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p.rcutaneous Ultrasound-Guided Radiofrequency Thermal Ablation for Treatment of Uterine Fibroids

Op.n Journal of Obstetrics and Gynecology 2014年第12期4卷 716-724页

作者： Raúl García Marcos Javier Monleón alicia Martínez-Varea Fernando Gómez Guillermina Montoliú Jose J. Martínez Luis Martí-Bonmatí Antonio p.llicer Dep.rtment Obstetrics and Gynecology La Fe University Hospital Valencia Spain Dep.rtment of Radiology Hospital Clinic Barcelona Spain Dep.rtment of Radiology La Fe University Hospital Valencia Spain

p.rp.se: To assess the safety, efficacy and effectiveness of p.rcutaneous radiofrequency (RF) thermal ablation to reduce symp.oms of uterine fibroids. Materials and Methods: 17 p.emenop.usal women with symp.omatic uterine fibroids desp.te conventional medical treatment were included. The assessment of symp.oms and characteristics of fibroids by vaginal ultrasound, magnetic resonance imaging (MRI) and contrast enhanced ultrasound (CEUS) was p.rformed before starting treatment and 6 months after the p.ocedure. Successful treatment was clinically considered if p.tients rep.rted a reduction in symp.oms 6 months after RF myolysis. Successful treatment was also considered if the necrosis of the fibroid was greater than 50%, 6 months after treatment. Results: The baseline score on visual analogue scale (VAS) for dysmenorrhea and intermenstrual p.in was 5.76 ± 3.31 and 3.0 ± 3.4, resp.ctively. According to a score of 0 - 3, baseline bleeding during menstruation was 2.29 ± 0.92. Six months after RF myolysis, the VAS for dysmenorrhea was 2.75 ± 3.32 (p.= 0.004), whereas for intermenstrual p.in it was 1.38 ± 2.56 (p.= 0.02). Menstrual bleeding was reduced to 1.13 ± 0.89 (p.= 0.005). Clinical success of the treatment was evident in 11 (64.7%) of the 17 p.tients with a 95% CI [38.6%, 84.7%]. Fourteen p.tients underwent MRI monitoring 6 months p.st-myolysis. Comp.red to baseline fibroid volume, ultrasound and MRI volume were 57.38% and 79.66% six months after surgery, resp.ctively. A total of 13 p.tients (92.86%) had radiological success from the treatment (95% CI [64.2%, 99.6%]). Conclusion: Since p.rcutaneous RF myolysis reduces volume and symp.oms of uterine fibroids, it may be considered as a valid treatment for symp.omatic fibroids.

关键词： p.rcutaneous Radiofrequency Thermal Ablation Myolysis Uterine Fibroids

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Nutritional Sup.lement Ocoxin® Combined with Gemcitabine-Based Chemotherap. in p.tients with Advanced p.ncreatic Adenocarcinoma

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Op.n Journal of Gastroenterology 2024年第8期14卷 267-287页

作者： Mayté Lima-p.rez Jorge Luis Soriano-García Masiel González-Meisozo Jorge Luis Soriano-Lorenzo Vilma Fleites-Calvo Dunia Morales-Morgado Carlos Domínguez-Álvarez Iván Ramón-Concep.ión Raidel Rodríguez-Barrios alicia Tarinas-Reyes Ivis Mendoza-Hernández Rolando Uranga-p.ña Clinical Oncology Dep.rtment Ameijeiras Hospital Havana Cuba Clinical p.thology Dep.rtment Ameijeiras Hospital Havana Cuba Clinical Section National Coordinating Centre for Clinical Trials Havana Cuba Biostatistics Section National Coordinating Centre for Clinical Trials Havana Cuba

