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Role of Urokinase-Type Plasminogen Activator Receptors as an Early Detector for Treatment Outcome in Adult Acute Myeloid Leukemia in Egyptian Patients

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Journal of Cancer Therapy 2015年第11期6卷 963-970页

作者： Hanan R. Nassar Eman Z. Kandeel Laila A. E. Hegazy amany M. helal Tarek Darwish Soad A. Eltokhy Medical Oncology NCI Cairo Egypt Clinical Pathology NCI Cairo Egypt Clinical Pathology Faculty of Medicine Cairo University Cairo Egypt

Background: The urokinase-type plasminogen activator system which consists of a proteinase (the urokinase-type plasminogen activator, uPA), a receptor (the urokinase-type plasminogen activator receptor uPAR or CD87) and inhibitors (PAI1) is enriched in several types of tumors and involved in proteolysis, cell migration and invasion. High expression of uPA and uPAR is associated with an increased relapse rate and shorter survival in breast cancer and colorectal carcinomas. Aims: This study shed light on the expression of uPAR in adult acute myeloid leukemia (AML) and its prognostic relevance. Methods: Peripheral blood and bone marrow samples are obtained from 54 newly diagnosed AML adult patients, 20 healthy controls stained with anti CD87 and estimated on flow cytometry. Results: CD87 expression was heterogeneous in different FAB subtypes of AML with high expression in monocytic leukemia (M4/M5) (P value 0.001). High expression of CD87 was associated with shorter survival and poor response to therapy (P = 0.028, 0.002 respectively). The most discriminating cut off value of CD87 expression was 20%, patients with less than 20% expression had 4.6 times better treatment outcome than those with more than or equal to 20%. On the multivariate analysis, CD87 was the most significant single variable that affect treatment outcome compared to total leucocytic count, hemoglobin level, platelets count, cytogenetic and FLT expression. Summary/Conclusion: High CD87 expression is an independent prognostic parameter associated with poor response and shorter overall survival in adult AML patients.

关键词： AML Plasminogen Survival uPAR CD87

Regulating microstructure and composition by carbonizing in-situ grown metal-organic frameworks on cotton fabrics for boosting electromagnetic wave absorption

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Nano Research 2024年第8期17卷 7290-7300页

作者： Jie Jin Hongsen Long Hu Liu Yan Guo Tiantian Bai Ben Bin Xu Mohammed A.Amin Hua Qiu Mohamed H.helal Chuntai Liu Changyu Shen Zeinhom M.El-Bahy Zhanhu Guo State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410000China School of Electronic Engineering North China University of Water Resources and Electric PowerZhengzhou 450046China Complex Conditions of High-end Tire Technology Innovation Center Shuguang Rubber Industry Research&Design Institute Co.LtdGuilin 541004China Integrated Composites Lab Department of Mechanical and Civil EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Chemistry Faculty of Arts and ScienceNorthern Border UniversityRafha 73213Saudi Arabia Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt

High-temperature carbonized metal-organic frameworks(MOFs)derivatives have demonstrated their superiority for promising electromagnetic wave(EMW)absorbers,but they still suffer from limited EMW absorption capacity and narrow *** the advantage of microstructure and chemical composition regulation for the design of EMW absorber,hierarchical heterostructured MoS_(2)/CoS_(2)-Co_(3)O_(4)@cabonized cotton fabric(CF)(MCC@CCF)is prepared by growing ZIF-67 MOFs onto CF surface,chemical etching,and *** from the dual loss mechanism of magnetic-dielectric multicomponent carbonized MOFs,chemical etching and carbonization process can effectively introduce abundant micro-gap structure that can result in better impedance matching and stronger absorption capacity via internal reflection,doped heteroatoms(Mo,N,S)to supply additional dipolar polarization loss,and numerous heterointerfaces among MoS_(2),CoS_(2),Co_(3)O_(4),and CCF that produce promoted conduction loss and interfacial polarization ***,a minimal reflection loss of−52.87 dB and a broadest effective absorption bandwidth of 6.88 GHz were achieved via tunning the sample thickness and filler loading,showing excellent EMW absorption *** research is of great value for guiding the research on MOFs derivatives based EMW absorbing materials.

