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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

Fate and Behavior of Tetracycline Resistance Genes in Activated Carbon Adsorption

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Journal of Water Resource and Protection 2024年第1期16卷 1-16页

作者： Sri Anggreini alma Rizky Aurellya Wenqing Li Fusheng Li Graduate School of Engineering Gifu University Gifu Japan Graduate School of Natural Science and Technology Gifu University Gifu Japan River Basin Research Center Gifu University Gifu Japan

The accessibility of tetracycline resistance gene (tetG) into the pores of activated carbon (AC), as well as the impact of the pore size distribution (PSD) of AC on the uptake capacity of tetG, were investigated using eight types of AC (four coal-based and four wood-based). AC showed the capability to admit tetG and the average reduction of tetG for coal-based and wood-based ACs at the AC dose of 1 g·L-1 was 3.12 log and 3.65 log, respectively. The uptake kinetic analysis showed that the uptake of the gene followed the pseudo-second-order kinetics reaction, and the uptake rate constant for the coal-based and wood-based ACs was in the range of 5.97 × 10-12 - 4.64 × 10-9 and 7.02 × 10-11 - 1.59 × 10-8 copies·mg-1·min-1, respectively. The uptake capacity analysis by fitting the obtained experiment data with the Freundlich isotherm model indicated that the uptake constant (KF) values were 1.71 × 103 - 8.00 × 109 (copies·g-1)1-1/n for coal-based ACs and 7.00 × 108 - 3.00 × 1010 (copies·g-1)1-1/n for wood-based ones. In addition, the correlation analysis between KF values and pore volume as well as pore surface at different pore size regions of ACs showed that relatively higher positive correlation was found for pores of 50 - 100 Å, suggesting ACs with more pores in this size region can uptake more tetG. The findings of this study are valuable as reference for optimizing the adsorption process regarding antibiotic resistance-related concerns in drinking water treatment.

关键词： Antibiotic Resistance Genes Adsorption Activated Carbon Drinking Water Treatment

Childhood Papillary Thyroid Carcinoma: A Case Report

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Case Reports in Clinical Medicine 2024年第4期13卷 108-114页

作者： alma Al Mansour Hayder Makki Hamadi Mahmoud Elshafey Mohamed Maryam Alkhatry Alqassemi Hospital Emirates Health Services Sharjah UAE Ibrahim Bin Hamad Obaidulla Hospital Ras Al Khaimah UAE

Background: Thyroid cancer is a rare disease yet the most common endocrine malignancy in pediatrics. Unlike adult patients, children with thyroid nodules typically don’t complain of pain, soreness, or difficulty swallowing. Additionally, using the recommended therapy for adults to treat paediatrics is not appropriate. There is an unmet need for updated unique guidelines for the management of papillary thyroid carcinoma (PTC) in paediatrics and adolescents. Case Report: A 12-year-old girl had an atypical presentation of metastatic PTC in lymph nodes. She was treated initially with hemi-thyroidectomy, followed by total thyroidectomy. A multidisciplinary team followed her up till successful results were found. Conclusion: Due to the difference in pathophysiology between thyroid tumors in children and adults, a unique approach to PTC management is to be implemented. Further trials are required for a better understanding of risk factors, the likelihood of recurrence, and the long-term side effects of the chosen management plan.

关键词： Papillary Thyroid Carcinoma Childhood Thyroidectomy Case Report

Using dummy data for RFID tag and reader authentication

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Digital Communications and Networks 2022年第5期8卷 804-813页

作者： Baha’A.Alsaify Dale R.Thompson Abdallah alma'aitah Jia Di Department of Network Engineering and Security Jordan University of Science and TechnologyIrbid21163Jordan Computer Science and Computer Engineering Department University of ArkansasFayetteville72701ARUSA

Radio-Frequency IDentification(RFID)technology is an essential enabler of a multitude of intelligent *** robust authentication of RFID system components is critical in providing trustworthy data delivery from/to *** this paper,we propose an authentication protocol based on monitoring the transmissions between readers and tags in the *** proposed authentication scheme is based on injecting decoys within the exchanged communications(between RFID readers and tags)and is used in the authentication ***,the proposed authentication scheme is mathematically modeled and validated using extensive *** simulations results show that the proposed scheme provides a 100%confidence level in the authentication of tags and detection of compromised readers.

关键词： RFID Authentication Dummy data Security Decoys

Authors and Open Access:Effective Ways to Achieve OA in China

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图书情报工作 2005年第12期49卷 17-25页

作者： alma Swan Key Perspectives Ltd. 48 Old Coach Road Playing PlaceTruroTR3 6ETUnited Kingdom

Although there are effective methods available to authors for providing open access to their work, more than half are still not doing so and provision in China is poorer than in many other countries. There are a number of issues and concerns that dissuade authors from making their work open access: some are still unaware of the concept and of the increased visibility and impact that open access brings; many are unfamiliar with open access journals and how they work; many are uninformed about self-archiving and for some of those who are aware of the possibility of providing open access by this means, concerns about copyright and technical issues *** all these worries can be addressed with simple facts that reassure and encourage authors to adopt open access to benefit themselves,their research and their teaching. There is also a wealth of resources now available to authors that provide information and advice on open access and its effects. As institutions and research funders, both with a strong interest in maximising the visibility and impact of research they support, begin to develop formal policies on open access, models for its provision are emerging. The optimal model is a frills' variant) or by service providers who add functionality or selectivity to provide users with value-enhanced products.

