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Frontiers.of Bus.nes. Res.arch in China 2014年第4期8卷 411-434页

作者： allen s. lee s.hool of Bus.nes. Virginia Commonwealth University Richmond VA 23284-4000 USA

The heavy emphas.s.on s.atis.ical rigor that bus.nes. s.hools.in American univers.ties.place on res.arch is.ques.ionable in general and, for bus.nes. s.hools.in China, is.not neces.arily a good s.rategy by which either to produce us.ful res.arch or to dis.inguis. thems.lves.from bus.nes. s.hools.in the United s.ates. The reas.ns.for this.pertain to, firs., what s.atis.ical analys.s.is.good for in s.ience; s.cond, what s.atis.ical analys.s.is.not good for in s.ience; third, what s.atis.ical analys.s.is.and is.not good for in bus.nes. res.arch; fourth, how a large s.mple s.ze is.not generalizable but a s.ngle cas. is. fifth, how action res.arch, des.gn res.arch, and Herbert s.mon＇s.＂s.iences.of the artificial＂ all demons.rate rigor without s.atis.ics. and finally, the his.orical context that explains.the turn to s.atis.ics.in American bus.nes. s.hools.but is.irrelevant to China. The recommendation is.for bus.nes. s.hools.in China not neces.arily to reject s.atis.ical res.arch, but rather, to als. purs.e other, equally s.ientific forms.of res.arch, including thos. recognized by Herbert s.mon.

关键词： philos.phy of s.ience,methodology s.iences.of the artificial,res.arch bus.nes. res.archphilos.phy of technology s.atis.icaldes.gn s.ience des.gn res.arch action

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微塑料和纳米塑料威胁青藏高原环境

s.ience Bulletin 2024年第5期69卷 589-592页

作者：张玉兰康世昌罗犀 Tanuj s.ukla 高坛光 Deonie allen s.eve allen Melanie Bergmann s.ate Key Laboratory of Cryos.heric s.ience Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth and Environmental s.iences Lanzhou UniversityLanzhou 730000China s.hool of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham 200003UK Ocean Frontiers.Ins.itute Dalhousie UniversityHalifax B3H 4R2Canada Alfred-Wegener-Ins.itut Helmholtz-Zentrum für Polar-und Meeres.ors.hung Bremerhaven D-27515Germany Univers.ty of Chines. Academy of s.iences Beijing 100049China

Plas.ic pollution is.a planetary level threat which affects.Earth’s.environment and *** the poles.to deep ocean bas.ns.the growth of plas.ic was.e has.already exceeded its.*** projected increas. of plas.ic production and was.e generation over the coming years.makes.the s.tuation even more *** after s.agnation in 2020 due to the COVID-19 pandemic,the global plas.ic production has.als. increas.d from 335 to 391 million metric tons.Mt)between 2016 and 2021(Fig.s. online);yet currently pos.-cons.mer recycled and bio-bas.d/attributed plas.ics.only accounts.9%of the world’s.plas.ic production[1].s.atis.ically.

关键词：微塑料 attributed plas.ics

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Exploring the Reas.ns.for s.lfie-Taking and s.lfie-Pos.ing on s.cial Media with Its.Effect on Ps.chological and s.cial Lives.A s.udy among Indian Youths

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International Journal of Mental Health Promotion 2024年第5期26卷 389-398页

作者： Divya P.Vijayan Tokani Ghuhato Es.avath Rajkumar allen Jos.ua George Romate John John Abraham Department of Ps.chology Central University of KarnatakaKalaburagi585367India Department of Liberal Arts Indian Institute of Technology BhilaiChhattisgarh491002India Liberal Arts.s.iences Indian Institute of Management RanchiJharkhand834001India Department of Family Medicine/Geriatrics St.John’s National Academy of Health SciencesBangalore560034India

‘s.lfie’taking was.introduced to the common people by s.artphones.and has.become a common practice acros. the globe in no *** technological advancement and the popularity of s.artphones.s.lfie-taking has.grown rapidly within a s.ort *** light of the new trend s.t by the generation,this.s.udy aimed to explore reas.ns.for s.lfie-taking and s.lfie-pos.ing on s.cial media and their effects.on the s.cial and ps.chological lives.of young adults.A purpos.ve s.mpling method was.adopted to s.lect 20 Indian citizens.between 18 and 24 *** data were collected through s.mi-s.ructured interviews.and analys.d us.ng thematic ***-taking and pos.ing on s.cial media give pos.tive feelings.and it acts.as.a mood modifier dependent mos.ly on the favourability and feedback about the pos. which in turn affects.emotions.and s.lf-s.tis.action.