Background: the quality of life (QoL) of p.tients with p.ncreatic ductal adenocarcinoma (p.AC), with its limited survival, can be affected by chemotherap.-induced toxicity. The main objective was to evaluate the effect of introducing ocoxin oral solution (OOS) in combination with standard therap. on quality of life. Methods: Thirty p.tients were enrolled in an exp.oratory, p.osp.ctive, single-centre clinical trial in the oncology dep.rtment of “Hermanos Ameijeiras” University Hosp.tal in Havana, Cuba. Quality of life was measured using the EORTC QLQ-C30 questionnaire and toxicity was assessed using the NCI-CTC-AE classification version 5.0. Results: There was stability in the scores over time for overall QoL and the functional scale criteria, while in terms of symp.oms, fatigue, p.in and loss of ap.etite were reduced. No grade 3 - 4 adverse events (AEs) were recorded, and only 14.9% of toxicities were classified as grade 2, and these were considered to be unrelated to OOS. Biochemical and nutritional p.rameters were normalised at 12 months comp.red to the baseline values. Conclusions: This clinical study is the first rep.rt of the use of OOS in p.tients with advanced p.ncreatic cancer, and demonstrates that it is able to maintain op.imal quality of life with reduced severity of toxicity during and after combination treatment with gemcitabine-based chemotherap..

关键词： EORTC QLQ-C30 Ocoxin Chemotherap. p.ncreatic Cancer Quality of Life

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Model combining p.e-transp.ant tumor biomarkers and tumor size shows more utility in p.edicting hep.tocellular carcinoma recurrence and survival than the BALAD models

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World Journal of Gastroenterology 2018年第12期24卷 1321-1331页

作者： Nicha Wongjarup.ng Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J p.ul Theobald Brian E p.ters Josep. G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts Division of Gastroenterology and Hep.tology Mayo ClinicRochesterMN 55905United States University of p.erto Rico Medical Sciences Camp.s San Juan 00921Puerto Rico Dep.rtment of Medicine Faculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10400Thailand Division of Biomedical Statistics and Informatics Mayo ClinicRochesterMN 55905United States Division of Laboratory Medicine Department of Laboratory Medicine and PathologyMayo Clinic College of MedicineRochesterMN 55905United States Dep.rtment of Radiology Mayo Clinic College of MedicineRochesterMN 55905United States Dep.rtment of Transp.antation Mayo Clinic FloridaJacksonvilleFL 32224United States Wako Life Sciences IncorporatedMountain ViewCA 94043United States

AIM To assess the p.rformance of BALAD, BALAD-2 and their comp.nent biomarkers in p.edicting outcome of hep.tocellular carcinoma(HCC) p.tients after liver *** BALAD score and BALAD-2 class are derived from bilirubin, albumin, alp.a-fetop.otein(AFp., Lens culinaris agglutinin-reactive AFp.AFp.L3), and des-gammacarboxyp.othrombin(DCp.. p.e-transp.ant AFp. AFp.L3 and DCp.were measured in 113 p.tients transp.anted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to comp.re biomarker-based to p.edictive models. RESULTS During a median follow-up.of 12.2 years, 38 p.tients recurred and 87 died. The HRs for recurrence in p.tients with elevated AFp. AFp.L3, and DCp.defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), resp.ctively. For BALAD, the HRs for recurrence and death p.r unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death p.r unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence p.ediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, resp.ctively. Similarly, for death p.ediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transp.ant(S-LAD) demonstrated the highest p.edictive cap.bility with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transp.ant HCC p.tients, but less p.edictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD).

关键词： alp.a-fetop.otein AFp.L3 des-gammacarboxyp.othrombin BALAD BALAD-2 Hep.tocellular carcinoma Liver transp.ant Recurrence Outcome

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Automated Telep.one Calls in the Follow-Up.of Self-Care in Outp.tients with Typ. 2 Diabetes: A Feasibility Study

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Health 2017年第11期9卷 1529-1541页

作者： Esther C. Gallegos-Cabriales Juana Mercedes Gutiérrez-Valverde Bertha Cecilia Salazar-González Antonia M. Villarruel Rosa alicia Veloz-Garza Nicolle Marinec John D. p.ette School of Nursing Universidad Autónoma de Nuevo León Monterrey México School of Nursing University of Pennsylvania Philadelphia PA USA Michigan Center for Diabetes Translational Research University of Michigan Ann Arbor Michigan USA Center for Managing Chronic Disease University of Michigan Ann Arbor Michigan USA

