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From Simulation to Reality: A Comprehensive Study on the Efficacy of a Rotating Monopolar and Bipolar Radiofrequency System through In-Silico Modeling and Pre-Clinical and Clinical Validation

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Journal of Biomedical Science and Engineering 2024年第6期17卷 107-128页

作者： Gregorio Viera Mármol Ana Lorena Urbano Bojorge alicia robledo jorge José Antonio Ferrández Martínez Olalla Calvo Lozano High Technology Products S.L.U. (Sinclair) Barcelona Spain

Background: Skin aging is an unavoidable process aggravated by environmental agents. Among other energy devices, non-invasive radiofrequency (RF) technology is widely used for skin tightening and body contouring as it is simpler and more affordable than other technologies that also minimize pain and side-effects. However, most of the current RF devices do not provide automatic skin temperature control and it is difficult to achieve controlled, deep, and harmless thermal increase, so treatment performance and safety is dependent on the operator’s movements and expertise. Objective: To show the potential of numerical simulations for optimizing the design of monopolar and bipolar RF electrodes that are capable of providing homogeneous, deep and controlled heating. Materials and methods: In-silico models were developed and analyzed using Comsol Multiphysics software to simulate the RF effect produced in tissue by rotating monopolar and bipolar electrodes with different geometries from the Sculpt & Shape RF device (Sinclair, Spain), operating at frequencies of 0.5 and 1 MHz. Ex-vivo and in-vivo proof-of-concept tests were carried out to validate the simulations. Finally, treatments were performed on 16 subjects and a total of 78 body areas to assess the clinical results generated by the RF electrodes for skin tightening and body contouring. Results: In-silico studies emulated the superficial and deep dispersion of heat due to the release of RF energy into human skin tissue. The rotating electrodes (monopolar and bipolar) and the selected RF frequency (0.5 and 1 MHz) determined the homogeneity of the thermal distribution, the penetration depth (between 4.37 mm and 25.0 mm) and the heating dynamics (between 30 and 100 seconds to reach the target skin temperature), which were confirmed by ex-vivo and in-vivo tests. In addition, real treatments on facial and body areas using skin temperatures of between 43˚C and 44˚C showed consistent results with good clinical efficacy for

关键词： Comsol Multiphysics Simulations Radiofrequency Skin Tightening Fat Reduction Body Contouring Cellulite

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New Rotative Radiofrequency Technology: A Multicenter Retrospective Study on Efficacy and Safety

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 69-83页

作者： José Antonio Ferrández Martínez Gregorio Viera Mármol Fabrizio Vignoli Joanet Perera Agustin Blanch Mara Suárez alicia robledo jorge Reyna Vargas Lamas Sinclair Barcelona Spain Studio Vignoli Bologna Italy Clinica Perla Medic Alicante Spain Dr. Agustin Blanch Clinica Barcelona Spain Intek Medical Technology S.L.U. Barcelona Spain

Background: Non-ablative radiofrequency (RF) technology is widely used for the treatment of signs of aging, skin laxity, localized fat and cellulite. However, many RF devices suffer from technical limitations that make the results highly dependent on the user’s experience or clinical limitations that compromise safety, efficacy and comfort. Objective: To evaluate the efficacy and safety of a novel semi-automatic non-ablative RF device for skin tightening, body shaping and cellulite reduction. Materials and methods: A retrospective multicenter study was performed using a novel rotative RF device with temperature and impedance control (Sculpt&Shape®, Sinclair, Spain). 58 subjects underwent a minimum of 4 treatments every 1-2 weeks. A total of 120 treatments (56.7% body and 43.3% facial) and 1034 sessions were performed. Efficacy was evaluated by 3 researchers using the Global Aesthetic Improvement Scale (GAIS) and anthropometric measurements were collected. Subject and practitioner satisfaction were recorded. Safety was evaluated by analyzing the perception of pain during the treatment and the side and adverse effects immediately after treatment and over the next 48 hours. Results: Between 25% and 50% improvement was achieved according to the GAIS. Statistically significant (p < 0.01) abdominal fold reduction of 5.1 mm and circumference reduction of 32.0 mm, 16.4 mm and 13.9 mm were recorded for the abdomen, legs and arms, respectively. 77.5% of subjects and 94.9% of practitioners were either satisfied or very satisfied. Minor adverse effects were found in 0.97% of the sessions. Conclusion: This novel semi-automatic rotative RF device has been found to provide treatments that are effective, safe and comfortable for both practitioners and subjects. .

