Serological diagnostics of myocardium diseases based on multivariate analysis of cardiotrophic autoantibodies’ profiles
Serological diagnostics of myocardium diseases based on multivariate analysis of cardiotrophic autoantibodies’ profiles作者机构：Medical Research Center “Immunculus” Moscow Russia V.A. Almazov’s Federal Center for Heart Blood and Endocrinology St. Petersburg Russia
出 版 物：《Open Journal of Immunology》 (免疫学期刊（英文）)
年 卷 期：2012年第2卷第1期
页 面：49-58页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Autoantibody Autoimmunity B-Epitope Autoantibody Profiling Cardiology Principal component Analysis
摘 要：We analyzed profiles of IgG autoantibodies to 16 cardiac specific proteins and their main immunogenic region B-epitopes, in the groups of already verified cardiac pathology: acute and chronic lymphocytic myocarditis, ST elevation myocardial infarction, postinfarction remodeling of myocardium, dilated cardiomyopathy and in healthy controls along with patients, suffered from gastritis (to evaluate immune response against cross-reactive B-epitopes). AAB specific patterns allowed us to distinguish cases among themselves by means of multiparametrical canonical discriminant analysis in approximately 95% of cases. Positive predictive value in the group of MYO reached 95%, in the STEMI—89%, in the PIR—99%, in the DCM—99%, in the group of gastritis—88%. Principal component analysis of mentioned cardiac pathologies extended current clinical knowledge of their immunopathogenesis. Obtained data markedly proved a usability of serum AAB profiling for non invasive screening, differential diagnostics and working hypothesis composition.
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