关键词： metal-organic frameworks hierarchical structure chemical etching sulfurization electromagnetic wave absorption

Epidemiological and histopathological characteristics of thyroid carcinoma in a Tunisian health care center

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 37-42页

作者： Maissa Ben Thayer Fatma Khanchel Imen helal Dorra Chiboub Hedhli Raoueh Ehsen Ben Brahim Raja Jouini Aschraf Chadli-Debbiche Faculty of Medicine of Tunis Tunis El Manar UniversityTunisTunisia Depatment of Pathology Habib Thameur's HospitalTunisTunisia Department of Otorhinolaryngology-Head and Neck surgery Habib Thameur's HospitalTunisTunisia

Background:Thyroid carcinoma(TC)accounts for almost 0.5%–1%of total *** incidence is increasing rapidly *** studies have drawn up the epidemiological profile of TC and its clinical and pathological ***,to date,no similar studies have been conducted in ***:To establish an epidemiological profile of TC in a Tunisian health care institute and to analyze its clinical and histopathological characteristics in our *** and Methods:We present a retrospective study reviewing the cases of TC diagnosed in our institution in a 4-year ***:We collected a sample of 192 cases of *** consisted of 31 males and 161 females(83.8%)with a sex-ratio M/F of *** mean age was 46.4 *** thyroid carcinoma was the most frequent histological *** multifocality rate was 33.8%.The mean size of TC was 2.2±1.9 cm.60.9%of TC were staged pT1 and 20.3%had nodal *** thyroid microcarcinomas were noted in 37.5%of ***:Our results were consistent with those of the literature.A high proportion of pT1 and pN0 tumors were noted in our series,suggesting that TC's diagnosis and management was performed at an early stage of the disease in our *** addition,our study enabled us to notice the impact of the Coronavirus disease 19 crisis on the management of TC in our *** studies are needed to establish the epidemiological profile of TC in Tunisia and to assess its clinical and pathological features.

关键词： coronavirus disease 19 epidemiology papillary thyroid carcinoma papillary thyroid microcarcinoma pathology thyroid carcinoma

Subgroup Discovery Algorithms： A Survey and Empirical Evaluation

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Journal of Computer Science & Technology 2016年第3期31卷 561-576页

作者： Sumyea helal School of Information Technology and Mathematical Sciences University of South Australia Adelaide SA5001 Australia

Subgroup discovery is a data mining technique that discovers interesting associations among different variables with respect to a property of interest. Existing subgroup discovery methods employ different strategies for searching, pruning and ranking subgroups. It is very crucial to learn which features of a subgroup discovery algorithm should be considered for generating quality subgroups. In this regard, a number of reviews have been conducted on subgroup discovery. Although they provide a broad overview on some popular subgroup discovery methods, they employ few datasets and measures for subgroup evaluation. In the light of the existing measures, the subgroups cannot be appraised from all perspectives. Our work performs an extensive analysis on some popular subgroup discovery methods by using a wide range of datasets and by defining new measures for subgroup evaluation. The analysis result will help with understanding the major subgroup discovery methods, uncovering the gaps for further improvement and selecting the suitable category of algorithms for specific application domains.

关键词： subgroup discovery searching pruning measure evaluation

Environmental pollution and diabetes mellitus

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World Journal of Meta-Analysis 2021年第3期9卷 234-256页

作者： amany El-Sikaily Mohamed helal National Institute of Oceanography and Fisheries(NIOF) Cairo 21513Egypt

Diabetes mellitus(DM)is a chromic metabolic disease that affects a large segment of the population *** inactivity,poor nutrition,and genetic predisposition are main risk factors for disease *** the last decade,it was clear to the scientific community that DM development is linked to a novel disease inducer that was later defined as diabetogenic factors of pollution and endocrine disrupting *** pollution is exponentially increasing in uncontrolled manner in several *** pollutants are of diverse nature and toxicities,including polyaromatic hydrocarbons(PAHs),pesticides,and heavy *** the current review,we shed light on the impact of each class of these pollutants and the underlined molecular mechanism of diabetes induction and biological ***,a brief overview about the connection between coronavirus disease 2019 and diabetes pandemics is presented.

