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Deposition of Titanium Layer on Steel Substrate Using PECVD Method: A Parametric Study

Materials Sciences and Applications 2014年第3期5卷 140-148页

作者： Haman Hedaiatmofidi alireza sabour rouh aghdam Shahrokh Ahangarani Mansour Bozorg Mahboube Azadi Maryam Valiei Advanced Materials & Renewable Energies Department Iranian Research Organization for Science and Technology Tehran Iran Material Science and Technology Azad University Tehran Iran Surface Engineering Laboratory Materials Engineering Department Faculty of Engineering Tarbiat Modares University Tehran Iran

Metallic titanium film was deposited on H-13 steel substrate at 470°C - 530°C using plasma enhanced chemical vapor deposition (PECVD) method. In this paper, the effects of manufacturing parameters were investigated on deposited titanium coating characteristics. XRD, FESEM, XPS and AFM were used in order to study coating characteristics. Increasing hydrogen flow rate from 200 to 360 sccm, resulted in a 72% decrease in oxygen content and 38% decrease in chlorine content of the film. Applied plasma voltage has a severe effect on nanohardness of coating. Pressure of the deposition chamber has a negative effect on titanium characteristics.

关键词： PECVD Titanium Layer Oxygen Content XPS

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The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line

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Journal of Biosciences and Medicines 2024年第8期12卷 141-153页

作者： alireza Khorshid Jafar Nouri Nojadeh Javid sabour Takanlu alireza Tavasoli Department of Clinical Laboratory Sciences University of Texas Medical Branch at Galveston Galveston TX USA Department of Medical Genetics Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran Apoptosis Research Centre Department of Biochemistry School of Natural Sciences National University of Ireland Galway Galway Ireland Department of Pathology School of Medicine Fasa University of Medical Science Fasa Iran

Background: Herbal medicine is well-known among the ancient medical sciences. Healing properties have been observed in some species of Daphne plant. The effect of Daphne plant extract on the K562 cell line has been previously studied, and Gleevec is a well-known and effective medicine for the treatment of chronic myelogenous leukemia. Material and Methods: In this study, the simultaneous effects of using herbal medicine and a target therapy medicine on the K562 cell line were investigated. The presence of some species of Daphne in Iran motivated us to evaluate the cytotoxic effect of Daphne mucronata on human leukemia cancer cells. The antiproliferative activity of the dichloromethane extract of Daphne mucronate (Thymelaeaceae), a new anticancer medicinal plant, was evaluated. Cell viability was quantitated by MTT assay. Apoptotic and necrotic changes in the cell membrane were examined using flow cytometry. Changes in Bax and Bcl2 gene expression were investigated using real-time PCR. The MIC and the IC50 of the crude extract were calculated, and the MIC and IC50 of the Daphne extract in combination of imatinib were tested in the K-562 cell line. Results: K-562 cells responded to the extract treatments in a dose-dependent manner, and the increase in the expression of Bcl2 and decrease in the expression of the Bax gene intensified with increasing extract concentration. Flow cytometry revealed that most of the cells underwent necrosis. Conclusion: Daphne extract effectively decreased the viability of the K562 cell line. The necrotic effect of the Daphne extract was evaluated, and an increase in the gene expression of Bcl2 was observed in cells exposed to the Daphne extract. The combination of Daphne extracts with imatinib enhances the cytotoxic effect of imatinib.

关键词： Daphne Imatinib Apoptosis Herbal Medicine Bax Bcl-2 CML

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