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Sphingomyelin phosphodiesterase acid like 3B(SMPDL3b)regulates Perilipin5(PLIN5)expression and mediates lipid droplet formation

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Genes & Diseases 2022年第6期9卷 1397-1400页

作者： Shamroop Kumar Mallela Mengyuan Ge Judith Molina Javier Varona Santos Jin-Ju Kim alla mitrofanova Hassan Al-Ali Brian Marples Sandra Merscher Alessia Fornoni Katz Family Division of Nephrology and Hypertension Department of MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136USA Peggy and Harold Katz Family Drug Discovery Center University of MiamiMiller School of MedicineMiamiFL 33136USA Department of Radiation Oncology University of RochesterRochesterNY 14627USA

Lipid droplets(LDs)are lipid storage organelles with a central hydrophobic core of neutral lipids that is enclosed in a monolayer of *** the storage of lipids,mainly cholesterol and triglycerides,was thought to be the primary function of LDs,studies have shown that they have important functions in maintaining lipid homeostasis and modulating various signaling *** lipid accumulation has been recognized as a key feature in several human diseases such as obesity,diabetes,cancer,neurological diseases,cardiovascular diseases,insulin resistance,liver diseases and kidney *** play an important role in innate immunity,in the fight against infections,and in the replication of *** a tight regulation of LD metabolism is essential for proper functioning of a cell.

关键词： metabolism immunity Lipid

Long-term Speckle Interferometric Monitoring of Binary Systems:2007–2023Positional Measurements and Orbits of Seven Objects

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Research in Astronomy and Astrophysics 2024年第9期24卷 147-155页

作者： Arina mitrofanova Vladimir Dyachenko Anatoly Beskakotov Yuri Balega Alexander Maksimov Denis Rastegaev Special Astrophysical Observatory 369167 Nizhnij ArkhyzRussia

The results of seventeen years of speckle interferometric monitoring of seven objects(Chara 122Aa,GJ 3010,HIP1987,GJ 3076,HIP 11253,HIP 11352,and HIP 14929)are *** data were obtained at the 6 m Big Telescope Alt-azimuthal Special Astrophysical Observatory of the Russian Academy of Science(BTA SAO RAS)from 2007 to the *** of previously published and new measurements made it possible to construct completely new orbits for Chara 122Aa,HIP 11253,and HIP *** orbit of GJ 3076 cannot be constructed accurately due to the large influence of the weights assigned to the *** resulting orbital solutions are classified based on a grading scheme suggested by ***,*** and ***;most orbits are“definitive”(Grade 1).The mass sums and masses of components calculated by two independent methods using Hipparcos and Gaia DR2 and DR3 parallaxes were compared for the objects under study.

关键词： techniques:high angular resolution (stars:)binaries:visual stars:fundamental parameters stars:low-mass stars:solar-type

Large-scale genome-wide SNP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： Natalia V.DEMENTIEVA Yuri S.SHCHERBAKOV Olga I.STANISHEVSKAYA Anatoly B.VAKHRAMEEV Tatiana A.LARKINA Artem P.DYSIN Olga A.NIKOLAEVA Anna E.RYABOVA Anastasiia I.AZOVTSEVA Olga V.mitrofanova Grigoriy K.PEGLIVANYAN Natalia R.REINBACH Darren K.GRIFFIN Michael N.ROMANOV Russian Research Institute of Farm Animal Genetics and Breeding-Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.Ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from Europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),North America(USA),and Oceania(Australia).Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SNP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURE-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SNP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry Phylogeny Demographic history

The first results of observations of lunar occultations in different spectral ranges at the 6-m telescope of the SAO RAS

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Research in Astronomy and Astrophysics 2020年第11期20卷 231-234页

作者： Ekaterina Shmaylova Vladimir Dyachenko Andrea Richichi Anatoly Beskakotov AleksandrMaksimov Arina mitrofanova Yuri Balega Special Astrophysical Observatory Russian Academy of SciencesNizhniy ArkhyzKarachai-Cherkessian RepublicRussia 369167 Astronomical Institute St.Petersburg State UniversityUniversitetskij Pr.28Petrodvorets198504St.PetersburgRussia INAF-Osservatorio Astrofisico di Arcetri Largo E.Fermi 550125FirenzeItaly

Observations by the method of lunar occultations at the 6-m telescope of the SAO RAS reach a resolution limit better than *** have devised a new method of observation,which allows obtaining the curves of lunar occultations simultaneously in different ranges of the visible part of the spectrum,and conducted the first observations using amodified optical *** January 2019,applying the newmethod,the magnitude differences of the components of the binary star HD 36524 in the R and I bands were measured,which were 1.5 and 1.3mag,respectively,in good agreement with values calculated from the Gaia *** to the obtained data,it was determined that with this method it is possible to reach a signal-to-noise ratio of about 5–10 for stars of 10th *** discuss the applicability of the proposed optical scheme for the study of binary stars.