关键词： Rotative Radiofrequency RF Cellulite Skin Tightening Body Shaping

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From Simulation to Reality: A Comprehensive Study on the Efficacy of a Rotating Monopolar and Bipolar Radiofrequency System through In-Silico Modeling and Pre-Clinical and Clinical Validation

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Journal of Biomedical Science and Engineering（生物医学工程） 2024年第6期 107页

作者： Gregorio Viera Mármol Ana Lorena Urbano Bojorge alicia robledo jorge José Antonio Ferrández Martínez Olalla Calvo Lozano

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New Rotative Radiofrequency Technology: A Multicenter Retrospective Study on Efficacy and Safety

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Journal of Cosmetics, Dermatological Sciences and Applications（化妆品、皮肤病及应用期刊） 2024年第1期 69页

作者： José Antonio Ferrández Martínez Gregorio Viera Mármol Fabrizio Vignoli Joanet Perera Agustin Blanch Mara Suárez alicia robledo jorge Reyna Vargas Lamas

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Rainfall Sensitivity to Microphysics and Planetary Boundary Layer Parameterizations in Convection-Permitting Simulations over Northwestern South America

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Journal of Meteorological Research 2024年第4期38卷 805-825页

作者： K.Santiago HERNANDEZ Sebastian GOMEZ-RIOS Juan J.HENAO Vanessa robledo Alvaro RAMiREZ-CARDONA Angela M.RENDON Geolimna Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Grupo de Ingenieria y Gestion Ambiental(GIGA) Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Division of Atmospheric Sciences Desert Research InstituteRenoNV 89512USA

Convection-permitting modeling allows us to understand mechanisms that influence rainfall in specific ***,microphysics parameterization(MP) and planetary boundary layer(PBL) schemes remain an important source of uncertainty,affecting rainfall intensity,occurrence,duration,and ***,we study the sensitivity of rainfall to three MP [Weather Research and Forecasting(WRF) Single-Moment 6-class(WSM6),Thompson,and Morrison] and two PBL [the Yonsei University(YSU) and Mellor–Yamada Nakanishi Niino(MYNN)] schemes with a convection-permitting resolution(4 km) over northwestern South America(NWSA).Simulations were performed by using the WRF model and the results were evaluated against soundings,rain gauges,and satellite data,considering the spatio-temporal variability of rainfall over diverse regions prone to deep convection in *** and PBL schemes largely influenced simulated rainfall,with better results for the less computationally expensive WSM6 MP and YSU PBL *** rain gauges and satellite estimates,simulations with Morrison MP overestimated rainfall,especially westward of the Andes,whereas the MYNN PBL underestimated precipitation in the Amazon–Savannas *** found that the uncertainty in the rainfall representation is highly dependent on the region,with a higher influence of MP in the Colombian Pacific and PBL in the Amazon–Savannas *** analyzing rainfall-related processes,the selection of both MP and PBL parameterizations exerted a large influence on the simulated lower tropospheric moisture flux and moisture *** schemes significantly influenced the downward shortwave radiation,with MYNN simulating a greater amount of low clouds,which decreased the radiation ***,latent heat fluxes were greater for YSU,favoring moist convection and *** schemes had a marked impact on vertical ***,Morrison MP showed stronger convection and higher precipitation rates,which is assoc

关键词： sensitivity microphysics planetary boundary layer(PBL) Weather Research and Forecasting(WRF) processes

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Review of Networked Microgrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 448-467页

作者： jorge de la Cruz Ying Wu John E.Candelo-Becerra Juan C.Vasquez Josep M.Guerrero Center for Research on Microgrids(CROM) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de Minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on Microgrids at UPC(UPC CROM) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on Microgrids at AAU(AAU CROM) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked *** protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and ***,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected *** of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection *** paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to ***—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

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Laws of Zipf and Benford, intermittency, and critical fluctuations

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Chinese Science Bulletin 2011年第34期56卷 3643-3648页

作者： robledo Alberto Instituto de Física Universidad Nacional Autónoma de México Grupo Interdisciplinar de Sistemas Complejos Departamento de Matemáticas Universidad Carlos III de Madrid

We describe precise equivalences between theoretical descriptions of: (i) size-rank and first-digit laws for numerical data sets, (ii) intermittency at the transition to chaos in nonlinear maps, and (iii) cluster fluctuations at criticality. The equivalences stem from a common statistical-mechanical structure that departs from the usual via a one-parameter deformation of the exponential and logarithmic functions. The generalized structure arises when configurational phase space is incompletely visited such that the accessible fraction has fractal properties. Thermodynamically, the common focal expression is an (incomplete) Legendre transform between two entropy (or Massieu) potentials. The theory is in quantitative agreement with real size-rank data and it naturally includes the bends or tails observed for small and large rank.