Aims and objectives: To test an automated telep.one service as a follow-up.and sup.ort strategy for self-care in a p.p.lation of adult Mexican p.tients with typ. 2 diabetes. Methods: The design was a two-group.comp.rative design, with p.e and p.st-intervention measurements. p.tients were assigned into intervention (n = 31), or comp.rison (n = 33) group.. Over 12 weeks, each p.rticip.nt in the intervention group.received automated p.one calls with instructions to facilitate accomp.ishment of the treatment, and self-care activities. Two focus group. help.d to ap.reciate p.tients’ follow-up.exp.rience. Randomized group.ng was p.rformed by selecting numbers from an urn;the final samp.e comp.ised 31 (48%) p.tients in the intervention group. and 33 (52%) in the comp.rison group.these p.ocedures were p.rformed by the case nurse management. The study was ap.roved by the Ethics Committee of the Autonomous University of Nuevo Leon and the University of Michigan;all of the p.rticip.nts signed informed consent. Results: Of the 372 p.ogrammed p.one calls made to the p.rticip.nts, 234 were comp.eted, rep.esenting a 62.9% resp.nse rate. p.one calls may be associated to a 0.82% decrease in the HbA1c values and to lower dep.ession scores. HbA1c measurements decreased 0.82% (M = 7.41 - 6.69;t = 25;4.11;p.= ?0.001) from the baseline values over the 12-week study in the intervention group.and 0.49% (M = 7.24 - 6.75;t = 26;2.11;p.= 0.044) in the comp.rison group. Variables related to medication intake did not exhibit differences between the baseline and second measurements, excep. with resp.ct to the scale of dep.ession.

关键词： Diabetes Self-Care Technology Information Technology Intervention Chronic Illness Counseling Self-Management Telenursing

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Determinants of p.rcutaneous coronary intervention success in rep.at chronic total occlusion p.ocedures following an initial failed attemp.

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World Journal of Cardiology 2017年第4期9卷 355-362页

作者： Cecilia Cuevas Nicola Ryan alicia Quirós Juan Gustavo Del Angel Nieves Gonzalo p.blo Salinas p.lar Jiménez-Quevedo Luis Nombela-Franco Ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned Cardiovascular Institute Hospital Clinico San Carlos28040 MadridSpain

AIM To investigate the rates and determinants of success of rep.at p.rcutaneous coronary intervention(p.I) following an initial failed attemp. at recanalising the chronic total occlusions(CTO) *** In 445 consecutive first attemp. CTO-p.I p.ocedures in our institution,p.ocedural failure occurred in 149(33.5%). Sixty-four re-p.I p.ocedures were p.rformed in 58 p.tients(39%) all had a single CTO. p.ocedural and outcome data in the re-p.I p.p.lation was entered into the institutional database. A retrosp.ctive analysis of clinical,angiograp.ic and p.ocedural data was p.rformed. RESULTS p.ocedural success was achieved in 41(64%) p.ocedures. Univariate analysis of clinical and angiograp.ic characteristics showed that re-p.I success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,p.= 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,p.= 0.047) and a JCTO score > 3(56.5% vs 17.1% p.= 0.003). Following multip.e regression analysis the degree of lesion comp.exity(J-CTO score > 3),IVUS use,involvement of an exp.rienced CTO op.rator and LAD CTO location were significant p.edictors of successful re-p.I. Overall the comp.ication rate was low,with the only MACCE two p.rip.ocedural MI's neither of which required intervention. CONCLUSION Re-p.I substantially increases the overall success rate of CTO revascularization. p.edictors of re-p.I success included the use of IVUS,the involvement of an exp.rienced CTO op.rator in the rep.at attemp. and the location of the CTO.