关键词： star binaries general instrumentation high angular resolution methods observational

On the correctness of orbital solutions obtained from a small set of *** of HIP 53731

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Research in Astronomy and Astrophysics 2020年第11期20卷 321-324页

作者： Arina mitrofanova Vladimir Dyachenko Anatoly Beskakotov Yury Balega Alexander Maksimov Denis Rastegaev Sergey Komarinsky Special Astrophysical Observatory of the Russian Academy of Sciences Nizhnij ArkhyzRussia 369167

HIP 53731 is a binary consisting of stars of the spectral types K0 and *** orbit of this object was constructed previously by Cvetkovic et *** improved by *** should be noted that there is a 180°ambiguity in the position angles of some published *** interferometric observations were obtained in 2007–2020(21 measurements)at the 6-m telescope of the SAO RAS(BTA)by the authors of this *** analysis of new data together with previously published ones made it possible to construct an accurate orbit of HIP 53731 and to halve the already known values of the orbital period of the *** a result of the study,the mass sum,the masses of each component and their spectral types were determined by two independent *** to the qualitative classification of orbits,the orbital solution has grade 2–"good"(observations cover more than half of the orbital period and correspond to different phases).

关键词： techniques high angular resolution,speckle interferometry stars low-mass,fundamental parameters stars binaries spectroscopic stars individual HIP 53731

The determination of white dwarf parameters in dwarf novae by optical spectral modeling

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Research in Astronomy and Astrophysics 2021年第7期21卷 37-40页

作者： Anastasiya Andreevna Dudnik Arina Alekseevna mitrofanova Vladislav Vladimirovich Shimansky Nikolay Vladimirovich Borisov Nail Abdullovich Sakhibullin Kazan(Volga Region)Federal University KazanRepublic of TatarstanRussia Special Astrophysical Observatory Russian Academy of ScienceNizhnii ArkhysKarachai-Cherkessian RepublicRussia

This paper presents the results of a model analysis of optical spectra and determination of the parameters of three individual SU UMa and WZ Sge type dwarf *** moderate resolution spectra of TY Psc,FL Psc and V455 And were obtained at the 6-m BTA of the SAO RAS in the low state of these systems with the determination of white dwarf *** theoretical spectra were calculated using the grid models of hydrogen dwarf atmospheres of white dwarfs by varying the parameters(T_(eff) and log g) to reach the best agreement with the observed *** highlight different effects of the parameters on the shape and intensity of the HI ***,it is possible to unambiguously determine T_(eff) and log g from the analysis of *** fundamental parameters of white dwarfs(M and R) were found by comparing the parameters of atmospheres with theoretical models of the internal *** obtained parameters of the primaries of TY Psc,FL Psc and V455 And are consistent with the average values for SU UMa and WZ Sge *** a result,we demonstrate the efficiency of the method for determining the parameters of such systems based on the analysis of a limited set of observed optical spectra.

关键词： techniques:spectroscopic stars:variables:dwarf novae stars:individual:TY Psc stars:individual:FL Psc stars:individual:V455 And

Research on the HIP 18856 binary system

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Research in Astronomy and Astrophysics 2021年第3期21卷 69-72页

作者： Polina Efremova Arina mitrofanova Vladimir Dyachenko Anatoly Beskakotov Alexander Maksimov Denis Rastegaev Yury BalegaSergey Komarinsky Kazan Federal University Kazan 420008Russia Special Astrophysical Observatory of the Russian Academy of Sciences Nizhnij ArkhyzRussia 369167

The results of a study on the binary HIP 18856 and construction of its orbit are *** observational data were obtained at the BTA of SAO RAS in ***,Cvetkovic et *** the orbit for this ***,it is based on six measurements,which cover a small part of the *** positional parameters of the ESA astrometric satellite Hipparcos published speckle interferometric data(Mason et al.,Balega et al.,Horch et al.)and new ones were used in this *** on the new orbital parameters,the mass sum was calculated and the physical parameters of the components were *** obtained orbital and fundamental parameters were compared with the data from the study by Cvetkovic et al..The comparison shows that the new orbital solution is better than the old one,since it fits new observational data *** based on a qualitative evaluation performed by Worley&Heintz,the new orbit was classified as"reliable",which means data cover more than half of the orbit with sufficient quantities of residuals of measurements.