关键词：中国 OA 信息资源网格技术学术材料资源共享

Constant-gain nonlinear adaptive observers revisited: an application to chemostat systems

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Frontiers of Information Technology & Electronic Engineering 2021年第1期22卷 68-78页

作者： Jorge A.TORRES Arno SONCK Sergej CELIKOVSKY alma R.DOMINGUEZ Automatic Control Department CINVESTAVMexico City 07360Mexico The Czech Academy of Sciences Institute of Information Theory and AutomationPrague 18200Czech Republic Biotechnology and Bioengineering Department CINVESTAVMexico City 07360Mexico

This study deals with constant-gain adaptive observers for nonlinear systems,for which relatively few solutions are available for some particular *** introduce an asymptotic observer of constant gain for nonlinear systems that have linear *** allows the observer design to be formulated within the linear matrix inequality paradigm provided that a strictly positive real condition bet ween the inpu t disturbance and the output is *** proposed observer is t hen applied to a large class of nonlinear chemos tat dynamical systems that are widely used in the fermentation process,cell cultures,medicine,*** fact,under standard practical assumptions,the necessary change of the chemos tat state coordinates exis ts,allowing use of the const ant-gain ***,the developed theory is illustrated by estimating pollutant concentration in a Spirulina maxima wastewater treatment facility.

关键词： Nonlinear observers Adaptive observers Coordinate change Chemos tat Pollu taut observation

Evaluation of Red Blood Cell Contribution to Platelet Activation in the Bulk Applying Red Blood Cell—Platelet Thrombus as a Point Source Model

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Advances in Bioscience and Biotechnology 2022年第2期13卷 92-111页

作者： Taha M. Alkhamis Bahieh M. alma’atah Department of Chemical Engineering Mutah University Mutah Jordan

In this study, a point source mathematical model is proposed to describe the diffusion of adenosine di-phosphate (ADP) from either damaged red blood cell (RBC) or activated platelet. The convective diffusion equation is reduced to describe the suggested problem. The final differential equation is solved using Laplace transforms and ADP concentration profiles around the source are obtained. Thrombi of 5 to 20 μm3 containing platelets and a range of red blood cells (RBCs) (0%, 25%, 50%, 75%, 100%) concentrations are used to apply the model. Reported ADP concentrations in the literature are used and its dynamic release from the point source is calculated. Results suggest that RBC chemical contribution to platelet aggregation in the bulk is much less than that of platelet (almost) negligible. However, the physical effect of RBCs is dominant in the bulk through augmentation of released ADP and platelets diffusivities. Moreover, the chemical contribution reported in previous studies is suggested to be as a result of interaction of RBC with the surface under the influence of shear stresses in the boundary region.

关键词： Platelet Red Blood Cell Aggregation Adhesion Diffusion ADP Point Source Chemical Contribution Physical Contribution Shear Stresses Hemolysis

Marine Metagenome as A Resource for Novel Enzymes

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Genomics, Proteomics & Bioinformatics 2015年第5期13卷 290-295页

作者： Amani D.alma'abadi Takashi Gojobori Katsuhiko Mineta Computational Bioscience Research Center (CBRC) King Abdullah University of Science and Technology (KAUST)

More than 99% of identified prokaryotes, including many from the marine environment, cannot be cultured in the laboratory. This lack of capability restricts our knowledge of microbial genetics and community ecology. Metagenomics, the culture-independent cloning of environmental DNAs that are isolated directly from an environmental sample, has already provided a wealth of information about the uncultured microbial world. It has also facilitated the discovery of novel bio- catalysts by allowing researchers to probe directly into a huge diversity of enzymes within natural microbial communities. Recent advances in these studies have led to a great interest in recruiting microbial enzymes for the development of environmentally-friendly industry. Although the metage- nomics approach has many limitations, it is expected to provide not only scientific insights but also economic benefits, especially in industry. This review highlights the importance of metagenomics in mining microbial lipases, as an example, by using high-throughput techniques. In addition, we dis- cuss challenges in the metagenomics as an important part of bioinformatics analysis in big data.

关键词： Microbial diversity Culture-independent studies Catalysis Lipase Biotechnology

Sustainability of microporous polymers and their applications

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Science China Chemistry 2017年第8期60卷 1033-1055页

作者： Tamara L.Church alma Berenice Jasso-Salcedo Fredrik Bjrnerbck Niklas Hedin Department of Materials and Environmental Chemistry Stockholm University

Microporous polymers(MPs) are studied for their intriguing chemistry and physics as well as their potential application in catalytic transformations, gas-separation processes, water purification and so on. Here, we critically review MPs with respect to the sustainability aspects of their synthesis as well as their applications that have sustainable character. Some MPs have been synthesized from monomers derived from biomass resources, but there is certainly a large potential for further *** are also opportunities to improve the sustainability of MP synthesis in terms of the use of solvents, catalysts, and related aspects. The applications of MPs in processes related to sustainability depend upon multiple properties. A rich and flexible chemistry is important to applications as catalysts for, among other useful reactions, the photoreduction of CO_2 and selective oxidation. The(ultra)micropore volume of MPs are crucial in gas-separation applications such as CO_2 capture, and the chemisorption of CO_2 on MP-tethered alkylamines could offer a means to remove that gas from dilute mixtures. When it comes to the storage of H_2 and CH_4 in MPs for onboard use in fuel cell or biogas cars, volumetric capacity is paramount, meaning that the density of the MPs must be considered. Finally, for use in separation and purifications from liquid mixtures(aqueous or hydrocarbon-based), crosslinked MPs are more limited than the solution-processable MPs that can be more easily processed into films and membranes.

关键词： microporous polymers biomass sustainability CO2 capture catalysis H2 storage CH4 storage separation purification