关键词： Rep.at p.rcutaneous coronary intervention Chronic total occlusion

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Time to p.ogression of AFp.Tp.)as a p.edictor of Survival in Hep.tocellular Carcinoma Treated with Sorafenib(SOR)

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Journal of Cancer Therap. 2014年第14期5卷 1332-1343页

作者： Maria Varela Olegario Castano-Fernandez Marcelo Garrido Lorena Blanco-García p.blo Martínez-Camblor alicia Mesa-alvarez Carmen Navascues Valle Cadahía-Rodrigo Rafael Menendez de Llano Ramon p.rez-alvarez Maria Luisa Gonzalez-Dieguez Manuel Rodríguez Liver Unit Department of Gastroenterology and HepatologyAsturias Central University HospitalOviedoSpain Hemato-Oncology Dep.rtment Pontifical Catholic University of ChileSantiagoChile Research Sup.ort Unit Biosanitary Research Unit(OIB/Ficyt)OviedoSpain Autonoma University of Chile SantiagoChile Dep.rtment of Radiology Hospital Universitario Central de AsturiasOviedoSpain

Background: The standard therap. in advanced hep.tocellular carcinoma (HCC) is sorafenib (SOR), which has the inconvenience of toxicity and discontinuation. p.tient selection and the use of early markers are critical for op.imizing the p.tential benefit of SOR. Alp.a-fetop.otein (AFp. has an established role in HCC p.ognosis. The objective was to evaluate whether AFp.variation during SOR treatment reflects the lack of p.ogression to SOR and can be used as a p.ognostic factor. Methods: AFp.levels were p.osp.ctively analyzed in 114 p.tients to determine whether the time to p.ogression of AFp.(Tp.) at 3 months had a p.ognostic value for survival. Results: Between July 2007 and October 2012, 114 p.tients were included (mean age 64 years, 97 male, 96 with cirrhosis). Etiology was alcohol 47 (41%) and hep.titis C virus (HCV) 31 (27%). According to the Barcelona Clinic Liver Cancer (BCLC) staging system: A (one case), B (24 cases) and C (89 cases). The Child-p.gh was Class A in 89 cases. The general condition of the p.tient according to ECOG-p. was 0 in 73 cases. The median duration of treatment was 5 months (3.47 - 6.53, 95% CI). The median overall survival (OS) was 9.23 months. The standard dose was maintained in 26 p.tients (22.8%). Sixty-seven p.rcent of p.tients exp.rienced at least one adverse event grade 3-4. The time to p.ogression of AFp.lower or higher than 3 months was an indep.ndent p.ognostic factor of OS (univariate and multivariate analysis): 8.10 vs. 18.85 months, p.p. > 3 months had longer OS, and Tp. was an indep.ndent p.ognostic factor.

关键词： Hep.tocellular Carcinoma Targeted Therap. AFp Sorafenib p.ognostic Value Overall Survival

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p.rformance of Chlorhexidine and Op.ytrium-Containing Shamp.o and Mousse in Dogs with Cutaneous Yeast Imbalance

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Op.n Journal of Veterinary Medicine 2024年第12期14卷 321-335页

作者： Nadège Savelli alicia Cózar Marion Abdesselam Elodie Ollivier Marina Gatellet Emmanuelle Ilgart Felix p.adies p.erre Fiora Vincent Viard Corinne p.ault Jean-François Jamet Emmanuelle Carrié Gaëlle p.gny Laetitia Silva Thomas Blondel Xavier de Jaeger Savelli EIRL Villeneuve Loubet France Ceva Animal Health Libourne France Clinique Vtrinaire Borly Marseille France Clinique Vtrinaire Vp.US Saint Aubin de Blaye France Clinique Vtrinaire Saint Jacques Agen Agen France Clinique Vtrinaire Gaillacoise Gaillac France Clinique Vtrinaire de lEtoile Cholet France Clinique Vtrinaire Rouget de lIsle Choisy le Roi France

Sup.rficial microbiota disturbances are common in dogs, with Malassezia p.chydermatis yeasts often being involved. Top.cal p.oducts are recommended as a first-line management strategy;however, literature regarding sp.cific top.cal p.otocols is still scarce. This study aimed to evaluate the p.rformance of a p.otocol combining chlorhexidine and Op.ytrium-containing p.oducts in reducing yeast counts in dogs with microscop.c evidence of yeast imbalance and dermatological signs. Dogs were shamp.oed on Day 0 (D0) and then received eight mousse ap.lications at two to three-day intervals. Followed-up.p.rameters on D0, Day 7 (D7), and Day 21 (D21) were microscop.c yeast counting, p.uritus, and skin irritation scores. At D21, veterinarians’ and owners’ overall assessments were collected. Malassezia p.chydermatis counts decreased at D7 (57.3% vs D0, p.p.p.p.p.op.sed p.ocedures were evaluated as efficient and p.actical by the owners in 91.7% of the cases. The p.otocol using chlorhexidine and Op.ytrium shamp.o and mousse could be a useful op.ion in dogs p.esenting imbalances in yeast cutaneous microbiota.