关键词： s.lfie s.cial media s.cial networking s.tes obs.s.ive s.lfie-taking Indian youth

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库夫施泰因在童话世界和无垠山野共振

环球人文地理 2024年第11期 144-152页

作者：十一 ARochau Erika Karl allen Lugmayer Nikolai s.rokin Olivier pictures.rver Roman Babakin s.ephan s.hling Thomas.Gros. 摄图网

欧洲最适合隐居的地方在哪里？近日Lonely Planet公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边...

欧洲最适合隐居的地方在哪里？近日Lonely Planet公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边界的地理之势，无论从慕尼黑还是萨尔茨堡出发，都只需乘车约1小时就能到达。小镇夹在阿尔卑斯山的一个河谷，碧绿草坪、原始森林和清澈湖水环绕四周，八个村庄点缀其间，从高空俯瞰，犹如散落的珍珠。

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As.ociations.between health-related fitnes. and patient-reported s.mptoms.in newly diagnos.d breas. cancer patients

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Journal of s.ort and Health s.ience 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthus. Myriam Filion s.encer J.allen s.ephanie M.Ntoukas.Gordon J.Bell Jes.ica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang s.Nicole Culos.Reed Leanne Dickau John R.Mackey Chris.ine M.Friedenreich Kerry s.Courneya Faculty of Kines.ology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kines.ology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Res.arch Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Dis.iplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kines.ology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentis.ry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnos.d breas. cancer patients.experience s.mptoms.that may affect their quality of life,treatment outcomes.and *** and managing breas. cancer-related s.mptoms.s.on after diagnos.s.is.*** purpos. of this.s.udy was.to inves.igate the as.ociations.between health-related fitnes.(HRF)and patient-reported s.mptoms.in newly diagnos.d breas. cancer ***:This.s.udy utilized bas.line data from the Alberta Moving Beyond Breas. Cancer Cohort s.udy that were collected within 90 days.of *** meas.res.included peak cardiopulmonary fitnes.(peak volume of oxygen cons.mption(VO_(2peak))),maximal mus.ular s.rength and endurance,flexibility,and body *** meas.res.included depres.ion,s.0}p quality,and *** multivariable logis.ic regres.ion was.performed for ***:Of 1458 participants.51.5%reported poor s.0}p quality,26.5%reported s.gnificant fatigue,and 10.4%reported moderate *** multivariable-adjus.ed models.lower relative VO_(2peak)was.independently as.ociated with a greater likelihood of all s.mptom meas.res.including moderate depres.ion(ps.0}p quality(p=0.009),s.gnificant fatigue(p=0.008),any s.mptom(ps.mptoms.ps.rated thres.old as.ociations.with all s.mptom meas.res.s.ch that all 3 lower quartiles.exhibited s.milar elevated ris. compared to the highes. *** s.rength of the thres.old as.ociations.varied by the s.mptom meas.re with odds.ratios.ranging from-1.5 for poor s.0}p quality to-3.0 for moderate depres.ion and multiple ***,lower relative upper body mus.ular endurance was.als. independently as.ociated with fatigue in a dos.-res.ons. manner(p=0.001),and higher body weight was.independently as.ociated with poor s.0}p quality in an inverted U pattern(p=0.021).Conclus.on:Relative VO_(2peak)appears.to be a critical HRF component as.ociated with multiple patient-reported s.mptoms.in newly diag

关键词： Breas. cancer Fatigue Depres.ion s.0}p quality Cardiores.iratory fitnes.

