant FOxTROT Minimal residual disease International duration evaluation of adjuvant chemotherapy

Assessment of interobserver variation in Garden classification and management of fresh intracapsular femoral neck fracture in adults

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Chinese Journal of Traumatology 2014年第2期17卷 99-102页

作者： amit Aggarwal mahipal Singh Aditya N Aggarwal Shuchi Bhatt Department of Orthopaedics University College ofMedical Sciences Guru Teg Bahadur Hospital Delhi110095 India

Objective： To assess the interobserver agreement on Garden classification of fresh femoral neck fracture and management plan based on anteroposterior （AP） view and also assess if the addition of lateral view changes the classification and management plan. Methods： Ten orthopaedic surgeons were asked to classify 35 femoral neck fractures on AP view only and propose the management plan. Then the same films were reshown in conjunction with their lateral view after 10 days. Results were compared with respect to the classification and management plan between two groups. Interobserver agreement was calculated using Fleiss＇ kappa. Results： There was only a fair interobserver agreement （kappa value 0.39） on Garden classification on AP view only which improved to moderate agreement （kappa value 0.52） after adding a lateral view. While there was only a slight improvement in the interobserver agreement on the management plan on AP view only （kappa value 0.50） and AP combined with lateral views （kappa value 0.52）. Supplementation of the lateral view changed the classification in 15.42% of the cases and altered the management plan in 23.14% of the cases. Conclusion： We conclude that lateral view should be obtained routinely on all patients with suspected femoral neck fracture as it definitely has a role in planning treatment of femoral neck fracture.

关键词： Classification Disease management Femoral neck fractures X-rays

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

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Neural Regeneration Research 2025年第10期20卷 2862-2871页

作者： Prajakta Deshpande Anuradha Venkatakrishnan Chimata amit Singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and *** acetylation is a common post-translational modification pivotal to basic cellular *** to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and *** this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in ***,we have focused on N-acetyltransferase 9 and its role in microtubule *** have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative *** have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

关键词： acetyl-coenzyme A Alzheimer’s disease animal models cell death drosophila eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 neurodegeneration

A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

A highly stable explicit scheme for a fourth-order nonlinear diffusion filter

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第4期11卷 121-138页

作者： mahipal Jetta Department of Mathematics Mahindra Ecole Centrale´Hyderabad 500043India

The standard finite difference scheme(forward difference approximation for time derivative and central difference approximations for spatial derivatives)for fourth-order nonlinear diffusion filter allows very small time-step size to obtain stable *** alternating directional implicit(ADI)splitting scheme such as Douglas method is highly stable but compromises accuracy for a relatively larger time-step *** this paper,we develop 3×3 stencils for the approximation of second-order spatial derivatives based on the finite pointset *** then make use of these stencils for approximating the fourth-order partial differential *** show that the proposed scheme allows relatively bigger time-step size than the standard finite difference scheme,without compromising on the quality of the filtered ***,we demonstrate through numerical simulations that the proposed scheme is more efficient,in obtaining quality filtered image,than an ADI splitting scheme.

关键词： Fourth-order partial differential equation image denoising multiplicative noise finite pointset method finite difference method stability.

Nephroprotective effect of Murraya koenigii on Cyclophosphamide induced nephrotoxicity in rats

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 869-873页

作者： Patel mahipal Pawar Rajesh Singh Pharmacognosy Phytochemistry&Ethnophamacology LaboratoryVNS Group of InstitutionFaculty of PharmacyVNS CampusVidya ViharNeelbudBhopalMadhya Pradesh462044India

Objective: To evaluate the nephroprotective effect of defatted mehtanolic extract and aqueous extract of Murraya koenigii against Cyclophosphamide drug. Methods: Nephrotoxicity was induced by Cyclophosphamide in 7 d at 150 mg/kg body weight through intraperitoneal route in rat model. Nephroprotective activity of Murraya koenigii(M. koenigii) extract(100 mg/kg and 200 mg/kg in intraperitoneal route) was measured, including nephrological source, oxidative stress parameters like superoxide dismutase, glutathione, the lipid peroxide and in vivo assay like blood urea nitrogen, creatinine were determined and analyzed by One way analysis of variance followed by Tukey's test. Results: The study result showed that important phytochemicals such as carbohydrates, flavonoids, tannin, alkaloids, glycosides, protein and steroids were found to be present in the extract of M. koenigii. The renal function markers like blood urea nitrogen and ceatinine level were found to be decreased significantly by M. koenigii extract treatment. A significant difference was found to be at P<0.01. Conclusions: The present study reveals the protective role of M. koenigii extract against Cyclophosphamide induced nephrotoxicity.

关键词： Nephrotoxicity Murraya koenigii Cyclophosphamide

Foliar Micromorphology of In Vitro-cultured Shoots and Field-grown Plants of Passiflora foetida

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Horticultural Plant Journal 2017年第1期3卷 34-40页

作者： Manokari Mani mahipal Singh Shekhawat Department of Botany Kanchi Mamunivar Centre for Post Graduate Studies Biotechnology Laboratory Department of Plant ScienceMahatma Gandhi Government College

The present report describes the development of quantitative and qualitative foliar micromorphological and architectural features in the field environment which elucidated the adaptation of micropropagated plants of Passiflora foetida L. in the natural soil conditions. The field environment(high light intensity in comparison to in vitro culture conditions) promotes the autotrophy through decrease in stomatal index(from 23.2 ± 0.15 to 21.0 ± 0.19), increased vein-islets(from 10.0 ± 0.14 to 15.6 ± 0.24 per square millimeters) and veinlet terminations(from 1.6 ± 0.14 to 5.0 ± 0.20 per square millimeters), and trichome density in P. foetida plantlets. The in vitro and field grown leaves mostly possessed anomocytic and anisocytic types of stomata. Two types of trichomes were observed on the surface of leaves of in vitro as well as field transferred plants of P. foetida: the unicellular hairy trichomes(non-glandular), and the multicellular(glandular) trichomes. The trichomes density was less under in vitro conditions as compared to the in vivo environments. The new leaves formed during the ex vitro rooting stage(in greenhouse) and after transplantation of plantlets to the field exhibited the development of adaptive micromorphological features in micropropagated plants, which enabled them to survive under field conditions.

关键词： Passiflora foetida micromorphology micropropagation stomata trichomes