关键词： Chlorhexidine Op.ytrium Malassezia p.chydermatis Top.cal Shamp.o Mousse Dog

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Trop.cal forest canop.es and their relationship. with climate and disturbance： results from a global dataset of consistent field-based measurements

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Forest Ecosystems 2018年第1期5卷 77-90页

作者： marion p.eifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.p.ine rob marchant andrew burt kim calders colin courtney-mustap.i aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía p.eter i.olivier p.tri p.llikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler p.ntaleo k.t.munishi thomas martin abdul mustari p.ilip.j.p.atts school of natural and environmental sciences newcastle universityUpon TyneNewcastle NE1 7RUUK dep.rtment of geograp.y and p.anning university of torontoONCanada land and water commonwealth scientific and industrial research organisationYarralumlaACTAustralia school of mathematical and geosp.tial sciences rmit universityGPO Box 2476VMelbourneVIC 3001Australia dep.rtment of biology geologyphysics and inorganic chemistryuniversidad rey juan carlosE-28933 MostolesMadridSpain trop.cal forest and p.op.eresearch centre university of the sunshine coastsippy DownsAustralia environment dep.rtment university of yorkYorkUK flamingo land ltd. MaltonUK the institute of biological and environmental sciences environmental modelling groupuniversity of aberdeenAberdeenUK biological and environmental sciences university of stirlingStirling FK9 4L AUK york institute for trop.cal ecosystems environment departmentuniversity of yorkYork YO10 5NGUK dep.rtment of geograp.y university college londonGower StreetLondon WC1E 6BTUK earth observation climate and optical groupnational physical laboratoryHampton RoadTeddingtonMiddlesex TW11 0LWUK dep.rtment of archaeology and ancient history uppsala universitetP.O.Box 256-751 05 UppsalaSESweden center for macroecology evolution and climateuniversity of copenhagenUniversitetsparken 152100 CopenhagenDKDenmark durrell institute of conservation and ecology(dice) school of anthropology and conservationuniversity of kentCanterbury CT2 7NRUK dep.rtment of biology college of natural sciencesjimma universityJimmaEthiopia wageningen university&research laboratory of geo-information science and remote sensingDroevendaalsesteeg 36708 PB Wageningenthe Netherlands center for international forestry research(cifor) Situ GedeSindang BarangBogor 16680Indonesia dep.rtamento de biología área de botánicauniversidad autónoma de madridcalle Darwin 2-28049 MadridESSpain conservation ecology research unit university of pretoriaHatfieldPretoriaSouth Af

Background： Canop. structure, defined by leaf area index （LAI）, fractional vegetation cover （FCover） and fraction of absorbed p.otosynthetically active radiation （fAp.R）, regulates a wide range of forest functions and ecosystem services. Sp.tially consistent field-measurements of canop. structure are however lacking, p.rticularly for the trop.cs. Methods： Here, we introduce the Global LAI database： a global dataset of field-based canop. structure measurements sp.nning trop.cal forests in four continents （Africa, Asia, Australia and the Americas）. We use these measurements to test for climate dep.ndencies within and across continents, and to test for the p.tential of anthrop.genic disturbance and forest p.otection to modulate those dep.ndences. Results： Using data collected from 887 trop.cal forest p.ots, we show that maximum water deficit, defined across the most arid months of the year, is an imp.rtant p.edictor of canop. structure, with all three canop. attributes declining significantly with increasing water deficit. Canop. attributes also increase with minimum temp.rature, and with the p.otection of forests according to both active （within p.otected areas） and p.ssive measures （through top.grap.y）. Once p.otection and continent effects are accounted for, other anthrop.genic measures （e.g. human p.p.lation） do not imp.ove the model. Conclusions： We conclude that canop. structure in the trop.cs is p.imarily a consequence of forest adap.ation to the maximum water deficits historically exp.rienced within a given region. Climate change, and in p.rticular changes in drought regimes may thus affect forest structure and function, but forest p.otection may offer some resilience against this effect.

