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Diversity of dictyostelid social amoebae in high latitude habitats of Northern Sweden

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Fungal Diversity 2013年第1期58卷 185-198页

作者： allison L.Perrigo Sandra L.Baldauf Maria Romeralo Program in Systematic Biology Department of Organismal BiologyEvolutionary Biology CenterUppsala UniversityNorbyvägen 18D75236 UppsalaSweden

The dictyostelid social amoebae(Dictyostelia)occur in terrestrial habitats *** has been observed previously that their diversity decreases with increasing latitude and *** we look at dictyostelid diversity in the high latitude habitats of Northern *** were recovered from soil samples using traditional plating methods and then identified using morphological characters and molecular sequence(small subunit ribosomal RNA)*** total,nine species were recovered,including two new species,described herein as Dictyostelium barbibulus and Polysphondylium *** species diversity found here is discussed in relation to previous findings in the area as well as other high-latitude studies,and biogeographical patterns are *** total number of species found in Northern Sweden is lower than the numbers recorded for regions further south in Europe,a finding consistent with a latitudinal gradient of species *** findings highlight the benefit of using molecular data for accurate species identification in Dictyostelia and the need for a continued sampling effort to better understand their diversity and distribution,especially in high latitude habitats.

关键词： Cellular slime mold Dictyostelium Molecular identification New species Protist biogeography Sweden

Re: Errors in Zhao et al(2015), Impact of enteral nutrition on energy metabolism in patients with Crohn's disease

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World Journal of Gastroenterology 2016年第9期22卷 2867-2868页

作者： Kathryn A Kaiser Brandon J George david B allison Office of Energetics School of Public Health University of Alabama at Birmingham

We report invalidating errors related to the statistical approach in the analysis and data inconsistencies in a published single cohort study of patients with Crohn's disease. We provide corrected calculations from the available data and request that a corrected analysis be provided by the authors. These errors should be corrected.

关键词： statistical error differences in nominal significance data inconsistency

Suicide transport blockade of motor neuron survival generates a focal graded injury and functional deficit

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Neural Regeneration Research 2021年第7期16卷 1281-1287页

作者： allison S.Liang Joanna E.Pagano Christopher A.Chrzan Randall D.McKinnon Department of Neurosurgery Rutgers-Robert Wood Johnson Medical SchoolPiscatawayNJUSA Member The Cancer Institute of New JerseyNew BrunswickNJUSA

We describe a pre-clinical spinal cord motor neuron injury model that is minimal invasive, reproducible, focal and easily applied to small *** axonal transport of a pro-apoptotic phosphatidylinosotol 3'-kinase inhibitor, wortmannin, via the sciatic nerve results in loss of ipsilateral lumbar motor neurons proportional to the level of drug *** neuron loss was detected by choline acetyltransferase(ChAT) immunostaining and with a transgenic thy1-eGFP *** short half-life of wortmannin generates minimal wound spread, and wortmannin does not affect axon transport, as determined by co-injection of a pseudorabies virus *** quantitative transcript analysis, we found that ChAT transcripts significantly decreased at 14 days post-delivery of 1 μg wortmannin, relative to sham controls, and remained low after 90 *** effects were observed with 200 ng and 100 ng *** also generated a transient and significant increase in astrocyte Gfap transcripts after 14 days with a return to control levels at 90 *** mice had hind limb spasticity and a forced motor function defect that was quantified using a water exit *** rapidly exit a shallow water tray, and wortmannin treated animals were up to 12-fold slower, a phenotype that persisted for at least 3 *** the focal delivery of wortmannin to motor neurons generates a reproducible and scalable injury that can facilitate quantitative studies on neural regeneration and *** efficacy of sciatic nerve suicide transport can also explain neurotoxin-mediated selective loss of motor neurons in diseases such as amyotrophic lateral *** procedures were performed at Rutgers under established Institutional Animal Care and Use protocols(eIACUC_TR201800022, approved on March 20, 2018).

关键词： amyotrophic lateral sclerosis injury motor function motor neuron PI3'kinase sciatic nerve suicide transport wortmannin

Role of alcohol in pathogenesis of hepatitis B virus infection

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World Journal of Gastroenterology 2020年第9期26卷 883-903页

作者： Murali Ganesan allison Eikenberry Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna Research Service Veterans Affairs Nebraska-Western Iowa Health Care SystemOmahaNE 68105United States Department of Internal Medicine Division of Gastroenterology and HepatologyUniversity of Nebraska Medical CenterOmahaNE 68105United States

Hepatitis B virus(HBV)and alcohol abuse often contribute to the development of end-stage liver *** abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist ***,the mechanism by which alcohol promotes the progression of HBVassociated liver disease are not completely *** mechanisms include a suppressed immune response,oxidative stress,endoplasmic reticulum and Golgi apparatus stresses,and increased HBV ***,more research is necessary to gain a better understanding of these mechanisms such that treatment(s)to prevent rapid liver disease progression in alcohol-abusing HBV patients could be *** this review,we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field.

关键词： Hepatitis B virus Alcohol Immunity Oxidative stress Liver disease

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应用两相流模型模拟压铸充型过程的卷气现象

金属学报 2009年第10期45卷 1153-1158页

作者：李帅君熊守美 Mei Li John allison 清华大学机械工程系先进成形制造教育部重点实验室北京100084 Research & Advanced Engineering Department Scientific Research LaboratoryFord Motor Company

通过对压铸充型过程中卷气缺陷形成机理的分析,认为型腔中空气的流动以及与金属液之间的相互作用是形成卷气现象的主要原因.为了考虑型腔中空气的流动,采用了一种不可压缩两相流数学模型来模拟压铸充型过程的卷气现象.通过计算流体力学... 详细信息

通过对压铸充型过程中卷气缺陷形成机理的分析,认为型腔中空气的流动以及与金属液之间的相互作用是形成卷气现象的主要原因.为了考虑型腔中空气的流动,采用了一种不可压缩两相流数学模型来模拟压铸充型过程的卷气现象.通过计算流体力学中的两个基准算例,较为全面地验证了该模型的准确性和可靠性.在此基础上,设计了专门针对压铸充型过程的高速水模拟实验,通过对可视化实验结果与两相流模拟结果的比较,证实二者吻合较好,说明了该模型能够较好地模拟液体的充填行为和卷入其中的气泡.