关键词：间歇性法律波动 Legendre变换变形结构非线性映射理论描述统计力学

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Electrical Discharges in Planetary Atmospheres： Review and Selected Experiments

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高电压技术 2013年第9期39卷 2089-2094页

作者： A. robledo-Martinez Universidad Aut6noma Metropolitana Av. San Pablo 180 02200 Mexico City Mexico

Beyond Earth,electrical discharges have also been observed,or postulated to exist,on other bodies of the Solar *** this work the state of the art of research on electrical discharges in the atmosphere of several planets and one moon is *** main charging mechanisms as well as the discharge characteristics and its effect on the atmosphere are *** of the current research activities being carried out by the author’s team are also *** lab simulations can achieve realistic plasma parameters;for example:the arc temperature in the lab was found to be 33 000 K which compares favourably with field observations reporting temperatures～30 *** lab work with a synthetic Mars atmosphere allow us to predict that the conjunction of electrostatic discharges and the presence of water ice could lead to the production of methane with an efficiency of up to 1021molecules per joule of applied energy.

关键词：实验室模拟行星大气放电特性等离子体参数实验室工作状态报告研究活动观测报告

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Fabrication of paper-based devices for in vitro tissue modeling

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Bio-Design and Manufacturing 2020年第3期3卷 252-265页

作者： Hongbin Li Feng Cheng Juan A.robledo-Lara Junlong Liao Zixuan Wang Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA College of Light Industry and Textile Qiqihar UniversityQiqihar 161000HeilongjiangPeople’s Republic of China Departamento de Ingeniería Mecatrónica y Eléctrica Escuela de Ingeniería y CienciasTecnológico de MonterreyCP 78211 San Luis PotosíSan Luis PotosíMexico

Paper devices have recently attracted considerable attention as a class of cost-effective cell culture substrates for various biomedical *** paper biomaterial can be used to partially mimic the in vivo cell microenvironments mainly due to its natural three-dimensional *** paper-based devices provide precise control over their structures as well as cell distributions,allowing recapitulation of certain interactions between the cells and the extracellular *** features have shown great potential for the development of normal and diseased human tissue *** this review,we discuss the fabrication of paper-based devices for in vitro tissue modeling,as well as the applications of these devices toward drug screening and personalized *** is believed that paper as a biomaterial will play an essential role in the field of tissue model engineering due to its unique performances,such as good biocompatibility,eco-friendliness,cost-effectiveness,and amenability to various biodesign and manufacturing needs.

关键词： Paper-based devices In vitro Tissue modeling Disease modeling Drug screening Personalized medicine

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Wound healing activity of Ullucus tuberosus,an Andean tuber crop

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 538-543页

作者： Nathalie Heil Karent Bravo Andrés Montoya Sara robledo Edison Osorio Grupo de Investigación en Sustancias Bioactivas Facultad de Ciencias Farmacéuticas y AlimentariasUniversidad de Antioquia PECET–Medical Research Institute School of MedicineUniversity of Antioquia

Objective:This study was designed to investigate the wound healing activity of aqueous extracts of Ullucus tuberosus(***) using in vitro ***:Lyophilized pulp and acetone extracts of *** were produced using ultrasound *** capacity for collagenase activation was evaluated using fluorescence detection of the enzymatic ***,the influence of *** extracts on cell proliferation,cell migration and synthesis of the extracellular matrix(ECM)proteins,metalloproteinase(MMP-1) and pro-collagen was analyzed using human dermal fibroblasts in ***:An increase in collagenase activity of 12% supports the utility of *** as an agent for scar *** addition,the extracts showed an increase in the proliferation and migration of human dermal fibroblasts and the production of pro-collagen and MMP-1 after treatment with *** *** increase in proliferation,migration and pro-collagen levels positively influenced the regeneration of scarless tissue during the proliferation phase,whereas the increase in MMP-1 may have favored the wound healing process during the remodeling and cellular differentiation ***:The results of this study show for first time that *** is a promising candidate to support scarless tissue regeneration.

关键词： Wound healing Collagenase Pro-collagen MMP-1 Ullucus tuberosus

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