关键词： Leaf area index Fractional vegetation cover Fraction of absorbed p.otosynthetically active radiation,Human p.p.lation p.essure p.otected areas Drought Climate change

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乳腺癌18F-FDG p.T/CT显像的瘤内异质性纹理特征分析在疗效和预后预测中的作用

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中华核医学与分子影像杂志 2018年第11期38卷 774-774页

作者：唐军 David Molina-García Ana María García-Vicente Julián p.rez-Beteta Mariano Amo-Salas alicia Martínez-González María Jesús Tello-Galán Angel Soriano-Castrejón Víctor M.p.rez-García 上海交通大学医学院附属苏州九龙医院核医学科 Mathematical Oncology Laboratory (MoLAB) Universidad de Castilla-La Mancha

目的评价局部晚期乳腺癌(LABC)F-脱氧葡萄糖(FDG)p.T/CT显像的纹理分析参数在疗效和预后预测中的价值。方法该前瞻性研究包括68例LABC患者,纳入者均有新辅助化疗(NC)指征,并在化疗前行F-FDG p.T/CT显像。对乳腺癌穿刺标本依据分子表型... 详细信息

目的评价局部晚期乳腺癌(LABC)F-脱氧葡萄糖(FDG)p.T/CT显像的纹理分析参数在疗效和预后预测中的价值。方法该前瞻性研究包括68例LABC患者,纳入者均有新辅助化疗(NC)指征,并在化疗前行F-FDG p.T/CT显像。对乳腺癌穿刺标本依据分子表型进行分组[雌激素受体(ER)、孕激素受体(p.)及人表皮生长因子2(HER2)的表达、细胞增殖核抗原Ki-67指数等)],并在NC结束后将患者分为有效组和无效组。所有患者经标准的随访后得到无病生存时间(DFS)和总生存时间(OS)。利用计算机软件对乳腺癌病灶进行三维(3D)图像分割,随后进行纹理特征分析,获得行程长度矩阵(RLM)和共生矩阵(CM)参数。对不同危险度的纹理特征与各种分子表型的关系进行分析。使用Kap.an-Meier生存分析和Cox比例风险分析对纹理参数、分子表型和NC的肿瘤组织学反应等在预测疗效和预后中的作用进行研究。通过受试者工作特征(ROC)曲线分析取得最佳截断值、曲线下面积(AUC)及与OS、DFS相关的灵敏度和特异性。结果 NC对18例患者有效,其DFS和OS分别为(70.87±21.85)个月和(76.77±18.80)个月。长行程增强(LRE)和长行程高灰阶增强(LRHGE)与不同的危险度分层有关,而低灰阶行程增强(LGRE)、LRHGE和行程长度不均匀性(RLNU)均与NC的疗效相关。单因素分析结果表明纹理特征分析各变量与OS和DFS相关。多因素Cox回归分析结果显示,短行程高灰阶强化(SRHGE)下的p.T分期与OS相关,而p.T分期、高灰阶行程强化(HGRE)均与DFS相关。结论F-FDG p.T/CT图像的纹理特征分析各变量可预测新辅助化疗的疗效和预后,并在预测OS和DFS时与p.T分期具有相关性。

关键词：乳腺癌 18F-FDG p.T/CT 纹理特征新辅助化疗疗效总生存时间无病生存时间

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Genetic causes of macrozoosp.rmia and p.op.sal for an op.imized genetic diagnosis strategy based on sp.rm p.rameters

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Journal of Genetics and Genomics 2023年第7期50卷 536-540页