关键词： Diabetes mellitus Glucose Heavy metals Polyaromatic hydrocarbons Pesticide COVID-19

Biochemical Liver Functions and Molecular Identification of Fasciola hepatica from Experimentally Infected Rat Model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia M. Kandil Emad B. Ata Margarita P. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz Noha M. F. Hassan Soad M. Nasr Mohamed A. helal Ebtesam M. Al-Olayan Department of Parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental Morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum Protein Electrophoresis Molecular Characterization

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ACHILLES HEEL （Cord）

中华骨科杂志 1995年第1期15卷 43-48页

作者：Ｂ．ＨＥＬＡＬ

ＡＣＨＩＬＬＥＳＨＥＥＬ（Ｃｏｒｄ）Ｂ．ＨＥＬＡＬＲｅｃｍｖｅｄ１０Ｊｕｌｙ１９９３Ｔｈｅｔｅｎｄｏｎｉｔｓｅｌｆｉｓａｎｅｎｏｒｍｏｕｓｌｙｓｔｒｏｎｇｓｔｒｕｃｔｕｒｅａｎｄｗｈｅｎｎｏｒｍａｌｉｔｓｉｎｕｓｃｌ... 详细信息

ＡＣＨＩＬＬＥＳＨＥＥＬ（Ｃｏｒｄ）Ｂ．ＨＥＬＡＬＲｅｃｍｖｅｄ１０Ｊｕｌｙ１９９３Ｔｈｅｔｅｎｄｏｎｉｔｓｅｌｆｉｓａｎｅｎｏｒｍｏｕｓｌｙｓｔｒｏｎｇｓｔｒｕｃｔｕｒｅａｎｄｗｈｅｎｎｏｒｍａｌｉｔｓｉｎｕｓｃｌｅｂｅｌｌｙｏｒｔｈｅｏｓｃａｌｃ...

关键词：跟腱断裂石膏固定肌腱附着点 ACHILLES HEEL Cord

Effects of grid size on predictions of bed expansion in bubbling fluidized beds of Geldart B particles： A generalized rule for a grid-independent solution of TFM simulations

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Particuology 2017年第5期15卷 61-69页

作者： M. helal Uddin Charles J. Coronella Department of Chemical and Materials Engineering University of Nevada Reno NV 89557 USA

Numerical simulations of gas-solid fluidized beds based on the kinetic theory of granular flow exhibit a significant dependence on domain discretization. Bubble formation, bubble size and shape all vary greatly with the discretization, and the use of an inappropriate scale resolution leads to inaccurate predictions of fluidization hydrodynamics. In this study, grid-independent solutions of the two fluid model were examined by comparing the bed expansions obtained from numerical simulations with experimental results and empirical predictions, based on bubbling fluidized beds of Geldart B particles. Grid indepen- dence was achieved with a grid resolution equal to 18 times the particle diameter. The simulation results were compared with previously published data for verification purposes. The results of this work should provide a guideline for choosing the appropriate grid size and thereby minimize the time and expense associated with large simulations.

关键词： Mesh effectHydrodynamicsComputational fluid dynamicsEuler-Euler method MFIX

A new approach for fuel injection into a solar receiver/ reactor:Numerical and experimental investigation

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Frontiers of Chemical Science and Engineering 2018年第4期12卷 683-696页

作者： M helal Uddin Nesrin Ozalp Jens Heylen Cedric Ophoff Mechanical and Industrial Engineering Department University of Minnesota DuluthDuluthMN 55812-3042USA Mechanical Engineering Department 3001 LeuvenBelgium

An innovative and efficient design of solar receivers/reactors can enhance the production of clean fuels via concentrated solar energy. This study presents a new jet-type burner nozzle for gaseous feedstock injection into a cavity solar receiver inspired from the combustion technology. The nozzle design was adapted from a combustion burner and successfully implemented into a solar receiver and studied the influence of the nozzle design on the fluid mixing and temperature distribution inside the solar receiver using a 7 kW solar simulator and nitrogen as working fluid. Finally, a thorough computational fluid dynamics (CFD) analysis was performed and validated against the experimental results. The CFD results showed a variation of the gas flow pattern and gas mixing after the burner nozzle adaptation, which resulted an intense effect on the heat transfer inside the solar receiver.

关键词： solar reactor nozzle CFD heat transfer mixing and recirculation