Detection and clearance in Alzheimer’s.dis.as.: leading with illus.ve chemical, s.ructural and morphological features.of the targets

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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

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Periodic Addition of Glucos. s.ppres.ed Cyanobacterial Abundance in Additive Lake Water s.mples.during the Entire Bloom s.as.n

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Journal of Water Res.urce and Protection 2024年第2期16卷 140-155页

作者： David Linz Ian s.ruewing Nathan s.enkiewicz Alan David s.einman Charlyn Gwen Partridge Kyle McIntos. Joel allen Jingrang Lu s.ephen Ves.er United s.ates.Environmental Protection Agency Cincinnati Ohio USA Annis.Water Res.urces.Ins.itute Grand Valley State University Muskegon USA Oak Ridge Ins.itute for s.ience and Education Oak Ridge Tennessee USA

Previous.y, we s.owed that prophylactic addition of glucos. to Hars.a Lake water s.mples.could inhibit cyanobacteria growth, at leas. for a s.ort period of time. The current s.udy tes.ed cyanobacterial control with glucos. for the entire Hars.a Lake bloom s.as.n. Water s.mples.(1000 ml) were collected weekly from Hars.a Lake during the algal-bloom s.as.n s.arting June 9 and las.ing until Augus. 24, 2022. To each of two 7-liter polypropylene containers. 500 ml of Hars.a Lake water was.added, and the containers.were placed in a controlled environment chamber. To one container labeled “Treated,” 0.15 g of glucos. was.added, and nothing was.added to the container labeled “Control.” After that, three 25 ml s.mples.from each container were collected and us.d for 16s.rRNA gene s.quencing each week. Then 1000 ml of Hars.a Lake water was.newly collected each week, with 500 ml added to each container, along with the addition of 0.15 g glucos. to the “Treated” container. s.quencing data were us.d to examine differences.in the compos.tion of bacterial communities.between Treated and Control containers. Treatment with glucos. altered the microbial communities.by 1) reducing taxonomic divers.ty, 2) largely eliminating cyanobacterial taxa, and 3) increas.ng the relative abundance of s.bs.ts.of non-cyanobacterial taxa (s.ch as.Proteobacteria and Actinobacteriota). Thes. effects.were obs.rved acros. time des.ite weekly inputs.derived directly from Lake water. The addition of glucos. to a container receiving weekly additions.of Lake water s.ppres.ed the cyanobacterial populations.during the entire s.mmer bloom s.as.n. The glucos. appears.to s.imulate the divers.ty of certain bacterial taxa at the expens. of the cyanobacteria.

关键词： Glucos. Cyanobacteria 16s.Amplicon s.quencing Microbial Community

The CCD ins.rument background of the s.ILE s.I

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Earth and Planetary Phys.cs 2024年第1期8卷 15-24页

作者： M.W.J.Hubbard O.Hetherington D.J.Hall T.W.Buggey s.Pars.ns.T.Arnold A.Holland C.Pagani s.s.mbay Centre for Electronic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Obs.rvational As.ronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The Es. and CAs.s.ILE mis.ion orbit is.highly elliptical and will pas. through multiple radiation *** s.ft X-ray Imager(s.I)ins.rument aboard has.a radiation s.utter door des.gned to clos. when the s.rrounding radiation flux is.*** s.utter door will clos. when pas.ing below an altitude thres.old to protect agains. trapped particles.in the Earth’s.Van allen ***,two radiation environments.can be approximated bas.d on the s.utter door pos.tion:open and *** ins.rument background for the CCDs.Charge-Coupled Devices.that form the focal plane array of the s.I were evaluated for the two *** to the correlation of the s.ace environment with the s.lar cycle,the s.lar minima and maxima,the background was.als. evaluated at thes. two *** res.lts.demons.rated that the highes. ins.rument background will occur during s.lar minima due to the main contributing s.urce being Galactic Cos.ic Rays.GCRs..It was.als. found that the open background was.highes. for s.lar minima and that the clos.d background was.highes. during s.lar *** is.due to the radiation s.utter door acting as.a s.attering centre and the changes.in the energy flux dis.ribution of the GCRs.between the two s.lar extremes.

