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SARS-CoV-2-induced liver injury:A review article on the high-risk populations,manifestations,mechanisms,pathological changes,management,and outcomes

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World Journal of Gastroenterology 2022年第39期28卷 5723-5730页

作者： alvin oliver payus Malehah Mohd Noh Nornazirah Azizan Raman Muthukaruppan Chettiar Department of Medicine Faculty of Medicine and Health SciencesUniversiti Malaysia SabahKota Kinabalu 88400SabahMalaysia Department of Pathobiology and Medical Diagnostic Faculty of Medicine and Health SciencesUniversiti Malaysia SabahKota Kinabalu 88400Malaysia Department of Medicine Hospital Queen Elizabeth Ⅰ13aJalan PenampangKota Kinabalu 88200Malaysia

The novel coronavirus disease 2019 is an infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and was declared a global pandemic with more than 500 million reported cases and more than 6 million deaths worldwide to *** it has transitioned into the endemic phase in many countries,the mortality rate and overall prognosis of the disease are still abysmal and need further *** has been evidence that shows the significance of SARS-CoV-2-related liver ***,we review the literature on the various spectrum of SARS-CoV-2 infection-induced liver injury and the possible mechanisms of damage to the hepatobiliary *** review aimed to illustrate the latest understanding regarding SARS-CoV-2-induced liver injury including the high-risk populations,the characteristic clinical manifestations,the possible pathogenic mechanism,the pathological changes,the current suggestions for clinical treatment for various spectrum of populations,and the prognosis of the *** conclusion,SARS-CoV-2 patients with a liver injury warrant close monitoring as it is associated with the more severe and poorer outcome of the infection.

关键词： COVID-19 SARS-CoV-2 Pandemic Liver injury Pandemics Prognosis

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Case Report: Dual Antiplatelet in Capsular Warning Syndrome

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Neuroscience & Medicine 2021年第2期12卷 55-61页

作者： Azliza Ibrahim Ahmad Firdaus alvin oliver payus Abdul Hanif Khan Liyana Najwa Hamidon Basri Mohd Fandi Department of Neurology Hospital Pengajar Universiti Putra Malaysia Kuala Lumpur Malaysia Department of Medicine Based Faculty of Health Sciences Malaysia Sabah University Sabah Malaysia Department of Neurology Faculty of Medicine and Health Sciences Universiti Putra Malaysia Kuala Lumpur Malaysia Department of Radiology Hospital Pengajar Universiti Putra Malaysia Kuala Lumpur Malaysia

Background: Capsular warning syndrome (CWS) is defined as a recurrent stereotype transient lacunar syndrome without cortical symptoms. However, to date, there is limited literature proposed on the definitive treatment options for the prevention of persistent stroke in cases of capsular warning syndrome. Aim: The aim of this case report is to address dual antiplatelet therapy as a treatment choice in CWS to prevent progressive stroke. Case presentation: A 56-year-old man with several comorbidities experienced recurrent periods of limb weakness and dysarthria lasting 5 - 20 minutes with a complete resolution of symptoms in between. The fluctuating episodes lasted for 72 hours followed by a persistent minor stroke. A gadolinium-enhanced MRI scan of the brain revealed a right basal ganglia infarct. He was treated with dual antiplatelet, and his functional outcome was favourable at 90 days post stroke. Conclusion: Dual antiplatelet may be a beneficial therapeutic option in CWS in improving functional outcomes in the early neurological deficit and decreasing the clinical fluctuation.

关键词： Capsular Warning Syndrome Ischaemic Stroke Aspirin

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