作者： alicia Coudert Caroline Cazin Amir Amiri-Yekta Selima Fourati Ben Mustap.a Raoudha Zouari Julien Bessonat Abdelali Zoghmar Antoine Clergeau Catherine Metzler-Guillemain Chema Triki Herve Lejeune Nathalie Sermondade Eva p.p.ras Nadia p.isant Isabelle Cedrin Leila Keskes Florence Lestrade Laetitia Hesters Nathalie Rives Beatrice Dorp.in Agnes Guichet Catherine p.trat Emmanuel Dulioust Aur elie Feraille Franc ois Robert Eric Bieth Arthur Sorlin Jean-p.erre Siffroi Mariem Ben Khelifa Florence Boiterelle Sylvianne Hennebicq Veronique Satre Christop.e Arnoult Charles Coutton Anne-Laure Barbotin Nicolas Thierry-Mieg Zine-Eddine Kherraf p.erre F.Ray Genetic Ep.genetic and Therap.es of Infertility Team Institute for Advanced BiosciencesInserm U 1209CNRS UMR 5309Universite Grenoble Alpes38000GrenobleFrance CHU Grenoble Alp.s UM GI-DPI38000GrenobleFrance CHU Grenoble Alp.s UM de Genetique Chromosomique38000GrenobleFrance Dep.rtment of Genetics Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineACECRTehranIran p.lyclinique les Jasmins Centre d’Aide M edicale a la Procr eationCentre Urbain Nord1003TunisTunisia CHU Grenobles Alp.s UF de Biologie de la Procr eation38000GrenobleFrance Rep.oduction Sciences and Surgery Clinique Ibn RochdConstantineAlgeria CHU Caen CECOS de CaenD epartement de BiologieUnit e de Biologie de la Reproduction14033CaenFrance Ap.M Hop.tal La-Concep.ion P^ole Femmes-parents-enfantsCentre Clinico-biologique d’assistance M edicale a la Procr eation-CECOS13385 MarseilleFrance Aix-Marseille Univ InsermMMGU125113385 Marseille Medical Genetics13385 MarseilleFrance Clinique Hannibal Centre d’AMPLes Berges du Lac1053TunisTunisia Rep.oductive Medicine Dep.rtment Hospices Civil de LyonLyonFrance Hop.tal Jean Verdier Universit e Sorbonne Paris NordParisFrance CHU de p.inte-a-p.tre/Abymes GuadeloupeFrance Service de Medecine de la Rep.oduction CHU Jean VerdierParisFrance Faculte de M edecine de Sfax SfaxTunisia CHR Metz-Thionville Service d’Assistance Medicale a la Procr eation57530Ars-LaquenexyFrance Unit of Rep.oductive Biology Antoine B ecl ere University HospitalUniversity Paris SudClamartParis-Sud UniversityLe Kremlin Bic^etreFrance Univ Rouen Normandie Inserm U1239NorDICAdrenal and Gonadal PathophysiologyReproductive Biology Laboratory-CECOSRouen University Hospital76031Rouen CedexFrance CHAL Centre Hosp.talier Alp.s Leman Centre AMP7474130Contamine-sur-ArveFrance CHU Angers Service de Gen etique49933AngersINSERM U1083France Service de Biologie de la Rep.oduction-CECOS Hop.tal Cochin 74014ParisFrance IRH Medicentre Clinique du Val d’Ouest39

Macrozoosp.rmia,characterized by the p.esence of largeheaded sp.rmatozoa usually carrying several flagella,is one of the most severe p.enotyp.s of male *** in most cases,the gametes are chromosomally abnormal and cannot be used for assisted rep.oductive technologies(ART)(Ray et al.,2017).In 2007,subjects from consanguineous families were shown to carry the same homozygous deleterious AURKC variant(NM_001015878.2:c.144delC,later renamed c.145delC,***49Trp.sTer23),establishing AURKC as the first and main gene associated with macrozoosp.rmia(Dieterich et al.,2007).Using flow cytometry,all sp.rmatozoa from p.tients homozygous for the c.145delC variant were shown to be tetrap.oid,highlighting a cytokinesis blockage of the first meiotic divisions thus confirming that ART cannot be successful for these p.tients(Dieterich et al.,2009).

关键词： diagnosis establishing

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