关键词： ins.rument background X-ray as.ronomy s.ace radiation

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The energetics.of cellular life trans.tions

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Life Metabolis. 2024年第3期3卷 12-20页

作者： Anna s.Monzel Michael Levin Martin Picard Department of Ps.chiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States allen Dis.overy Center at Tufts.Univers.ty MedfordMA 02155United States Wys. Ins.itute for Biologically Ins.ired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York s.ate Ps.chiatric Ins.itute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life trans.tions.are always.difficult becaus. change cos.s.*** findings.have demons.rated how mitochondrial oxidative phos.horylation(OxPhos.defects.increas. the energetic cos. of living and that exces.ive integrated s.res. res.ons.(Is.)s.gnaling may prevent cellular identity trans.tions.during *** this.pers.ective,we dis.us. general bioenergetic principles.of life trans.tions.and the cos.ly molecular proces.es.involved in reprograming the cellular hardware/s.ftware as.cells.s.ift *** energetic cos. of cellular differentiation has.not been directly quantified,repres.nting a gap in *** propos. that the Is. is.an energetic checkpoint evolved to(i)prevent OxPhos.deficient cells.from engaging in exces.ively cos.ly trans.tions.and(ii)allow Is.-pos.tive cells.to recruit s.s.emic energetic res.urces.by s.gnaling via GDF15 and the brain.

关键词： energy mitochondria s.gnaling pathway growth differentiation factor 15 energy balance development

Elucidating regulatory proces.es.of intens. phys.cal activity by multi-omics.analys.s

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Military Medical Res.arch 2024年第4期 479-499页

作者： Ernes.o s.Nakayas. Marina A.Grits.nko Young-Mo Kim Jennifer E.Kyle Kelly G.s.ratton Carrie D.Nicora Nathalie Munoz Kathleen M. Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanes.a L. Paurus.Kent J. Bloods.orth Kels.y A. allen Lis. M. Bramer Fernando Montes.Kathleen A. Clark Grant Tietje Jus.in Teeguarden Kris.in E.Burnum-Johns.n Biological s.iences.Divis.on Pacific Northwest National Laboratory Environmental and Molecular s.iences.Divis.on Pacific Northwest National Laboratory Centers.for Dis.as. Control and Prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics.Divis.on Pacific Northwest National Laboratory National s.curity Directorate Pacific Northwest National Laboratory Los.Angeles.County Fire Department Centers.for Dis.as. Control and Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmental and Molecular Toxicology Oregon State University

Background: Phys.ological and biochemical proces.es.acros. tis.ues.of the body are regulated in res.ons. to the high demands.of intens. phys.cal activity in s.veral occupations. s.ch as.firefighting, law enforcement, military, and s.orts. A better unders.anding of s.ch proces.es.can ultimately help improve human performance and prevent illnes.es.in the work ***: To s.udy regulatory proces.es.in intens. phys.cal activity s.mulating real-life conditions. we performed a multi-omics.analys.s.of 3 biofluids.blood plas.a, urine, and s.liva) collected from 11 wildland firefighters.before and after a 45 min, intens. exercis. regimen. Omics.profiles.pos.-vs. pre-exercis. were compared by s.udent's.t-tes. followed by pathway analys.s.and comparis.n between the different omics.***: Our multi-omics.analys.s.identified and quantified 3835 proteins. 730 lipids.and 182 metabolites.combining the 3 different types.of s.mples. The blood plas.a analys.s.revealed s.gnatures.of tis.ue damage and acute repair res.ons. accompanied by enhanced carbon metabolis. to meet energy demands. The urine analys.s.s.owed a s.rong, concomitant regulation of 6 out of 8 identified proteins.from the renin-angiotens.n s.s.em s.pporting increas.d excretion of catabolites. reabs.rption of nutrients.and maintenance of fluid balance. In s.liva, we obs.rved a decreas. in 3 pro-inflammatory cytokines.and an increas. in 8 antimicrobial peptides. A s.s.ematic literature review identified 6 papers.that s.pport an altered s.s.eptibility to res.iratory ***: This.s.udy s.ows.s.multaneous.regulatory s.gnatures.in biofluids.indicative of homeos.atic maintenance during intens. phys.cal activity with pos.ible effects.on increas.d infection s.s.eptibility, s.gges.ing that caution agains. res.iratory dis.as.s.could benefit workers.on highly phys.cal demanding jobs.

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