关键词： techniques:high angular resolution,speckle interferometry stars:low-mass,fundamental parameters stars:binaries:spectroscopic stars:individual:HIP 18856

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东正教圣像史与俄罗斯圣像画形成过程

东正教圣像史与俄罗斯圣像画形成过程

作者： mitrofanova, Maria 浙江大学

学位级别：硕士

俄罗斯是一个信奉东正教的国家。圣像画作为一种艺术品,印证了俄罗斯民众对信仰的强烈渴求。在俄罗斯,圣像画常被安放在教堂和一些公共场所。虔诚的东正教徒把圣像画视如珍宝,他们会在众人面前,顶礼膜拜、虔诚地亲吻圣像,亲切的抚摸圣像... 详细信息

俄罗斯是一个信奉东正教的国家。圣像画作为一种艺术品,印证了俄罗斯民众对信仰的强烈渴求。在俄罗斯,圣像画常被安放在教堂和一些公共场所。虔诚的东正教徒把圣像画视如珍宝,他们会在众人面前,顶礼膜拜、虔诚地亲吻圣像,亲切的抚摸圣像,直面圣像说着自己内心深处的祈祷。在圣徒家中,圣像要摆放在显要位置,因为人们会经常祈求它庇护家人的安康。更有甚者小幅圣像常被圣徒随身携带以便随时祈祷。在俄罗斯,大量圣像画免于战乱与人为的破坏,得以完整保存,可见圣像在俄罗斯民众心目中的地位是极其重要的。本文主要论述了俄罗斯传统圣像画的起源、发展以及它的装饰特征。圣像画起源于拜占廷,并在拜占廷得到一定的发展。公元988年,古罗斯的基辅公国皈依了基督教,圣像画这种艺术形式也随之传入俄罗斯,并与俄罗斯的民间艺术相结合,在历代艺术家、画匠的不懈努力下,逐渐形成了其显著的装饰特征。圣像画在俄罗斯传统艺术中占有很大的比重,通过对它的研究,有助于我们理解俄罗斯艺术发展的脉络,本文力求归纳出俄罗斯圣像画的特征,以期对圣像画这一艺术形式有更深层次地认识。

关键词：圣像画东正教俄罗斯艺术

Serological diagnostics of myocardium diseases based on multivariate analysis of cardiotrophic autoantibodies’ profiles

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Open Journal of Immunology 2012年第1期2卷 49-58页

作者： Olga Moiseeva Lubov mitrofanova Elena Karelkina Dmitry Zverev Dmitry Lebedev Serge Skurydin Alexander Poletaev Medical Research Center “Immunculus” Moscow Russia V.A. Almazov’s Federal Center for Heart Blood and Endocrinology St. Petersburg Russia

We analyzed profiles of IgG autoantibodies to 16 cardiac specific proteins and their main immunogenic region B-epitopes, in the groups of already verified cardiac pathology: acute and chronic lymphocytic myocarditis, ST elevation myocardial infarction, postinfarction remodeling of myocardium, dilated cardiomyopathy and in healthy controls along with patients, suffered from gastritis (to evaluate immune response against cross-reactive B-epitopes). AAB specific patterns allowed us to distinguish cases among themselves by means of multiparametrical canonical discriminant analysis in approximately 95% of cases. Positive predictive value in the group of MYO reached 95%, in the STEMI—89%, in the PIR—99%, in the DCM—99%, in the group of gastritis—88%. Principal component analysis of mentioned cardiac pathologies extended current clinical knowledge of their immunopathogenesis. Obtained data markedly proved a usability of serum AAB profiling for non invasive screening, differential diagnostics and working hypothesis composition.

关键词： Autoantibody Autoimmunity B-Epitope Autoantibody Profiling Cardiology Principal component Analysis