关键词：压铸卷气两相流模拟

Chronic hemodynamic adaptations induced by resistance training with and without blood flow restriction in adults:A systematic review and meta-analysis

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Sports Medicine and Health Science 2023年第4期5卷 259-268页

作者： allison Russo Giorjines Boppre Cristine Schmidt Lucimere Bohn Lusofona University Faculty of PsychologyEducation and SportPortoPortugal University of Porto Faculty of Sports(FADEUP)PortoPortugal Human Motricity Research Center University AdventistChillanChile Research Center in Physical Activity Healthand Leisure(CIAFEL)Laboratory for Integrative and Translational Research in Population Health(ITR)Portugal Surgery and Physiology Department University of PortoFaculty of Medicine(FMUP)PortoPortugal

The purposes of this systematic review and meta-analysis of peer-reviewed literature were to examine the chronic effects of resistance training with blood flow restriction(RT-BFR)on hemodynamics,and to compare these adaptations to those induced by traditional resistance training(TRT)programs in adults(PROSPERO:Registry:CRD42022339510).A literature search was conducted across PubMed,Sports Discus,Scielo,and Web of Science *** independent reviewers extracted study characteristics and blood pressure *** of bias(The Cochrane risk of bias tool for randomized controlled trials[RoB-2]),and the certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation[GRADE])were used.A total of eight studies met the inclusion criteria for systolic(SBP),diastolic(DBP),and mean arterial pressure(MAP).Regarding the comparison of RT-BFR ***-exercise,no significant differences favoring the exercise group were observed(p>0.05).However,when compared to TRT,RT-BFR elicited additional improvements on DBP(-3.35;95%CI-6.00 to-0.71;I^(2)=14%;z=-2.48,p=0.01),and on MAP(-3.96;95%CI-7.94 to 0.02;I^(2)=43%;z=-1.95,p=0.05).Results indicate that RT-BFR may elicit a decrease in DBP in comparison with TRT,but the lack of data addressing this topic makes any conclusion *** research on this topic is warranted.

关键词： Strength training Blood flow restriction Blood pressure Chronic effect

Transient occult cardiotoxicity in children receiving continuous beta-agonist therapy

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World Journal of Pediatrics 2014年第4期10卷 324-329页

作者： Christopher L Carroll Melinda Coro allison Cowl Kathleen A Sala Craig M Schramm Department of Pediatrics Connecticut Children's Medical CenterHartfordCTUSA

Background:Continuous beta-agonist therapy,typically in the form of inhaled albuterol,is the first line therapy for the treatment of acute and severe bronchospasm in *** this treatment is commonly used,concerns about cardiotoxicity have been *** aimed to investigate the cardiotoxic effects of continuous beta-agonist therapy in ***:We conducted a retrospective review of children admitted to the intensive care unit(ICU)between May 2008 and April 2009,who were treated with continuous beta-agonist therapy(intravenous and nebulized).Results:Twenty of the 36 children treated with continuous albuterol had repeated serum troponin-T and lactate levels *** patients(55%)were also treated with continuous intravenous *** levels of troponin-T levels were found in 25%of children,and elevated lactate levels were found in 60%.However,all returned to normal levels within 48 hours of ICU admission,despite continued beta-agonist *** children experienced arrhythmias during *** was no association between intravenous terbutaline use and elevated troponin-T[odds ratio(OR),1.3;95%CI,0.2-10.3]or with elevated serum lactate(OR,0.6;95%CI,0.1-3.7).There was also no association between elevated troponin-T or lactate and ICU or hospital length of ***:In this small study,a significant proportion of children had elevated serum troponin-T and lactate levels while receiving inhaled continuous beta-agonist therapy,irrespective of intravenous ***,these abnormal values all returned to normal within 48 hours of ICU admission and were not associated with increased duration of hospitalization.

关键词： asthma beta-agonist pediatric

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压铸充型过程中卷气现象的数值模拟研究

金属学报 2010年第5期46卷 554-560页

作者：李帅君熊守美 Mei Li John allison 清华大学机械工程系汽车安全与节能国家重点实验室北京100084 Research &: Advanced Engineering Department Scientific Research Laboratory FordMotor Company Dearborn MI 48121 USA

采用一种液-气两相耦合模型模拟了压铸充型过程中的卷气现象,对卷入金属液中的每个气泡均单独计算其压力变化的趋势,通过压力传递将液-气两相联系在一起.为了验证模型的可靠性和准确性,开展了专门针对压铸的高速水模拟实验,并采用液-气... 详细信息

采用一种液-气两相耦合模型模拟了压铸充型过程中的卷气现象,对卷入金属液中的每个气泡均单独计算其压力变化的趋势,通过压力传递将液-气两相联系在一起.为了验证模型的可靠性和准确性,开展了专门针对压铸的高速水模拟实验,并采用液-气两相耦合模型以及单相流模型分别进行了模拟,通过比较可以证实两相耦合模型在模拟卷气方面比单相流模型具有更高的精确度.

关键词：压铸卷气液-气两相耦合模型

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